Yale University

This study tests two existing medications, anakinra and tocilizumab, to see which works better for a rare brain condition called NORSE that causes continuous seizures and doesn't respond to standard treatments. About 438 children and adults across 33 hospitals will be randomly as…

This study tests whether sending tailored alerts to doctors can increase prescriptions of recommended medications for chronic kidney disease (CKD). About 1,000 adults with CKD will be included, and researchers will track if more patients receive guideline-directed therapy within …

This study tests a new virtual reality program called E-Invite Only VR for 8th graders. The program teaches students how to handle emotions and resist peer pressure to try e-cigarettes. About 1,250 students from schools in Connecticut and Massachusetts will play the VR game for a…

This study will develop and test a chatbot to help Black men who have sex with men in the Southern United States learn about and use PrEP, a medication that prevents HIV. About 145 participants will use the chatbot and report their awareness and use of PrEP over 90 days. The goal…

This study tests whether using RECELL® (a spray made from the patient's own skin cells) on the surgical site leads to better skin color matching than standard methods. Twenty adults having head and neck reconstructive surgery will be enrolled. Researchers will measure color match…

This study will follow 300 adults with hard-to-treat headaches who are already scheduled to receive a 60-day nerve stimulation treatment for their occipital nerves. Researchers want to see if the device reduces headache impact and how often people need emergency care. The goal is…

This study tests a mobile health program called SAMU to help screen and diagnose depression, anxiety, and alcohol use in 1,500 adults living with HIV and high blood pressure in Uganda. Participants use their phones to complete mental health check-ins, and the program connects the…

This early-phase study at Yale will give 20 healthy adults who have never used psychedelics either a very low (micro) dose of psilocybin or a placebo over 30 days. Researchers will measure changes in mood, memory, and brain scans to see if microdosing can improve well-being witho…

This study tests whether a personal health app is easy to use and helpful for people who were recently in prison and have a chronic health condition. About 100 participants will use the app and report how often they access it. The goal is to see if the app helps them manage their…

This study aims to see if a digital biomarker score can better predict how quickly aortic stenosis (a heart valve narrowing) gets worse in people aged 65 and older who have mild valve disease. Researchers will track changes in heart function over time using data from 210 particip…