SURGICAL SITE INFECTION

This study tests if a special 'figure-of-X' stitching method can lower the risk of the belly wound bursting open after colorectal cancer surgery, compared to the usual continuous stitch. About 40 adults having open surgery will take part. The goal is to see which method leads to …

This study tests whether placing vancomycin powder directly into the wound during spine surgery can prevent infections in patients at high risk. About 76 adults having open back surgery for spinal deformity, trauma, or tumors will take part. Half will get the powder, half will no…

This study compares a special bioelectric wound dressing to the standard chlorhexidine skin cleaning for preventing infections after colon surgery. About 20 adults having elective surgery for diverticulitis, polyps, or colon cancer will take part. Researchers will measure bacteri…

This study tests whether giving tranexamic acid before major gastrointestinal surgery can lower the chance of delirium (sudden confusion) after the operation. Delirium is common in older or frail patients and may be caused by inflammation harming the brain. The trial involves 826…

This study tests whether adding a local antibiotic (tobramycin) directly into the wound, along with standard IV antibiotics, can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because blood flow to the injured area is often poor. T…

This study looks at whether applying povidone iodine (a germ-killing solution) inside the nose before surgery can lower the chance of getting a serious infection after fixing severe leg, ankle, or foot fractures. About 2000 adults having high-energy fracture repair will receive t…

This study tests whether taking a single dose of antibiotic just before certain skin surgeries can lower the chance of infection afterward. About 574 adults having surgery on the nose, ear, or lower leg will be randomly given either the antibiotic or a placebo pill. Researchers w…

This study watches 120 adults having planned abdominal surgery to see how their gut bacteria change during the operation. Researchers collect samples like blood and tissue to check if these changes allow bacteria to move to other parts of the body and cause surgical site infectio…

This study looks at whether bacteria from the gut can travel to other parts of the body during abdominal surgery and cause wound infections. About 209 adults having planned abdominal surgery will provide skin, gut, blood, and tissue samples. Researchers will use genetic sequencin…

This study looks at how certain immune cells (neutrophils) behave in patients having open gastrointestinal or spine surgery. Researchers want to see if differences in these cells can help explain why some people get surgical site infections. The goal is to better understand and p…

This study is collecting samples from over 1,200 surgery patients to see if changes in the body's chemistry can predict surgical site infections. The goal is to find early warning signs that could help personalize care. No treatment is being tested—only observation and analysis.…