National Institutes Of Health Clinical Center (cc)

This study is testing if spironolactone, a drug often used for heart failure, can help people with pulmonary arterial hypertension (PAH), a rare and serious condition of high blood pressure in the lungs. Researchers want to see if the drug can improve how far patients can walk an…

This study is exploring whether community-based cooking classes can help African American adults in specific Washington D.C. neighborhoods reduce their risk of heart disease. Researchers want to see if learning to cook healthy meals at home can improve eating habits and lower ris…

This early-stage study is testing the safety of a single injection of an experimental, non-opioid drug called resiniferatoxin (RTX) for people with severe, treatment-resistant foot pain from Morton's neuroma. The goal is to see if this injection can provide long-lasting pain reli…

This study is testing whether a robotic exoskeleton worn on the legs can improve walking ability in children with movement disorders like cerebral palsy or spina bifida. Children aged 3 to 17 will use the device at home for 12 weeks to see if it helps their knee movement and walk…

This study is testing whether watching calming nature scenes through a virtual reality (VR) headset can help reduce stress in people caring for a loved one after a bone marrow transplant. Caregivers will use a VR headset daily for four weeks while researchers measure their stress…

This study aims to collect blood and urine samples from healthy adults and patients with certain heart, lung, or blood vessel conditions. The samples will be used by researchers to develop new laboratory tests and to better understand how genes, proteins, and other substances in …

This study aims to discover protein patterns in lung fluid that could help identify specific types of pneumonia. Researchers will analyze fluid collected from 750 patients undergoing standard lung examination procedures. The goal is to find biological markers that distinguish bet…

This study collects blood from healthy, paid volunteers to supply scientists at the National Institutes of Health (NIH) and the Food and Drug Administration (FDA) for laboratory research. The goal is to provide researchers with the materials they need to study diseases and develo…

This study aims to better understand how children and young adults with cerebral palsy move by testing new measurement technologies. Researchers will use sensors, ultrasound, and a robotic leg brace to record brain activity, muscle function, and movement patterns during simple ta…

This study aims to develop better MRI scanning methods and create new imaging techniques. Researchers are recruiting 1,000 healthy volunteers and people with cardiac risk factors to undergo MRI scans that will help optimize scanning parameters. Participants will have one or more …

This study aims to develop better tools for diagnosing movement problems by creating detailed 3D images of bones, muscles, and tendons while they are in motion. Researchers will use MRI and ultrasound scans on up to 750 volunteers, including both healthy people and those with joi…

This study aims to understand how the brain controls movement in children with cerebral palsy compared to healthy children. Researchers will use safe, non-invasive brain scanning techniques (NIRS and EEG) while participants perform simple tasks. The goal is to gather knowledge th…

This study aims to understand the connection between alcohol use disorder, oral health, and body-wide inflammation. Researchers are recruiting 72 people, including those being treated for alcohol use disorder and healthy volunteers, to test a new oral health survey and collect sa…

This study aims to understand how a common anesthesia drug, propofol, changes proteins in a person's blood. Researchers will collect small blood samples from 10 adults before and after they receive propofol for scheduled surgery. The goal is to learn how to better interpret blood…

This study aims to improve how infection-fighting white blood cells (called granulocytes) are collected from healthy donors for transfusion to patients with weakened immune systems, such as those undergoing chemotherapy or bone marrow transplants. Researchers will recruit up to 1…

This study aims to better understand RYR1-related disorders, a group of rare genetic conditions that cause muscle weakness. Researchers will track 150 children and adults with the condition over 3 to 5 years, collecting detailed health information through annual visits and questi…

This study is exploring new ways to control robotic leg braces (exoskeletons) to help children and young adults with conditions like cerebral palsy or muscular dystrophy walk better in different daily situations. Researchers are testing how different control settings work during …

This study aims to understand how diet, eating habits, and nutrition affect the overall health of adults living with sickle cell disease. Researchers will observe 80 participants, collecting information through interviews, surveys, and lab tests to look for connections between wh…

This study aims to understand how pulmonary arterial hypertension (PAH) progresses over time by tracking 270 adults, including patients and healthy volunteers. Researchers will collect blood samples and perform heart and lung scans to identify new biological markers that could im…

This study is testing whether a new type of blood analysis can detect signs of infections in people receiving a stem cell transplant. Researchers will collect blood samples from 30 participants before and for six months after their transplant to look for bacteria, viruses, or fun…

This study aims to create a large database of how people move, both normally and when adapting to a movement disorder. Researchers will record volunteers—from infants to older adults, with and without movement problems—performing everyday tasks like walking and reaching. The goal…

This study aims to understand how people with intellectual disabilities experience pain compared to those without. Researchers will measure brain activity, heart rate, and other responses while participants feel mild heat, cold, and touch sensations. The goal is to gather knowled…