New study targets lingering concussion symptoms in teens
NCT ID NCT05446597
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested three different treatment approaches for teens aged 13-19 who had a concussion within the past three weeks and were still experiencing moderate to severe symptoms like headaches, dizziness, and neck pain. The goal was to see if early, symptom-specific treatments could reduce symptom burden and speed up return to normal activities. The trial compared a headache-focused nerve block, a dizziness/neck pain physiotherapy program, and a general 'lite' combination of advice and relaxation techniques.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Greater Occipital Nerve Block, cervicovestibular physiotherapy, and a lite combination of headache advice, general physiotherapy, mindfulness, visualization, and relaxation
- What this could lead to
- If successful, this could point toward better, personalized treatment plans for teens recovering from concussion, reducing long-term symptoms.
- What could go wrong
- This is a small, completed trial with only 62 participants, so results may not apply to all teens. The treatments are early-stage and may not work for everyone.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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62 people
The number who actually took part.
- Started
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Apr 2023
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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13 to 19 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 13 - 19 years of age at the start of treatment * Diagnosed by the study physician with a concussion as per the 5th International Consensus Statement on Concussion in Sport1 * Glasgow Coma Scale 13-15 if recorded * Loss of consciousness \< 30 minutes if present * Post-traumatic amnesia \< 24 hours if present * Diagnosis within 2 weeks of injury * Moderate-severe symptoms of dizziness, neck pain, headaches, or sleep disturbance at \> one week and \< three weeks post injury reported on the PCSS (3-6 on 0-6 Likert scale for at least one of three symptoms) * Patients can have a history of migraine or a family history of migraine Exclusion Criteria: * Inability to communicate orally and/or in writing in English language * Significant developmental delay or intellectual disability * No access to smartphone or computer * Red flags or other clinical indication suggesting that further medical investigation is warranted (e.g., neurological scan - reflexes, dermatomes, myotomes, long tract signs, CN II-XII, Cerebellar Scan * Unresolved Benign Paroxysmal Positional Vertigo (BPPV) (Dix-Hallpike and Roll Test) * Inability to participate in physical activity for a reason other than concussion * Orthopedic or other injury precluding ability to participate * Medical history of neurological conditions: seizures (febrile SZ will be allowed), stroke, previous moderate/severe TBI, CNS cancers, SCI * Psychotic disorder * Inability to provide informed consent * History of surgery in the occipital region * Uncontrolled rheumatologic, inflammatory, or neurologic disorders (eg MS); Fibromyalgia/chronic fatigue syndrome; coagulopathy; immunosuppression * Active cancer * Herpes zoster infection in last 6 months * Pregnancy * Steroid injection to the greater or lesser occipital nerve infiltration in past 3 months * Previously enrolled in the trial
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Calgary
Calgary, Alberta, T2N 1N4, Canada
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Other studies related to the condition(s) this trial covers.
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