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Nerve-Zapping showdown: which procedure best stops a runny nose?

NCT ID NCT07706595

Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial compares three FDA-cleared in-office procedures that treat chronic non-allergic rhinitis by targeting the posterior nasal nerve. Radiofrequency ablation (using RhinAer or Neuromark) uses heat, while cryoablation (ClariFix) uses extreme cold to reduce nerve signals that cause runny nose, congestion, and postnasal drip. About 50 adults with chronic rhinitis will be randomly assigned to one of the three treatments and report their symptom changes and quality of life over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
radiofrequency ablation (RhinAer or Neuromark) or cryoablation (ClariFix) of the posterior nasal nerve
What this could lead to
If one method proves superior, it could become the preferred in-office procedure for long-term relief from chronic rhinitis symptoms like runny nose and congestion.
What could go wrong
This is a small, single-center trial (50 participants) comparing already-approved devices, so differences may be subtle or not generalizable. All procedures carry risks of temporary discomfort, bleeding, or incomplete symptom relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Diagnosis of chronic rhinitis (non-allergic rhinitis) Exclusion Criteria: \- Under 18 years of age

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Conditions

The condition(s) this trial relates to.

chronic rhinitis common cold vasomotor rhinitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic rhinitis Non-allergic rhinitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Perlman Medical Office at UC San Diego

    La Jolla, California, 92037, United States

  • Veterans Affairs San Diego Healthcare System

    San Diego, California, 92161, United States

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