LUNG NEOPLASMS

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer ce…

This study tests a new medicine called PF-08634404, given with chemotherapy, for adults with transformed small cell lung cancer (T-SCLC), a rare and aggressive cancer that develops after other treatments stop working. About 40 participants who have not yet been treated for T-SCLC…

This study is testing whether a team of doctors from different specialties can create better treatment plans for older adults (ages 60-90) with lung cancer. Each patient will get a personalized plan based on a full health assessment. The goal is to see if this team approach helps…

This study tests a drug called teniposide in people with a hard-to-treat type of lung cancer that has spread and has not responded to standard treatments. The cancer must have a specific gene change (c-Myc-driven). The goal is to see if the drug can shrink tumors and control the …

This study is testing whether a blood test can be used as a first step to screen for lung cancer in people at high risk. If the blood test is negative, those individuals might not need a CT scan, reducing radiation exposure and healthcare costs. The study involves 140 participant…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more) and live in North or South Carolina. The goal is to see if screening at a younger age can catch lung cancer earlier, when it's easier to treat. About 1,160 partici…

This study tests whether a dexamethasone mouthwash can reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 60 adults with advanced HER2-negative breast cancer or non-small cell lung cancer will use the mouthwash four times a day for the first fiv…

This study is developing a new, non-invasive way to monitor lung cancer patients after surgery using blood tests and artificial intelligence. Researchers will analyze blood samples from 100 patients who have had surgery and chemotherapy to look for signs of cancer returning. The …

This study is a registry that collects information from 3,750 adults with lung cancer across 21 hospitals in Algeria. Researchers will track patient details, tumor types, treatments, and outcomes over time. The goal is to understand how lung cancer is diagnosed and managed in rea…

This study tests a culturally adapted coaching program to help Hispanic smokers and former smokers decide whether to get screened for lung cancer. About 91 participants will work with bilingual patient navigators to learn about screening options. The goal is to see if this approa…

This study looks at whether a decision coach can help people aged 50-77 who smoke or used to smoke make better choices about lung cancer screening. About 594 participants will either get coaching or usual care. The goal is to see if coaching leads to better shared decisions, more…

This study observes 200 adults with advanced non-small cell lung cancer starting their first treatment in Brazil between 2025 and 2026. Researchers will review medical records and survey doctors to understand which therapies are chosen and if they follow national guidelines. The …

This study will review health records of up to 60,000 people with lung cancer in Alberta and Ontario to understand how the disease is treated, what it costs, and what outcomes patients experience. It aims to describe current treatment patterns, survival rates, and healthcare use.…

This study collects blood and tissue samples from 2,000 people being tested or treated for lung cancer. The samples are stored in a bank for future research aimed at earlier detection, better treatments, and prevention strategies. Participants give consent and provide samples dur…

This study collects tumor samples from 500 adults with lung or other chest cancers to learn why targeted therapies stop working. Researchers will look for genetic changes in the cancer cells. No new treatment is given; the goal is to gather information that may guide future care.

This study tests a new way to predict how well your lungs will work after lung cancer surgery. Doctors use a 3D CT scan to create a virtual model of your lungs and simulate the surgery beforehand. The goal is to improve safety and help plan recovery. About 60 adults with non-smal…