Upper respiratory tract disorder

This study looked at the long-term safety of an inhaled drug called treprostinil in people who have both pulmonary hypertension (high blood pressure in the lungs) and COPD. It included 41 adults who had already completed a previous study. The trial was terminated early, and the m…

This study compared two procedures—laser resection and dilatation—for treating benign (non-cancerous) narrowing of the windpipe. The goal was to see which one better prevents the narrowing from coming back within two years. The trial was terminated early, so the results are limit…

This study tested a new microwave device used through a thin tube to destroy tumors blocking the main airways in people with lung cancer. Only 3 patients were enrolled before the study was stopped. The goal was to see if the device could safely and effectively open the airway.

This small, early-stage trial tested a combination of a steroid spray (triamcinolone) and a decongestant spray (oxymetazoline) to help people who were dependent on decongestants stop using them. The study planned to slowly reduce the decongestant dose while keeping the steroid st…

This study aimed to find the best oxygen level for people hospitalized with a sudden worsening of COPD. It compared giving enough oxygen to reach 88-92% saturation versus over 94%. The trial was stopped early after only 23 people took part, so the results are not strong enough to…

This study tested a drug called PRO1160 in people with advanced kidney cancer, nasopharyngeal cancer, or non-Hodgkin lymphoma. The goal was to find a safe dose and see if the drug shrinks tumors. The trial was stopped early, so results are limited.

This study looked at whether taking probiotics alongside regular treatment could help lower blood sugar and improve lung function in people with both type 2 diabetes and chronic obstructive pulmonary disease (COPD). The trial planned to enroll 30 adults aged 50-85, but it was ter…

This study tested whether adding the drug xevinapant to standard radiation therapy could help prevent head and neck cancer from coming back after surgery. It included 166 people with high-risk cancer who could not take the usual chemotherapy drug cisplatin. The trial was stopped …

This phase 3 study tested the drug benralizumab in 295 adults with severe nasal polyps and eosinophilic chronic sinusitis. Participants received injections of benralizumab or a placebo every 4 to 8 weeks for about a year. The goal was to see if the drug could shrink polyps and im…

This study tested an experimental drug called vobramitamab duocarmazine in people with advanced prostate cancer and other solid tumors that stopped responding to standard treatments. The goal was to see if the drug could shrink tumors or slow cancer growth. The trial was terminat…

This study tested two doses of an inhaled drug called CHF6001 (Tanimilast) added to standard triple therapy in people with severe COPD and chronic bronchitis. The goal was to see if it could reduce the number of moderate or severe flare-ups over a year. The trial was terminated e…

This study tested whether metformin (a diabetes drug) and doxycycline (an antibiotic) could help treat head and neck cancer when taken before surgery. The trial aimed to see if these drugs could change certain proteins in the tumor's supportive tissue. Only 7 people took part bef…

This early-phase trial tested an experimental drug called TAK-500, alone or with the immunotherapy pembrolizumab, in 61 adults with advanced solid tumors like pancreatic, liver, and lung cancer. The main goals were to check safety and see if the drug could shrink tumors. The stud…

This trial tested the drug Cayston (aztreonam lysine) in adults with bronchiectasis, a chronic lung disease causing cough and infections. The goal was to see if it could safely delay or reduce lung flare-ups. However, the study was stopped early and only enrolled 34 people, so we…

This early-stage trial tested a combination of two drugs, APG-1387 and toripalimab, in 40 people with advanced solid tumors including colorectal, nasopharyngeal, and lung cancers. The goal was to find a safe dose and see if the combination could control the disease. However, the …

This study tested a high-flow nasal cannula device (Airvo) in COPD patients with high carbon dioxide levels who could not or would not use standard non-invasive ventilation. The goal was to see if the device improved blood gas levels and reduced flare-ups over one year. Only 3 pa…

This study tested an experimental inhaled drug called HRG2005 in people with moderate to severe chronic obstructive pulmonary disease (COPD). The goal was to see if it improves lung function compared to a standard treatment. About 82 participants were enrolled, but the study was …

This study tested a peptide-based immunotherapy in 17 people with head and neck cancer who were scheduled for surgery. The goal was to see if the vaccine could boost the immune system's attack on cancer cells and to check for side effects. The trial was stopped early, but the res…

This study tested an inhaled drug called CHF6001 (Tanimilast) in people with COPD and chronic bronchitis who were already on triple therapy. The goal was to see if adding this drug could reduce flare-ups. The trial was stopped early and involved about 4,700 participants.

This study tested a device called the SPIRION Laryngeal Pacemaker in 10 people with bilateral vocal cord paralysis who had prior vocal fold surgery. The device is implanted to help open the vocal cords during breathing. Researchers checked if it was safe and if it improved breath…

This phase 3 study tested an inhaled form of the antibiotic clofazimine added to standard therapy for people with MAC lung disease that did not respond to previous treatment. The goal was to see if the drug could clear the infection from sputum cultures and improve quality of lif…

This early-phase trial tested an inhaled drug called ARO-MUC5AC in healthy volunteers and people with asthma or COPD. The goal was to see if it is safe and how it affects lung function by targeting mucus production. The study was terminated early, so we have less information than…

This early-phase trial tested a new drug called INCB062079 in 25 people with advanced liver cancer and other solid tumors. The main goal was to check safety and find the best dose. The study was terminated early, so results are limited.

This early-stage study tested an experimental drug called INCB099318 in people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check the drug's safety and how the body processes it. The study was terminated early, so results are…

This study looked at whether adding the immunotherapy drug nivolumab to standard chemotherapy could help people with nasopharyngeal cancer that has returned or spread. The trial was planned for many participants but was stopped early, so only 15 people took part. Because of the e…

This study tested an experimental drug called QBW251 in 42 adults with bronchiectasis, a lung condition that causes mucus buildup and infections. The goal was to see if the drug could reduce bacteria in the lungs and improve symptoms like coughing and breathing. However, the stud…

This study tested a device called FreeO2 that automatically adjusts oxygen levels for people hospitalized with a COPD flare-up. The goal was to see if it could shorten hospital stays compared to manual oxygen adjustment by staff. Only 17 people took part, and the study was stoppe…

This study tested a French version of the CAPTURE tool, which uses a short questionnaire and a peak flow breath test, to find people with undiagnosed obstructive lung disease (like COPD). Over 1,000 adults aged 40 and older who had not been diagnosed with asthma or COPD took part…

This study tested a radioactive tracer called Annexin to see if it can detect early lung damage in people with COPD and in smokers. Researchers compared scans from healthy non-smokers, healthy smokers, and people with moderate to severe COPD. The goal was to find a better way to …

This study tested a device that delivers high-flow oxygen through the nose during throat surgery. The goal was to keep patients' oxygen levels safe without using a breathing tube. The trial included 29 adults in two French hospitals. The device was considered safe if blood oxygen…

This study tested whether a low dose of fentanyl, a strong painkiller, placed under the tongue could help people with severe COPD feel less breathless during exercise. The trial planned to include 40 participants but was stopped early. Because it was terminated, we cannot draw cl…

This study tested whether teaching teens and young adults (ages 14-29) the correct way to use nasal sprays for hay fever would improve their symptoms compared to standard care. The trial was terminated early and enrolled only 18 participants. The goal was to see if repeat educati…

This phase 2 pilot study tested a new dual bronchodilator inhaler called PT003 in 4 people with stable moderate-to-severe COPD. Researchers measured breathing patterns and lung function right after the first dose and again after 4 weeks of treatment. The goal was to see if PT003 …

This study looked at whether a gentle electrical stimulation device (TENS) placed on the skin could help people with COPD exercise longer after a serious flare-up. The plan was to compare exercise time with and without TENS in a small group of patients. However, the study was sto…

This study tested whether using the SinuSonic device—a handheld tool that uses sound and gentle pressure to relieve nasal congestion—could also improve anxiety, depression, and overall well-being in adults with chronic stuffy nose. Sixteen participants used the device for 5 weeks…

This study looked at how well Petit Drill syrup works and how safe it is for calming throat irritation and dry cough in children from 6 months to 6 years old. The syrup is a soothing substance recommended by the World Health Organization for this age group. The study planned to t…

This study looked at whether doing breathing and exercise training at home works as well as doing it at a rehab center for people with chronic obstructive pulmonary disease (COPD). The goal was to see if home rehab could improve exercise tolerance just as much, while also being c…

This pilot study explored whether adding acupuncture to standard pulmonary rehabilitation can improve lung function, exercise tolerance, and quality of life in people with COPD. Thirteen adults took part, receiving either electro-acupuncture at specific points or a control acupun…

This early-phase study aimed to see if adding the drug xevinapant to standard chemoradiotherapy is safe for people with advanced head and neck cancer that cannot be removed by surgery. The study planned to enroll 18 participants but was terminated early. The main focus was on sid…

This study tested whether providing palliative care at home, through a team of doctors, nurses, social workers, and chaplains, could improve symptoms and quality of life for people with advanced cancer, heart failure, or COPD. The plan was to enroll over 1,100 patients, but the t…

This study looked at whether adding functional strength training and neuromuscular electrical stimulation to usual hospital care helps people with COPD exacerbations recover better. The 35 participants did exercises like sit-to-stand and received mild electrical pulses to their t…

This study aims to collect up to 10 years of electronic medical records and a one-time questionnaire from over 1,100 asthma and COPD patients who previously took part in the Salford Lung Study. The goal is to better understand how these lung diseases progress and how treatments w…

This study looked at why exercise training improves blood vessel function less in some people with COPD than in healthy individuals. Researchers measured blood vessel health before and after a 4-week exercise program in 69 participants, including COPD patients and healthy volunte…

This study looked at whether a weak immune response to bacteria in COPD patients leads to more lung infections and flare-ups. Researchers collected sputum, blood, and nasal swabs from 23 hospitalized COPD patients during a flare-up and again 8 to 16 weeks later. The goal was to m…

This study used a special microscope on the tip of a thin tube (bronchoscope) to look at the smallest blood vessels in the lungs of people with scleroderma or emphysema. The goal was to see how these vessels change in each disease. Only 9 patients were enrolled before the study w…

This study aimed to track lung function in children born prematurely (before 37 weeks) aged 3 to 5 years, comparing them to full-term children. Researchers used breathing tests and samples to look for early signs of asthma and allergies. The study was terminated early, so results…

This study looked at why people with mouth or throat cancer wait before seeing a doctor. Researchers interviewed 90 patients and asked them to fill out questionnaires about their feelings, thoughts, and social situation. The goal was to understand what factors cause the delay, so…

This study is for people with cystic fibrosis and their family members. Its goal is to collect medical information and biological samples during regular clinic visits. These will be stored and used by researchers to learn more about how cystic fibrosis affects the body and how it…

This study tested whether artificial intelligence can detect and classify abnormal lung sounds in people with cystic fibrosis, COPD, or pulmonary fibrosis. Researchers recorded lung sounds with an electronic stethoscope during routine checkups and analyzed them using AI. The goal…

This study aimed to see if spraying water on the body could help older adults with COPD stay cool during heat waves. Researchers planned to measure body temperature and lung function in a climate chamber. However, only one person took part before the study was stopped, so no mean…

This study used a special type of MRI (called hyperpolarized xenon-129 MRI) to take detailed pictures of lung function in 27 people with COPD who were scheduled to receive endobronchial valve therapy as part of their normal care. The goal was to see how the lungs work before and …

This study used a special MRI technique with a harmless gas called hyperpolarized xenon-129 to take detailed pictures of lung function in people who had a lung transplant. The goal was to see if this scan could detect early signs of chronic lung allograft dysfunction (CLAD), a co…

This pilot study tested an e-health system that uses tele-monitoring, tele-notification, and tele-coaching to help manage adults with at least two chronic conditions like heart failure, COPD, or diabetes. The goal was to see how well the system could detect health problems early.…