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Spinal vs. general anesthesia: which protects leg tissue better during surgery?

NCT ID NCT07474480

Knowledge-focused Sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 60 adults having leg surgery with a tourniquet to see if spinal or general anesthesia better maintains blood flow in the leg. Researchers used a light-based sensor to measure tissue oxygen levels. The goal was to understand which method might reduce injury from reduced blood flow.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Mar 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18 to 65 years with ASA physical status I-II who were scheduled for elective lower extremity orthopedic surgery with tourniquet use at Prof. Dr. Cemil Taşcıoğlu City Hospital between 01 March 2025 and 30 September 2025. Eligible patients were assessed consecutively and enrolled after providing informed consent. Patients were analyzed in 2 observational cohorts according to anesthesia method used in routine clinical practice: general anesthesia and spinal anesthesia.

Ages

18 to 65 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 65 years * Scheduled for elective lower extremity orthopedic surgery * ASA physical status I or II * Expected operation duration 30 to 120 minutes * Expected tourniquet duration 30 to 90 minutes * Informed about the anesthesia method and agreed to participate voluntarily * No contraindication to neuraxial block Exclusion Criteria: * Refusal to participate * History of peripheral arterial disease, diabetic neuropathy, or advanced vascular insufficiency * Severe or uncontrolled systemic disease, including ASA III or higher * Coagulopathy, local infection, or contraindication to spinal anesthesia * Body mass index greater than 35 kg/m² * Pregnancy or impaired consciousness * Intraoperative hemodynamic instability or anticipated instability * Need for additional intraoperative sedative or analgesic medication * Inability to obtain adequate and reliable NIRS signal for technical reasons

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Conditions

The condition(s) this trial relates to.

ischemia reperfusion injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

General anesthesia Lower extremity surgery Tissue perfusion Tourniquet-induced ischemia-reperfusion injury

Contacts and locations

Locations

  • Cemil Tasciogu Research and Training Hospital

    Istanbul, Sisli, Turkey (Türkiye)

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