Yale University

This study tests a drug called sacituzumab tirumotecan in 20 people with triple-negative breast cancer that has spread to the brain. The drug is given through a vein twice a month. The main goal is to see if it can shrink brain tumors. This is a phase 2 trial, meaning it is still…

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to a standard hip procedure (core decompression with bone marrow cells) can reduce pain in people with early-stage avascular necrosis of the hip. The trial will enroll 400 p…

This study looks at whether eating table olives every day for 5 weeks can improve health markers like cholesterol in healthy young adults. About 226 Yale college students will eat 6 olives daily or follow their usual diet. Researchers will compare blood tests at the start and end…

This pilot study will test whether giving monthly extended-release buprenorphine injections from a mobile pharmacy is acceptable and practical for people with opioid use disorder. Sixty adults who choose this treatment will receive injections for 6 months. The main goal is to see…

This study tests whether a comprehensive telehealth platform called RecoveryPad helps adults with moderate to severe opioid use disorder start and stay in medication treatment. Researchers will enroll 470 participants and track attendance at treatment appointments within 30 and 9…

This study tests whether sending tailored reminders to doctors can increase the use of recommended medications for chronic kidney disease (CKD). About 1,000 adults with CKD will be included, and doctors will receive alerts through their computer system. The goal is to see if thes…

This study looks at whether emergency medical workers can safely start the medication buprenorphine for people with opioid use disorder right in the ambulance. About 495 adults who agree to the protocol will be followed to see if they stay in treatment within 10 days. The goal is…

This study will develop and test a culturally adapted version of contingency management—a program that gives rewards for staying drug-free—for Black adults with stimulant use disorder. About 70 participants will provide urine samples twice weekly to measure abstinence. The goal i…

This study tests whether two existing medications, anakinra and tocilizumab, can improve outcomes for people with a rare brain condition called NORSE, which causes continuous seizures that don't respond to standard treatments. About 438 children and adults across 33 hospitals wil…

This study tests a computer tool that helps emergency room doctors follow best practices for treating opioid use disorder. The tool guides doctors to order addiction counseling and start buprenorphine medication when appropriate. About 300 ER patients with moderate to severe opio…

This study tests whether an AI tool called FibroX helps primary care providers better diagnose liver scarring (fibrosis) in people with a fatty liver condition called MASLD. About 40 doctors will review pretend patient cases, using either standard methods or the AI tool, and then…

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This study tests different methods to help people complete their colorectal cancer screening. Researchers will enroll 2000 adults from community health clinics who have an outstanding screening order. The goal is to see which approach works best to get people screened and reduce …

This study will test a chatbot designed to help Black men who have sex with men learn about and take PrEP, a daily pill that prevents HIV. About 145 participants in the Southern U.S. will use the chatbot and report their PrEP awareness and use over 90 days. The goal is to see if …

This study tests a counseling program called Healthy Families-PrEP that helps women in rural Uganda use HIV prevention medicine (PrEP) when trying to get pregnant, during pregnancy, and after giving birth. About 660 women who are HIV-negative but at risk will take part. The goal …

This study tests whether the drug adalimumab can prevent or slow brain changes linked to Parkinson's disease in 108 people with REM sleep behavior disorder (RBD), a condition that often leads to Parkinson's. Participants will receive either adalimumab or a placebo for 96 weeks, a…

This study tests a virtual reality program called E-Invite Only VR for 8th graders in 20 schools. The program teaches skills to handle emotions and resist e-cigarettes. Researchers will track whether students start vaping and measure their knowledge about e-cigarette risks. The g…

This study will adapt two proven prevention programs (SISTA/SIHLE) to help Black adolescent girls in Paterson, New Jersey avoid HIV/AIDS and substance abuse. Researchers will use focus groups with 10 girls aged 13-18 to understand their needs and then measure changes in drug use,…

This study looks at two programs designed to help Black men who have sex with men take PrEP regularly to prevent HIV. About 500 participants will receive either a care coordination program or that program plus extra behavioral support. Researchers will track adherence through blo…

This study tests a virtual program called LEARN 2 in 164 men aged 18+ living with HIV. The goal is to see if weekly online sessions and daily health tracking can improve quality of life and reduce risk factors for heart disease and metabolic problems. Participants are randomly as…

This early study will test whether nimodipine, a drug usually used for blood pressure, can reduce alcohol drinking and cravings in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then have the option to drink alcohol o…

This study looks at whether a single session of moderate exercise (like a brisk walk) can help adults with OCD feel less distressed and think more flexibly. Fifty adults with OCD will be randomly assigned to either moderate or light exercise. Researchers will measure changes in s…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can improve depression symptoms in people with Parkinson's disease. Researchers will give the therapy to 40 participants and measure changes in mood and safety. The goal is to see if this approach offe…

This study tests whether inulin, a natural dietary fiber, can reduce inflammation and knee pain in older adults with osteoarthritis. About 84 participants will take either inulin or a placebo daily for 8 weeks. Researchers will measure changes in blood markers of inflammation and…

This study tests whether adding peer support specialists to emergency department crisis response teams can reduce the use of physical and chemical restraints for agitated patients. About 58,000 adults with behavioral health concerns will take part across several hospitals. The go…

This study will follow 300 adults who are already scheduled to receive a temporary 60-day nerve stimulation treatment for their chronic headaches. The treatment uses a small device to stimulate nerves at the back of the head. Researchers want to see if it reduces headache impact …

This study tests whether a single dose of psilocybin can help people with chronic low back pain become more aware of their body, which may lead to better pain relief and improved results from physical therapy. About 45 adults aged 18-65 with long-lasting back pain will receive ps…

This study tests whether a mobile app called Tools for Coping with Cancer can help people with a history of cancer reduce distress and improve mood and quality of life. About 50 adults who have had cancer will use the app at home for 8 weeks and fill out questionnaires about thei…

This pilot study from Yale University will test whether a 4-week music-based intervention can reduce pain and stress in people with Irritable Bowel Syndrome (IBS). Thirty adults with moderate IBS pain will listen to music for 20 minutes twice daily, at least five days a week. The…

This study aims to improve a short motivational conversation for young adults (ages 18-25) who were injured in an assault and also misuse alcohol or cannabis. Researchers will interview and survey 50 participants from the emergency department to understand their confidence to cha…

This study checks if it's possible to run a larger trial of a breathing treatment called bubble CPAP for children with severe pneumonia in Pakistan. About 95 children will take part, and researchers will see if families and doctors find the treatment acceptable. The goal is to le…

This early-phase study at Yale will give 20 healthy adults who have never used psychedelics either very low doses of psilocybin or a placebo over 30 days. Researchers will measure changes in mood, thinking skills, and brain scans to see if microdosing can improve well-being witho…

This study is developing and testing a text-messaging program for caregivers of people with dementia after an emergency room visit. About 80 caregivers will receive text messages for 30 days to see if the program is easy to use and helpful. The goal is to learn if this approach c…

This study tests two different ultrasound machines to see which one helps less-experienced doctors place labor epidurals more accurately. About 200 women getting epidurals during childbirth will take part. The main goal is to see which device leads to fewer needle movements, maki…

This small study tests whether fMRI neurofeedback can help people with glioma shift language-related brain activity away from tumor areas before surgery. Four participants will complete multiple sessions to see if the approach is feasible, safe, and acceptable. The goal is to gat…

This study will test whether the Thrive AI Health app helps adults aged 40 and older who have type 2 diabetes or are overweight improve their daily habits like eating, exercise, and sleep. About 20 participants will either use the app or not, and researchers will compare changes …

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study is testing a digital pill system that tracks when someone takes their medication and provides personalized support to help them stay on track. The goal is to see if this approach is practical and acceptable for people with alcohol-related liver disease who are taking a…

This study tests a short digital program delivered via messaging apps like Telegram or WhatsApp to help people who use drugs in Kazakhstan overcome stigma and learn about PrEP, a medication that prevents HIV. About 40 participants will receive informational messages over 2-3 week…

This early-phase study tests a new imaging tracer called 18F-TPP to see how well it can map the electrical activity inside human cells using PET scans. Researchers will study 24 healthy volunteers to understand how the tracer moves through the body and how to create clear images …

This study looks at how men and women differ in their attraction to and addiction risk from menthol-flavored e-cigarettes, both with and without nicotine. Researchers will measure choices and effort to get the product in 60 adult smokers who already use e-cigarettes. The goal is …

This study will test whether a new smartphone app helps people recently released from prison manage their health information. Researchers will enroll 100 adults with at least one chronic condition who have been out of jail for less than a year. The goal is to see if the app is ea…

This study will test a new device called the Accuro 3S, which uses ultrasound to guide doctors when placing spinal or epidural needles. About 50 adults who are already scheduled for a neuraxial procedure (like for labor or surgery) will take part. The main goal is to see how accu…

This study will test whether an artificial intelligence chatbot can encourage more men who have sex with men in Kuala Lumpur, Malaysia to get tested for HIV. 80 participants will be randomly assigned to either receive automated, personalized messages from the chatbot or to receiv…

This study looks at whether making it easier for teens to have private, confidential talks with their doctor can increase HIV testing. Researchers will work with 4 pediatric clinics to see if this approach is practical and well-liked by staff. The goal is to learn how to make HIV…

This study tests a computer tool that helps doctors decide when to refer heart failure patients to palliative care, which focuses on comfort and quality of life. About 2,260 patients and their healthcare providers will take part. The goal is to see if the tool is easy to use and …

This study aims to improve how nicotine strength is shown on e-cigarette labels. Researchers will survey 2500 youth and adults in the US to see if new labels (nicotine concentration and flux) are easier to understand than current ones. The goal is to help people make more informe…

This study looks at what happens in the brain when two people interact face-to-face. Researchers will use brain scans and eye tracking to measure how brain activity and gaze patterns sync up during live conversations. The goal is to better understand the neural basis of social in…