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Simple heparin dressing may reduce scars and pain after skin grafts

NCT ID NCT07196358

Disease control Sponsor: Dr. Ruth K.M. Pfau Civil Hospital, Karachi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a dressing soaked in heparin, a blood-thinning medicine, can prevent thick, raised scars and reduce pain at the site where skin is taken for a graft. 400 patients each had one donor site treated with standard care and the other with a heparin dressing. The researchers compared scarring and pain over three months to see if this low-cost method improves healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
heparin (topical solution)
What this could lead to
If it works, this could offer a simple, low-cost way to reduce scarring and pain after skin graft surgery.
What could go wrong
This is a completed study, but results are not yet widely confirmed. The effect may be modest, and heparin can cause allergic reactions in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

400 people

The number who actually took part.

Started

Aug 2024

Finished

Sep 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients of age 2 years and above, of any gender. Patients requiring a split-thickness skin graft. Patients giving informed consent for study participation. Patients with serum albumin \> 3 g/dL. Exclusion Criteria: * Patients allergic to heparin. Patients with diabetes, hematological disorders, kidney or liver diseases, or malignancies. Patients on medications affecting wound healing. Patients with existing hypertrophic scarring at the donor site

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Conditions

The condition(s) this trial relates to.

Cicatrix, Hypertrophic injury Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertrophic scarring Pain, postoperative Wound healing

Contacts and locations

Locations

  • Plastic & Reconstructive Surgery Department, Ruth Pfau Civil Hospita

    Karachi, Sindh, Pakistan

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