National Institutes Of Health Clinical Center (cc)

This phase II trial tests whether a new drug called Briquilimab can make stem cell transplants safer for people with GATA2 deficiency, a rare genetic condition that weakens the immune system and raises the risk of infections and blood cancers. The study involves 13 participants a…

This study looks at whether the MCV test (which measures red blood cell size) is as good as or better than the standard ferritin test for guiding phlebotomy (blood removal) therapy in people with hereditary hemochromatosis, a condition causing too much iron absorption. About 622 …

This pilot study is testing a device that uses ultrasound images to guide a laser or freezing probe directly into prostate tumors. The goal is to destroy only the cancerous tissue while sparing healthy areas. Thirty men with low- to intermediate-risk prostate cancer that hasn't s…

This study looks at whether the antibiotic cefiderocol can lower death rates in hospitalized adults with a tough, drug-resistant Acinetobacter infection. Researchers will compare patients who got cefiderocol to those who received the best available treatment. The goal is to see w…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

This study tests whether a 10-week aerobic exercise program can improve physical function and reduce symptoms in adults still struggling after a COVID-19 infection. Participants will exercise three times a week and attend weekly education classes. The goal is to see if exercise h…

This study tests a special needle with a tiny tracking device inside, like a mini GPS, to help doctors find tumors that are hard to see on CT scans. About 3,900 adults with certain cancers or growths will have their biopsy or ablation procedure done using this smart needle. The g…

Researchers have interviewed 25 Swiss experts—including doctors, academics, and right-to-die society representatives—to learn how assisted suicide works in Switzerland. The study aims to describe the policy, how it is carried out, and the ethical issues involved. This is a qualit…

This study looks at how healthy lungs respond to a substance called endotoxin, which mimics a bacterial infection. Researchers will collect lung cells and fluid from 58 healthy, non-smoking adults using a thin tube inserted into the airways. The goal is to understand inflammation…

This study looks at how the bacteria and fungi living in and on our bodies change when someone stays in the hospital. Researchers will take swabs and samples from 250 patients aged 2 and older during their hospital stay and follow-up visits. The goal is to learn which germs sprea…

This study creates a pregnancy registry for people who took part in NIH clinical trials and became pregnant during or within one year after the study. Researchers will collect health and birth information through interviews and medical records to monitor outcomes after unplanned …

This pilot study aimed to see if a self-paced virtual education video could help adolescents and young adults (ages 16-22) with congenital adrenal hyperplasia (CAH) become more independent in managing their health. Participants would have been split into two groups: one watching …

This study uses over 144,000 existing medical images (like CT and MRI scans) to develop computer programs that can help detect and diagnose diseases. Researchers aim to create algorithms that find lesions, model anatomy, and track disease over time. The study includes people of a…