Myopathy

This study tests two experimental drugs, ENTR-601-44 and ENTR-601-45, in people with Duchenne muscular dystrophy (DMD) who have already taken part in earlier studies. The goal is to see if long-term use is safe and tolerable, and whether it can help maintain muscle function. Part…

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This study tests whether Maraviroc, a drug currently used for HIV, can reduce muscle inflammation and improve function in adults with myositis that hasn't responded to standard treatments. Ten participants will take a daily 300mg tablet for 12 weeks and undergo muscle biopsies an…

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This small study will test a drug called emapalumab in 5 adults with a rare, rapidly worsening lung disease linked to dermatomyositis. The drug is already used for a similar immune overreaction condition. Researchers will check if it improves oxygen needs, lung function, and CT s…

This study tests whether semaglutide (a GLP-1 drug used for weight loss) is safe for adolescents and young adults with Duchenne muscular dystrophy (DMD) who are also overweight or obese. The main concern is that the drug might reduce muscle mass, which is already weak in DMD. Par…

This early-stage trial tests a one-time infusion of donor immune cells (CAR-γδT cells) designed to target and destroy faulty B cells in people with severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and find the right dose in 9 adults whose di…

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study tests whether adding sirolimus (a drug that calms the immune system) to ELEVIDYS gene therapy can prevent serious liver injury in boys with Duchenne muscular dystrophy. About 20 participants will receive the treatment and be monitored for side effects. The goal is to m…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This study tests an experimental drug called AOC 1044 for boys with Duchenne muscular dystrophy (DMD) who have a specific genetic change (exon 44 skipping). About 70 boys aged 7 to 16 who can still walk will receive either the drug or a placebo. The main goal is to see if the dru…

This study tests a daily injection called elamipretide in 48 people with genetically confirmed Barth syndrome, a rare condition that causes muscle weakness and heart problems. Participants will receive either the drug or a placebo for 72 weeks. The main goal is to see if the drug…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This Phase 3 trial tests garetosmab, an antibody that blocks activin A, in 18 children and teens with fibrodysplasia ossificans progressiva (FOP), a rare disease where muscle and tissue turn into bone. The study will check safety, side effects, and whether the drug reduces new ab…

This study tests a medicine called surlorian in 28 adults with a rare genetic muscle disease (RYR1-related myopathy) that causes weakness. The goal is to see if surlorian improves muscle strength and function, like standing from a chair or walking. Participants will be randomly a…

This study tests whether a 12-week program of exercise and personalized diet counseling can help preserve muscle mass in obese adults taking GLP-1 medications like Wegovy. Twenty participants aged 40-55 will be followed to see if these lifestyle changes prevent the muscle loss of…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This phase 3 trial tests whether injecting a concentrate of your own bone marrow (BMAC) into the jaw joint during arthroscopy reduces pain and damage better than a standard steroid shot. Twenty adults with long-lasting TMJ pain will be randomly assigned to one of the two treatmen…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This early-stage trial tests UX016, a drug designed to help people with GNE myopathy, a rare genetic muscle-weakening disease. Researchers will give the drug or a placebo to 24 adults to see if it is safe and improves muscle strength. The study is not yet recruiting.

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study tests the safety of a drug called rituximab in 5 boys aged 6-10 with Duchenne muscular dystrophy (DMD) who can still walk. The drug aims to lower certain immune proteins to possibly slow muscle damage. Researchers will monitor side effects and measure changes in walkin…

This study tests whether a person's own stem cells, processed and given by IV, can safely help with multiple system atrophy (MSA) — a rare, worsening brain disease that affects movement and automatic body functions like blood pressure. Fifty adults aged 35 to 65 will receive eith…

This Phase 2 study tests a drug called apitegromab in 60 adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes muscle weakness. Participants will receive either the drug or a placebo every 4 weeks for a year. The main goal is to see if the dru…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This very early trial will test whether injecting a patient's own lab-grown muscle cells under the skin is safe for people with muscle atrophy from long-term bed rest. Only 6 participants will receive the transplant and be closely monitored for side effects and signs of muscle re…

This study tests a drug called telitacicept in 30 adults with inflammatory myopathy, a condition where the immune system attacks muscles, causing weakness. The goal is to see if the drug is safe and can control the disease. Participants must have not responded well to standard tr…

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that haven't responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the di…

This study tests whether a new Fast Fix suturing system works better than the usual method for repositioning the jaw joint disc in people with TMJ internal derangement. About 50 adults who need surgery after other treatments failed will be randomly assigned to one of the two tech…

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe …

This study explores whether a painless ultrasound technique, called shear wave elastography, can detect early signs of muscle weakness in critically ill patients on breathing machines. About 98 adults will have their nerves scanned on days 1, 4, and 7 in the ICU. The goal is to s…

This study will check if an AI system can accurately measure eye movements from smartphone videos. About 1,000 adults with suspected eye movement issues will record a short video while following a moving target. The AI's measurements will be compared to expert ratings to see if i…

This study will check if a muscle ultrasound can reliably detect muscle loss (sarcopenia) in 140 adults getting a kidney transplant. Researchers will compare ultrasound results with a standard body-composition test before and up to one year after transplant. If it works, this cou…

This study will check if a new physical exam called Said's test can accurately diagnose biceps tendon injuries in the shoulder. Researchers will test 144 adults, including those with shoulder injuries and healthy volunteers. Two doctors will perform the new test and standard test…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This pilot study tests whether focused shockwave therapy can reduce pain and improve function in people with chronic neck and shoulder muscle pain. Sixty adults will be randomly assigned to receive either three weekly shockwave sessions or a home exercise program. Researchers wil…

This study tests whether a gentle neck mobilization technique can improve jaw movement and reduce pain in people with chronic jaw muscle pain (TMD myalgia). 48 adults with jaw pain will receive either the neck treatment or a placebo. Researchers will measure jaw motion, muscle ac…

This study tests whether adding deep breathing exercises to a massage routine can quickly reduce neck pain and stiffness in operating room nurses after surgery. Thirty-eight nurses will receive either massage alone or massage plus breathing exercises in a single session. Research…

This study tests whether shining specific light wavelengths (635, 940, or 1064 nm) on the jaw muscles can reduce pain and improve jaw function in people with chronic jaw muscle disorder (TMD). About 45 adults with moderate-to-severe jaw pain lasting over 3 months will receive sev…

This study tests two different manual therapy techniques—Active Release Technique and Myofascial Release—each paired with eye exercises, to see which better reduces eye strain, improves sleep quality, and lowers stress in people with neck pain. 44 adults aged 18-40 with neck pain…

This study compares two non-invasive treatments—high-intensity laser therapy and shock wave therapy—for people with chronic shoulder pain from supraspinatus tendinitis. Researchers will measure pain and disability in 48 adults over several weeks to see which approach works better…

This study looks at two treatments for a jaw joint condition called disc displacement without reduction, which causes pain and trouble opening the mouth. Fifty-two adults who haven't gotten better with standard care will be randomly assigned to get either arthroscopic surgery alo…

This study tests whether applying local heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults with TMD will receive heat therapy and report their pain levels daily for 8 days. Researchers will com…

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study tests whether myofascial release therapy, a type of hands-on treatment that loosens tight connective tissue, can improve body posture and facial symmetry in healthy adults. Sixty participants will be randomly assigned to receive the therapy twice a week for six weeks o…

This study tests whether injections of platelet-rich plasma (PRP) can reduce pain and improve jaw function in people with chronic jaw muscle pain (myogenous TMD). Fifty women aged 20–50 with at least 3 months of pain will receive either PRP or a saltwater shot, then be followed f…

This study tests which injection mixture works better for people with a displaced jaw joint (TMJ) that still clicks and moves. Twenty adults will receive either a mix of hyaluronic acid and steroids or hyaluronic acid and platelet-rich plasma after a joint washout. The goal is to…

This study tests two treatments—trigger point activator and shock wave therapy—for people with painful knots in the upper neck muscle. One hundred adults aged 25–40 with active trigger points will be randomly assigned to one of the two therapies. Researchers will measure pain and…

This study tests if a newer ultrasound-guided needle works better than a standard needle to treat gluteal tendinosis—a painful tendon condition in the buttock area. About 110 adults who haven't improved after 3 months of other treatments will be randomly assigned to one of the tw…

This study tests a hands-on technique called Integrated Neuromuscular Inhibition (INIMT) for people with painful muscle knots in the upper neck. 60 adults with trigger points will receive either INIMT plus standard therapy or standard therapy alone for four weeks. Researchers wil…

This study tests whether adding shockwave therapy or platelet-rich plasma (PRP) injections to a standard exercise program helps people with long-term Achilles tendon pain. One hundred active adults aged 18-65 with symptoms lasting over 3 months will be randomly assigned to exerci…

This study tests whether cycling while using a virtual park app can slow the loss of motor function in children and teens with neuromuscular diseases like muscular dystrophy. Twenty-two participants will first receive standard care for 3 months, then use the virtual park bike 3 t…

This study will test different types of strengthening exercises in 45 children aged 6 to 10 with Duchenne muscular dystrophy (DMD). The goal is to see if these exercises can improve muscle strength, walking distance, and chemical markers in the blood. The results could help guide…

This study tests whether tele-rehabilitation—guided video sessions with self-massage, stretches, and posture tips—can reduce pain and improve neck movement in people with rhomboid trigger points. Thirty-six adults with neck and upper back pain will be randomly assigned to either …

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study tests whether adding dual-task exercises (combining physical movements with mental tasks) to standard physiotherapy, delivered via telerehabilitation, can reduce pain and improve jaw function in young adults with temporomandibular joint (TMJ) dysfunction. Thirty partic…

This study looks at whether adding famotidine (an acid-reducing drug) to standard painkillers (paracetamol and ibuprofen) helps people with calcific tendinitis of the shoulder feel less pain and move better. About 200 adults with shoulder pain and calcium deposits will be followe…

This study tests whether a stronger laser (high-intensity) works better than a standard low-level laser for reducing pain and improving jaw movement in people with chronic jaw muscle pain. Forty adults will receive 12 laser sessions over one month and be followed for six months. …

This study tests two methods of injecting platelet-rich fibrin (PRF) into the jaw joint for people with a displaced disc that causes pain and limited mouth opening. One method uses ultrasound to guide the needle, the other uses a tiny camera (arthroscope). The goal is to see whic…

This study tests whether a supervised exercise program combining resistance training and walking can improve physical function, fitness, and quality of life in women with stage IV breast cancer. 78 women currently on medical treatment will be randomly assigned to either the exerc…

This study tests whether a supervised exercise program can help women who have had breast or gynecological cancer and now suffer from muscle loss (sarcopenia). The 78 participants will do resistance, aerobic, balance, and stretching exercises. Researchers will measure changes in …

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This study compares two treatments for buttock pain caused by piriformis syndrome and related muscle pain. Researchers will use ultrasound to guide either a sugar-water injection or a dry needle into the affected area. The goal is to see which method provides better pain relief o…

This study tests whether taking a supplement called HMB, along with a standard rehab program, can reduce pain and improve knee function in athletes with patellar tendinopathy (jumper's knee). Thirty athletes will receive either HMB or a placebo for 8 weeks. Researchers will measu…

This study tests whether a special light therapy (photobiomodulation) can reduce pain and improve jaw function in people with myofascial temporomandibular disorder (TMD), a condition causing muscle pain in the face and jaw. About 140 adults will be split into three groups: light …

This study tests three treatments for myofascial pain in the upper trapezius muscle: dry needling alone, dry needling plus a lidocaine injection, and a sham needling plus lidocaine. All groups also do stretching exercises. Ninety adults aged 18–65 with active trigger points will …

This study tests whether a mix of two drugs (triamcinolone and lidocaine) injected into jaw muscle trigger points can reduce pain in people with TMJ disorders. About 30 adults will receive either the active injection or a placebo. The main goal is to see if it lowers pain intensi…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study tests if an experimental drug called BIO101 can help prevent muscle weakness in people taking the weight-loss drug semaglutide. About 164 obese or overweight adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide and a reduced…

This study compares two hands-on treatments—Integrated Neuromuscular Inhibition and Active Release Technique—for people with neck pain caused by trigger points in the upper trapezius muscle. About 64 adults with active trigger points and forward head posture will receive one of t…

This study tests whether a gamified mobile app can help 46 boys aged 6–12 with Duchenne muscular dystrophy stay motivated with their home physiotherapy. The app includes rewards, levels, and feedback to make exercise more engaging. Researchers will measure physical function, endu…

This study tests whether a long-hold isometric exercise can reduce pain and improve function in competitive weightlifters with patellar tendinopathy (jumper's knee). About 24 athletes will either do the supervised exercise or follow routine training. Researchers will measure pain…

This study tests whether hypnotherapy can reduce pain and anxiety in children aged 6 to 18 during needle procedures like injections or blood draws. About 70 kids with conditions like juvenile arthritis or lupus will be randomly assigned to receive either hypnotherapy or standard …

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests whether high-intensity laser therapy can reduce pain and improve neck movement, daily function, and mood in people with trapezius myofascial pain syndrome. About 104 adults with neck pain for at least 4 weeks will receive either real or sham laser treatment. Rese…

This study tests whether inhaled salbutamol, a drug used for asthma, can reduce breathing distress in newborns with transient tachypnea of the newborn (TTN). TTN is a common lung condition after birth where fluid stays in the lungs, causing fast breathing. The trial will enroll j…

This study tests whether a multicomponent support group can improve the confidence (self-efficacy) of primary caregivers of children with Duchenne muscular dystrophy or spinal muscular atrophy in Pakistan. Thirty caregivers will join group sessions with doctors, therapists, and o…

This study compares two methods of injecting medicine into the jaw joint to relieve pain and improve function: one using a tiny camera (arthroscopy) and the other using ultrasound guidance. About 50 adults with long-term jaw pain will take part. The goal is to see which approach …

This study tests whether applying an ozonated gel with ultrasound (phonophoresis) can reduce pain and improve shoulder function in people with chronic supraspinatus tendinitis. Forty adults aged 30-60 with mild to moderate tendon issues will receive either the ozone gel treatment…

This study looks at whether TECAR therapy, a type of energy treatment, can reduce pain and improve shoulder movement in people with chronic supraspinatus tendinitis (a common tendon injury). About 46 adults with grade II tendinitis will receive the therapy. Researchers will measu…

This early-stage trial tests amlodipine, a calcium channel blocker used for high blood pressure, in 20 adults with myotonic dystrophy type 1. The goal is to see if the drug is safe and can improve muscle strength, reduce stiffness, and help with daily function. All participants w…

This study compares two needle-based treatments—electrolysis and dry needling—against standard physiotherapy for whiplash pain from car accidents. Thirty-six adults with neck pain and active trigger points will receive one of the three approaches. The goal is to see which method …

This study tests whether adding core-strengthening exercises to standard physical therapy can reduce pain and improve function in people with temporomandibular joint (TMJ) disorders. Fifty adults with jaw pain will be randomly assigned to either standard TMJ therapy or standard t…

This study looks at whether hands-on myofascial release or a tool called Graston can improve flexibility, balance, and agility better than home exercises in people with tight hamstrings. About 45 adults with hamstring shortness will be randomly assigned to one of three groups and…

This study tests whether a personalized exercise program based on muscle structure works better than a standard eccentric heel-drop program for people with chronic Achilles tendinopathy. Twenty adults with mid-tendon pain for at least 3 months will be randomly assigned to one of …

This study tests whether a wearable sensor (Syde device) can reliably measure arm and hand function in boys with Duchenne muscular dystrophy who can no longer walk. Current tests are done in clinics and may miss small changes. The goal is to see if home-based digital monitoring i…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study aims to better understand and treat myofascial pelvic pain, a common cause of long-term pelvic pain in women. Researchers will use a noninvasive imaging technique to measure pelvic floor muscle function before and after three different treatments: education with relaxa…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study looks at whether a specially trained physical therapist can diagnose jaw disorders (like TMJ) as accurately as an oral surgeon. 70 people with jaw pain will be checked by both a physical therapist and a surgeon, and their diagnoses will be compared. The goal is to see …

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This study tests a new imaging technique called full-field OCT to see if it can spot muscle inflammation faster than the usual method, which takes weeks. Researchers will compare both methods on muscle samples from 20 healthy adults and people with suspected myositis. The goal is…

This study will use ultrasound to check for tendon inflammation (tenosynovitis) in children with two types of juvenile idiopathic arthritis (JIA): polyarticular and oligoarticular. Researchers will examine 106 children under 16 at Assiut University Hospital, comparing physical ex…

This study aims to understand if diet influences muscle health and daily function in adults with inclusion body myositis (IBM), a rare muscle disease. Researchers will compare 47 adults with IBM to healthy volunteers aged 40 and older. Participants will track their diet and activ…

This study will follow 500 boys aged 1 to 18 with Duchenne or Becker muscular dystrophy for several years. Researchers will track their muscle function, body composition, lab tests, and heart and lung imaging to map how the disease changes over time. The goal is to create a model…

This study follows up to 10 people of any age with nemaline myopathy, a rare muscle disease, for three years. Researchers will collect information during regular hospital visits to understand how the disease changes over time. The goal is to find better ways to measure disease pr…

This study will observe 300 people with long-term jaw and face muscle pain (TMD) to see how psychological factors relate to their physical symptoms. Participants will fill out questionnaires about their pain and other body symptoms. The goal is to better understand the role of me…

This study looks at how taking caffeine in different ways—daily low doses, gradually increasing doses, or only on workout days—affects muscle growth and strength in 180 young men who don't normally drink caffeine or exercise with weights. Participants will follow two 4-week super…

This study is creating a registry for people with Duchenne and Becker muscular dystrophy, as well as symptomatic female carriers. The goal is to collect health data and quality-of-life information to monitor how new therapies work in real-world settings. Up to 1,500 participants …

This study looks at how athletes at risk for patellar tendinopathy (jumper's knee) move during jumps. Researchers will use a camera system to track knee, hip, and ankle angles in 60 male athletes over 12 months. The goal is to find early movement changes that could lead to better…

This observational study will measure how well the upper neck moves and how that relates to jaw motion in 50 adults with temporomandibular disorders (TMD). Participants will have their neck and jaw movements measured with simple tools. The goal is to understand if limited neck mo…

This study aims to identify the many factors that influence how physically active children with Duchenne Muscular Dystrophy (DMD) are. Researchers will look at muscle strength, balance, thinking skills, sleep, behavior, and family environment. The goal is to gather information th…

This study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday medical practice. Researchers will measure disabili…

This study looks at whether using artificial intelligence (AI) can help physical therapists make better treatment choices for people with myofascial pain syndrome (a type of muscle pain). About 70 adults with chronic muscle pain will be split into two groups: one gets therapy dec…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study will follow 100 people who have had their stomach removed (gastrectomy) to see how their muscles change over time. Researchers will measure muscle thickness in the arms and legs to understand the pattern of muscle loss and how nutrition plays a role. The goal is to gat…

This study will follow 386 critically ill patients on breathing machines to see if losing 10% or more of thigh muscle within the first week in the hospital is linked to a higher chance of dying within 28 days. Researchers will use ultrasound to measure muscle size. The goal is to…

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study checks how often doctors can accurately needle specific hip muscles using only touch and landmarks, without ultrasound guidance. Forty adults with hip pain will receive dry needling, and a second doctor will use ultrasound to see if the needle hit the right spot. The g…

This study will collect health information, samples, and data from 100 people in Luxembourg (800 total across Europe) who have rheumatoid diseases and are starting or changing treatment. Researchers hope to find patterns that can predict which treatments work best for each person…