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Shock and awe: new combo therapy sparks hope for paraplegia recovery

NCT ID NCT04790149

Disease control Sponsor: Lebanese University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether combining a mild brain stimulation technique (tDCS) with a new mental and physical rehab method (NEUROM) can help people with chronic spinal cord injury regain leg movement and feeling. Fifty-six participants with paralysis below the lower back were randomly assigned to different rehab groups. The goal was to see if the combo approach boosts recovery more than standard therapy alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS) combined with a motor imagery and exercise protocol called NEUROM
What this could lead to
If it works, this could point toward a non-invasive way to improve leg movement and sensation in people with chronic spinal cord injury.
What could go wrong
This is a small, early-stage trial with only 56 participants. The results may not apply to everyone, and the improvements might be modest or not last long.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

56 people

The number who actually took part.

Started

Dec 2022

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Age: Between 16 and 45 years. * Diagnosis: Chronic spinal cord injury (at least 3 months post-injury). * Level of Injury: Lower dorsal (below T10) or lumbar. * Classification: American Spinal Injury Association Impairment Scale (AIS) grade A, B, or C. * Signed Informed Consent. Exclusion Criteria * Comorbidities: Neuropsychiatric comorbidities or Traumatic Brain Injury (TBI). * Concurrent Treatment: Involvement in any specific rehabilitation program other than the conventional protocol since injury. * tDCS Contraindications: Presence of metal in the head or implanted medical devices (e.g., pacemaker, cochlear implant). * Seizure History: Any history of epilepsy or seizures. * Medications: Current use of medications containing sodium channel blockers (e.g., carbamazepine) or history of substance abuse. * Spasticity: Severe spasticity defined as a Modified Ashworth Scale score ≥ 3. Crucial Data Fixes (You must update these fields in the registry UI):

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injuries

Contacts and locations

Locations

  • Lebanese University

    Beirut, Lebanon

More trials for these conditions

Other studies related to the condition(s) this trial covers.