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Soccer headers: do mouthguards protect your brain?

NCT ID NCT04426188

Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how heading a soccer ball changes the brain and whether wearing a mouthguard makes a difference. Twenty-one male soccer players did 10 headers in two sessions—once with a mouthguard and once without. Before and after, they had brain scans, cognitive tests, and measurements of neck strength and jaw muscle activity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help understand how soccer headers affect the brain and whether mouthguards reduce that impact.
What could go wrong
This is a very small, early study with only 21 male players. It looks at short-term changes, not long-term brain health, so results may not apply widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Jun 2020

Finished

Jan 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 25 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Male 18 to 25 years, enrolled in French Social Security, recruited from the soccer teams of the University of Bordeaux Exclusion Criteria: * Abnormal neurological examination * Taking drugs targeting the central nervous system * Any unhealed injury * History of head trauma, or other notion of central nervous system injury * History of severe high blood pressure, diabetes, chronic cardiovascular pathology, progressive or debilitating disease * Family history of epilepsy * Contraindication to MRI: head circumference\> 60 - Claustrophobia - Pacemaker, Implantable Neurostimulation, Implantable Defibrillator - Cochlear Implants - Ocular or cerebral ferromagnetic foreign body - refusal to be informed of an anomaly detected with MRI * Individuals under legal protection or unable of giving their informed consent

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Conditions

The condition(s) this trial relates to.

Brain Concussion Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Concussion, brain Traumatic brain injury

Contacts and locations

Locations

  • CHU de Bordeaux

    Bordeaux, 33 076, France

More trials for these conditions

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