National Institutes Of Health Clinical Center (cc)

This study tested whether delivering a synthetic parathyroid hormone (PTH 1-34) through an insulin pump works better than twice-daily injections for people with chronic hypoparathyroidism. The goal was to keep blood and urine calcium levels stable with fewer fluctuations. The tri…

This study tested whether a daily 20-minute stress reduction program (gentle stretches and breathing exercises) could lower stress and improve health in 53 caregivers of stem cell transplant patients. Caregivers in the program used an MP3 player with guided exercises and tracked …

This study looked at whether a 3-month home exercise program or bright light therapy could improve movement, balance, mood, and thinking in adults with traumatic brain injury. 34 people with TBI and healthy volunteers took part. Participants did either exercise on an elliptical m…

This early-phase study tested a non-opioid drug called resiniferatoxin (RTX) for people with Morton's neuroma, a nerve condition causing burning or shooting foot pain. Three adults who had not found relief from standard treatments received a single injection into the painful foot…

This study looked at whether using a virtual reality headset to watch 360-degree nature videos for 20 minutes a day could lower stress in family caregivers of stem cell transplant patients. 28 adult caregivers took part over 4 weeks, completing surveys and providing saliva or blo…

This study looked at whether a 10-week aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) walk farther and feel better. About 97 adults aged 21 to 82 took part, with some starting exercise right away and others waiting 10 weeks…

This study tested a special adjustable brace to help children with cerebral palsy and other movement disorders walk more easily. 24 children aged 5-17 took part. The brace was customized for each child and adjusted over several visits to find the best way to reduce crouch gait.

This study looked at whether a 12-week treadmill walking program could boost physical fitness, reduce fatigue, and improve mood in people with traumatic brain injury (TBI). Thirteen adults with TBI who were not physically active took part. They exercised three times a week, and r…

This study looked at the bacteria living in the mouth and gut of 23 adults with alcohol dependence as they went through detox. Researchers collected stool and mouth samples along with diet and mood information to see how the bacteria changed over time. The goal was to learn more …

This study looked at how vitamin C levels in red blood cells relate to blood sugar in people with type 2 diabetes. Researchers measured red blood cell flexibility and vitamin C levels before and after 8 weeks of vitamin C and E supplements. The goal was to understand if vitamin C…

This study looked at how the thigh muscles control kneecap movement in people with long-term kneecap pain. Researchers used MRI scans to watch the knee move, both normally and after numbing a specific thigh muscle. The goal was to understand the muscle's role in pain, not to test…

This study followed 1,771 people who received blood transfusions to check if any infections were passed along through the blood. Researchers tested blood samples before and after transfusion for viruses like HIV, hepatitis, and others. The goal was to keep the blood supply safe a…

This study looked at blood type genes in 95 healthy Ethiopian adults from three different regions. The goal was to understand genetic differences that can affect blood transfusions. By learning more about these unique blood markers, doctors hope to find better donor matches for E…

This study looks at hepatitis C virus (HCV) infection in blood donors who tested positive for it. The goal is to learn how the virus spreads, how many people develop liver disease, and what happens over time. About 805 participants will give blood samples and answer health questi…

This study looked at how muscles around the knee work together to control movement in 28 healthy adults. Researchers used MRI scans and temporarily numbed a specific knee muscle with lidocaine to see how it affects kneecap motion. The goal was to better understand what causes fro…

This study tested whether a small motion sensor taped to the chest can measure the volume of air a person breathes in. Thirty healthy adults took 18 breaths of different depths through a tube while the sensor recorded chest movement. The goal was to see if the sensor data could b…

This study used MRI scans to measure how the brain moves inside the skull during gentle head movements, like turning or nodding. Researchers studied 90 healthy adults aged 18 to 65 to create a detailed map of brain deformation. The goal was to develop a new imaging method that co…

This study looked at how the body's pain signals start at the skin incision during surgery. Researchers took small skin samples from 12 adults having long surgeries to measure chemical changes and find genes linked to pain. The goal is to develop better pain treatments with fewer…

This study looked at different methods for collecting sputum (phlegm) from people with a chronic lung infection called pulmonary nontuberculous mycobacterial (NTM) infection. The goal was to see which collection method—coughing up phlegm, using a mist to produce phlegm, or a thro…

This study looked at how the anesthesia drug propofol changes proteins in the blood. Ten adults having surgery with propofol gave blood samples before and after the drug was given. Researchers compared the samples to understand if propofol interferes with blood tests, which is im…

This study looked at how people with alcohol use disorder process social and alcohol-related images in their brains. Researchers used MRI scans and a technique called neurofeedback to see if people could learn to control their brain activity. The goal was to better understand the…

This study looked at how sleep problems affect the risk of returning to drinking in people recovering from alcohol dependence. Researchers followed 198 adults as they left inpatient rehab and returned home. They measured sleep quality with questionnaires and activity monitors, an…

This study used a special 3D camera system (stereophotogrammetry) to take pictures of people's torsos without any radiation. Researchers aimed to better understand body shapes in people with scoliosis, chest wall deformities, obesity, and healthy volunteers. About 199 participant…

This study looked at how COVID-19 affects different organs like the lungs, heart, brain, and kidneys. Researchers used advanced scans and lab tests to track inflammation and damage in 202 people with COVID-19, from early infection through recovery. The goal was to understand why …

This study tested two experimental methods (a laser and a plastic block) to help doctors choose the correct needle angle during CT-guided biopsies. Seventeen adults scheduled for a biopsy took part. The goal was to see if these tools improve accuracy compared to the standard meth…

This study aims to find substances in blood or urine that signal when a transplanted heart is being rejected. Researchers will collect samples from heart transplant patients and healthy volunteers to identify these markers. The goal is to develop a simple test that catches reject…

This study looked at 27 healthy volunteers and people with pulmonary hypertension, a rare and serious lung blood vessel disorder. Researchers used heart tests, exercise tests, and blood samples to study genes and proteins that might help detect the disease or predict its progress…

This study looks at the long-term physical and emotional well-being of people who had a donor stem cell transplant at least three years ago. Researchers want to understand what life is like years after the procedure, including any lasting symptoms or challenges. Participants fill…

This study looked at how switching from a typical Western diet (low fiber, high fat) to a Mediterranean-like diet (rich in vegetables, fruits, and whole grains) affects the trillions of tiny organisms living in the gut. Healthy adults aged 18 to 60 either followed the new diet fo…

This study looked at 68 people who need frequent platelet transfusions because of low platelet counts. Researchers tested whether a new method (C1q binding) could better predict if a transfusion would help compared to the standard test. They used stored blood samples to compare t…