National Institutes Of Health Clinical Center (cc)

This study tests whether spironolactone, a drug already used for fluid retention, can improve exercise ability and blood vessel health in people with pulmonary arterial hypertension (PAH). About 70 adults with PAH will take either spironolactone or a placebo for 24 weeks. Researc…

This study explores whether a community-based cooking program can help African American adults in Washington, D.C. who are at risk for heart disease cook and eat healthier. Participants will attend cooking classes led by a trained chef and share their experiences. The goal is to …

This study tests a robotic leg brace (exoskeleton) designed to improve walking in children aged 3 to 17 with conditions like cerebral palsy, spina bifida, muscular dystrophy, or incomplete spinal cord injury. The device can assist or resist leg movement during walking. The trial …

This study looks at how well a new robotic leg brace (exoskeleton) helps children and young adults with muscle weakness from conditions like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury. Researchers will test the device during different activities like …

This study aims to collect information on the signs, symptoms, and progression of RYR1-related disorders, a group of genetic muscle conditions. About 150 people aged 7 and older with a confirmed RYR1-related disorder will participate. Participants will have yearly visits for 3 to…

This study looks at proteins in lung fluid from people with pneumonia to find out what is causing their lung inflammation. Researchers hope to discover protein patterns that can help doctors diagnose different types of pneumonia more accurately. About 750 patients already schedul…

This study uses MRI and ultrasound to see how muscles, tendons, and bones move together during activities like bending the knee. Researchers hope to learn more about normal and impaired movement to improve diagnosis and treatment of joint problems. Healthy volunteers and people w…

This study aims to develop better ways to perform MRI scans by testing new imaging techniques in healthy volunteers and current NIH participants. Up to 1,000 adults aged 18 and older will have one or more MRI scans, each lasting 20 minutes to 2 hours, with some requiring contrast…

This study collects blood from up to 5,000 healthy paid volunteers to provide samples for laboratory research at NIH and FDA. Donors give blood through standard donation or apheresis. The blood is used for in vitro studies only, not for treating people. The goal is to support bas…

This study looks at how stress and mouth inflammation are linked in people with alcohol use disorder (AUD). Researchers will test a new oral health questionnaire and collect saliva, blood, and dental X-rays from 72 participants (AUD patients and healthy volunteers). The goal is t…

This study looks at how diet and eating habits affect the health of adults with sickle cell disease. Researchers will interview participants about their food intake and behaviors, collect blood and urine samples, and have them complete surveys. The goal is to understand links bet…

This study looks at how children and young adults with cerebral palsy (CP) move, using special sensors like ultrasound, EEG (brain wave cap), and muscle stickers. Participants will do simple movements with and without a robotic leg brace. The goal is to gather data to make future…

This study follows people with pulmonary arterial hypertension (PAH) and healthy volunteers to see how the disease progresses. Researchers will use blood tests, heart and lung imaging, and walking tests to find new markers that could lead to better treatments. About 270 adults ag…

This study aims to improve how we collect infection-fighting white blood cells (granulocytes) from healthy volunteers. Donors receive two drugs before donation to move cells into the bloodstream for collection. The goal is to build a reliable donor program to help patients with l…

This study tests a new genetic method to find bacteria, viruses, and other germs in the blood of people getting a stem cell transplant. Infections are a major risk for these patients, and standard tests may miss them. By taking blood samples before and up to 6 months after transp…

This study collects blood and urine samples from healthy volunteers and patients to help researchers study genes, proteins, and other substances. The goal is to develop new lab tests and better understand diseases. Participants must be 18 or older and can join if they have certai…

This study uses safe brain imaging techniques (NIRS and EEG) to see how the brain controls movement in people with cerebral palsy and healthy volunteers. Researchers will compare brain activity patterns and test if biofeedback training can help improve movement coordination. The …

This study aims to collect information on how people move their limbs and bodies, both normally and when affected by movement disorders. Up to 7,500 volunteers, from one month old to elderly, will perform tasks like walking or reaching while cameras and sensors record their motio…

This study compares brain activity and pain responses between people with intellectual disability (ID) and healthy volunteers. Participants aged 8 to 30 will receive mild heat, cold, brushing, or electrical stimuli while wearing a brain-monitoring cap. The goal is to better under…