Myopathy

This study looked at whether tocilizumab, a drug already used for arthritis, can help people with a rare autoimmune lung condition called anti-synthetase syndrome-associated interstitial lung disease (ASyS-ILD) that hasn't responded to standard treatments. Researchers reviewed me…

This study tested whether giving protein-rich formula in short bursts (intermittent feeding) is better than the standard continuous drip for preventing muscle loss in critically ill patients. 113 ICU adults expected to stay at least 5 days were randomly assigned to one of the two…

This pilot study tested whether giving critically ill children on breathing machines extra protein along with a personalized exercise program could help preserve muscle mass and improve recovery. The trial enrolled 18 children in the ICU and measured how feasible and safe the app…

This study tested an experimental drug called daxdilimab in 12 adults with dermatomyositis or anti-synthetase myositis that wasn't well controlled by standard treatments. The goal was to see if the drug could reduce disease activity and skin symptoms, and help lower steroid use o…

This study tested an oral drug called GLPG3667 (Cadefrecitinib) in 40 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants took the drug or a placebo daily for 24 weeks to see if it improves symptoms. The trial is complete, and results w…

This study tested a new medicine called AOC 1020 in 90 adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes muscle weakness. The goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a p…

This study looked at whether a high-fat diet changes how children with mitochondrial disease burn energy. 36 children aged 5 to 21 were randomly assigned to eat either a normal or high-fat diet for a month, then switched. Researchers measured their resting energy use and body com…

This study tested the drug baricitinib, given with steroids, in 16 children aged 3-18 with newly diagnosed juvenile dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal was to see if baricitinib works better than the standard treatment (methotrexate p…

This study tested a treatment for a common jaw joint problem called TMJ anterior displacement, where the joint disc slips out of place. The treatment involved flushing the joint (arthrocentesis), then injecting platelet-rich plasma (a concentrate of the patient's own healing cell…

This study tested an oral drug called ifetroban in 46 males aged 7 and older with Duchenne muscular dystrophy (DMD). The goal was to see if the drug is safe and can help prevent or treat heart problems, which are a leading cause of death in DMD. Participants received either ifetr…

This study looked at whether giving a steroid called prednisone twice a week at a lower dose, along with exercise training, could help boys with Duchenne muscular dystrophy (DMD) maintain muscle strength and function. The goal was to find a treatment that works as well as daily s…

This study tested a new drug called AOC 1001 in 39 adults with myotonic dystrophy type 1, a genetic muscle disorder. Participants received either the drug or a placebo by IV infusion. The goal was to check safety and how the drug moves through the body. Results will help decide i…

This study tested the safety of a drug called ataluren (also known as Translarna) in 270 people with Duchenne muscular dystrophy caused by a specific type of genetic mistake (nonsense mutation). Participants had already taken ataluren in earlier studies. The goal was to monitor s…

This study tested a drug called ataluren in 360 boys with Duchenne muscular dystrophy caused by a specific genetic mistake (nonsense mutation). The main goal was to see if ataluren could help them walk farther over 72 weeks compared to a placebo. All participants were also taking…

This study tested whether adding nintedanib (OFEV) to standard immunosuppressant therapy can improve symptoms in people with myositis-associated interstitial lung disease, a condition where lung tissue becomes scarred and stiff. 49 adults in the U.S. participated, receiving eithe…

This early-phase study tested a new gene editing treatment called HG302 in 4 boys with Duchenne muscular dystrophy (DMD), a severe muscle-wasting disease. The therapy uses CRISPR technology to fix the genetic error and help muscles produce dystrophin, a protein essential for musc…

This study tested a custom-made digital splint to reposition the jaw in 48 adolescents with painful, clicking jaw joints due to disc displacement. Participants wore the splint 24/7 and had regular check-ups with imaging. The goal was to improve pain, chewing, and quality of life.…

This early-stage trial tested a single dose of the drug PGN-EDODM1 in 24 adults with myotonic dystrophy type 1, a genetic muscle disorder. The main goal was to check safety and how the body handles the drug. The study is complete, but results are not yet available.

This study tested a new drug, ABC008, in 272 adults with inclusion body myositis, a rare muscle-weakening disease. The goal was to see if the drug is safe and can help slow the disease's progression. Participants received either ABC008 or a placebo, and their muscle function was …

This study tested a new drug called OMT-28 in 28 people with primary mitochondrial disease, a condition that affects how cells produce energy. Participants took the drug once daily for 6 months, and researchers measured safety, blood markers of inflammation, and symptoms like fat…

This Phase 3 trial tested apitegromab, a drug that blocks a muscle-limiting protein, in 188 nonambulatory children and young adults with later-onset spinal muscular atrophy (SMA types 2 and 3). All participants were already taking standard SMA therapies (nusinersen or risdiplam).…

This study tested a one-time gene therapy called OAV101 (Zolgensma) in 27 children aged 2 to 18 with spinal muscular atrophy (SMA) who had previously stopped taking other SMA medications (Spinraza or Evrysdi). The goal was to see if the treatment is safe and can help maintain or …

This study tested a one-time gene therapy called OAV101 in 126 children aged 2 to 18 with type 2 spinal muscular atrophy (SMA) who had never received other SMA treatments. The therapy was given as a spinal injection and compared to a sham procedure. The goal was to see if it coul…

This study looked at the safety of vatiquinone in 101 people with inherited mitochondrial disease who had already taken the drug in a previous study or treatment plan. The goal was to track any side effects until the drug became commercially available or the program ended. Partic…

This study tested whether using computer-guided surgery is better than the standard approach for fixing a jaw that keeps dislocating. Seven adults with the condition took part. The main goal was to see if the jaw stayed in place after surgery, and the study also measured how wide…

This study looked back at 214 patients who had shoulder surgery using two specific devices (ToggleLoc and JuggerLoc) to reattach soft tissue to bone. The goal was to see if the devices helped the tissue heal properly and were safe. Results showed most patients had good healing wi…

This study tested whether a personalized diet could improve nutrition and movement in children aged 4-8 with Duchenne muscular dystrophy (DMD). Nine children in Ankara, Turkey, received dietary counseling focused on energy, protein, calcium, and fluid needs. Researchers measured …

This pilot study tested whether taking omega-3 fatty acids (fish oil) and essential amino acids (protein building blocks) before and after knee surgery could help prevent muscle loss. Thirty adults scheduled for ACL reconstruction took either the supplements or a placebo for 4 we…

This study tested the long-term safety and effectiveness of a drug called KZR-616 in 18 adults with active polymyositis or dermatomyositis, rare diseases that cause muscle inflammation and weakness. Participants who completed an earlier study received weekly injections of KZR-616…

This study tested two drugs, casimersen and golodirsen, in 228 boys with Duchenne muscular dystrophy who have specific genetic mutations. The goal was to see if these drugs could slow muscle decline, measured by how fast they could climb four steps. Participants received either t…

This Phase 2 trial tested a drug called KZR-616 (zetomipzomib) in 25 adults with active polymyositis or dermatomyositis, two rare diseases that cause muscle inflammation and weakness. Participants received either the drug or a placebo for 16 weeks, then switched to the other trea…

This study tested a drug called vamorolone in 54 boys with Duchenne muscular dystrophy, aged 2 to under 4 years and 7 to under 18 years. The goal was to check safety and how the body processes the drug over 12 weeks. Researchers hope vamorolone may help control the disease with f…

This Phase 3 trial tested a daily injection called elamipretide in 102 adults with primary mitochondrial myopathy, a genetic condition that causes muscle weakness and fatigue. Participants received either the drug or a placebo for 48 weeks. The main goal was to see if the drug co…

This study tested a drug called tideglusib against a placebo in 56 children aged 6 to 16 with congenital myotonic dystrophy, a rare genetic muscle disorder. The goal was to see if tideglusib could reduce symptoms like muscle weakness and breathing problems. The trial was complete…

This study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…

This study looked at whether adding casein protein and leucine (an amino acid) to meals could help people with COPD and healthy older adults build more muscle. Weight loss and muscle loss are common in COPD and can make the disease worse. Researchers tested different meal combina…

This study tested whether taking fish oil supplements (containing EPA and DHA) along with a protein drink could help people with COPD build muscle. Sixty-four participants took either fish oil or a placebo for four weeks. Researchers measured muscle protein synthesis to see if th…

This phase 2 trial tested vamorolone, a drug similar to steroids, against a placebo in 46 males with Becker muscular dystrophy. The goal was to check safety and tolerability over 24 weeks, while also looking for early signs of benefit. The study is complete, but results are not y…

This completed Phase 2 trial tested whether enobosarm, an experimental oral drug, can prevent muscle loss in older adults (aged 60+) who are taking GLP-1 receptor agonists like Wegovy for chronic weight management. The study enrolled 168 participants and measured changes in lean …

Nearly 60% of children with cancer become malnourished, which can lead to infections and worse outcomes. This pilot study tested three nutrition approaches—oral supplements, appetite-stimulating drugs, and tube feeding—in 19 children to see which best improved body composition an…

This study tested an injection of stromal vascular fraction, a mixture of cells from the patient's own fat tissue, for patellar tendinopathy (jumper's knee). Thirty participants received the injection under ultrasound guidance. The goal was to see if it could improve symptoms and…

This phase 2 study tested the safety and effectiveness of tideglusib, an experimental drug, in 16 adolescents and adults with congenital or juvenile-onset myotonic dystrophy type 1. Participants received either 400 mg or 1000 mg of tideglusib daily. The study measured side effect…

This study looked at whether combining aerobic and resistance exercise with protein supplements can improve muscle, strength, and quality of life in older adults with sarcopenia (age-related muscle loss). 110 people aged 60-90 took part. The goal was to see if this combination wo…

This early-stage trial tested a single-dose gene therapy called scAAV9.U7.ACCA in 3 boys with Duchenne muscular dystrophy caused by a duplication of exon 2. The therapy was given through a vein and aimed to help muscle cells produce dystrophin, a protein missing in this disease. …

This study tested whether rapamycin, a drug used in organ transplants, can help people with Inclusion Body Myositis (IBM), a rare muscle disease that causes progressive weakness and has no approved treatment. Forty-four adults with IBM received either rapamycin or a placebo for o…

This completed pilot study tested whether a computer algorithm could diagnose facioscapulohumeral muscular dystrophy (FSHMD) by analyzing video recordings of people's faces. Researchers recorded 17 participants, including patients with FSHMD, other muscle diseases, and healthy co…

This study examined whether the level of neutrophils, a type of white blood cell, in the blood can help predict how severe antisynthetase syndrome (ASyS) will be. ASyS is a rare autoimmune disease that can cause muscle inflammation, lung disease, and other symptoms. Researchers l…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

Myofascial pain syndrome is common but hard to diagnose accurately. This completed study tested several imaging and electrical measurement tools—like ultrasound and muscle activity sensors—to find objective signs of the condition. Researchers studied 96 adults to see if these too…

This study aimed to develop a non-invasive prenatal test using fetal cells from a mother's blood to detect triplet repeat diseases like Huntington's disease, Fragile X syndrome, and certain types of muscular dystrophy and ataxia. Researchers enrolled 60 pregnant women at risk and…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This study looked at whether infrared thermography (a heat-sensing camera) can help diagnose patellar tendinopathy, a common knee injury in athletes. Researchers compared thermal images from 54 athletes—some with the condition and some healthy—to see if heat patterns and texture …

This study tested whether a single infusion of zoledronic acid can prevent bone and muscle loss in adults aged 35 and older who are undergoing bariatric surgery. Fifty-nine participants were randomly assigned to receive either the drug or a placebo. The main goal was to measure c…

This pilot study tested a virtual program designed to help older men at high risk for fractures reduce their risk of falls and broken bones. The program included personalized exercise plans delivered through a smartphone app and virtual nutrition counseling. Researchers enrolled …

This study tested whether nebivolol, a beta-blocker heart drug, could prevent heart failure in 51 boys aged 10-15 with Duchenne muscular dystrophy. Participants had normal heart function at the start and were randomly given either nebivolol or a placebo. The trial found that nebi…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This trial investigates whether jaw exercises (Rocabado programme) work better when guided by a physiotherapist through online video sessions versus doing them at home with written instructions alone. Adults aged 18-60 with jaw-joint pain and teeth grinding are randomly assigned …

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This study tested two different strengths of ozone gas injections into the jaw joint for people with TMJ disorders. Twenty adults who had clicking, popping, or limited mouth opening that didn't improve with other treatments received the injections. Researchers measured pain and j…

This study tested whether injecting botulinum toxin (Botox) into jaw muscles can reduce pain and improve mouth opening in people with temporomandibular joint (TMJ) myofascial pain. 118 adults with at least moderate pain for over a month received injections in their masseter and t…

This study tested whether adding a nerve-stimulating technique (ultrasound-guided percutaneous neuromodulation) to standard treatments (electrolysis and eccentric exercises) helps athletes with jumper's knee. 26 adults aged 18-50 who played sports at least 3 times a week and had …

This study followed 53 adults with non-dystrophic myotonic disorders who were taking Namuscla (mexiletine) to manage muscle stiffness. Researchers monitored side effects and how often patients needed to reduce their dose or stop treatment over up to 36 months. The goal was to see…

This study looked at whether a 30-minute myofascial massage can reduce shoulder stiffness and improve blood flow in breast cancer survivors who have myofascial pain. Twenty-one women who had completed breast cancer treatment 3 months to 2 years earlier received one massage sessio…

This study tests two short behavioral therapies delivered over video calls for adults with chronic orofacial (jaw or face) muscle pain and insomnia. One therapy focuses on sleep habits and routines; the other uses jaw relaxation and breathing exercises. The goal is to see which a…

This study tested two treatments for neck pain caused by forward head posture and trigger points: dry needling (thin needles inserted into tight muscle knots) and phonophoresis (ultrasound with anti-inflammatory gel). Forty adults with chronic neck pain and trigger points were sp…

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This study looked at whether mesotherapy — injecting anti-inflammatory medicine into the skin near the jaw — can help people with chronic jaw muscle pain. Twenty-two adults with myofascial pain syndrome received treatment over 4 weeks. Researchers measured pain levels and how wid…

This study tested whether a non-invasive device that stimulates the vagus nerve, combined with self-care exercises, can reduce jaw and neck pain in people with temporomandibular disorders (TMD). 48 adults with jaw muscle pain participated. They received either real or placebo ner…

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study tested whether a single session of radial shock wave therapy combined with either stretching or isometric contraction could immediately reduce muscle tightness and stiffness in the upper neck. Thirty healthy adults with no recent neck pain participated. Researchers mea…

This study tested if a dual-frequency laser can reduce pain and improve neck movement in people with myofascial trigger points (muscle knots) in the upper neck. 48 adults with chronic neck pain received either a single-wavelength laser or a dual-frequency laser, plus standard exe…

This study tested whether a non-invasive, FDA-approved device called cranial electrical stimulation (CES) can reduce chronic pain in veterans with fibromyalgia. Fifty veterans received either real CES or a placebo treatment for several weeks. Researchers used brain scans and pain…

This study compared two non-invasive treatments for neck muscle pain in 50 adults. One group received shockwave therapy, the other low-level laser therapy, both once a week for three weeks. Laser therapy led to greater pain reduction and improved neck movement at the three-week m…

This study looked at whether classical massage can reduce pain and improve daily function in people with myofascial pain syndrome, a condition that causes muscle knots and radiating pain. Sixty adults aged 30–50 with active trigger points in the upper back took part. Researchers …

This study tested whether adding a manual therapy called Graston technique to standard McKenzie back exercises helps people with chronic lower back myofascial pain. 70 adults were split into two groups: one did McKenzie exercises alone, the other added Graston. Researchers measur…

This completed study tested whether a nerve block (erector spinae plane block) works better than standard trigger point injections for easing myofascial back pain. 60 adults with myofascial pain syndrome received one of the two procedures. Researchers measured pain levels using a…

This study tested three ways to treat jaw pain caused by teeth grinding (bruxism): a custom mouthguard (occlusal splint), Botox injections, or both together. Sixty adults completed the 3-month trial. Researchers measured pain and jaw function changes to see which approach worked …

This study tested two treatments for neck pain caused by muscle knots (myofascial pain syndrome). Forty adults received either high-intensity laser therapy or shockwave therapy, plus standard physical therapy, over 4 weeks. The goal was to see which treatment better reduces pain …

This study tested two non-drug treatments—whole-body vibration and neuromuscular electrical stimulation—in 60 ICU patients with muscle weakness. Patients received one of the therapies twice daily for two weeks, alongside standard care. Researchers measured muscle strength and thi…

This study tested two different hands-on treatments for neck pain caused by trigger points (knots in the muscle). 34 adults with at least one trigger point received either a gentle hold-and-release technique or a scraping tool technique. Researchers measured pain, neck disability…

This study looked at whether adding robot-assisted walking training to stationary cycling helps people who recently had a stroke and are losing muscle. 53 participants did either cycling alone or cycling plus robot walking for 4 weeks. The goal was to see if the combination impro…

This study tested a new injection treatment called PIT (using a sugar-water solution) against TENS (a mild electrical stimulation device) for people with shoulder pain. Thirty-two adults with ongoing shoulder pain received either PIT or TENS, plus exercises, over two weeks. The g…

This study looked at whether adding aerobic or strength exercises to standard physical therapy can better reduce pain and sensitivity in people with chronic jaw disorders. 51 adults with jaw pain and nociplastic pain (widespread sensitivity) participated. The goal was to see if t…

This study looked at whether taking creatine and coenzyme Q10 supplements, along with exercise, could help children with juvenile myositis (a disease that causes muscle weakness and fatigue). Fifteen children aged 7 to 18 took part. The goal was to see if these supplements could …

This study tested two non-drug approaches for temporomandibular disorder (TMD), a condition causing jaw pain and stiffness. Fifty adults with TMD were randomly assigned to receive either osteopathic manipulative treatment (hands-on therapy) or a home exercise program. Researchers…

This study tested whether virtual reality (using Xbox Kinect) or biofeedback training could improve motor function and balance in 24 children with neuromuscular diseases like Duchenne muscular dystrophy and spinal muscular atrophy. Participants were split into three groups: VR tr…

This study looked at 80 people with painful calcium deposits in the shoulder tendon that didn't get better with standard care. All received a needle procedure to remove the deposits, and half also got an injection of their own platelet-rich plasma (PRP). The goal was to see if ad…

This small study looked at 17 adults with bruxism (teeth grinding) who received Botox injections into their jaw muscle. Researchers used ultrasound to measure muscle thickness and texture before treatment, at 14 days, and at 90 days. They also tracked pain levels. The goal was to…

This study tested whether a 12-week virtual exercise program called Vivo could improve leg strength and blood sugar levels in sedentary older adults with prediabetes. 74 people aged 60 and older participated, meeting twice a week online with a trainer. The goal was to see if this…

This study tested whether an interactive virtual reality (VR) system could help children aged 5–10 with Duchenne muscular dystrophy (DMD) stick to their physiotherapy exercises at home. Fourteen children used the VR system for 8 weeks, and researchers measured how often and how l…

This study tested a powered leg exoskeleton (Keeogo) in 50 people with various muscle disorders to see if it is safe and helps them walk better. Participants performed walking tests with and without the device. The goal was to see if the device could improve walking distance and …

This study tested a wearable robotic suit called MyoSuit that assists knee and hip movement in people with various muscle disorders. 32 participants used the device to perform walking tests, and researchers checked for safety and any immediate improvements in walking ability. The…

This study looked at two treatments for jaw pain caused by teeth grinding (bruxism) and related muscle pain. Forty adults either got a custom mouth splint to wear most of the day or had thin needles inserted into their jaw muscles (dry needling) in three weekly sessions. Research…

This study looked at whether adding a technique called tissue flossing (wrapping an elastic band around the lower leg and doing exercises) to standard heel-drop exercises can reduce pain and improve movement in people with Achilles tendinopathy. Thirty adults aged 20-45 with long…

This study tested two common treatments for painful knots in the upper back muscles: dry needling (inserting thin needles) and manual trigger point release (applying pressure and stretching). Forty-eight adults with at least four weeks of moderate to severe pain took part. Resear…

This study tested two physical therapy techniques—myofascial release and positional release—in 30 young adults with neck pain from a condition called unilateral trapezitis. Both treatments reduced pain, improved neck movement, and eased disability when added to standard exercises…

This study tested two types of injections for people with long-lasting neck pain caused by muscle knots that didn't get better with usual treatments. 96 adults received either a dextrose solution or a lidocaine-saltwater mix injected between layers of tissue under ultrasound guid…

This study tested whether a virtual reality-based robot-assisted exercise program helps people with inflammatory myopathy (a muscle disease causing weakness) more than standard physical therapy. 33 adults trained 5 times a week for 4-6 weeks using either robotic devices or standa…

This study tested two different exercise programs in 28 children and teens with rheumatic diseases like juvenile arthritis and familial Mediterranean fever. One program used external focus (thinking about the movement's effect), the other used internal focus (thinking about the b…

This study tested whether drinking a set amount of water each day (30-35 ml per kg of body weight) for one week could improve how older adults in nursing homes build muscle protein. Seventeen people aged 65 and older took part. The goal was to see if better hydration could help w…

This study tested if dry needling (inserting thin needles into muscle knots) can reduce jaw pain in people with temporomandibular disorder (TMD). 40 adults with jaw pain for at least 3 months were randomly assigned to receive either dry needling or standard physical therapy. The …

This study tested whether adding an injection of hyaluronic acid, platelet-rich fibrin, or dextrose to a standard jaw washout procedure (arthrocentesis) improves pain and jaw function more than the washout alone. Thirty-six adults with TMJ disorders who hadn't improved with other…

This study looked at whether adding manual therapy (spinal manipulation) to Pilates helps people with non-specific spinal problems feel better and move more easily. 43 adults were split into two groups: one did only Pilates, the other did Pilates plus manual therapy for 8 session…

This study looked at whether a treatment called percutaneous electrolysis (using a tiny electric current through a needle) can help people with calf muscle tears feel better and move more easily. About 75 adults with a torn medial gastrocnemius muscle were split into three groups…

This study tested two common treatments for jaw muscle pain (TMD) in 24 adults: a 6-week physiotherapy program with hands-on massage and exercises, versus wearing a mouth splint at night. The goal was to see which better reduces pain, improves mouth opening, and boosts quality of…

This study tested whether placing a cold tube in the vagina for 10 minutes can reduce pelvic floor muscle pain in women. 165 women with pelvic pain used either a cold or room-temperature tube. Researchers measured pain changes right after use and after two weeks of daily use.

This study tested whether using sound waves (phonophoresis) to push anti-inflammatory gel into the skin can reduce pain and improve neck movement in people with painful muscle knots (trigger points) in the upper shoulder. Twenty adults with trigger points took part. Researchers m…

This completed study tested whether adding dry needling to standard treatment (medication and physiotherapy) improves pain and function in people with myofascial low back pain. 156 adults with at least 3 months of pain took part. The researchers measured pain intensity, pressure …

This study looked at whether Botox injections can reduce pain and improve jaw movement in people with chronic jaw muscle pain that didn't get better with standard treatments. Twenty-five participants received Botox injections into their jaw muscles. Researchers measured pain leve…

This study tested a set of jaw and neck exercises in 64 adults with craniomandibular dysfunction (jaw joint problems). The exercises included chin tucks, chest stretches, and gentle neck and jaw movements. Researchers measured pain levels and jaw function before and after four we…

This study tested whether adding pain neuroscience education (PNE) to standard physiotherapy helps people with myofascial pain syndrome, a condition causing muscle knots and pain. Forty adults aged 18-50 were split into two groups: one got only physiotherapy, the other also recei…

This study tested whether giving a lidocaine injection into specific muscles right after knee replacement surgery could lower pain and the need for opioid painkillers. Eleven adults aged 45 and older who had knee surgery took part. Some received the real injection, while others g…

This study tested a specific technique for adjusting occlusal stabilizing splints used to treat temporomandibular disorders (TMD), which cause jaw pain and dysfunction. Researchers enrolled 800 patients with TMD and assessed their satisfaction after using the adjusted splints. Th…

This study compared two treatments for myofascial pain syndrome in the upper trapezius muscle: focused shockwave therapy and dry needling. Fifty-three adults with chronic shoulder pain received either three weekly shockwave sessions or dry needling. Researchers measured pain leve…

This study tested whether a hands-on technique called fascial manipulation can improve shoulder movement and body awareness in people with rotator cuff tendinitis. Thirty-two adults with persistent shoulder pain received the therapy twice a week for four weeks. Researchers measur…

This study tested two injection treatments for temporomandibular joint (TMJ) problems that cause jaw pain and clicking. Twenty patients received either Botox into a jaw muscle or platelet-rich fibrin (a substance made from their own blood) into the joint space. Researchers measur…

This study tested a traditional Chinese medicine patch made from herbs like ginger and Artemisia on 21 dialysis patients who had pain from their fistula. The patch was placed on specific acupoints during dialysis sessions for 4 weeks. Researchers measured pain, depression, and qu…

This study tested two dry needling techniques—superficial and deep—guided by ultrasound for people with upper trapezius muscle pain. 80 adults aged 20-50 with myofascial pain syndrome received a single session. Researchers measured pain, neck disability, and quality of life to se…

This completed study tested whether injecting a mix of platelet-rich fibrin and hyaluronic acid into the jaw joint could help people with TMJ disc problems. Thirty adults with jaw pain, clicking, and limited movement received the treatment or a standard injection. Researchers mea…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study looked at whether adding postural exercises to standard occlusal splint therapy can better reduce pain and improve jaw function in people with internal temporomandibular joint (TMJ) disorders. Fifty-seven adults were split into three groups: one received only a mouth s…

This study tested two common treatments for Achilles tendinopathy in 24 male football players aged 18-30: eccentric calf exercises (lowering the heel off a step) and wearing heel insoles. Over 12 weeks, researchers measured pain, ankle movement, and function. The goal is to find …

This study tested whether a technique called intratissue percutaneous electrolysis (IPE) works better than dry needling for a tight foot muscle caused by myofascial pain syndrome. Forty adults with foot pain received three treatments over 12 weeks. Researchers measured pressure o…

This study looked at whether virtual reality exercises and whole-body vibration can improve muscle strength and balance in children with Duchenne muscular dystrophy (DMD). Fifty children aged 6 to 10 years who could still walk took part. The goal was to see if these fun, non-drug…

This study tested whether adding pain neuroscience education, motor imagery, and action observation to standard treatment (splint, exercises, counseling) helps people with chronic temporomandibular disorders (TMD). Fifty adults with jaw pain for at least 3 months participated. Th…

This completed study tested whether adding breathing exercises or back exercises to standard jaw muscle therapy could improve pain, jaw function, spine mobility, and mood in people with temporomandibular joint (TMJ) dysfunction. 63 adults aged 18-65 with muscle-related TMJ issues…

This completed study tested whether botulinum toxin type-A injections relieve pain from myofascial pain syndrome better than a standard local anesthetic (prilocaine). Thirty-eight adults with long-term muscle pain were randomly assigned to receive either botulinum toxin or priloc…

This study tested whether a combination of two medicines (etoricoxib and betamethasone) works better than just one (etoricoxib) for reducing pain from sudden joint swelling conditions like bursitis, tendinitis, or synovitis. About 89 adults with pain in their shoulder, elbow, kne…

This study looked at whether stretching the pelvic floor muscles can reduce pain and improve quality of life in postmenopausal women aged 45-55 who have chronic pelvic pain. Sixty women took part, and the researchers measured pain levels and menopausal symptoms before and after t…

This study tested whether combining two physical therapies—extracorporeal shockwave therapy and cryoflow (cold) therapy—can reduce shoulder pain and spasticity in stroke survivors with rotator cuff tendonitis. Thirty participants received either one therapy alone or both together…

This study tested whether physical therapy for temporomandibular disorders (TMD) — which cause jaw pain, headaches, and clicking — works just as well when done virtually (via video calls) as in person. Over 200 adults with TMD were split into two groups: one received standard in-…

This study tested whether electrical muscle stimulation (EMS) combined with stretching can reduce pain from myofascial trigger points (muscle knots) in the upper back. 65 working adults with this condition received several treatments in one visit, including EMS, stretching, and p…

This study tested whether neuromuscular electrical stimulation (NMES) can help Veterans with blood cancers maintain physical function and reduce fatigue during stem cell transplant. 46 participants used NMES while in the hospital. The goal was to see if this approach could preven…

This study tested two types of Kinesio Taping (a special elastic tape) in 42 people with patellar tendinopathy, also known as jumper's knee. The goal was to see if the tape could reduce pain and improve how the knee moves during walking, jogging, and other activities. Researchers…

This study tested a new way to design a jaw splint for people with a common jaw joint problem (TMJ disc displacement). Instead of the usual method, doctors used a computer analysis called VTO to find the best splint position. 20 adults with confirmed TMJ disc displacement took pa…

This study tested whether a personalized exercise program can improve daily function and quality of life for people with dermatomyositis or polymyositis, two rare diseases that cause muscle weakness and inflammation. 80 adults with stable muscle impairment took part. The program …

This study tested a procedure called transcatheter arterial embolization (TAE) in 12 people with long-term elbow or foot pain that didn't get better with usual treatments like physical therapy or medication. The procedure uses tiny particles to block abnormal blood vessels though…

This study tested whether stem cells taken from a person's own fat tissue are safe to inject into weakened muscles. Nine people with inclusion body myositis received injections in their forearm and thigh. The main goal was to check for side effects, not to measure improvement, th…

This study tested whether using ultrasound to guide hyaluronic acid injections into the jaw joint works better than the usual method for people with a displaced jaw disc. Forty adults who had not improved with other treatments received either ultrasound-guided or standard injecti…

This study compared two procedures for treating painful calcium buildup in the shoulder: barbotage (a needle-guided washout) and shock wave therapy. Sixty-three adults aged 30–60 with chronic shoulder pain were randomly assigned to one treatment. Researchers tracked pain levels a…

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study looked at whether adding Traditional Chinese Medicine (TCM) to a self-care program helps people with jaw pain (TMD). 135 adults with moderate to severe pain were given different levels of care based on how they responded. The goal was to see if TCM could improve pain a…

This study tested two different low-level laser wavelengths (635nm and 980nm) to see if they could reduce pain and improve jaw function in people with myofascial pain syndrome of the jaw. Thirty participants received laser treatment twice a week for five weeks. The main goal was …

This study looked at whether deep tissue massage can reduce pain, improve neck movement, and boost quality of life in people with myofascial pain syndrome. Eighty adults with at least one active trigger point and neck pain for three months or more took part. Researchers measured …

This study tested whether an online, live strength training program called Vivo is feasible and acceptable for sedentary older adults with prediabetes. Twenty-eight participants took part in 45-minute classes twice a week for 12 weeks. The study measured leg strength, attendance,…

This study tested whether breathing muscle exercises done at home via video calls could improve lung function and quality of life in 40 children with Duchenne muscular dystrophy. The children, aged 5-17, used a device to strengthen their breathing muscles. Researchers measured ch…

This study tested two types of manual therapy (myofascial mobilization and joint mobilization) in 57 people with rheumatoid arthritis who also had jaw joint problems. Participants received therapy twice a week for six weeks, while a control group got no treatment. Both therapy gr…

This study looked at whether manual therapy (hands-on treatment) and a cognitive exercise therapy approach (BETY) can reduce headache pain and improve quality of life in people with temporomandibular disorder (TMD)-related headaches. 60 adults with TMD headaches were split into g…

This study tested whether adding dry needling to standard exercises helps people with mild to moderate carpal tunnel syndrome. 78 adults received either exercises alone or exercises plus dry needling for 3 weeks. Researchers measured pain, wrist movement, and hand function to see…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This study followed 78 people with GNE myopathy, a rare genetic disease that causes progressive muscle weakness starting in young adulthood. Researchers collected medical history, blood samples, and muscle function tests over up to two years to understand how the disease progress…

This study looks at how getting too little sleep and not putting weight on one leg affects muscle strength and balance. Healthy adults who exercise regularly will walk on one leg and sleep either 5 or 9 hours for three days. Researchers will measure muscle size, strength, and how…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This completed study examined muscle cells from 8 children with obstetrical brachial plexus palsy, a birth injury that affects arm nerves. Researchers took small muscle samples during planned shoulder surgery to see if the cells can repair themselves. The goal was to understand w…

This study compared 80 women with and without fibromyalgia to measure muscle strength, muscle thickness, vitamin D levels, and sleep quality. Researchers used advanced tools like isokinetic dynamometers and ultrasound to find differences between the groups. The goal was to better…

This completed study surveyed 566 adolescents aged 14 to 16 to understand how jaw pain (temporomandibular disorders) relates to other painful conditions like headaches, neck pain, and back pain. Researchers used anonymous questionnaires to identify common co-occurring health issu…

This study looked at the extra costs that families of people with Duchenne muscular dystrophy (DMD) in France have to pay out of their own pockets. It included 28 patients of any age who had been diagnosed for at least six months. The researchers measured things like uninsured me…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study tested whether a telehealth system could help people with motor neurone disease (MND) receive specialist care from home, avoiding long trips to the clinic. It involved 40 patients and their caregivers, with half using the system for up to 18 months. The goal was to see…

This study tested whether doctors can accurately assess physical function and quality of life in children with Duchenne muscular dystrophy (DMD) through video calls. Twenty ambulatory patients aged 5-18 completed timed tests and questionnaires remotely. The goal was to see if tel…

This study looked at how eating more or fewer calories affects muscle protein production and muscle size in healthy middle-aged adults during a short period of leg immobilization. Twenty-three participants were monitored under different energy intake conditions. The goal is to un…

This study checked how accurately a practitioner can locate a rib by touch (palpation) compared to using ultrasound. 44 healthy adults took part. The goal was to see if palpation alone is reliable enough for dry needling of deep shoulder muscles. Results help guide safer practice…

This completed study looked at how muscle oxygen levels change during exercise in people with various neuromuscular diseases compared to healthy volunteers. Seventeen participants did a knee-extension exercise while a device measured muscle oxygen. The goal was to understand diff…

This study looked at how critically ill patients on breathing machines process protein. Researchers gave 8 patients two different protein amounts (1.3 vs 2.0 grams per kilogram per day) and measured protein breakdown using a special breath test. The goal was to learn more about m…

This completed observational study from Latvia looked at whether statin-related muscle symptoms are linked to problems in fat metabolism in muscle cells. Researchers measured acylcarnitine levels in blood and muscle samples from 38 adults, comparing those with statin-related musc…

This study followed 44 adults with a confirmed VCP gene mutation to learn how their disease (IBMPFD) naturally progresses over one year. Participants completed walking tests, strength assessments, and surveys about daily function and quality of life. The goal was to gather data t…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This pilot study examined whether inflammation, measured by cytokines in the blood, plays a role in type 1 facioscapulohumeral muscular dystrophy (FSHD1). Researchers compared 20 FSHD1 patients with healthy controls to see if certain inflammatory markers are higher in the disease…

This study looked at a new way to measure muscle function in people with inflammatory myopathies (diseases that cause muscle weakness). Researchers compared a simple test called the Myositis Functional Index-3 with advanced computerised muscle testing. They also tested whether a …

This study looked at 537 people with myotonic dystrophy type 1 to understand their risk of serious heart rhythm problems, including sudden cardiac arrest. Researchers tracked participants for two years to see how often these events happened and what factors might predict them. Th…

This study tested whether a combined breathing muscle training program is safe and practical for adult ICU patients who are on or recently off a ventilator. Twenty-two patients received the training alongside usual care. The main goal was to see if patients could stick with the p…

This study looked at how people with patellar tendinopathy (a common knee overuse injury in sports) move their legs during side-cutting, compared to healthy individuals. Sixty participants—30 with the injury and 30 without—performed side-cutting tasks while motion capture cameras…

This study looked at 84 adults with chronic neck pain to see how central sensitization (a condition where the nervous system becomes overly sensitive) relates to pain intensity, thinking patterns, sleep quality, and jaw function. Researchers used questionnaires to measure these f…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This completed study enrolled 150 people with Duchenne muscular dystrophy to create a video database of their movement abilities. Caregivers recorded children doing specific tasks at home using a secure app. The goal was to help validate a new tool called the Duchenne Video Asses…

This study tested a new method to evaluate the strength and function of face and mouth muscles in people with facioscapulohumeral muscular dystrophy (FSHD). Twenty-two adults with a genetic diagnosis of FSHD took part. The goal was to see if this new assessment tool can reliably …

This study involved 116 people with Limb Girdle Muscular Dystrophy (LGMD), a group of rare muscle-weakening disorders. Researchers measured how well participants could walk, move their arms, and breathe, and asked about their daily activities and overall health. The goal was to i…

This study measured calf muscle thickness and length in 26 children with Duchenne muscular dystrophy (ages 6-12) who could still walk. Researchers used ultrasound and motion analysis to see how muscle structure relates to walking and other movements. The goal was to better unders…

This study followed 316 people with Duchenne muscular dystrophy who were taking Translarna (ataluren) as part of their normal medical care. The goal was to monitor side effects and see how well the drug works in everyday use. Researchers also checked if doctors and patients follo…

This study tested whether a mobile app (myFSHD) can help doctors monitor patients with facioscapulohumeral muscular dystrophy (FSHD) remotely. 70 adults with FSHD used the app at home for 12 months, completing questionnaires and video-recorded exercises. The goal was to see if pa…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This study followed 52 people with limb-girdle muscular dystrophy 2I (LGMD2I) for up to two years to learn more about how the disease changes over time. Researchers measured walking ability, muscle strength, heart function, and daily activities. The goal was to better understand …

This early-stage trial tested a single dose of the study drug GRT6019 in 18 healthy men to check its safety and how the body processes it. The study also looked at whether food changes drug absorption. Results will guide future research for Duchenne muscular dystrophy, but this t…

This study followed 30 adults with myotonic dystrophy type 1 (Steinert disease) and 30 healthy volunteers over three years to see how muscle strength and function change naturally over time. Researchers measured things like muscle power, walking ability, and nerve responses to fi…

This study looked at how reducing daily steps by about 70% affects blood vessel function and muscle health in older adults. Researchers measured blood flow in arm and leg arteries to understand the role of oxidative stress. The goal is to learn why inactivity leads to muscle loss…

This study looked at 28 elite male ice hockey players to see how patellar tendinopathy (a common knee overuse injury) affects leg strength and power. Players were grouped by ultrasound findings into healthy, one-sided, or both-sided tendon issues. They performed leg strength test…

This study looked at whether a tailored program of protein supplements and exercise can increase muscle protein production in people with advanced chronic kidney disease (CKD) who are not yet on dialysis. Researchers compared these patients to healthy adults to see how their bodi…

This study interviewed 26 adults who either have behavioral variant frontotemporal dementia (bvFTD) or carry a gene that puts them at risk. The goal was to learn how the condition affects daily life, emotions, and coping. No treatment or medication was tested—just listening and g…

This study tested whether ultrasound can detect early facial muscle changes in people with facioscapulohumeral muscular dystrophy (FSHD), a rare muscle disease. Researchers compared 20 FSHD patients with 19 healthy adults, measuring muscle thickness and echo intensity in key faci…

This completed study looked at 62 people with patellar tendon injuries to see if a special MRI technique called diffusion tensor imaging (DTI) can better measure tendon structure. Participants had MRI and ultrasound scans, did knee function tests, and filled out questionnaires. T…

This study looked at whether people with long-term neck pain (cervical myofascial pain syndrome) are more likely to have a 'Type D' or distressed personality and feel stigma about their condition. Researchers compared 54 patients with healthy individuals using questionnaires. The…

This study looked at how traumatic experiences—both in childhood and later in life—impact jaw function and quality of life in people with temporomandibular joint disorder (TMD). Researchers compared 102 adults with TMD to healthy volunteers using questionnaires about trauma, jaw …

This study looked at whether MRI scans can reliably find a torn disc in the jaw joint (temporomandibular joint). Researchers reviewed MRI images and medical records from 282 people to see how often disc tears occur and how they relate to pain, disc shape, and bone changes. The go…

This study looked at whether showing health warning messages in a mobile app where people buy alcohol affects their purchasing. Over 11,700 adults in Sweden took part. One group saw rotating health warnings, while the other saw standard messages. The researchers tracked purchases…

This study looked at whether daily protein supplements (from plants or milk) can help healthy older adults build and maintain muscle, especially when combined with exercise. Fifty-one participants aged 60-80 received either a plant protein blend, milk protein, or a placebo, along…

This study followed 113 adults with myotonic dystrophy (Steinert's disease) for 5 years to find out what factors lead to low breathing (hypoventilation). Researchers measured lung function, sleepiness, fatigue, and thinking skills. The goal is to better understand which patients …

This small pilot study looked at whether simple breath and urine tests can measure how well muscles produce energy in children with metabolic myopathies (rare muscle disorders). Three participants completed a 12-week at-home physiotherapy program. The goal was to see if these non…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked at 80 people with muscle pain to see if genetics can predict which treatment works best. Participants received laser, ultrasound, or sugar-water injections. Researchers analyzed blood and urine to find markers that could guide personalized pain care in the futur…

This study tested a special sensor that measures nitric oxide (NO) levels in open wounds. Researchers think NO levels can show how well a wound is healing. Ten adults with muscle loss injuries had the sensor placed in their wound for 30-60 minutes, then had follow-up visits to tr…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study looked at how resistance exercise and leg immobilization affect muscle protein production in 15 healthy women aged 18-30. Participants did leg exercises with one leg while the other leg was immobilized. Researchers measured changes in muscle protein synthesis and break…

This study tests whether doing heavy resistance exercise before a period of leg immobilization can prevent muscle loss. 48 healthy adults (young and older) will have one knee immobilized for 7-10 days, then undergo 4 weeks of retraining. Half will also exercise for 4 weeks before…

This pilot study looked at 30 people with chronic neck or shoulder pain from myofascial pain syndrome. Researchers wanted to see if certain pain features (called nociplastic pain) affect how well patients respond to physical therapy. Participants were followed for 3 months after …

This completed observational study looked at 110 breast cancer patients to see if arm swelling (lymphedema) is linked to a specific type of muscle pain called myofascial pain syndrome. Researchers examined trigger points in key muscles and measured pain thresholds. The goal was t…

This study investigates why people with myotonic dystrophy type 1 are 10 times more likely to develop dangerous blood clots in the legs or lungs. Researchers will compare blood samples from 130 participants—including patients with the disease, those with a history of clots, and h…