National Institutes Of Health Clinical Center (cc)

This study tested whether delivering parathyroid hormone (PTH 1-34) through a small pump, similar to an insulin pump, works better than standard twice-daily injections for people with chronic hypoparathyroidism. The goal was to keep blood and urine calcium levels stable throughou…

This study tested whether a daily 20-minute stress reduction program (gentle stretches and breathing exercises) could lower stress and improve health in 53 caregivers of stem cell transplant patients. Caregivers in the program used an MP3 player with guided exercises and tracked …

This study looked at whether watching 360-degree nature videos through a virtual reality headset for 20 minutes each day could lower stress in people caring for a loved one who had a stem cell transplant. 28 adult caregivers took part for 4 weeks, filling out surveys and giving s…

This study looked at whether a supervised exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more physically active. About 97 adults aged 21 to 82 took part, with some starting exercise right away and others waiting 10 weeks. Th…

This early-phase study tested a single injection of resiniferatoxin (RTX) in 3 adults with Morton's neuroma, a painful foot nerve condition that didn't improve with standard treatments. The goal was to check safety and see if the drug could ease pain. Participants were monitored …

This study looked at whether a 12-week treadmill walking program could boost physical fitness, reduce fatigue, and improve mood in people with traumatic brain injury (TBI). Thirteen adults with TBI who were not physically active took part. They exercised three times a week, and r…

This study looked at whether a 3-month home exercise program and a 3-month bright light therapy program could improve movement, balance, thinking, and mood in adults with traumatic brain injury (TBI). 34 people with TBI and healthy volunteers took part. The goal was to see if the…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was adjustable to fit each child's needs. Researchers measured how well children walked with the brace by looking at knee angle, walkin…

This study tested two experimental methods (a laser and a plastic block) to help doctors insert a biopsy needle at the correct angle during CT scans. Seventeen adults scheduled for a standard CT-guided biopsy took part. The goal was to see if these methods improve accuracy compar…

This study looked at how muscles around the knee work together to control movement in 28 healthy adults. Researchers used MRI scans and temporarily numbed a specific knee muscle with lidocaine to see how it affects kneecap position. The goal was to better understand what causes f…

This study looked at how sleep problems affect people recovering from alcohol addiction. Researchers followed 198 adults leaving inpatient treatment to see if poor sleep led to relapse. They used sleep questionnaires and activity monitors to track sleep quality and drinking behav…

This study looked at how the muscles around the knee affect knee cap movement in people with long-term knee pain. Researchers used MRI scans to watch the knee move, both normally and after numbing a thigh muscle. The goal was to understand the link between muscle control and pain…

This study used special 3D cameras to take pictures of people's torsos without any radiation. Researchers wanted to learn more about body shapes in people with scoliosis, chest wall deformities, obesity, and healthy volunteers. About 199 participants aged 2 and older had their to…

This study looked at how COVID-19 causes different symptoms in different people, from no symptoms to severe illness. Researchers used scans, blood tests, and lung washes to track inflammation in the heart, lungs, brain, and kidneys. The goal was to understand why some people get …

This study looks at how people are doing three or more years after receiving a donor stem cell transplant. Researchers want to understand their physical health, emotions, and overall quality of life. Participants fill out yearly questionnaires for three years. The goal is to help…

This study followed 1,771 adults and children who received blood transfusions to check for infections that might be passed through donated blood. Researchers took blood samples before and after transfusion to test for viruses like HIV, hepatitis, and others. The goal was to keep …

This study used MRI scans to measure how the brain moves inside the skull during gentle head motions, like turning your head. Researchers studied 90 healthy adults aged 18-65 to create a database of normal brain movement. The goal was to develop a new imaging method that could he…

This study looked at blood group genes in 95 healthy Ethiopian adults from three distinct sub-populations. The goal was to understand genetic differences that affect blood transfusions, especially for Ethiopian-American patients. Researchers collected blood samples and used genet…

This study looked at three ways to collect mucus samples from the lungs of people with a hard-to-diagnose infection called pulmonary nontuberculous mycobacterial (NTM) disease. Researchers compared throat swabs, coughed-up phlegm, and phlegm brought up using a mist inhaler to see…

This study looked at 68 people who need frequent platelet transfusions because of low platelet counts. Researchers tested whether a new method (C1q binding) could better predict if a transfusion would help compared to the standard test. They used stored blood samples to compare t…

This study looked at how the brains of people with alcohol use disorder respond to pictures of social situations and alcohol. Researchers used MRI scans to measure brain activity while participants viewed these images. The goal was to better understand the link between drinking a…

This study looked at how the anesthesia drug propofol changes proteins in the blood. Ten adults having surgery gave blood samples right before and after receiving propofol. Researchers compared the samples to understand if the drug interferes with blood test results, helping doct…

This study looked at 27 healthy volunteers and people with pulmonary hypertension, a rare and serious lung blood vessel disorder. The goal was to learn more about the disease by measuring heart and lung pressures, testing exercise ability, and studying blood samples for genetic c…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads, who gets sick, and what happens over time. Participants gave blood samples and answered questions about their health and lifestyle. The goal was to better underst…

This study looked at how switching from a typical Western diet (low fiber, high fat) to a Mediterranean-like diet full of vegetables, fruits, and whole grains affects the trillions of tiny organisms living in our intestines. Healthy adults aged 18 to 60 either followed the new di…

This study looked at how the body produces pain after surgery by taking small skin samples from the incision site during the operation. Researchers measured chemical changes and gene activity to find pain signals. The goal is to develop better pain treatments with fewer side effe…

This study tested whether a small motion sensor taped to the chest can accurately measure the volume of air a person breathes in. 30 healthy adults took deep and shallow breaths through a standard breathing tube while the sensor recorded their chest movements. The goal was to see…

This study aims to find blood or urine tests that can spot early signs of heart transplant rejection. Researchers will analyze genes and proteins from 188 participants, including people waiting for a heart transplant, those who have already received one, and healthy volunteers. T…

This study looked at how heavy alcohol use changes the bacteria living in the mouth and gut. Researchers followed 23 adults going through alcohol detox to see if these bacteria change during treatment. Participants provided stool and mouth samples and answered questions about the…