National Institutes Of Health Clinical Center (cc)

This Phase 1 trial tested a new live-attenuated dengue vaccine in 127 healthy adults aged 18 to 59. The goal was to see how safe the vaccine is and how the immune system responds, especially in people who have had dengue before. Participants received one shot and were monitored f…

This study tested two ways of delivering synthetic parathyroid hormone (PTH) to people with chronic hypoparathyroidism, a condition where the body doesn't make enough PTH, causing low calcium. Researchers compared using an insulin pump to give steady, small doses versus twice-dai…

This study tested whether a booster dose of the Ebola vaccine (V920) could improve and extend immune protection in 248 healthy adults at risk of Ebola exposure through their jobs. Participants received the primary vaccine and were randomly assigned 18 months later to get a booste…

This study tested whether a daily 20-minute routine of gentle chair yoga and breathing exercises could reduce stress in caregivers of patients receiving a stem cell transplant. 53 adult caregivers participated, with half doing the yoga and breathing program for about two months. …

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

This study looked at whether a 12-week treadmill exercise program can improve cardiorespiratory fitness, reduce fatigue, and boost mood in people with traumatic brain injury (TBI). Thirteen physically inactive adults with TBI walked on a treadmill three times a week for 30 minute…

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This study explored whether watching 360-degree nature videos through a virtual reality headset could lower stress in people caring for a loved one who had a stem cell transplant. Twenty-eight caregivers used the VR headset for 20 minutes each day over four weeks. Researchers mea…

This early-phase study tested a single injection of resiniferatoxin (RTX), a non-opioid drug, in 3 adults with Morton's neuroma whose pain did not improve with standard treatments. The goal was to check safety and see if the injection could ease burning or shooting foot pain. Par…

This study looked at 68 people with low platelet counts who had become resistant to platelet transfusions due to HLA antibodies. Researchers tested a new lab method (C1q binding) on stored blood samples to see if it could better predict whether a transfusion would work compared t…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This study followed 1,771 adults and children who received blood transfusions to check how safe the blood supply is. Researchers tested patients' blood for viruses like HIV and hepatitis before and after transfusion, and stored samples for future testing. The goal was to keep blo…

This study looked at the genes that determine blood types in three distinct Ethiopian communities. The goal was to understand the unique blood type patterns in these groups, which can help find better blood donor matches for Ethiopian patients in the U.S. and reduce transfusion c…

This study looks at how the muscles around the knee work together to control movement, especially in the kneecap area. Researchers temporarily numbed one muscle with lidocaine in 28 healthy volunteers and used MRI scans to see how the knee moved. The goal is to better understand …

This study followed 173 adults who had a donor stem cell transplant at least three years earlier. Participants filled out yearly surveys about their physical health, emotions, social life, and symptoms. The goal is to learn what long-term survivors experience, so doctors and fami…

This study looks at how drinking alcohol changes the way people make decisions about risky sexual behavior, which could lead to HIV. Twenty healthy adults aged 21-65 will have two visits: one where they drink alcohol and one where they drink a placebo. During brain scans, they wi…

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This study looks at how the thigh muscles control the movement of the knee cap in people with long-term knee cap pain. Researchers will use MRI scans to compare knee movement in people with pain and healthy volunteers. In a second session, they will temporarily numb a thigh muscl…

This study looked at how sleep quality and beliefs about sleep affect the risk of relapse in people recovering from alcohol dependence. Researchers followed 198 adults as they left inpatient rehab and returned home, measuring sleep with questionnaires and activity monitors. The g…

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads and affects health over time. Researchers collected blood samples and health information to track infection and liver disease. The goal was to better understand HC…

This completed study looked at how COVID-19 affects the heart, lungs, brain, and kidneys in 202 people aged 18 to 80. Participants had imaging scans, blood tests, and other procedures to track inflammation and organ function over time. The goal was to understand why some people g…

This study aims to find substances in blood or urine that can signal when a transplanted heart is being rejected. By analyzing samples from 188 heart transplant patients and healthy volunteers, researchers hope to develop a simple test for early detection. The goal is to catch re…

This study looked at whether taking vitamin C (and vitamin E) supplements for 8 weeks can make red blood cells more flexible in people with type 2 diabetes. Stiff red blood cells can lead to tiny blood vessel damage. Researchers measured red blood cell flexibility before and afte…

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity and tested whether a technique called neurofeedback could help people control their cravings. The stu…

This study looked at how the sleep drug propofol changes proteins in the blood. Ten adults having surgery gave blood samples before and after receiving propofol. Researchers compared the samples to understand how the drug might affect blood test results. No treatment was given; t…

This study looked at how switching from a typical Western diet (low fiber, high fat) to a Mediterranean-like diet (lots of veggies, fruits, whole grains) affects the trillions of tiny organisms living in your gut. 160 healthy adults aged 18 to 60 either followed the new diet for …

This study took small skin samples from 12 adults during long surgeries (over 4 hours) to measure chemical reactions and genes linked to pain. The goal is to better understand how pain starts at the incision site, which could lead to safer pain relief options. Participants also f…

This study tested whether a small motion sensor taped to the chest can measure the volume of air a person inhales, similar to a standard incentive spirometer. Thirty healthy adults took 18 different breaths while wearing the sensor and breathing through a spirometer. The goal was…

This study uses MRI to measure how the brain moves inside the skull during gentle head motions, like turning your head while swimming. Researchers will scan 90 healthy adults aged 18-65 as they perform small, repeated head movements. The goal is to develop a fast imaging method t…

This study tested two simple tools—a laser pointer and a plastic block—to help doctors pick the correct angle for inserting a biopsy needle during CT scans. Seventeen adults scheduled for a CT-guided biopsy took part. The goal was to see if these tools improved angle selection co…