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New MRI technique maps Brain's inner workings during simple head turns

NCT ID NCT01633268

Knowledge-focused Sponsor: National Institutes of Health Clinical Center (CC) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses MRI to measure how the brain moves inside the skull during gentle head motions, like turning your head while swimming. Researchers will scan 90 healthy adults aged 18-65 as they perform small, repeated head movements. The goal is to develop a fast imaging method that can create 3D maps of brain deformation, which could eventually help predict brain injury risks from accidents or sports.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better computer models that predict which parts of the brain are most at risk during head impacts, helping prevent traumatic brain injuries.
What could go wrong
This is a small, early-stage technical study in healthy volunteers, not a treatment trial. The methods may not translate to real-world injury scenarios or be reproducible in larger, more diverse groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

101 people

The number who actually took part.

Started

Jul 2012

Finished

Nov 2025

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy volunteers between age 18 and 65.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: * Between 18 and 65 years of age * Able to provide written informed consent * Able to lie flat for up to 2 hours * Able to move head up to 220 times within 45 minutes without discomfort * Good general health based on History and Physical (H\&P) or History and Assessment (H\&A) EXCLUSION CRITERIA: * Contra-indications to MRI scanning without contrast based on RADIS department MRI safety questionnaire * Pregnancy * Inner ear problems causing vertigo * History of spinal cord injury, head injury or other musculoskeletal condition that may result in an aversion to or difficulty with turning one s head multiple times in succession * Claustrophobia (no sedation is permitted under this protocol) * Weight more than 250 lbs * Height greater than 6'4" * All employees/staff supervised by the Principle Investigator or Lead Associate Investigator are excluded from participation.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic Craniocerebral Trauma traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain mapping Craniocerebral trauma Healthy volunteer Magnetic resonance imaging Traumatic brain injury

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

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