Yale University

This study aims to find the best way to help people control their blood pressure. It compares two approaches: remote blood pressure monitoring alone, or remote monitoring plus support from a community health worker. About 1440 adults with high blood pressure will take part. The g…

This study tests a program called Fathers for Change (F4C) for fathers who have been violent with their partner. The goal is to see if F4C works better than standard anger management classes at stopping family violence and improving children's mental health. About 1,080 fathers w…

This study provides continuous glucose monitors (CGMs) at no cost to 17 adults with poorly controlled type 2 diabetes. Researchers want to see if easier access to real-time blood sugar data helps lower A1c levels and improves quality of life. Participants wear the sensor for 14-d…

This study looks at whether starting HIV treatment soon after diagnosis can reduce stigma and improve health in people who inject drugs. Researchers will test a new approach that speeds up when doctors prescribe medication. The goal is to lower HIV-related stigma and help more pe…

This study tests if empagliflozin, a diabetes drug, can reduce sugar absorption during peritoneal dialysis in 30 adults with end-stage kidney disease. Participants will receive either the drug or a placebo in a crossover design, followed by an 8-week open-label phase where everyo…

This study tests whether a structured nutrition and exercise program can improve the chance of having no cancer left after chemo-immunotherapy in women with triple-negative breast cancer. About 160 women who are not currently active or eating many fruits and vegetables will be ra…

This study tests whether adding bipolar androgen therapy (BAT) to the standard Sipuleucel-T vaccine can boost the immune system's ability to fight metastatic castration-resistant prostate cancer. About 26 men with this advanced cancer will receive both treatments. The goal is to …

This study looks at whether enoxaparin, a blood thinner, can prevent blood clots caused by central catheters in critically ill children. Researchers want to see if the drug works differently depending on the child's age. About 258 children from newborns to age 17 will take part.

This early-stage study tests whether the psychedelic DMT, combined with talk therapy, can help people with alcohol use disorder drink less. About 63 adults with alcohol use disorder will receive either DMT or a placebo in a controlled setting. Researchers will monitor safety and …

This early-stage study tests whether the drug mavoglurant can help heavy drinkers with Alcohol Use Disorder reduce their cravings and alcohol consumption. About 63 adults aged 21-50 who drink heavily will take the drug and then have their drinking and cravings measured in a contr…

This study tests adding the drug mogamulizumab to standard chemotherapy for people with aggressive T-cell lymphoma, a type of blood cancer. About 22 adults with newly diagnosed or returning lymphoma will receive the combination treatment. The goal is to see if more patients achie…

This study looks at whether e-cigarettes or nicotine pouches can help adults who smoke cigarettes reduce how much they smoke. About 256 people will try one of these products for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they s…

This study tests a new drug called CUE-101, alone or with another drug (pembrolizumab), in 30 people with newly diagnosed HPV-16 positive head and neck cancer that cannot be easily removed with surgery. The goal is to see if these drugs can boost the immune system to fight the ca…

This study compares two blood thinners, apixaban and aspirin, in 700 people who have had a brain bleed (intracerebral hemorrhage) and also have atrial fibrillation, an irregular heartbeat. The goal is to see which drug better prevents future strokes or death. Participants will ta…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This study tests two combinations of cancer drugs for people with metastatic triple-negative breast cancer that has not responded to one prior treatment. The first combo uses sacituzumab govitecan plus nivolumab; the second adds a third drug, relatlimab. The goal is to see if the…

This study tests whether adding a short course of the oral hormone drug Relugolix to targeted radiation (SBRT) works better than radiation alone for men with unfavorable intermediate-risk prostate cancer. About 60 men will be randomly assigned to one of the two treatments. The ma…

This study tests a drug called afatinib in people with a rare and aggressive uterine cancer (HER2-positive uterine serous carcinoma) that has come back or not gone away. The goal is to see if the drug can stop the cancer from growing for at least 6 months. About 50 participants w…

This study tests whether combining two drugs, luspatercept and darbepoetin alfa, can help people with a specific type of lower-risk MDS (a blood disorder) go without red blood cell transfusions for at least 12 weeks. About 60 adults who currently need regular transfusions will re…

This study tests whether precisely targeted radiation can control kidney cancer that has started growing in a few spots while a patient is on immunotherapy. About 30 adults with metastatic renal cell carcinoma will receive radiation to up to 5 progressing tumors and continue thei…

This study tests a program called Fathers for Change (F4C) for 280 fathers who struggle with substance misuse and have been violent toward family. The program aims to help them control emotions, stop substance use, and prevent violence. Researchers compare F4C to standard drug co…

This study tests whether the medication varenicline can help adults quit using e-cigarettes. Researchers will compare varenicline to a placebo in 326 people who vape daily. The main goal is to see if more participants can stop vaping for at least a week by the 12-week mark, with …

This study tests whether prazosin, a blood pressure medicine, can help people with alcohol use disorder who also have withdrawal symptoms drink less heavily. About 150 adults will receive either prazosin or a placebo for 12 weeks, along with weekly counseling. The main goal is to…

This study tests a new way to give radiation to people with relapsed or hard-to-treat large B-cell lymphoma before they receive T-cell therapy (CAR T or bispecific antibodies). The goal is to see if giving radiation twice a day is safe and possible. About 10 adults will take part…

This study tests whether using a PAP machine (a device that helps keep your airway open during sleep) can improve recovery after a stroke. Researchers will enroll 360 people who have had an ischemic stroke and also have moderate to severe obstructive sleep apnea. Half will receiv…

This study tests whether community health workers can help people in Nepal manage their high blood pressure. About 3,572 adults with high blood pressure will receive regular home visits or group meetings from a trained health worker over one year. The goal is to see if this appro…

This study tests a new stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD. The program adds counseling and support to standard medication treatment, with the goal of helping women stay in treatment…

This study looks at whether guanfacine, a medicine used for high blood pressure, can help people with alcohol use disorder drink less. Researchers will compare how men and women respond to the drug under stress or stimulation. About 160 adults aged 21–70 who drink heavily will ta…

This study tests whether adding an SGLT2 inhibitor (a type of diabetes drug) to standard hospital care helps patients with heart failure who also develop acute kidney injury. About 130 adults will receive either the drug or a placebo. The goal is to see if the drug improves survi…

This study tests a drug called elacestrant in 50 adults with ER+ breast cancer who have a high risk of the cancer coming back years later. Participants must have cancer DNA in their blood but no signs of spread on scans. The goal is to see if elacestrant can clear that DNA and im…

This study aims to expand medication-assisted treatment (opioid agonist therapy) for people with opioid use disorder in Kazakhstan, Kyrgyzstan, and Tajikistan. The goal is to prevent new HIV infections by making treatment more available and effective. Researchers will work with 9…

This study tests a program called T1CARE that connects young adults with type 1 diabetes to a community health navigator who helps them resolve social needs like food, housing, or transportation. About 100 participants will be randomly assigned to get the program right away or af…

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer over 168 days. About 600 adults starting a new treatment episode will take part. The go…

This study looks at a special stent that doctors modify by hand to treat large aneurysms in the chest and belly area. The goal is to see if this less invasive approach is safer and works as well as open surgery. About 80 people aged 50 and older with aneurysms at least 5.5 cm wid…

This study tests whether a higher starting dose of buprenorphine in the emergency room helps more people with opioid use disorder engage in treatment within 10 days. It also looks at whether the higher dose reduces cravings, withdrawal symptoms, and use of illicit opioids. The tr…

This study tests a drug called sacituzumab govitecan in 20 people whose cervical cancer has returned or not gone away after at least one prior treatment. The drug works like a guided missile, delivering chemotherapy directly to cancer cells. The main goal is to see how many patie…

This early study is testing if a special ultrasound device placed on the belly can help people with type 2 diabetes manage their blood sugar. About 30 adults on stable diabetes pills will receive the treatment. The main goal is to check safety, especially for the liver, and see i…

This study looks at whether a sleep medication (eszopiclone) can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. Researchers will study 250 adults with sleep apnea to see if raising the brain's arousal threshold…

This study tests a drug called guselkumab for people with Hailey-Hailey disease, a painful genetic skin condition that causes blisters and sores in body folds. The trial will include 10 adults with moderate to severe disease. Researchers want to see if the drug can improve skin s…

This study looks at whether improving sleep can help heavy smokers quit by reducing negative feelings and improving self-control. Researchers will use brain scans and behavioral therapy to understand the connection. About 114 adult smokers with insomnia will participate.

This study tests whether a natural hormone called pregnenolone can help people with alcohol use disorder drink less. About 150 adults will take either pregnenolone or a placebo daily for 12 weeks. The goal is to see if the hormone reduces heavy drinking days and is safe to use.

This early-phase study tests two drugs, lenvatinib and pembrolizumab, in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink growths and reduce the need for repeated surgeries. Partic…

This early-phase study is for people with extensive-stage small-cell lung cancer whose disease persists, returns, or progresses after initial chemotherapy. Researchers are testing whether adding an experimental drug (iadademstat) to standard radiation and immunotherapy (atezolizu…

This study looks at whether surgery to remove remaining cancer spots can help people with advanced bladder cancer that has been controlled by drug therapy. About 32 adults whose cancer has not spread widely will receive surgery on the main tumor and any other treatable spots. The…

This study is for people with a common type of breast cancer (ER-positive, HER2-negative) that has a moderate to high risk of coming back based on tumor size and lymph node involvement, but a low genetic risk score. The goal is to see if patients can safely skip chemotherapy and …

This study is testing a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults who are planning to have bariatric surgery lose weight and quit smoking. The goal is to see if this approach is practical and acceptable for patients. About 20 p…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in 40 adults with metastatic breast cancer that is HER2-negative (IHC 0). The goal is to see how well the drug shrinks tumors and which patients benefit most. Participants receive the drug and are monitored for respons…

This study tests whether empagliflozin, a diabetes drug, can help people with cirrhosis and ascites (fluid buildup in the belly) get rid of excess salt and water. About 20 adults on stable diuretics will take the drug or a placebo for 14 days. Researchers will measure changes in …

This study is testing whether placing a contraceptive implant in the shoulder blade area works as well as the usual arm placement. Researchers will check hormone levels and side effects in 62 women over two years. The goal is to see if this new spot is a good option for long-term…

This early-stage study tests a new drug called AB821 in people with advanced melanoma or other solid tumors that have spread. The main goal is to check safety and find the right dose. About 50 adults will take part at Yale University.

This study tests a special device that uses sound waves (shockwaves) to crack calcium deposits in leg arteries, helping blood flow better. About 50 people with leg pain or wounds from peripheral artery disease will get this treatment. The goal is to see if it improves quality of …

This study tests whether adding ertugliflozin (a diabetes drug) or metolazone to standard diuretics helps control fluid buildup and heart failure symptoms better than placebo. About 60 adults with chronic heart failure who already take daily diuretics will participate. Researcher…

This study tests whether adding surgery or radiation to standard chemotherapy helps people with metastatic upper GI cancer live longer without the disease getting worse. It includes 54 adults whose cancer has spread but whose blood shows no detectable tumor DNA after three months…

This study tests whether a low dose of digoxin, a drug normally used for heart conditions, can help people with a severe form of fatty liver disease called NASH (also known as MASH). About 144 adults with confirmed NASH and liver scarring will take digoxin or a placebo for a peri…

This study tests whether a medication already approved for other uses can help people with HIV who also have alcohol use disorder drink less. Researchers will enroll 30 adults from the Atlanta VA Healthcare System. Participants will receive the medication along with counseling fr…

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults aged 21 to 65 who currently drink heavily will receive either apremilast or a placebo. Researchers will measure how much alcohol participants consume during a lab dr…

This study tests whether the diabetes drug metformin can protect kidney cells in people with a rare kidney disease called FSGS. About 30 adults will receive either metformin or a placebo for 6 months, alongside their usual treatments. The goal is to see if metformin reduces kidne…

This study aims to see if a self-administered fingerstick glucose test at home is as accurate as the standard clinic-based oral glucose tolerance test for screening type 1 diabetes. Researchers will enroll 60 people at risk for or recently diagnosed with type 1 diabetes. Particip…

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This study tests a new decision-making tool to help women discuss and decide about PrEP (a daily pill to prevent HIV) during regular sexual and reproductive health visits. About 50 women who are HIV-negative, not currently on PrEP, and able to become pregnant will participate. Th…

This study tests two approaches to help people recently involved with the justice system start HIV prevention (PrEP) or treatment (ART) and substance use care. About 400 participants will either receive standard patient navigation or a shared decision-making model where they choo…

This study tests whether providing housing help and financial education to people returning from prison and their families can lower gun violence in high-risk neighborhoods. Researchers will also train community members to offer trauma-informed support. The goal is to see if thes…

This study aims to reduce COVID-19 illness and death among people who live or work in prisons. Researchers will test different ways to encourage COVID-19 vaccination in Pennsylvania prisons, involving over 37,000 participants. The goal is to find what works best to increase vacci…

This study looks at whether vitamin D supplements can improve menstrual cycles and emotional health in teenage girls aged 13-21 who have PCOS and low vitamin D levels. Participants will receive either vitamin D or a placebo for 6 months, and neither they nor their doctors will kn…

This study tests whether a gentle, non-invasive ultrasound treatment can reduce or stop seizure activity in people with a severe type of ongoing seizure called status epilepticus that hasn't improved with standard medications. Ten participants in the ICU will receive a 10-minute …

This study tests whether a mobile app can help people recovering from hip, knee, or spine surgery do simple exercises while still in bed. About 100 adults will use the app during their hospital stay to see if it improves their physical therapy performance and satisfaction. The go…

This study tests whether a mindfulness-based sleep program can improve sleep and reduce stress in Black women with insomnia. Researchers will enroll 340 Black women who have trouble sleeping. The goal is to see if better sleep can lower the risk of heart disease and other health …

This study tests whether real-time brain scans (fMRI) can teach teens aged 10-16 with Tourette Syndrome to better control their tics. Participants will receive neurofeedback from a brain region linked to movement, while a control group gets feedback from a different area. The goa…

This study follows 200 people with chronic low back pain who are scheduled for a procedure called basivertebral nerve ablation. The goal is to see how much pain and function improve over two years and to figure out which patients benefit the most. Participants will answer weekly …

This study tests a mobile app that gives personalized encouragement and health tips based on blood sugar, exercise, mood, and sleep patterns. It aims to help 60 adults aged 30-65 with type 1 diabetes or similar conditions exercise more often and with confidence. All participation…

This study tests whether bexagliflozin, a drug typically used for diabetes, can reduce the severity of sleep apnea in overweight or obese adults. About 164 participants will receive either the drug or a placebo for 6 months, along with routine care. Researchers will measure chang…

This study tests whether using a spray of a patient's own skin cells (RECELL) on the surgical site leads to a better skin color match after head and neck reconstruction. About 20 adults having reconstructive surgery will receive the same treatment. The goal is to see if this meth…

This study tests a portable device called PoRI that helps stroke survivors regain hand movement. About 12 people who had a stroke within the past 2 days to 2 months will use the device or receive standard hand therapy. The goal is to see if the device improves hand function and r…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve voice quality in people with laryngeal dystonia (also known as spasmodic dysphonia). Ten participants will receive active, sham, and no stimulation to compare effects. The goal is to see i…

This study looks at how veterans with post-traumatic headache feel when they get a nerve block injection in the scalp. Each participant will receive three different doses of the numbing medicine, one week apart. The goal is to compare the sensations and side effects of each dose …

This study tests a 10-session LGBTQ-affirmative cognitive-behavioral therapy delivered via telehealth for sexual minority women who drink heavily and have anxiety or depression. Participants are 274 women in New York, New Jersey, and Pennsylvania. The goal is to see if this thera…

This study tests whether a special brain training technique, called mindfulness-based neurofeedback, can help adults with borderline personality disorder (BPD) get more out of their regular talk therapy. Researchers will use real-time brain scans to help participants learn to con…

This study tests if gentle nipple stimulation can help start labor in first-time mothers, as an alternative to the usual medication (oxytocin). About 988 women will be randomly assigned to one of two groups. The goal is to see if nipple stimulation leads to more natural deliverie…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study looks at two ways to help heart failure patients breathe after a breathing tube is removed. It compares high-flow nasal cannula (a device that delivers warm, moist air through the nose) with non-invasive ventilation (a mask that helps push air into the lungs). The goal…

This study is testing whether a combination of THC and CBD, taken by mouth, can help people who have both opioid use disorder and chronic pain. Participants are already on methadone treatment. The goal is to see if these cannabis compounds can reduce pain sensitivity and lower cr…

This study tests a mindfulness app called Calm Health in 10 young adults (ages 18-30) with type 1 diabetes or similar conditions. Participants use the app to track mindfulness, blood sugar, stress, and sleep, and get personalized feedback. The goal is to see if the app is easy to…

This study compares two forms of ketamine for people with depression that hasn't improved with other treatments. One is given through an IV drip, the other as a nasal spray. Researchers want to see which works better, is more acceptable to patients, and has fewer side effects. Ab…

This study tests whether a daily medication called valbenazine can reduce the urge to pull hair in adults with trichotillomania. About 20 people will receive either the drug or a placebo for 12 weeks, then everyone gets the drug for another 12 weeks. The goal is to see if it safe…

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study tests whether a small, home-use device that gently stimulates a nerve in the ear can help young adults (ages 18-29) manage pain and other symptoms of irritable bowel syndrome (IBS). Eighty participants will use either the active device or a sham (inactive) version twic…

This study tests whether a smartphone app called Change4Better (C4B) can help reduce problem gambling compared to standard treatment alone. About 128 adults who gamble and want help will use the app for 6 months. Researchers will track changes in gambling symptoms and how often p…

This study tests whether a smartphone app called Kick-Nic! can help high school students stop vaping. About 306 teens who want to quit will either use the app or visit a standard quit-smoking website. Their progress will be tracked over 6 months with surveys and saliva tests to c…

This study compares two common types of heart medications (beta-blockers and calcium channel blockers) in adults aged 65 and older who have stable angina and at least two other chronic health conditions. The goal is to see which medication improves quality of life more and is eas…

This study looks at whether cannabidiol (CBD) is safe and can help with pain and opioid cravings in people already receiving methadone or buprenorphine for opioid use disorder. About 34 adults with chronic pain will take part in a short, four-week trial where they receive CBD or …

This study tests two types of therapy for LGBTQ+ adults (age 20+) who have parents that are not accepting of their identity. The therapies, delivered online, aim to reduce symptoms of depression and anxiety. About 124 participants from the US and Israel will take part.

This study tests a daily pill called fezolinetant to see if it can reduce hot flashes in women who have had early-stage breast cancer and are taking hormone therapy. About 92 women will be randomly assigned to receive either the drug or a placebo. The main goal is to measure how …

This study looks at whether providing medically tailored groceries and nutrition counseling can improve diet quality, reduce symptoms, and lower healthcare costs for 100 adults with any type of cancer living in Maine. Participants are split into three groups: groceries plus couns…

This study looks at whether a single dose of MDMA can help adults with Borderline Personality Disorder better understand social cues and emotions. Ten participants will take MDMA and complete tasks measuring sociability and emotion recognition. The goal is to see if MDMA can temp…

This study compares music-backed mindfulness meditation to meditation alone for reducing stress and anxiety in people of African descent. 70 participants with anxiety or depression will join virtual sessions. The goal is to see if adding music makes stress management more effecti…

This study tests whether an inflatable balloon catheter works better than standard rod-shaped dilators for opening the cervix before a dilation and evacuation (D&E) procedure in the second trimester. About 50 pregnant people between 19 and 23 weeks will be randomly assigned to on…

This study tests a combination of sleep-promoting and circadian-aligning treatments (a "sleep chronobundle") in 160 critically ill ICU patients. The goal is to see if realigning the body's internal clock can improve sleep quality and metabolism. Participants will receive the bund…

This study tests whether people with pelvic floor disorders (like prolapse or incontinence) can learn and benefit from pelvic floor exercises through remote, video-based therapy. About 20 English-speaking adults will participate, doing exercises at home while researchers track ea…

This study tests a new treatment called SPACE, which helps parents support their anxious teens without the teen needing to attend therapy. It compares SPACE to a parent education program. About 108 teens with anxiety disorders will take part, and researchers will measure anxiety …

This study looks at whether taking sitz baths (sitting in warm water) after surgery for pelvic organ prolapse can help reduce pain and improve recovery. About 112 women will be randomly assigned to either use sitz baths or follow standard care. The main goal is to measure pain le…

This study tests whether brief training in managing alcohol cravings can help heavy-drinking young adults (ages 18-26) reduce how much they drink. Participants will attend 1-4 training sessions based on cognitive-behavioral or mindfulness techniques, then report their drinking vi…

This early study tests whether patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (like Tylenol) instead of waiting for a nurse to bring pills. About 24 adults will be enrolled to see if this approach is practical and accepta…

This study tests whether a virtual, community-based program combining music and mindfulness can help manage stress, anxiety, and depression in people of African descent during COVID-19. About 48 participants aged 16 and older will join online sessions and have their brain activit…

This study looks at whether dronabinol, a drug similar to THC in cannabis, can reduce pain sensitivity and improve thinking and mood in people being treated for opioid use disorder. About 36 adults aged 18-70 who are stable on methadone or buprenorphine will receive either dronab…

This study tests whether using a smartphone app with short mindfulness and light exercise modules can improve quality of life and reduce stress, anxiety, and depression. About 120 adults in the U.S. will use the app and report changes in mindfulness, exercise habits, and mood. Th…

This study tests whether a noninvasive brain stimulation technique called rTMS can improve social abilities in adults with autism. Researchers will measure brain responses and eye gaze patterns before and after treatment. The goal is to see if this approach can ease core social c…

This early-stage study at Yale University is testing whether a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for 50 adults whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Participants do not need a fo…

This study tests whether people with overweight or obesity and high food cravings can learn to change their brain's response to food cues using neurofeedback. Participants will undergo brain scans while receiving real-time feedback to help reduce cravings. The goal is to see if t…

This study tests a nutrition education program designed with local foods for first-time pregnant women in northern Ghana. The goal is to help them eat a more varied diet with more protein and iron, and to see if this improves their health knowledge and their babies' birth weight.…

This study looks at how a drug called dichloroacetate affects brain function when blood sugar drops too low in people with type 1 diabetes. It involves 16 adults who have had severe low blood sugar or don't notice symptoms of low blood sugar. Participants will receive the drug or…

This early-phase study is testing whether adding dapagliflozin, a diabetes drug, to standard chemotherapy can improve insulin resistance in women with early-stage HER2-negative breast cancer who have high insulin levels. About 20 participants will receive the drug alongside chemo…

This study looks at how HIV affects the brain even when the virus is controlled by medication. Researchers will use special PET and MRI scans to measure brain cell connections in 70 people with HIV and healthy volunteers. The goal is to understand why some people with HIV still h…

This study tests whether a short, low-intensity exercise test called SHAPE™ can be used in older adults (over 60) before moderate- to high-risk surgery. The goal is to see if the test is practical and if its results can help predict recovery and complications. Participants do one…

This study is testing whether an AI-powered chatbot on a smartphone can encourage more men in Malaysia to get tested for HIV. The study will enroll 296 men who have sex with men and have not been tested recently. Participants will use the chatbot and report every 30 days whether …

This study is creating a registry of 800 adults with Myasthenia Gravis (MG) at Yale University. Participants donate blood and stool samples, which will be used for future research projects to better understand MG. No treatment or intervention is provided; the goal is to collect d…

This study creates a live registry using electronic health records to track heart failure patients across the Yale New Haven Health System. It aims to monitor hospitalizations and use of recommended treatments in up to 40,000 participants. No new treatments are tested; instead, r…

This study looks at immune cells in the gut to understand how they might be involved in brain diseases like multiple sclerosis and Parkinson's. Researchers will collect tissue samples from 100 adults during colonoscopies. The goal is to learn more about the gut's role in these co…

This study looks at the immune cells in the lymph nodes near kidney tumors to learn how the body fights the cancer. Researchers will analyze tissue samples from 10 adult kidney cancer patients to find clues about why some treatments work and others don't. The goal is to discover …

This study looks at how ketamine helps people with hard-to-treat depression and PTSD. Researchers will give a drug called perampanel along with ketamine to see if it changes the brain's response. About 50 adults with depression that hasn't improved with other treatments will join…

This study aims to find the smallest amount of nicotine that smokers find rewarding or addictive. Researchers will test different nicotine doses in 45 adult smokers to see which dose they can identify and prefer. The goal is to better understand how addiction develops, which coul…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study is creating a large database to learn more about why some women receive general anesthesia during C-sections and how it affects their care. Researchers will collect information from thousands of pregnant women across many hospitals. The goal is to find patterns that ca…

This study aims to find early signs and risk factors that could predict if someone will develop multiple sclerosis (MS) before any symptoms appear. Researchers will collect data from 1,000 adults who have risk factors like a family history of MS or certain lifestyle factors. The …

This study looks at why some people with heart failure become resistant to diuretics (water pills). Researchers will test whether a medication called ammonium chloride can help the kidneys remove more sodium. 50 adults with heart failure and diuretic resistance will take either t…

This study aims to understand how the breakdown of food in the gut (colonic fermentation) affects insulin resistance in young people aged 15-22 with obesity. Researchers will compare two groups: those with and without insulin resistance, and also test if physical activity changes…

This study looks at why standard heart failure medications may not fully block a hormone called aldosterone. Researchers will give 20 adults with stable heart failure either a placebo or the drug spironolactone, then measure how the body handles salt and water. The goal is to und…

This study is testing a new lab test that helps doctors choose the most effective chemotherapy drugs for each patient. It involves 20 people with advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The test analyzes a small tissue sample to see wh…

This study looks at the best way to help parents get online access to their child's medical records. About 5,200 parents will either get a text, a message through their own patient portal, or no message at all. Researchers will then compare which group had more parents successful…

This study uses brain scans to measure the density of connections between brain cells in people with cocaine use disorder compared to healthy volunteers. Researchers aim to understand how cocaine affects brain plasticity. The study involves 80 participants aged 21-60, including t…

This study looks at why some people with heart failure don't get rid of enough fluid with standard water pills (diuretics). Researchers will test adding two different types of water pills, alone or together, to see if they help the body release more sodium and fluid. About 50 adu…

This study tests whether a video or a written guide helps women aged 75 and older make better decisions about breast cancer screening. About 300 women who have had screening before but never had breast cancer will take an online survey. The goal is to see which format reduces con…

This study looks at how the brain's arousal systems affect what we see and hear. Researchers will study healthy adults and epilepsy patients using brain scans, eye tracking, and behavioral tests. The goal is to understand how the brain processes sensory information, which could h…

This study is testing a new virtual reality (VR) tool called Life at 100.4 to help teenagers and young adults with cancer, along with their caregivers, learn about their diagnosis and treatment. About 45 participants will use the VR program, and researchers will measure how easy …

This study aims to develop a better way to measure calcium deposits under the skin in people with scleroderma. Researchers will use CT scans and special software to see if these measurements match how patients report their symptoms. About 56 adults with scleroderma and calcium de…

This study looks at whether a non-invasive brain stimulation technique called TMS can change brain activity related to understanding others' thoughts (mentalizing) in young adults with autism. Researchers will compare brain scans before and after stimulation in 80 participants, i…

This study tests a new, non-invasive device that measures blood pressure in the veins near the heart by pressing on the neck. It involves 40 adults in the cardiac ICU who already have standard invasive monitoring. The goal is to see if the device is safe and accurate enough to re…

This study looks at whether sudden stress can cause a worsening of congestive heart failure. Researchers will monitor heart pressure in 112 adults with heart failure who have an implanted monitor, comparing times of stress and calm. The goal is to understand the link between stre…

This study looks at how long-term phosphate therapy affects the kidneys, blood vessels, and heart in people with two rare bone disorders: X-linked hypophosphatemia (XLH) and hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Researchers will measure hormone levels an…

This study watches 150 people who had a stroke to see if ups and downs in blood pressure affect their recovery. Researchers will track brain scans and thinking skills to understand why blood pressure changes matter. The goal is to find new ways to treat blood pressure after a str…

This study aims to create a lab-based test to help screen medications for Alcohol Use Disorder (AUD). Researchers will observe how 90 adults with AUD resist drinking in a controlled setting. The goal is to develop a reliable method to test new treatments, not to provide direct th…

This study looks at whether liver doctors can be trained to offer medication and brief counseling for alcohol use disorder during regular liver clinic visits. The goal is to make treatment more accessible for patients with both alcohol-related liver disease and alcohol use disord…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This study aims to understand which parts of the brain help us learn and remember new ways of speaking. Researchers will use brain scans (fMRI) and magnetic pulses (TMS) to map brain activity in 160 healthy adults. Participants will speak words while hearing altered feedback, and…

This study looks at how the brain learns and remembers how to move the mouth and tongue to make speech sounds. Researchers will play with the sound of your voice as you speak to see how your brain adjusts. The goal is to understand the learning process, not to treat any condition…

This study looks at how blood flow changes in healthy volunteers when they lose a small amount of blood. Researchers use a special device to safely reduce blood flow and test different monitors. The goal is to find the most reliable spot on the body to detect early signs of blood…

This study aims to find out if the body can store sodium (salt) without holding onto extra water, and whether this stored sodium is inside or outside cells. Researchers will study 10 adults on peritoneal dialysis who also have heart failure. Over 5 days, they will measure how muc…

This study uses PET brain scans to measure cannabinoid receptors (CB1R) in healthy volunteers and people with conditions like schizophrenia, cannabis dependence, PTSD, and opioid use disorder. Researchers aim to understand how these receptors differ across groups and how they cha…

This study aims to see if a culturally responsive program, where trained peers use motivational interviewing, can help Latinos with serious mental illness engage in treatment. Researchers will recruit 30 participants in Connecticut who are not currently in treatment. The main goa…

This study is developing and testing two short online writing exercises to help parents in the Southeast US become more accepting of their sexual and gender minority children (ages 15-29). About 129 parents who identify as heterosexual and cisgender and who report some non-accept…

This study aims to understand how ketamine reduces suicidal thoughts by testing whether blocking a specific brain receptor (AMPA) stops ketamine's effects. Thirty adults with depression, bipolar disorder, or PTSD who have current suicidal thoughts will receive ketamine with eithe…

This study looks at how group drumming affects pain, brain activity, and stress hormones in people with early Alzheimer's or mild memory problems, as well as their caregivers. Over 8 weeks, participants will drum together while researchers measure heart rate, brain waves, and pai…

This study looks at how cannabis use changes brain cell connections (synapses) in people aged 50 and older. Researchers will use special brain scans to measure these connections. The goal is to understand, not treat, the effects of cannabis on the aging brain. About 24 volunteers…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study will take repeated brain scans of 10 people receiving medication for opioid use disorder to track how their brain activity changes during recovery. The goal is to identify key moments when the brain is more receptive to additional treatments like therapy or stimulation…

This study is testing whether a set of suicide prevention strategies can work in primary care clinics in rural Nepal. About 147 healthcare providers and patients will take part. The goal is to see if the program is practical and acceptable, so it can be tested in a larger study l…

This study aims to understand which parts of the brain help us learn and remember new ways of speaking. Researchers will use brain scans and magnetic pulses to observe brain activity in 120 healthy adults. The goal is to learn more about how speech motor learning works, not to te…

This study looks at whether a urine test can be used to monitor Wilson Disease instead of a blood test. Researchers will ask 30 stable patients to pause their medication for up to 4 days under close supervision. They will collect daily urine and blood samples to see if the urine …

This study uses a special brain scan (PET) with a new tracer called [11C]APP311 to measure synaptic density in people with psychotic disorders or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connections differ in these conditions. Res…

This study looks at why some people with heart failure don't respond well to diuretics (water pills). Researchers will give different doses of a diuretic to 75 heart failure patients and measure how their kidneys handle salt and water. The goal is to understand the mechanisms beh…

This study is building a large registry and biorepository of 5000 adults with various rheumatic diseases like rheumatoid arthritis and lupus. Researchers will collect medical information and biological samples over time to identify patterns and biomarkers. The goal is to better u…

This study looks at how feeling disconnected from others affects the brain in people aged 55 and older. Researchers will use brain scans like MRI and PET to measure brain activity and connections. The goal is to understand the link between social isolation and suicide risk in lat…

This study uses brain scans to compare a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment versus healthy volunteers. The goal is to understand how the endocannabinoid system works differently in addiction. No new treatment is tested; it is…

This study looks at how THC, the active ingredient in cannabis, affects memory and learning in healthy adults aged 21 to 55 who have used cannabis before. Participants will complete memory tasks and brain scans after taking THC or a placebo. The goal is to understand the short-te…

This study tests a portable MRI machine to look for brain injury in patients who have had a cardiac arrest. Researchers will scan the brain multiple times over several days to see how injuries change. The goal is to make brain imaging available at hospitals without specialized sc…

This study looks at how the active ingredient in cannabis, THC, affects men and women differently. Researchers will give THC to 100 healthy adults who have used cannabis before and measure their feelings of being 'high' and memory performance. The goal is to understand why men an…

This study looks at how alcohol, cannabis use, and certain medications might increase the risk of falls and memory or thinking problems in people with HIV. Researchers will enroll 100 participants who take five or more non-HIV medications. A clinical pharmacist will provide couns…

This study is creating a registry for children with PTEN Hamartoma Tumor Syndrome (PHTS), a rare genetic condition that increases cancer risk. Researchers will follow 100 participants for 3 years to link genetic changes with health outcomes. The goal is to develop better monitori…

This study looks at how THC, the main active part of cannabis, affects older adults aged 65 and up. Researchers want to understand how the body processes THC when taken as a pill or inhaled, and how it impacts pain and the risk of misuse. Twenty healthy volunteers with past canna…

This study aims to discover the genetic reasons behind recurrent pregnancy loss (RPL) by analyzing DNA from parents and pregnancy tissue. Researchers at Yale University will enroll 500 women who have had multiple pregnancy losses. The goal is to identify genetic markers that pred…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at how different types of insulin resistance (in fat or muscle) affect the liver's production of fats called triglycerides. Researchers will measure fat production after a meal, with and without exercise beforehand. The goal is to understand why some people have …

This study uses brain scans to find the specific brain areas linked to depression in people with Parkinson's disease. Researchers will study 120 adults aged 40 to 80 who have Parkinson's and depression symptoms. The goal is to identify targets for future treatments, not to test a…

This study aims to understand how the brain learns and remembers new ways of speaking. Researchers will use brain scans (fMRI) and magnetic pulses (TMS) to see which brain areas are involved. 50 healthy, right-handed, fluent English speakers with normal hearing will participate. …

This study looks at how cooling ingredients like menthol and WS-23 affect how much adults like e-cigarettes and how addictive they find them. About 66 adults who currently vape will test different e-liquid flavors and report their experiences. The goal is to understand which addi…

This study looks at how using a cuff to limit blood flow during exercise affects immune cells and energy use in people recovering from ACL surgery. Researchers will measure changes in genes, sugars, fats, and stress hormones in 20 adults aged 18-60. The goal is to understand the …

This early-phase study at Yale University is testing a new radioactive tracer called [18F]GATT-44 to see how well it can image GABA transporters in the brain using PET scans. The study involves 32 healthy adults aged 18 to 60. The goal is to understand how the tracer moves throug…

This study looks at how the brains of people with Obsessive-Compulsive Disorder (OCD) process fear and safety signals. Researchers will use MRI scans and mild brain stimulation (tDCS) to see if they can improve how the brain learns to feel safe. The goal is to understand OCD bett…

This study looks at brain changes in people who use cannabis heavily and want to quit. Researchers will use brain scans to measure a protein linked to brain cell connections, both before and after at least 4 weeks of not using cannabis. They will also test memory to see if brain …

This study will follow 10,000 people who need hip surgery to compare two approaches: hip preservation surgery (which tries to keep the natural hip joint) and total hip replacement (which replaces the joint). The goal is to see which surgery leads to better pain relief, function, …

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers will use brain scans, computer games, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to pr…

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …

This study aims to understand why some people are more vulnerable to alcoholism by looking at brain activity. Researchers will give 80 adults either a single dose of the drug mavoglurant or a placebo, then use MRI scans to see how their brains respond to rewards and alcohol-relat…

This study is testing whether a short exercise test done before surgery can help predict complications in adults over 45 having moderate- to high-risk operations. Researchers will collect data from routine care and exercise tests to see if results link to heart, lung, or other pr…

This study uses brain scans to understand why some people relapse to opioid use during treatment. Researchers at Yale will follow 240 adults recently started on methadone or buprenorphine, tracking their brain connectivity and drug use for six months. The goal is to identify patt…