New drug could ease constant allergy symptoms

NCT ID NCT06339008

Ongoing Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This phase 3 study tests lebrikizumab, an injectable drug, in 450 adults with perennial allergic rhinitis (year-round allergies). The goal is to see if it reduces nasal symptoms like congestion and sneezing compared to a placebo. Participants will be followed for up to 29.5 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lebrikizumab
What this could lead to: If it works, this could offer a new treatment option for people with year-round allergies, reducing nasal symptoms like congestion and sneezing.
What could go wrong: This is a phase 3 trial, but it's still experimental. The drug may not work better than placebo, and there could be side effects. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

perennial allergic rhinitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERENNIAL ALLERGIC RHINITIS (PAR)

Contacts and locations

Locations

310 Clinical Research

Inglewood, California, 90301, United States
AARA Research Center

Dallas, Texas, 75231, United States
ALL-MED - Specjalistyczna Opieka Medyczna

Wroclaw, 53-201, Poland
Alergo-Med Specjalistyczna Przychodnia Lekarska Sp Z O.O.

Tarnów, 33-100, Poland
Allergy & Asthma Associates of Southern California dba. Southern California Research

Laguna Niguel, California, 92677, United States
Allergy Partners

Asheville, North Carolina, 28803, United States
Allergy and Asthma

San Diego, California, 92123, United States
Allergy and Asthma Consultants

St Louis, Missouri, 63141, United States
Allergy and Asthma Diagnostic Center

Tallahassee, Florida, 32308, United States
Allergy and Asthma Specialists Medical Group

Huntington Beach, California, 92648, United States
Allergy and Clinical Immunology Associates

Pittsburgh, Pennsylvania, 15241, United States
Allergy, Asthma & Sinus Center

Greenfield, Wisconsin, 53228, United States
Asthma Allergy Center of Chicago

River Forest, Illinois, 60305, United States
Asthma and Allergy Associates, PC

Colorado Springs, Colorado, 80907-6231, United States
Asthma and Allergy Center

Bellevue, Nebraska, 68123, United States
B1F, Pharmacy department, Gachon University Gil Medical Center

Incheon, 21565, South Korea
Bernstein Clinical Research Center, LLC

Cincinnati, Ohio, 45236, United States
Bluegrass Allergy Research

Lexington, Kentucky, 40509, United States
Centrum Alergologii Teresa Hofman Sp z.o.o.

Piła, 64-920, Poland
Centrum Medyczne Promed ul. Olszańska 5G

Krakow, 31-513, Poland
Charité - Universitätsmedizin Berlin Klinik für Dermatologie

Berlin, 10117, Germany
Circuit Clinical/Hudson-Essex Allergy

Belleville, New Jersey, 07109, United States
Circuit Clinical/Mercer Allergy and Pulmonary Associates

Hamilton, New Jersey, 08619, United States
ClinMedica Research

Skierniewice, 96-100, Poland
Clinical Research Institute

Minneapolis, Minnesota, 55402, United States
Clinical trial Pharmacy

Seoul, 8308, South Korea
Department of Nasal Allergy

Beijing, 100730, China
Dr. Patrick Perin

Teaneck, New Jersey, 07666, United States
EMED Centrum Usług Medycznych

Rzeszów, 35-205, Poland
ETG Lublin

Lublin, 20-412, Poland
ETG Warszawa

Warsaw, 02-793, Poland
GCP Pharmacy

Guangzhou, 510000, China
Gangnam Severance Hospital 211

Seoul, 6273, South Korea
Hôpital Erasme, Service Pharmacie

Brussels, 1070, Belgium
Hôpital de la Citadelle

Liège, 4000, Belgium
IKF Pneumologie

Frankfurt am Main, 60596, Germany
Inje University Haeundae Paik Hospital

Busan, 48108, South Korea
Internal Medicine Building

Beijing, 100032, China
Jingzhou Central Hospital

Jingzhou, 434020, China
Kerrville Allergy and Asthma Associates

Kerrville, Texas, 78028, United States
Kyunghee University Hospital at Gangdong

Seoul, 05278, South Korea
Malopolskie Centrum Alergologii

Krakow, 31-623, Poland
Northern Jiangsu People's Hospital

Yangzhou, 225001, China
Northwest Research Center

Portland, Oregon, 97202, United States
Northwestern University

Chicago, Illinois, 60611, United States
Outpatient Department, Union Hospital

Wuhan, 430022, China
Outpatient building

Wuhan, 430014, China
People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, 530021, China
Pneumocare

Erpent, 5101, Belgium
Polimedica PTG Kielce

Kielce, 25-355, Poland
Praxis für HNO und Allergologie

Dresden, 1139, Germany
Renmin Hospital of Wuhan University

Wuhan, 430060, China
Respiratory Medicine Research Institute of Michigan, PLC

Ypsilanti, Michigan, 48197, United States
SMG-SNU Boramae Medical Center

Seoul, 7061, South Korea
Seoul National University Bundang Hospital

Seongnam-si, 13620, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Siteworks - Zentrum für klinische Studien Heidelberg

Heidelberg, 69115, Germany
Smith Allergy and Asthma

Horseheads, New York, 14845, United States
The First Affiliated Hospital of Guangxi Medical University

Nanning, 530021, China
The First Affiliated Hospital of Nanchang University

Nanchang, 330006, China
The Second Affiliated Hospital of Nanchang University

Nanchang, 330006, China
The Third Xiangya Hospital of Central South University

Changsha, 410013, China
Tongji Hospital

Shanghai, 200065, China
UZ Gent

Ghent, 9000, Belgium
UZ Leuven, Pharmacy

Leuven, 3000, Belgium
University of Missouri Hospital

Columbia, Missouri, 65212, United States
University of South Florida

Tampa, Florida, 33613, United States
Universitätsklinik Marburg,Hals-, Nasen- und Ohrenklinik, Sektion Rhinologie und Allergologie

Marburg, 35043, Germany
Universitätsklinikum Carl Gustav Carus an der TU

Dresden, 1307, Germany
Yangzhou University

Yangzhou, 225012, China
Zentrum für Rhinologie und Allergologie

Weisbaden, 65183, Germany
Zhejiang People's Hospital

Hangzhou, 310014, China
Zhongshan City People's Hospital

Zhongshan, 528403, China
gab. 114, ul. inż. pilota Wigury

Lodz, 90-302, Poland