LUNG NEOPLASMS

This early-phase study tests a new treatment called KSQ-001EX for people with advanced solid tumors like melanoma, lung, or head and neck cancers. The treatment uses a patient's own immune cells, which are modified in a lab to work better against cancer. The main goal is to see i…

This program gives adults with advanced or spreading ROS1-positive non-small cell lung cancer access to taletrectinib when they cannot use approved treatments or join ongoing studies. It is for patients who, in their doctor's opinion, might benefit from the drug. The goal is to p…

This study tests a new way to give proton radiation for stage II-III non-small cell lung cancer. Instead of daily low doses over many weeks, patients get higher doses over a shorter time (hypofractionation) along with standard chemotherapy. The goal is to find the safest high dos…

This study tests whether adding the drugs pembrolizumab and olaparib to standard chemoradiation helps people with stage III non-small cell lung cancer that cannot be surgically removed. About 870 participants will receive either pembrolizumab with or without olaparib after chemor…

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutant non-small cell lung cancer. It involves 532 adults with stage IIIB, IIIC, or IV disease who have not had prior therapy. The goal is to me…

This study compares a new technique that combines cone-beam CT scans with a robot-assisted bronchoscope against standard methods for taking lung tissue samples. The goal is to see if the new approach improves the chance of getting a clear diagnosis for suspicious lung spots or ot…

This study tests a new technology that adjusts the radiation beam to follow lung tumors as they move when a person breathes during treatment. About 20 adults with early-stage lung cancer or limited lung metastases will take part. The goal is to see if the system works reliably an…

This study looks at cancer cells found in the blood of people with advanced lung cancer. Researchers want to see if these cells have certain DNA repair problems that could help choose the right treatment. About 80 patients will give blood samples to help build tumor models and te…

This study looks at how well the Ion Endoluminal System works in everyday medical practice for taking tissue samples from lung spots or nodules. About 1,300 adults who need a lung biopsy or lesion localization will be observed. The goal is to see how often the system correctly di…

This study follows over 1,800 people who finished treatment for early-stage lung cancer to see how often they get follow-up CT scans. Researchers want to know if getting scans every 6 months helps find new cancers earlier or improves survival compared to yearly scans. The goal is…

This study looks at whether educating doctors in small and mid-sized city hospitals about standard guidelines helps improve testing and treatment for people with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more get the right molecular tests…

This study looks at whether a special CT scan (4DCT) can help doctors avoid giving too much radiation to healthy parts of the lung during lung cancer treatment. Researchers will compare standard radiation plans with new plans that protect well-working lung areas. The goal is to s…