Nerve-Zapping showdown: which procedure best stops a runny nose?
NCT ID NCT07706595
First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This trial compares three FDA-cleared in-office procedures that treat chronic non-allergic rhinitis by targeting the posterior nasal nerve. Radiofrequency ablation (using RhinAer or Neuromark) uses heat, while cryoablation (ClariFix) uses extreme cold to reduce nerve signals that cause runny nose, congestion, and postnasal drip. About 50 adults with chronic rhinitis will be randomly assigned to one of the three treatments and report their symptom changes and quality of life over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiofrequency ablation (RhinAer or Neuromark) or cryoablation (ClariFix) of the posterior nasal nerve
- What this could lead to
- If one method proves superior, it could become the preferred in-office procedure for long-term relief from chronic rhinitis symptoms like runny nose and congestion.
- What could go wrong
- This is a small, single-center trial (50 participants) comparing already-approved devices, so differences may be subtle or not generalizable. All procedures carry risks of temporary discomfort, bleeding, or incomplete symptom relief.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Perlman Medical Office at UC San Diego
La Jolla, California, 92037, United States
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Veterans Affairs San Diego Healthcare System
San Diego, California, 92161, United States
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