National Institutes Of Health Clinical Center (cc)

This study looks at whether spironolactone, a drug already used for fluid retention, can help people with pulmonary arterial hypertension (PAH) exercise longer and improve blood vessel function. About 70 adults with PAH will take either spironolactone or a placebo for 24 weeks. R…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. Participants will attend cooking classes led by a chef and complete surveys and health checks. The goal is to see if this approach is p…

This study tests a robotic leg brace (exoskeleton) designed to improve walking in children aged 3 to 17 with conditions like cerebral palsy, spina bifida, muscular dystrophy, or incomplete spinal cord injury. The device can assist or resist leg movement during walking. The trial …

This study aims to improve current methods and develop new techniques for magnetic resonance imaging (MRI). Researchers will test different scanning parameters on healthy volunteers and current NIH participants aged 18 and older. Participants will undergo one or more MRI scans, e…

This study uses MRI and ultrasound to watch how muscles, tendons, and bones move inside the body during activities like bending the knee. Healthy volunteers and people with joint problems (ages 5 to 95) can join. The goal is to better understand movement disorders and improve fut…

This study uses safe brain imaging techniques (NIRS and EEG) to see which parts of the brain are active during movement in people with cerebral palsy and healthy volunteers. Researchers hope to learn how the brain controls muscles differently in cerebral palsy, which could lead t…

This study collects blood from up to 5,000 healthy volunteers to provide samples for laboratory research at NIH and FDA. Donors are paid for their time and must meet standard blood donation safety rules. The blood is used only in lab experiments, not for treating people. The goal…

This study aims to learn more about the signs, symptoms, and progression of RYR1-related disorders, a group of genetic muscle conditions. About 150 people aged 7 and older with a confirmed RYR1 gene change will be followed for 3 to 5 years. Researchers will collect information th…

This study looks at how stress and oral health habits relate to inflammation in people with alcohol use disorder (AUD). Researchers will collect saliva, blood, and dental exams from 72 participants (AUD patients and healthy volunteers). The goal is to improve understanding of ora…

This study is testing new ways to use robotic leg braces (exoskeletons) in children and young adults who have muscle weakness from conditions like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury. Participants will try the braces while walking on a treadmil…

This study aims to collect information on how people with and without movement disorders control their limbs and body. Up to 7,500 volunteers, from infants to older adults, will perform tasks like walking or reaching while cameras record their movements. The data will help improv…

This study aims to improve how white blood cells (granulocytes) are collected from healthy volunteers to help patients with weak immune systems, like those after chemotherapy or bone marrow transplants. Up to 1,000 donors aged 18-75 will receive two drugs (filgrastim and dexameth…

This study looks at proteins in lung fluid from people with pneumonia to find clues about what causes the disease. Researchers hope to identify biomarkers that could help doctors choose the right treatment. Up to 750 patients already scheduled for a lung exam will provide a small…

This study collects blood and urine samples from 1,000 healthy volunteers and patients with heart or lung conditions. Researchers will analyze genes, proteins, and other substances to develop new lab tests and better understand diseases. Participants must be 18 or older and can p…

This study compares brain activity and pain responses between people with intellectual disability (ID) and healthy volunteers. Participants aged 8 to 30 will receive mild heat, cold, brushing, or electrical stimuli while wearing a brain-monitoring cap. The goal is to better under…

This study looks at how diet and eating habits affect the health of adults with sickle cell disease. Researchers will interview participants about their food intake and behaviors, collect blood and urine samples, and track symptoms like pain and mood. The goal is to understand ho…

This study aims to better understand how children and young adults with cerebral palsy move by using advanced sensors like ultrasound, brain wave caps, and muscle stickers. Participants aged 5 to 25 will perform simple movements with and without a robotic leg brace. The goal is t…

This study follows people with pulmonary arterial hypertension (PAH) over several years to learn how the disease changes and to find new markers that could lead to better treatments. About 270 adults with PAH and healthy volunteers will have regular tests like blood draws, heart …

This study is testing a new, advanced blood test to see if it can detect germs like bacteria and viruses in people receiving a stem cell transplant. Participants will have their blood drawn before the transplant and for six months after to look for signs of infection. The goal is…