National Institutes Of Health Clinical Center (cc)

This study is testing if spironolactone, a drug often used for heart failure, can help people with pulmonary arterial hypertension (PAH), a rare and serious condition of high blood pressure in the lungs. Researchers want to see if the drug can improve how far patients can walk an…

This study is exploring whether community-based cooking classes can help African American adults in specific Washington D.C. neighborhoods reduce their risk of heart disease. Researchers want to see if learning to cook healthy meals at home can improve eating habits and lower ris…

This study is testing whether a robotic exoskeleton worn on the legs can improve walking ability in children with movement disorders like cerebral palsy or spina bifida. Children aged 3 to 17 will use the device at home for 12 weeks to see if it helps their knee movement and walk…

This early-stage study is testing whether an injection derived from chili peppers (resiniferatoxin) can provide lasting relief for people with Morton's neuroma, a painful nerve condition in the foot. The trial will involve 24 adults whose foot pain hasn't improved with standard t…

This study is testing whether watching calming nature scenes through a virtual reality (VR) headset can help reduce stress in people caring for a loved one after a bone marrow transplant. Caregivers will use a VR headset daily for four weeks while researchers measure their stress…

This study aims to understand the connection between alcohol use disorder, oral health, and body-wide inflammation. Researchers are recruiting 72 people, including those being treated for alcohol use disorder and healthy volunteers, to test a new oral health survey and collect sa…

This study aims to understand how a common anesthesia drug, propofol, changes proteins in a person's blood. Researchers will collect small blood samples from 10 adults before and after they receive propofol for scheduled surgery. The goal is to learn how to better interpret blood…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to develop new laboratory tests and study genes, proteins, and other substances in the body. The goal is to build a resour…

This study aims to develop and improve MRI scanning techniques for better image quality. Researchers are recruiting 1,000 healthy volunteers and NIH patients to undergo MRI scans lasting 20 minutes to 2 hours. The goal is to refine scanning methods that could benefit future medic…

This study aims to identify specific proteins in lung fluid that could help doctors understand what causes different types of pneumonia. Researchers will analyze fluid samples from 750 patients undergoing a standard lung washing procedure for diagnosis. The goal is to find biolog…

This study aims to develop better tools for understanding how joints work. Researchers will use MRI and ultrasound scans to create detailed 3D pictures of bones, muscles, and tendons while people move their joints. The goal is to gather knowledge that could one day lead to improv…

This study aims to improve how infection-fighting white blood cells (called granulocytes) are collected from healthy donors for transfusion to patients with weakened immune systems, such as those undergoing chemotherapy or bone marrow transplants. Researchers will recruit up to 1…

This study aims to better understand RYR1-related disorders, a group of rare genetic conditions that cause muscle weakness. Researchers will track 150 children and adults with the condition over 3 to 5 years, collecting detailed health information through annual visits and questi…

This study aims to better understand how children and young adults with cerebral palsy move. Researchers will use several technologies—like ultrasound muscle imaging, brain wave caps, and muscle sensors—while participants perform simple movements with and without a robotic leg br…

This study is exploring new ways to control robotic leg braces (exoskeletons) to help children and young adults with conditions like cerebral palsy or muscular dystrophy walk better in different daily situations. Researchers are testing how different control settings work during …

This study aims to understand how diet, eating habits, and nutrition affect the overall health of adults living with sickle cell disease. Researchers will observe 80 participants, collecting information through interviews, surveys, and lab tests to look for connections between wh…

This study aims to understand how the brain controls movement in children with cerebral palsy compared to healthy children. Researchers will use safe, non-invasive brain scanning techniques (NIRS and EEG) while participants perform simple tasks. The goal is to gather knowledge ab…

This study aims to understand how pulmonary arterial hypertension (PAH) progresses over time by tracking 270 adults, including patients and healthy volunteers. Researchers will collect blood samples and perform heart and lung scans to identify new biological markers that could im…

This study is testing whether a new type of blood analysis can detect signs of infections in people receiving a stem cell transplant. Researchers will collect blood samples from 30 participants before and for six months after their transplant to look for bacteria, viruses, or fun…

This study collects blood from healthy volunteers to supply researchers at the National Institutes of Health (NIH) and the FDA. The blood is used for laboratory experiments to help scientists better understand diseases and develop new treatments. Volunteers are paid for their tim…

This study aims to create a large database of how people move, both normally and when adapting to a movement disorder. Researchers will record volunteers—from infants to older adults, with and without movement problems—performing everyday tasks like walking and reaching. The goal…

This study aims to understand how people with intellectual disabilities experience pain compared to those without. Researchers will measure brain activity, heart rate, and other responses while participants feel mild heat, cold, and touch sensations. The goal is to gather knowled…