Upper respiratory tract disorder

This study tests an experimental nasal vaccine made from a harmless virus (Sendai virus) that is similar to the one causing croup. The goal is to see if it is safe and helps children ages 1 to 5 build protection against croup. About 54 children will receive the vaccine as nose dr…

This phase 2 trial tests a weekly combination of two chemotherapy drugs (carboplatin and paclitaxel) plus the immunotherapy pembrolizumab in 31 patients with metastatic head and neck cancer who cannot receive the standard drug 5-fluorouracil. The goal is to see if this regimen sh…

This study tracks how often people get voice box injuries after having a breathing tube for 1 to 7 days in the ICU. It also tests whether a 14-day course of budesonide and azithromycin can help heal those injuries and improve breathing. About 64 adults who had a breathing tube wi…

This phase 3 trial tests whether a daily inhaler containing two bronchodilators (vilanterol and umeclidinium) can help preserve lung function and improve quality of life in people with mild-to-moderate COPD who are undergoing lung cancer surgery. About 204 participants will use t…

This study tests whether weekly infusions of Alpha-1 MP (a protein replacement) can slow lung damage in 345 people with emphysema caused by Alpha-1 antitrypsin deficiency. Participants receive one of two doses or a placebo for three years, with lung CT scans tracking changes. The…

This pilot study tests whether giving N95 masks and indoor air cleaners to 20 older adults with COPD can reduce lung flare-ups during poor air quality from wildfires. Participants are Kaiser Permanente members aged 65+ who use oxygen. The study focuses on whether this approach is…

This study compares two ways of giving the chemotherapy drug cisplatin alongside radiation for people with advanced head and neck cancer. One group gets a high dose every three weeks, the other gets a lower dose weekly. The goal is to see if the weekly schedule causes fewer side …

This phase 2 trial tests a drug called VK-2019 in 13 patients with Epstein-Barr virus (EBV)-positive nasopharyngeal cancer that has returned or spread and has no standard treatment. VK-2019 works by blocking a key viral protein, EBNA1, which the virus needs to survive. The main g…

This phase II trial tests whether combining the immunotherapy drug durvalumab (Imfinzi) with radiation therapy can effectively treat intermediate-risk head and neck cancer after surgery, while causing fewer serious side effects than the standard cisplatin-based chemo-radiation. T…

This study looks at the long-term safety of a weekly intravenous treatment for people with emphysema caused by alpha-1 antitrypsin deficiency. About 290 adults who completed a prior study will receive the drug for 2 more years. The main goal is to monitor side effects, not to cur…

This study tests whether a blood test for Epstein-Barr virus (EBV) DNA can help doctors choose the best chemotherapy after standard radiation for nasopharyngeal cancer. About 685 patients will first receive standard chemoradiation. Then, based on whether EBV DNA is still detectab…

This phase II trial is testing whether combining the immunotherapy drug cemiplimab with low doses of two chemotherapy drugs (paclitaxel and carboplatin) can shrink tumors in people with head and neck cancer that has come back or spread. The study includes 46 participants who have…

This phase 2 trial tests whether adding inhaled corticosteroids to standard COPD treatment improves blood vessel function in the lungs. Thirty adults with COPD, aged 40-80, will take either Bevespi or Bretzri for four weeks. Researchers will measure how well lung blood vessels wi…

This phase II trial tests whether combining two immunotherapy drugs, ipilimumab and nivolumab, can shrink tumors in people with advanced nasopharyngeal carcinoma (NPC) linked to the Epstein-Barr virus. About 113 patients with recurrent or metastatic NPC that can't be cured will r…

This early-phase trial is testing whether adding the drug peposertib to standard radiation therapy is safe and effective for people with advanced head and neck cancer who cannot take the chemotherapy drug cisplatin. The study involves 21 participants and aims to find the best dos…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This phase III trial compares the standard immunotherapy drug pembrolizumab alone versus pembrolizumab plus radiation therapy in 290 patients with metastatic head and neck cancer. The goal is to see if adding radiation improves overall survival. Participants receive pembrolizumab…

This study tests whether adding the targeted therapy cabozantinib to a standard immunotherapy combination (nivolumab and ipilimumab) can better control advanced nasopharyngeal cancer that has returned or spread. About 50 adults whose cancer worsened after platinum chemotherapy an…

This study tests a new drug called verekitug in 666 people with moderate-to-severe COPD, a long-term lung disease that makes breathing hard. The goal is to see if it can reduce serious flare-ups and improve lung function compared to a placebo. Participants must be current or form…

This study tests a daily tablet called BI 1291583 (Verducatib) in 268 adults with bronchiectasis, a long-term lung condition. Participants who were in earlier trials continue or switch to the drug for up to one year. The main goal is to check safety and see if the drug reduces lu…

This study tests a three-drug combination (sorafenib, carboplatin, and paclitaxel) in 48 people with head and neck cancer that has spread or returned. The goal is to see how well the treatment shrinks tumors and delays cancer growth. Participants must have a confirmed diagnosis a…

This early-phase trial studies whether a combination of regular check-ups, scans, blood tests, and ultrasound can safely find and guide removal of remaining cancer in neck lymph nodes after standard radiation for advanced nasopharyngeal cancer. About 50 adults aged 18-70 with N3 …

This study tests whether adding two drugs, niraparib and dostarlimab, to standard radiation therapy can better control advanced head and neck cancer. About 34 adults with stage III or IV cancer will receive the drugs before, during, and after radiation. The goal is to see if this…

This study tests whether giving an extra dose of radiation to oxygen-poor (hypoxic) areas of head and neck tumors can improve treatment response. About 91 adults with advanced squamous cell cancer of the throat or voice box will receive standard chemo-radiation with or without th…

This phase 2 trial is testing whether combining pembrolizumab (an immunotherapy) with olaparib (a PARP inhibitor) can shrink tumors in people with nasopharyngeal cancer that has become resistant to platinum-based chemotherapy. The study plans to enroll 30 adults whose cancer has …

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This early-phase trial tests a new drug called berzosertib (M6620) alongside standard chemotherapy (cisplatin) and radiation in people with advanced head and neck cancer that has spread to nearby tissues. The main goals are to find the safest dose and to see what side effects occ…

This study tests three different drug combinations in 430 adults with advanced head and neck cancer that has spread or returned after prior immunotherapy. The goal is to see if adding bevacizumab to standard chemo, or using atezolizumab plus bevacizumab, works better than the usu…

This phase 3 trial tests whether adding monalizumab to the standard drug cetuximab helps people with recurrent or metastatic head and neck cancer live longer. The study includes 370 adults who have already tried an immune checkpoint inhibitor and platinum-based chemotherapy. Part…

This phase 3 trial tested whether adding bevacizumab to standard chemotherapy helps people with head and neck cancer that has returned or spread. About 403 adults took part. The main goal was to see if the combination improved overall survival compared to chemotherapy alone.

This phase 3 trial is testing whether adding the immunotherapy drug tislelizumab to standard chemotherapy can improve outcomes for people with locoregionally advanced nasopharyngeal carcinoma. About 450 participants will receive either tislelizumab plus chemo or a placebo plus ch…

This study tests whether giving radiation only to the involved lymph nodes (instead of the whole neck area) can control early-stage nasopharyngeal cancer just as well, with fewer side effects. About 414 adults with limited lymph node involvement will be randomly assigned to eithe…

This study tests a drug called 177Lu-DOTATATE, which delivers radiation directly to cancer cells, in people with metastatic nasopharyngeal cancer that has not responded to at least two prior treatments. Only patients whose tumors show up on a special scan are eligible. The main g…

This phase 2 trial tests whether it is safe to skip radiation on one or both sides of the neck that show no signs of cancer after surgery. The goal is to reduce side effects like dry mouth and trouble swallowing without increasing the chance of cancer returning. The study include…

This study tests whether a structured care program (called a transition bundle) helps people with COPD recover better after a serious flare-up. The program includes guided steps and regular check-ins. About 1,368 patients across 36 hospitals will take part. The goal is to see if …

This study tests an experimental drug called astegolimab against a placebo in 1290 people with COPD who have frequent flare-ups. Participants are current or former smokers. The main goal is to see if the drug reduces the number of moderate to severe COPD attacks over one year.

This study looks at the long-term safety of a drug called itepekimab for people with chronic obstructive pulmonary disease (COPD). About 700 adults who already completed earlier itepekimab studies will receive the drug every 2 or 4 weeks for up to 52 weeks, plus a 20-week follow-…

This study tests whether adding the experimental drug ipatasertib to the standard immunotherapy pembrolizumab works better than pembrolizumab alone for people with head and neck cancer that has returned or spread. About 52 adults with incurable, advanced squamous cell carcinoma w…

This phase II trial is testing whether combining an immunotherapy drug (PD-1 antibody) with standard chemotherapy and radiation can help people whose nasopharyngeal cancer has come back after initial treatment. The study includes 68 participants with high-risk recurrent cancer th…

This study tests whether giving radiation to a smaller area of the neck is as good as the standard larger area for treating nasopharyngeal cancer that hasn't spread. About 474 adults with newly diagnosed cancer will be randomly assigned to one of two radiation plans. The goal is …

This study tests whether adding an experimental drug called INBRX-106 to the standard immunotherapy pembrolizumab (Keytruda) works better than pembrolizumab alone for people with advanced head and neck cancer that has spread or come back. About 410 participants whose tumors have …

This phase 2 trial tests the safety and effectiveness of SKB264, a new drug, in 321 adults with advanced solid tumors, specifically non-small cell lung cancer and nasopharyngeal carcinoma. Participants receive SKB264 alone until the drug stops working or side effects become too s…

This phase II trial is testing whether combining targeted radiation (SBRT) with an immunotherapy drug (camrelizumab) and standard chemotherapy can help control nasopharyngeal cancer that has spread to a few other parts of the body. The study involves 41 participants who have not …

This phase 3 trial tests whether adding the experimental drug KL-A167 to standard chemotherapy (cisplatin and gemcitabine) helps people with recurrent or metastatic nasopharyngeal carcinoma live longer without their cancer growing. About 295 adults aged 18–75 are participating. T…

This study tests a nasal spray called OPN-375 in about 72 teenagers (ages 12-17) who have nasal polyps—growths inside the nose that cause stuffiness and breathing trouble. The spray is given twice a day for 16 weeks, and some participants receive a placebo (inactive spray) for co…

This phase 2 trial tests whether adding the immunotherapy drug sintilimab to the chemotherapy drug capecitabine can better prevent nasopharyngeal cancer from returning after initial treatment. About 150 patients whose cancer did not fully respond to induction chemotherapy will re…

This study tests a shorter, more intense course of radiation therapy (hypofractionated IMRT) given after surgery for head and neck cancer. The goal is to see if it is safe and if it can help patients maintain better swallowing function compared to the standard longer radiation sc…

This study tests an inhaled drug called frespaciguat (MK-5475) in 129 adults who have high blood pressure in their lungs caused by COPD. The main goal is to see if the drug helps people walk farther in 6 minutes after 24 weeks compared to a placebo. Participants take one daily in…

This study compares three different dual bronchodilator inhalers (Anoro, Ultibro, Spiolto) against a single bronchodilator (Spiriva) in 100 people with COPD. The goal is to see which treatment improves exercise endurance the most. Each participant will try all four treatments for…

This study tests whether atorvastatin, a widely used cholesterol medication, can reduce inflammation and prevent flare-ups in smokers with chronic obstructive pulmonary disease (COPD). About 460 participants will receive either atorvastatin or a placebo for several months. The go…

This phase 3 trial tests a new drug called BL-B01D1 against standard chemotherapy for people with advanced nasopharyngeal cancer that has not responded to at least two prior treatments. About 386 participants will be randomly assigned to receive either the new drug or a standard …

This study tests whether online training and regular feedback reports can help doctors prescribe fewer antibiotics for common infections like ear infections, strep throat, sinusitis, and pneumonia in children. About 420 children aged 6 months to 12 years are included. The goal is…

This study tests whether a 13-week home exercise program, done via live video calls, can reduce hospital readmissions in people with COPD. 301 patients who were recently hospitalized for a COPD flare-up will either get the video rehab or standard care. The goal is to see if this …

This early-phase trial tests the combination of two drugs, vorinostat and azacitidine, in people with nasopharyngeal cancer or nasal NK-T cell lymphoma that has come back or spread. The main goal is to find the safest dose and see how the body responds. Only 18 participants are e…

This study tests a new drug called SAR447537 (INBRX-101) in 185 adults with alpha-1 antitrypsin deficiency (AATD) emphysema, a genetic condition that causes lung damage. The drug is a lab-made protein designed to replace the missing enzyme and slow disease progression. The main g…

This study is testing whether a precise form of radiation called proton therapy can control head and neck cancer after surgery as well as standard X-ray radiation, but with fewer side effects. About 174 adults with newly diagnosed head and neck cancer will receive either proton t…

This study tests an experimental inhaler called HSK39004 in 180 adults with COPD, a long-term lung disease that makes breathing hard. Participants will use the inhaler or a placebo for 4 weeks to see if it safely improves lung function. The goal is to control the disease and ease…

This study tests a drug called tozorakimab in people with chronic obstructive pulmonary disease (COPD) who have a history of flare-ups and high levels of eosinophils (a type of white blood cell). The trial involves 98 participants who receive either tozorakimab or a placebo every…

This phase 2 trial tests TQC2938, a lab-made antibody, in 256 people with moderate to severe COPD. The goal is to see if the drug can reduce the number of serious flare-ups over 24 weeks compared to a placebo. Participants receive injections and are monitored for safety and side …

This study tests a new device called the Apreo Implant, which is placed in the airways during a bronchoscopy to release trapped air in severely overinflated lungs. Up to 30 people with severe emphysema will receive up to two procedures, with follow-up for one year. The main goals…

This study tests whether adding a freezing spray (cryospray) to usual treatments can keep narrowed airways open longer in people with benign airway stenosis. About 40 adults will be randomly assigned to get either standard care alone or standard care plus cryospray. The goal is t…

This study tests whether using a handheld breathing device (OPEP) at home, combined with aerobic exercise, can reduce serious flare-ups and hospital visits in people with moderate to severe COPD. About 312 participants aged 40-80 will be split into four groups: standard care, OPE…

This study tests a new treatment for cancers linked to the Epstein-Barr virus (EBV), such as Hodgkin lymphoma and nasopharyngeal carcinoma. The treatment uses immune cells from healthy donors that are specially trained to attack EBV-infected cells. These cells are stored in a ban…

This study tests an investigational drug called tozorakimab in about 1,454 adults with symptomatic COPD who have had at least two moderate or one severe flare-up in the past year. Participants continue their usual inhaled medications and receive either tozorakimab or a placebo as…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study tests whether regular follow-up calls or visits from a nurse can help smokers aged 35-65 who are screened for COPD to quit smoking. About 233 participants will receive ongoing nursing support. The goal is to see if this simple, low-cost approach reduces the number of c…

This early trial is testing a device called the Implantable Artificial Bronchus (IAB) in 20 adults with COPD or emphysema. The device is placed in the airways using a bronchoscope to relieve lung overinflation and improve airflow. The main goal is to check safety, looking for ser…

This phase II trial tests whether combining two drugs, atezolizumab and bevacizumab, can shrink rare solid tumors like appendix cancer, anal cancer, and mesothelioma. About 133 participants with various rare cancers will receive the drugs intravenously. The goal is to see if the …

This study tests an experimental drug, YL201, in about 990 people with advanced solid tumors like lung, prostate, and liver cancers. The goal is to check safety and see if tumors shrink. It is an early-stage trial, so the drug is not yet proven to work.

This study tested a combination of two chemotherapy drugs (cisplatin and docetaxel) plus an immunotherapy drug (pembrolizumab) in 28 patients with stage II or III laryngeal cancer. The goal was to see if this drug-only approach could control the cancer and avoid the need for surg…

This early-stage trial tests a new inhaled nitric oxide treatment (RESP30X) in 60 adults with non-cystic fibrosis bronchiectasis who have stubborn lung infections like Pseudomonas. The main goals are to check safety and how well the body tolerates the mist, while also seeing if i…

This study is testing a new combination of two drugs (AK112 and AK117) in about 154 adults with advanced solid tumors that have not responded to standard treatments. The goal is to see if the combination can shrink tumors and how safe it is. Participants receive the drugs intrave…

This study tests whether an electronic visit (e-visit) can help adults aged 40+ in rural areas quit smoking and get screened for COPD. Participants are randomly assigned to receive the e-visit or standard care. The e-visit is like an online questionnaire about smoking history and…

This study tests whether a special training program for primary care doctors can help people with COPD take their medications more regularly. The training includes updated COPD guidelines, inhaler technique workshops, and motivational interviewing. Researchers will compare medica…

This Phase 2 trial tests a new biologic drug called JKN24011 in 215 people with moderate to severe COPD. Participants receive either the drug or a placebo as a shot under the skin every four weeks. The main goal is to see if the drug can reduce the number of moderate or severe CO…

This phase 2 trial tests a combination of two chemotherapy drugs (carboplatin and nab-paclitaxel) plus an immunotherapy drug (durvalumab) given before surgery for people with locally advanced head and neck cancer. The goal is to shrink or eliminate the tumor so that radiation—whi…

This early-phase study tests whether a personalized immune cell therapy (dendritic cells) is safe and can help control advanced nasopharyngeal cancer. The treatment uses the patient's own immune cells and donor cell secretions to boost the body's cancer fight. The study involves …

This early-phase trial is testing a new type of cell therapy called P-MUC1C-ALLO1 for people with advanced solid tumors (like breast, ovarian, lung, or pancreatic cancer) that have not responded to other treatments. The therapy uses donor immune cells engineered to recognize and …

This study tests whether digital tools can help people with allergic rhinitis (hay fever) better control their symptoms. About 240 adults will use a smartphone platform that tracks symptoms, sends reminders, and gives personalized advice. Researchers will compare their progress t…

This study tests a drug called MRG003 in adults whose nasopharyngeal cancer has come back or spread and hasn't responded to standard treatments. The goal is to see if the drug can shrink tumors and how safe it is. About 238 participants will receive the drug, and researchers will…

This study looks at 150 adults with COPD who have just had a breathing tube removed. It compares two ways to help them breathe: a high-flow nasal cannula (a soft tube that delivers warm, moist oxygen) versus noninvasive ventilation (a mask that pushes air into the lungs). The goa…

This 5-year study is looking at how well a year-round allergy treatment (MATA trees or MATA grass) works for children and adults with pollen allergies, including hay fever and mild asthma. Researchers want to see if the treatment is as effective in kids as it is in adults. About …

This study tests whether adding two drugs, pembrolizumab and olaparib, before and after standard chemoradiation can help control locally advanced head and neck cancer. About 45 adults with this cancer will receive the drug combination. The main goal is to see if this approach imp…

This early-stage trial tests whether specially trained immune cells (T cells) that are resistant to a cancer's defense protein (TGF-beta) can safely fight EBV-positive nasopharyngeal carcinoma. Fourteen patients with relapsed or hard-to-treat cancer will receive these gene-modifi…

This study tests whether doxycycline, an antibiotic, can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers with HIV will take doxycycline for 72 weeks. Researchers will measure lung function, walking ability, and check for antibiotic r…

This study tests two drugs, pembrolizumab and cabozantinib, in 36 people with head and neck cancer that has returned or spread and cannot be surgically removed. The goal is to see if the combination shrinks tumors and delays cancer growth. Participants receive both drugs intraven…

This phase II trial is testing a combination of three drugs—anlotinib, penpulimab, and capecitabine—as a first treatment for people whose nasopharyngeal cancer has come back or spread. The study includes 59 adults aged 18 to 65 who have not had prior systemic therapy for their re…

This early-phase study tests a new drug, DKY709, alone or with another drug (PDR001) in people with advanced solid tumors like lung cancer, melanoma, and breast cancer. The main goal is to find a safe dose and check for side effects. About 98 adults whose cancer worsened after st…

This study tests whether a video call with a pharmacist shortly after hospital discharge can help COPD patients use their inhalers correctly and avoid return trips to the hospital. About 218 adults hospitalized for a COPD flare-up will take part. The goal is to see if this telehe…

This study tests a new device that electrically stimulates the voice box muscles in people with bilateral vocal fold paralysis, a condition where both vocal cords are stuck closed. The main goal is to see if the device is safe and can improve breathing and voice quality. Eight ad…

This Phase 2 trial tests an inhaled drug called HSK39004 in 12 people with COPD. The study measures how much drug gets into the blood and how it affects lung function over 12 hours. It compares HSK39004 to an existing treatment to see if it works as well or better.

This early-stage trial is testing a new drug called KFA115, either by itself or combined with the immunotherapy Keytruda (pembrolizumab), in 126 people with advanced cancers like lung, skin, kidney, and others. The main goal is to check safety and find the best dose. It is not ye…

This study tests a treatment plan for people with stage IVA nasopharyngeal cancer (a type of nose and throat cancer). Participants receive a combination of the immunotherapy drug pembrolizumab and chemotherapy before and during radiation, followed by maintenance pembrolizumab for…

This early-phase trial is testing an experimental drug called INBRX-106, alone or combined with the immunotherapy Keytruda, in people with advanced solid tumors (including lung, head and neck, melanoma, and others) that have stopped responding to standard treatments. The main goa…

This early-stage trial tests a special balloon coated with a drug (paclitaxel) to treat non-cancerous narrowing of the central airways. The goal is to see if it is safe and helps keep the airway open longer than standard balloons. About 45 adults with severe airway blockage will …

This Phase 2 trial tests an injection called TQC2731 in 258 adults with moderate-to-severe COPD. The drug blocks a protein linked to airway inflammation. Researchers will measure how well it reduces the number of moderate or severe flare-ups over 24 weeks compared to a placebo.

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This phase 2 trial tests whether adding a PD-1 inhibitor (a type of immunotherapy) to standard chemotherapy before radiation can improve outcomes for people with advanced nasopharyngeal carcinoma. About 150 participants will receive either the combination or chemotherapy alone, f…

This study tests an investigational drug called 611 in 243 adults with chronic sinusitis and nasal polyps that haven't been well-controlled by other treatments. The goal is to see if 611 can shrink polyps and ease nasal congestion over 24 weeks. Participants receive either the dr…

This phase II trial tests a personalized treatment for metastatic nasopharyngeal carcinoma. Patients first receive tislelizumab (immunotherapy) plus chemotherapy. Those who respond well may avoid or reduce radiotherapy, while others get targeted radiation. The study aims to see i…

This Phase III trial tests whether adding a low-dose chemotherapy pill (capecitabine) after standard chemoradiation helps prevent cancer from returning in people with high-risk nasopharyngeal cancer. About 252 participants with stage T1-2N1M0 disease and certain high-risk feature…

This study tests whether a piece of donated aorta (the body's largest artery) can be used as a patch to repair severe windpipe or bronchial defects in children. The surgery is for kids who cannot have standard windpipe repair. Only 5 children will be enrolled, and the main goal i…

This study tests a new device called the SPIRION Laryngeal Pacemaker in 20 people with bilateral vocal cord paralysis, a condition that narrows the airway and makes breathing difficult. The device is implanted to help open the vocal cords during breathing. The main goals are to c…

This early-stage study is testing an experimental drug called GB-0895 in 156 adults with mild-to-moderate asthma or COPD. The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo as an injection under the skin.…

This study provides early access to brensocatib, an experimental tablet, for people with non-cystic fibrosis bronchiectasis who finished the ASPEN trial. Participants must have already taken brensocatib without serious side effects. The goal is to offer continued treatment while …

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) combined with radiation works better than the standard chemotherapy drug cisplatin with radiation for patients with a certain type of head and neck cancer (p16-positive). About 126 adults with advanced or in…

This study aimed to see if a salmon oil supplement called Cardio® could reduce inflammation and lower heart disease risk in people with chronic obstructive pulmonary disease (COPD). It planned to enroll adults with COPD who smoke or used to smoke. However, the study was withdrawn…

This Phase 2 trial is testing dupilumab (Dupixent) in 17 people with aspirin-exacerbated respiratory disease (AERD), a condition that includes asthma, nasal polyps, and severe reactions to aspirin. The study aims to see if the drug can reduce markers of inflammation and improve s…

This study tests whether stem cells taken from a person's own belly fat can safely help treat chronic lung diseases like COPD. About 100 adults with moderate to severe COPD will receive their own processed cells through an IV. The main goal is to check safety and see if lung func…

This study compares two ways to remove tonsils in adults with recurrent or chronic tonsillitis: the traditional method (extracapsular) and a newer partial removal method (intracapsular). Researchers will track pain, bleeding, and painkiller use after surgery in 167 adults. The go…

This study tests whether transplanting a donor voice box (larynx) can safely restore voice, swallowing, and breathing in people with severe larynx damage or who have had their larynx removed. Ten adults will receive the transplant and be followed for five years. The trial is curr…

This phase 3 trial tests whether using smaller radiation targets after initial chemotherapy can control advanced nasopharyngeal cancer just as well as standard larger targets, while reducing side effects. About 445 patients with stage III-IVa disease are enrolled. The study compa…

This Phase 3 trial tests whether giving a three-drug chemotherapy regimen (docetaxel, cisplatin, and fluorouracil) before radiotherapy helps people with advanced laryngeal or hypopharyngeal cancer avoid losing their voice box. The standard approach is to give cisplatin during rad…

This study tests a new type of CT scan, called Photon-Counting CT, to see if it can more accurately show how far laryngeal cancer has spread. Sixty adults with laryngeal cancer will get this scan while making a sound, which may help separate normal tissues from tumor. The goal is…

This study tests a lollipop-shaped device called CandyCollect to see if it can detect strep throat in children ages 5-17. Kids suck on the lollipop for a few minutes, and it captures bacteria in special channels. Researchers compare results to standard throat swabs to see if the …

This Italian study is testing whether heavy smokers can be screened for lung cancer just as effectively with a CT scan every two years instead of every year, and whether a simple blood test can help catch cancers early. Over 7,300 current or former heavy smokers are taking part a…

This study is testing whether an artificial intelligence program can detect chronic obstructive pulmonary disease (COPD) by analyzing cough sounds recorded on a smartphone. Researchers will collect cough recordings and medical data from 3,000 adults in China, both with and withou…

This study tests whether Withings bathroom scales can accurately measure pulse wave velocity (PWV), a key indicator of vascular stiffness. Researchers will compare readings from the scales with a standard medical device in 176 adults, including those with high blood pressure, sle…

This study is tracking the safety and performance of a device called ECE50 used during routine medical exams. It involves 384 adults who need a diagnosis for voice box muscle issues, like vocal fold paresis or laryngeal dystonia. The goal is to see if the device works as well as …

This study tests whether a specially designed probiotic, Streptococcus salivarius eK12, can prevent repeated strep throat infections in children aged 3 to 10. The probiotic is given as a daily supplement and aims to crowd out the harmful bacteria without antibiotics. Researchers …

This study tests whether using home sensors to monitor dehydration risk can reduce hospitalizations and emergency room visits in head and neck cancer patients. About 427 participants will either use the CYCORE sensor system plus standard care, or standard care alone. The goal is …

This study tests a propolis throat spray to see if it can reduce how often and how long healthy adults get sick. One hundred people aged 18 to 65 will use the spray or a placebo daily for 16 weeks and report any illnesses. The goal is to find a simple way to prevent common colds …

This study tests a new nurse-led counselling program designed to help people with stable COPD manage emotional distress. Fifteen outpatients will receive ten counselling sessions over three months. The main goal is to see if the program is feasible, not to prove it works. Researc…

This study tests a new counseling program designed to help people with COPD cope with emotional distress during a sudden worsening of their condition. Twenty adults hospitalized for a COPD flare-up will receive ten counseling sessions with a specialized nurse over three months. T…

This study tests a programmed weaning plan for patients with a sudden worsening of COPD who need a breathing machine (noninvasive ventilation). The goal is to see if a step-by-step reduction in machine use can safely shorten the time on ventilation and in the ICU. About 80 adults…

This small pilot study tests whether an inhaled medication called Treprostinil can reduce breathlessness and improve exercise ability in people with mild COPD. Twenty participants will take either the drug or a placebo and undergo lung function tests, exercise tests, and imaging.…

This phase 3 trial tests a daily tablet that dissolves under the tongue to treat house dust mite allergies. It includes 327 Chinese participants aged 12-65 with allergic rhinitis, with or without asthma. The goal is to see if the tablet reduces allergy symptoms and the need for o…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This early-stage study tests a new drug called GSK3862995B to see if it is safe and tolerable. First, healthy adults receive a single dose, then people with chronic obstructive pulmonary disease (COPD) receive multiple doses. The goal is to check for side effects and how the drug…

This early-stage trial tests a new biologic drug called ASP2390, given as a skin injection, in 28 adults with house dust mite allergies. The main goal is to check safety and how the immune system responds, not yet whether it works. If successful, it could lead to a new way to eas…

This pilot study tests whether an 8-week mindfulness program (MBSR) can reduce anxiety, depression, and stress in people with COPD who are already in pulmonary rehab. About 44 participants will be followed for 12 months. The goal is to see if this mind-body approach improves emot…

This study compares standard radiofrequency ablation of the front part of the nasal turbinates with an extended version that also treats the middle and back portions. Sixty adults with chronic rhinitis who still have symptoms despite medication will be randomly assigned to one of…

This study tests a new device called SonoHeal that uses sound waves to help people with cystic fibrosis, bronchiectasis, or COPD clear mucus from their lungs. Fifteen participants will try the device at home to see if it is easy to use and acceptable. The study also compares it t…

This study tests whether rinsing the nose with a xylitol solution can reduce sinus symptoms in adults with cystic fibrosis. Participants will use both xylitol and standard saline rinses at different times to compare effects. The goal is to see if xylitol, a natural sugar alcohol,…

This study tests whether wearing pressurized gloves and foot caps during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by the drug paclitaxel. It involves 182 people with nasopharyngeal cancer who have not yet started treatment. Each patient serves as their…

This pilot study tests whether TCM Daoyin, a traditional Chinese movement and breathing therapy, can improve lung function and exercise ability in 60 adults aged 40-75 who are at risk for early chronic obstructive pulmonary disease (COPD). Participants will be randomly assigned t…

This Phase 2 trial tests whether an injection called DM-101PX can reduce nasal symptoms caused by birch pollen allergy. About 100 adults with birch pollen allergic rhinitis or rhinoconjunctivitis will receive either the drug or a placebo. The main goal is to see if the treatment …

This study is testing whether taking probiotic capsules daily for 16 weeks can reduce shortness of breath and improve lung function in people with COPD. Sixty adults with stable COPD will receive either the probiotic or a placebo. Researchers will measure changes in breathing, sy…

This study tests whether taking oral probiotics can reduce symptoms of allergic rhinitis (hay fever) and improve quality of life. Researchers will give probiotics to 225 people aged 6 to 65 with diagnosed allergic rhinitis and measure changes in nasal symptoms, inflammation marke…

This study tests whether a simple vocal exercise—humming or singing through a straw—can help people with voice fatigue or hoarseness expand their pitch range and improve voice stability. About 120 adults with no current voice disorder but with high or low vocal activity will perf…

This study compares remimazolam, a new ultra-short-acting sedative, to propofol in 200 patients aged 65 or older with serious health conditions. The goal is to see if remimazolam provides better heart and breathing stability during endoscopic procedures. Researchers will also mea…

This study is tracking 150 adults with chronic rhinitis (long-term runny nose and congestion) who are receiving treatment with the NEUROMARK device. The device uses radiofrequency energy to disrupt nerves in the nose, aiming to reduce symptoms. Researchers are collecting real-wor…

This study explores whether training people with essential vocal tremor to speak with a breathy voice can reduce shakiness and improve their quality of life. Forty participants will learn the technique and rate its ease and effectiveness. Researchers will also measure voice recor…

This pilot study tests whether home-based or video-supervised exercise programs are acceptable and helpful for people with chronic lung diseases like IPF, sarcoidosis, bronchiectasis, asthma, and other interstitial lung diseases. Fifty participants will be randomly assigned to on…

This study looks at whether a breathing technique used by free divers can reduce symptoms of allergic rhinitis, like nasal congestion and sneezing. Thirty adults with persistent allergies will practice the 40-minute breathing sessions. Researchers will measure symptom scores, nas…

This study tests two new types of pulmonary rehabilitation—home-based and tele-rehabilitation—for people with COPD who cannot attend standard hospital or community programs. The goal is to see if these options are better than usual care (medication and check-ups) at reducing symp…

This study compares two nasal sprays for moderate-to-severe allergic rhinitis (hay fever): fluticasone alone versus a combination of fluticasone and azelastine. Researchers will track symptom relief and quality of life in 61 adults over two months to see which spray works better …

This study tests a procedure called RhinAer that uses heat to treat the nerves in the nose for people with chronic rhinitis (long-term stuffy or runny nose). Researchers want to see if it reduces inflammation and improves symptoms like cough and post-nasal drip. About 25 adults a…

This study explores whether adding guided meditation through a virtual reality headset at the start of voice therapy sessions can help people with voice disorders learn and retain treatment better. Sixty participants will use the TRIPP app on a Meta Quest 2 headset to meditate be…

This pilot study tests whether tezepelumab, a drug already approved for severe asthma, can also reduce nasal symptoms caused by hayfever in people who have both allergic asthma and allergic rhinitis. Nineteen participants will receive monthly injections of tezepelumab for 12 mont…

This early-phase study tests the safety of combining the drug tolinapant with radiation therapy for people with head and neck cancer that has spread locally but hasn't been treated yet. Participants are those who cannot receive the standard chemotherapy drug cisplatin. The goal i…

This study tests whether using lignocaine (a numbing medicine) instead of air to inflate the cuff of a breathing tube can lower the chance of sore throat, cough, and hoarseness after surgery. About 80 adults having general anesthesia will be randomly assigned to receive either ai…

This pilot study tests whether a small procedure done in the doctor's office (called EPIC) can work as well as standard sinus surgery for people with chronic sinusitis and nasal polyps. The EPIC procedure is done under local anesthesia and has a shorter recovery time. The study o…

This study tests an experimental injection called LP-003 in 546 adults with moderate to severe seasonal allergic rhinitis (hay fever) that standard medications don't manage well. Participants receive either the drug or a placebo, and report their nasal symptoms daily. The goal is…

This study was designed to see if a combination of levocetirizine (an allergy medicine) and pseudoephedrine (a decongestant) works better than levocetirizine alone for relieving nasal congestion in people with allergic rhinitis. It planned to enroll people aged 12 to 65 with the …

This study tests whether using a breathing muscle training device, along with standard physical therapy, helps people recover more quickly after a lung transplant. About 90 adults waiting for a lung transplant will take part. The goal is to see if this training improves breathing…

This study tests a laser procedure that targets nerves in the nose to relieve chronic rhinitis symptoms like runny nose, sneezing, and stuffiness. 120 adults who haven't gotten relief from standard medications will receive either the laser treatment or a sham procedure. Researche…

This study tests a low-cost, equipment-free exercise program for people with COPD who have trouble getting up from the floor. The program uses simple floor-to-stand movements done at home and with supervision for 9 weeks, with a check-up at 18 months. The goal is to see if this p…

This study tests whether an 8-week Clinical Pilates program can improve lung function, chest mobility, motor performance, sleep, and quality of life in 38 people with mild (Gold A) COPD. Participants will attend two 60-minute sessions per week using soft balls and elastic bands. …

This study compares two common surgical tools (monopolar and bipolar electrocautery) used during tonsil removal to see which one causes less pain and bleeding after surgery. It involves 74 people aged 5 to 40 who need their tonsils out due to chronic tonsillitis or other issues. …

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

This study tests whether a powered exoskeleton that helps the hips can improve walking endurance in people with very severe chronic lung disease. The device takes over some of the work of walking, lowering the energy and breathing demand. Twelve participants will compare walking …

This study tests whether using a device that sends mild electrical pulses to the leg muscles can help people with COPD feel more confident about exercise, reduce shortness of breath during activity, and lessen fatigue. Forty patients with mild to severe COPD will receive the stim…

This study tests a new epinephrine nasal powder (FMXIN002) against the standard EpiPen injection in 50 healthy adults with allergies. Researchers will measure how quickly and effectively the nasal spray delivers epinephrine into the body and its effects on vital signs. The goal i…

This early study looks at whether smokers with mild to moderate COPD can improve their symptoms and reduce lung inflammation by switching from regular cigarettes to e-cigarettes. About 30 participants will use e-cigarettes to cut down their smoking by at least 75%. Researchers wi…

This study compares standard pulmonary rehabilitation exercises to rehabilitation through dance for people with chronic obstructive pulmonary disease (COPD). Forty-four participants will be randomly assigned to either standard rehab or dance-based rehab for 8 weeks. The goal is t…

This study looks at two different procedures to help children aged 1 to 10 years who have trouble swallowing due to a laryngeal cleft (a gap in the airway). One procedure injects a gel to build up the airway wall, the other uses stitches to close the gap. The goal is to see which…

This study tests a new treatment called GNR-127 for people with seasonal allergies to birch pollen. The treatment is a protein that aims to reduce allergy symptoms like sneezing, runny nose, and itchy eyes. The trial involves 150 adults and will check for safety and how well it w…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study follows 200 adults aged 30-55 who smoke or have early COPD to learn how the disease progresses. Researchers will use breathing tests, symptom surveys, and CT scans to find early warning signs. The goal is to better understand risk factors and improve future care for CO…

This study will follow 3,000 people with COPD who have frequent flare-ups to see how the disease changes over time and what treatments they receive. Researchers will collect information from medical records and surveys to understand treatment patterns, quality of life, and caregi…

This study looks at whether having a heart doctor check patients during a COPD flare-up helps find and treat hidden heart problems. 150 hospitalized adults with COPD are randomly assigned to see only a lung doctor or also a heart doctor. Researchers then track changes in heart tr…

This study looks at how dupilumab changes the way the nose and blood respond to house dust mites in adults with allergic asthma. Participants will be exposed to dust mites in a special chamber and receive either dupilumab or a placebo. The goal is to understand the drug's effects…

This study looks at how ozone, a common air pollutant, affects immune cells in the lungs of people with COPD. Researchers will expose 72 participants (including healthy non-smokers, smokers without COPD, and COPD patients) to ozone in a controlled chamber and track changes in the…

This study looks at over 1,700 people in Russia who have moderate to severe COPD and often have flare-ups. Researchers will collect information on their health, lifestyle, and treatments to better understand the disease. The goal is to learn more about these patients to help impr…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study tests whether AI-generated messages can change how cancer survivors think about alcohol and cancer risk. About 850 adults who have had certain cancers and currently drink alcohol will view different messages. Researchers will measure changes in their beliefs about canc…

This study aims to find out how many people with high blood tryptase levels have a genetic condition called hereditary hyper-alpha-tryptasemia. Researchers will test 100 patients who have had allergic reactions and high tryptase levels. The results may help doctors better manage …

This pilot study is testing whether two natural dietary supplements—taxifolin (found in apples and onions) and ergothioneine (found in mushrooms)—can improve immune function in healthy adults aged 50 to 65. Researchers will measure how well immune cells engulf and destroy threats…

This study follows 500 adults with vocal cord paralysis or atrophy who undergo laryngeal framework surgery. Researchers will track voice quality, swallowing ability, and complication rates for two years after surgery. The goal is to understand which surgical techniques work best …

This pilot study from the University of Aberdeen is looking at how dietary protein (from plants and animals) relates to sarcopenic obesity—a condition where muscle loss and obesity happen together—in 30 women aged 55+ with COPD. Researchers will also check lung function and infla…

This study looks at lung problems in over 2,000 World Trade Center workers and volunteers. Researchers will review chest CT scans and breathing tests to find signs of airway disease, lung scarring, and cancer. The goal is to better understand how these conditions develop and how …

This large real-world study will follow 10,000 Italian patients with COPD to see how their treatments, flare-ups, and other health conditions affect their risk of death. Researchers will collect data on medications, lung function, and heart problems over time. The goal is to bett…

This study follows 100 adults with severe chronic sinusitis and nasal polyps who are starting biologic treatments. Researchers want to see how these drugs improve quality of life, smell, and breathing over 6 months, and track any side effects. The goal is to learn which patients …

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19. Researchers will follow up to 160 participants over several years to track changes in lung function. The goal is to better understand why some patients struggle wi…

This study explores how problems with blood vessel function and genetics may contribute to early-stage COPD and emphysema. Researchers followed over 4,300 adults from a larger heart study, measuring lung function and CT scans. The goal is to understand risk factors, not to test a…

This study tests a remote monitoring wristband (Bora Care) to see if it can detect early signs of worsening COPD. 64 people with COPD who have had recent flare-ups are being followed. The goal is to see if the device can alert patients and doctors before a serious attack happens.

This study tracks 40 people with nasal polyps and severe asthma who are taking mepolizumab, a drug that reduces inflammation. Researchers collect nose, blood, and sputum samples before treatment and at 3, 6, and 12 months to see how the drug affects symptoms, nose bacteria, and g…

This study tracks 210 people with COPD over 4 years to see how bacteria and other microbes in the airways relate to lung function decline. Researchers collect fluid from the lungs during a bronchoscopy and analyze the microbial DNA. The goal is to understand why COPD gets worse i…

This study is testing whether a breathing test called the lung clearance index (LCI) can detect small airways disease in adults with chronic lung conditions like asthma or fibrosis. Researchers will compare results from 300 patients with lung disease to 300 healthy volunteers. Th…

This study looks at whether high-intensity interval training (HIIT) can help regenerate lung tissue in people with COPD who are waiting for lung volume reduction surgery. 24 participants will be randomly assigned to either a HIIT exercise program or no exercise. Researchers will …

This study is looking for early signs of lung cancer in people at high risk, such as older smokers or those with COPD. Researchers will collect blood and airway samples from 665 participants to find biomarkers that could predict lung cancer before symptoms appear. The goal is to …

This project works to make sure children with common respiratory infections get the right antibiotics for the right amount of time. It involves over 259,000 kids across many clinics. The goal is to learn the best ways to help doctors follow antibiotic guidelines and reduce unnece…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study follows 200 adults in Taiwan who have bronchiectasis, a lung condition that causes widening of the airways and leads to repeated infections. Researchers will track their health problems, treatments, and how the disease changes over time. The goal is to learn more about…

This study tests whether a wearable skin sensor can tell the difference between mild, moderate, and severe pain in 37 adults with cancer or COPD. Participants wear the device for up to a week and report their pain levels. The goal is to create an algorithm that alerts caregivers …

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study looks at 1,600 adults in Hong Kong who have been diagnosed with asthma or COPD to find out how many have both conditions (called Asthma-COPD Overlap). Researchers will track their health for 3 years to see how they do and whether their treatment matches guidelines. The…

This study was designed to track how often people in Egypt have severe COPD flare-ups and how those flare-ups affect their health and use of healthcare. It planned to look back at medical records of adults over 40 with COPD. However, the study was withdrawn before enrolling any p…

This study follows 108 nasopharyngeal cancer survivors who had radiation and chemotherapy at least four years ago. Researchers are measuring long-term side effects like hormone problems, hearing loss, and memory issues using blood tests, cognitive exams, and quality-of-life surve…

This study compares 16 people with mild-to-moderate COPD to 16 healthy volunteers matched by age, sex, and height. Researchers measure blood volume in the lungs and the whole body to see if a smaller lung blood volume contributes to exercise problems. No treatment is given—the go…

This study looks at whether a structured exercise and education program (pulmonary rehabilitation) can reduce inflammation and oxidative stress in people with stable COPD. Researchers will measure specific blood markers before and after the program in 27 adults aged 40-80. The go…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study aims to improve how doctors communicate with patients facing serious illnesses like cancer, heart failure, COPD, or dementia. Researchers will give doctors detailed feedback on their conversations about goals of care. The goal is to help patients receive care that matc…

This study planned to test a 3D-printed device that helps people with chronic lung disease use their soft-mist inhaler correctly. It was designed for adults aged 45-80 who were new to this type of inhaler. The study was withdrawn before enrolling any participants, so no results a…

This study looks at the bacteria living in the nose and sinuses of people with chronic sinusitis, allergies, and healthy individuals. By analyzing tissue samples from 285 participants, researchers hope to identify which bacteria are linked to long-term inflammation. The goal is t…

This study was designed to test whether eccentric cycling (a type of exercise that focuses on lengthening muscles) could improve heart and lung fitness and quality of life in people with chronic obstructive pulmonary disease (COPD). The plan was to compare eccentric cycling to st…

This study tests whether giving patients an information sheet during a doctor's visit for a respiratory infection (like bronchitis, sinusitis, or sore throat) can lower antibiotic prescribing and improve communication. About 1,100 adults in Danish general practices will either re…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study is refining a questionnaire to help doctors detect small airway dysfunction in people with COPD. Researchers will also compare two breathing tests (spirometry and oscillometry) to see which works better in primary care. About 108 adults with asthma, COPD, or both will …

This observational study tracks how breathing during sleep changes in 60 adults hospitalized for a sudden worsening of COPD. Using sleep recordings and a sensor under the mattress, researchers aim to describe recovery patterns. The goal is to find simple ways to monitor improveme…

This study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…

This study aimed to use a special MRI technique with hyperpolarized xenon gas to see how lung function changes in people with COPD after a procedure called targeted lung denervation. The goal was to better understand how the treatment affects breathing. However, the study was wit…

This study tests a wearable device called the RESP™ Biosensor that listens to lung sounds and chest movements. It is designed to help monitor people with COPD after they leave the hospital. The goal is to see if the device can detect early signs of a COPD flare-up, so patients ca…

This study aims to see if a special cat allergen extract (AP Cat) can cause hay fever symptoms when sprayed into the nose of people with cat allergies. Twenty volunteers—some allergic to cats, some not—will receive the extract and have their symptoms and allergy markers measured.…

This study tests whether personalized emails to GP practices can improve prescribing for COPD, a long-term lung condition. About 270 practices in West Yorkshire, UK, will receive either a generic or a tailored email alongside their regular feedback reports. The goal is to see if …

This study is creating a personalized prediction system for acute exacerbations (sudden worsening) of chronic obstructive pulmonary disease (COPD). Over 3 years, researchers will collect health data from 442 COPD patients and healthy volunteers, including breathing tests, symptom…

This study is testing a tiny camera called micro OCT that can take detailed pictures of cells inside the lungs and nose. Researchers want to see if it works well in people with cystic fibrosis and other lung conditions. The goal is to eventually use this imaging to detect early d…

This study aims to find COPD earlier in people who are already getting a lung CT scan as part of a lung health check. Researchers will invite 568 current or former smokers to take a simple breathing test a few weeks after their CT scan. The goal is to see if this approach helps d…

This study looks at 400 people who had surgery to remove throat cancer (laryngectomy or pharyngolaryngectomy). The goal is to find out which factors, like using a surgical flap or muscle loss (sarcopenia), increase the risk of a fistula—a leak that can cause infection. Researcher…

This study looks at vitamin A levels in 90 adults with vocal fold leukoplakia, a condition that causes white patches on the vocal cords. Researchers want to see if vitamin A status differs between people with and without precancerous changes. Participants provide blood and tissue…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study looks at whether the newest version of the cancer staging system (TNM-9) accurately predicts outcomes for people with nasopharyngeal carcinoma in parts of China where the disease is less common. Researchers will review medical records from about 1,400 patients treated …

This study looks at 200 people with a narrow upper jaw who are getting a palate expander. Researchers want to see if the angle of the premolars on X-rays can predict how much the jaw will widen. The goal is to better understand the treatment process, not to test a new therapy.

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to understand how the disease progresses and what factors influence it. Researchers measure lung function, analyze mucus, and track environmental exposures like air pollution. The goal is…

This study looks at blood samples from 84 children aged 4-17 having their tonsils removed to find chemical clues about why Black children often report more pain afterward. Researchers will measure pain scores and compare blood metabolites between racial groups. The goal is to und…

This study looks back at 100 newborns who had a flexible bronchoscopy (a thin, flexible tube with a camera) to diagnose breathing problems in the neonatal intensive care unit over the past 10 years. Researchers want to see how often this procedure helped doctors find the exact ca…

This study looks at sleep quality in 60 adults with non-cystic fibrosis bronchiectasis, a chronic lung condition. Researchers will measure how well participants sleep and see if poor sleep is linked to more severe lung disease, worse breathing tests, or more lung damage on CT sca…

This study looks at how spasmodic dysphonia, a voice disorder causing uncontrollable vocal cord spasms, affects patients' jobs and social lives. Researchers will interview 20 adults who have received at least one botulinum toxin injection to understand if the treatment helps impr…

This study is looking at over 10,000 smokers to find out if certain genes make some people more likely to develop COPD, a serious long-term lung disease. Participants are having their lung function tested and getting chest CT scans. The goal is to understand why some smokers get …

This study looks at whether people with COPD can imagine movements as clearly as those without the disease. Researchers will compare 188 participants using questionnaires and timing tests. The goal is to better understand how COPD might affect the brain's ability to picture and f…

This study aims to find out how common lower urinary tract symptoms (like leaking or trouble emptying the bladder) are in people with COPD, and how much they know about pelvic floor health. Researchers will ask 30 participants to fill out questionnaires about their breathing, bla…