New blood test could help patients who Don't respond to platelet transfusions

NCT ID NCT02858323

Completed Knowledge-focused Sponsor: National Institutes of Health Clinical Center (CC) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 13 times

Summary

This study looked at 68 people with low platelet counts who had become resistant to platelet transfusions due to HLA antibodies. Researchers tested a new lab method (C1q binding) on stored blood samples to see if it could better predict whether a transfusion would work compared to the standard test. The goal was to improve matching for future transfusions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If the C1q method proves more accurate, it could help doctors choose better platelet donors for patients who don't respond to standard transfusions.
What could go wrong: This is a small, completed observational study using stored samples, not a treatment trial. The new test may not be more useful than the current method in real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

thrombocytopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLATELET TRANSFUSION REFRACTORINESS THROMBOCYTOPENIA

Contacts and locations

Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

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