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Ketamine may cut opioid needs for trauma patients

NCT ID NCT04833816

Symptom relief Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as well. The trial involved 140 adults with multiple severe injuries and compared ketamine to a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

140 people

The number who actually took part.

Started

Aug 2022

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female adult * Trauma patient presenting at least 2 lesions in two different regions as defined by the ISS (injury severity score) (Head or neck, Face, Thorax, Abdomen and pelvic contents, Upper limbs or pelvic girdle, Lower limbs, External (any skin surface). * Patient presenting at least two regional disorders classified as moderate to maximum defined by an AIS (Abbreviated Injury Scale)\> 1. * Patient having signed an informed consent Exclusion Criteria: * Patients with an indication for deep sedation (intracranial hypertension or acute respiratory distress syndrome). * Patient in whom the infusion could not be started within the first 6 hours of initial treatment. * Patient whose state of consciousness is incompatible with understanding the protocol. * Patient with chronic unbalanced arterial hypertension. * Patient with severe heart failure. * Patient with a BMI\> 35 kg / m² or a weight of more than 120 kg. * Patient with chronic analgesic consumption defined by consumption of opioid derivatives for more than a week for an intercurrent illness. * Presence of a history of chronic pain. * Presence of a history of epilepsy. * Presence of a history of psychosis or drug addiction. * Presence of a history of stroke. * Patients with an allergy to the molecule or excipients composing ketamine * Patients with an allergy to the molecule or to the excipients making up sufentanil or paracetamol. * Pregnant or breastfeeding woman. * Patient not understanding French. * Protected adult patient (under guardianship, curatorship or legal protection).

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Conditions

The condition(s) this trial relates to.

agnosia injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Traumatic injury

Contacts and locations

Locations

  • Service Anesthésie Réanimation - Hôpital nord

    Marseille, 13015, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.