National Institutes Of Health Clinical Center (cc)

This study tested if delivering a replacement hormone (PTH) through a small, wearable insulin pump is better than twice-daily injections for people with chronic hypoparathyroidism. This rare condition makes it hard for the body to regulate calcium. Researchers wanted to see if th…

This study tested three experimental tools designed to help doctors insert biopsy needles at the correct angle during CT-guided biopsies for cancer. The goal was to see if these tools—a laser pointer, a plastic block with pre-drilled holes, and a mobile device—could improve accur…

This study aimed to find better ways to detect when a body rejects a transplanted heart. Researchers looked for genetic and protein markers in blood and urine that could signal rejection earlier than current invasive methods. The study involved 188 people, including heart transpl…

This study tested whether a 12-week treadmill walking program could help adults who had a traumatic brain injury. Researchers wanted to see if regular aerobic exercise could improve their physical fitness, reduce severe fatigue, and help with mood. Participants completed exercise…

This study tested a new, adjustable leg brace designed to help children with movement disorders like cerebral palsy walk better. Researchers worked with 24 children to see if different settings on the brace could improve their crouched walking posture. They measured walking patte…

This study tested whether a simple, at-home stress reduction program could help caregivers of bone marrow transplant patients. 53 caregivers were randomly assigned to either receive daily gentle yoga and breathing exercises via an MP3 player or to a control group. The goal was to…

This study tested whether a home exercise program or bright light therapy could help adults with traumatic brain injury. Researchers compared the effects of three months of each therapy on movement, balance, thinking, and mood. The goal was to find new ways to improve daily funct…

This study tested whether a supervised 10-week aerobic exercise program (like treadmill walking) is safe and helpful for people with pulmonary hypertension, a serious lung condition that causes severe shortness of breath. Researchers compared people who did exercise plus educatio…

This study developed new MRI techniques to measure how the brain moves and deforms during mild head motions in healthy volunteers. Researchers scanned 101 healthy adults aged 18-65 while they performed controlled head movements in an MRI machine. The goal was to create detailed 3…

This study aimed to understand the very start of pain after surgery by collecting small skin samples from the surgical cut at different times during the operation. Researchers analyzed these samples to find chemical and genetic signals related to pain, hoping this knowledge will …

This study aimed to understand how muscles around the knee cap affect movement and pain in people with chronic knee pain not caused by injury. Researchers used MRI scans to compare knee movement in 35 healthy volunteers and people with knee pain, both before and after temporarily…

This study explored whether small motion sensors placed on the chest could accurately measure how much air a person breathes in. Researchers tested 30 healthy adults who wore these sensors while breathing through a standard breathing measurement device. The goal was to collect da…

This study aimed to understand the long-term physical, emotional, and social recovery of adults who survived at least three years after a donor stem cell transplant. It did not test a treatment but instead gathered information by having 173 participants fill out detailed question…

This study aimed to find the best way to collect spit and throat samples to improve the diagnosis of a hard-to-detect lung infection. Researchers compared three different collection methods from 177 adults who already had the infection. The goal was to see which method gave the m…

This study aimed to see if a newer lab test (C1q-binding) could better predict how well a patient will respond to a platelet transfusion compared to the standard test (IgG). Researchers analyzed stored blood samples from 68 patients with low platelet counts who had become resista…

This study aimed to understand how sleep problems might influence whether someone relapses after leaving alcohol addiction treatment. Researchers followed about 200 adults during their transition from inpatient rehab back to their homes, tracking their sleep patterns and intervie…

This study aimed to learn more about pulmonary arterial hypertension (PAH), a rare and serious lung blood vessel disorder. Researchers compared 27 healthy volunteers and patients with PAH, taking blood samples and performing heart and lung tests. The goal was to find biological m…

This study aimed to understand why COVID-19 affects people so differently, from no symptoms to severe organ damage. Researchers followed 202 adults with COVID-19 for up to three years, using detailed scans and tests of the heart, lungs, brain, and kidneys. The goal was to link th…

This study aimed to understand the genetic makeup of blood types in different Ethiopian communities. Researchers collected blood samples from 95 healthy adults in Ethiopia to analyze their blood group patterns. The goal was to improve blood matching for transfusions, especially f…

This study followed over 1,700 patients for up to 9 months after they received blood transfusions to monitor for infections that might have been passed through the blood. Researchers collected and stored blood samples from both patients and their donors to create a library for fu…

This study aimed to understand how a specific thigh muscle controls kneecap movement, which could help explain a common type of knee pain. Researchers used MRI scans to watch the knees of 28 healthy volunteers move naturally and then after temporarily numbing one muscle. The goal…

This study tested a special 3D camera system to create detailed images of people's torsos. Researchers wanted to see if this safe, radiation-free method could accurately measure body shape in people with conditions like scoliosis or obesity, and in healthy volunteers. The goal wa…

This study aimed to learn more about Hepatitis C virus (HCV) infection in people who donated blood. Researchers followed over 800 blood donors who tested positive for HCV antibodies to understand how the virus spreads, who remains infected, and what liver problems might develop. …

This study aimed to understand how the community of bacteria in the gut and mouth changes when a person stops drinking alcohol. Researchers followed 23 adults undergoing detox treatment, collecting daily samples to see if these bacteria return to normal on their own. The goal was…

This study looked at how switching from a typical Western diet to a Mediterranean-style diet affects the bacteria living in our intestines. Researchers followed 160 healthy adults, some for short periods and some for up to a year, while they changed their eating habits. The goal …