Walking it off: treadmill training may boost fitness and mood in brain injury survivors

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: Subjects eligible for participation in this research study must meet the following inclusion criteria: 1. Diagnosis of non-penetrating mild, moderate, or severe TBI 2. Injury occurred at least 6 months prior to enrollment 3. Age 21-45 years 4. Physically inactive as identified by a physician. 5. Able to stand and walk on a treadmill independently and safely without assistance 6. Able to follow the study protocol 7. Fluent in English and able to provide informed consent 8. Willing and safely able to forego starting or changing an exercise program or treatments that would potentially alter cardiorespiratory capacity or ability to exercise and/or treatment for mood disorders EXCLUSION CRITERIA: Subjects are not eligible for participation in this research study if any of the following medical conditions that would impair aerobic capacity or the ability to engage in physical activity exist, including diseases of the cardiovascular (other than hypertension controlled by medication to below 140/90 mmHg), pulmonary, neurological, metabolic, or musculoskeletal systems such as: 1. Diagnosis or history of ischemic heart disease, including those with CABG and PTCA 2. Dilated or hypertrophic cardiomyopathy 3. Non-idiopathic cardiomyopathy 4. Uncontrolled hypertension, defined as a resting blood pressure above 140/90 mmHg 5. Diagnosis or history of right or left-sided heart failure or pulmonary hypertension 6. Diagnosis or history of restrictive or obstructive lung disease 7. Diagnosis or history of stroke 8. Type I or Type II Diabetes Mellitus 9. Diagnosis of chronic kidney disease, chronic liver disease, acute kidney injury or acute liver failure 10. Metastatic cancer active within the previous five years 11. Mitochondrial disease 12. On medications that would influence aerobic capacity, the ability to adapt to exercise training, or treadmill performance such as beta blockers or antiretroviral therapy 13. Active substance abuse including ETOH 14. Ongoing tobacco use (any use within the past six months) 15. Medical or Psychological instability such that the subject could not reasonably be expected to fulfill the study requirements 16. Pregnancy 17. BMI greater than 40 kg/m(2)