Jaw pain breakthrough? three injections tested after TMJ procedure

NCT ID NCT07479693

Completed Symptom relief Sponsor: Ondokuz Mayıs University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding an injection of hyaluronic acid, platelet-rich fibrin, or dextrose to a standard jaw washout procedure (arthrocentesis) improves pain and jaw function more than the washout alone. Thirty-six adults with TMJ disorders who hadn't improved with other treatments took part. The goal was to see which, if any, of these add-on injections provides better relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyaluronic acid, injectable platelet-rich fibrin (i-PRF), and dextrose prolotherapy
What this could lead to: If one of these injections proves superior, it could offer a more effective, longer-lasting option for easing TMJ pain and improving jaw movement after a standard washout procedure.
What could go wrong: This is a small, completed trial with only 36 participants, so results may not apply to everyone. The study compared several treatments, and none may be clearly better than the standard procedure alone.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHROCENTESIS TEMPOROMANDIBULAR JOINT PAIN

Contacts and locations

Locations

Ondokuz Mayis University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery

Samsun, Atakum, Turkey (Türkiye)

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