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New Angle-Measuring tools could make biopsies more accurate

NCT ID NCT01218854

Knowledge-focused Sponsor: National Institutes of Health Clinical Center (CC) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two simple tools—a laser pointer and a plastic block—to help doctors pick the correct angle for inserting a biopsy needle during CT scans. Seventeen adults scheduled for a CT-guided biopsy took part. The goal was to see if these tools improved angle selection compared to the usual method of estimating by experience. No actual biopsies were performed using the tools; only the needle angle was measured.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, these guidance methods could make biopsies more accurate and reduce the need for repeat procedures.
What could go wrong
This was a very small, early-phase study (17 people) that only measured needle angle, not actual biopsy success. The methods may not improve outcomes in real procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

17 people

The number who actually took part.

Started

Mar 2012

Finished

Nov 2016

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: Patients must fulfill all of the following criteria to be eligible for study admission: * All patients must be undergoing a CT-guided biopsy. * Age greater than 18 years. * No serious concurrent medical illness that would preclude the patient from making a rational informed decision on participation. * The ability to understand and willingness to sign a written informed consent form, and to comply with the protocol. If in question, an ethics consult will be obtained. * Ability to follow breathing instructions like holding breath (if procedure is to be performed without general anesthesia). * Patients must be actively enrolled on an NIH protocol and be scheduled for a CT-guided biopsy. EXCLUSION CRITERIA: * Patients with an altered mental status that precludes understanding or consenting for the biopsy procedure will be excluded from this study. * Patients unlikely to be able to hold reasonably still on a procedure table for the length of the procedure. * Patients with any known allergy to plastics or polymers (since the Ultem -polymer could theoretically induce a rash in these patients, even though it is hypoallergenic). * Inability to follow breathing instructions, if without general anesthesia. * Patients with pacemakers or automatic implantable cardiac defibrillators. * Gross body weight above the CT table limit (450 pounds).

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Conditions

The condition(s) this trial relates to.

cancer kidney cancer kidney neoplasm liver and intrahepatic bile duct neoplasm Liver Neoplasms lung neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer Kidney neoplasms Liver neoplasms Lung neoplasms

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

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