Could less radiation be better for nasopharyngeal cancer patients?

NCT ID NCT04384627

Ongoing Disease control Sponsor: Sun Yat-sen University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether using smaller radiation targets after initial chemotherapy can control advanced nasopharyngeal cancer just as well as standard larger targets, while reducing side effects. About 445 patients with stage III-IVa disease are enrolled. The study compares relapse-free survival and quality of life between the two approaches.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy with reduced target volume
What this could lead to: If successful, this could allow doctors to use smaller radiation fields after chemotherapy, reducing long-term side effects while still controlling the cancer.
What could go wrong: This is a non-inferiority trial, so the smaller volume might prove slightly less effective at preventing recurrence. Long-term results are still being collected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for INDUCTION CHEMOTHERAPY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

nasopharyngeal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INDUCTION CHEMOTHERAPY NASOPHARYNGEAL CARCINOMA RADIOTHERAPY

Contacts and locations

Locations

First People's Hospital of Foshan, Foshan

Foshan, China
People's Hospital of Zhongshan City

Zhongshan, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.