Yale University

This early-stage study tests whether a drug called apremilast can help people with Alcohol Use Disorder drink less alcohol. Ten adults will take the medicine and then have their drinking measured in a lab setting. The goal is to see if the drug reduces alcohol consumption, especi…

This study looks at ways to help people of color living in areas with high opioid overdose rates start and continue medication-assisted treatment (MAT). About 525 adults who are currently using opioids or alcohol and want to cut down will take part. Researchers will track how man…

This study tests whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Thirty participants who have HIV, smoke, and drink heavily will receive the medication along with counseling. The goal is to see if this approach is practic…

This study compares behavioral therapy and a combination medication (naltrexone/bupropion) to help people who experience loss-of-control eating after bariatric surgery. About 160 adults who had gastric bypass or sleeve gastrectomy about six months ago will receive one of the trea…

This study tests whether taking an oral GnRH antagonist before IVF can improve the chance of a live birth for women with endometriosis. About 97 women will either receive the drug or no pre-treatment before their IVF cycle. The goal is to see if this approach leads to more succes…

This study tests a two-step treatment for people with pancreatic cancer that hasn't spread but can't be removed by surgery. First, patients receive a stronger chemotherapy cocktail (modified FOLFIRINOX), followed by precise, high-dose radiation (SBRT). The goal is to see if this …

This study looks at whether surgically removing the prostate, along with hormone therapy and possibly chemotherapy, can help men whose prostate cancer has already spread. About 190 men with newly diagnosed stage IV prostate cancer will be randomly assigned to get either standard …

This early-phase study tests a combination of two immunotherapy drugs (domvanalimab and zimberelimab) in people whose glioblastoma has come back after initial treatment. The goal is to check if the drugs are safe and to see how they affect the tumor and immune system. About 46 pa…

This study tests whether a combination medication (naltrexone/bupropion) can help people who had weight-loss surgery avoid a return of binge eating and weight gain. About 100 adults who responded well to an earlier treatment will receive either the medication or a placebo for mai…

This study looks at three types of weight loss surgery—gastric band, sleeve gastrectomy, and gastric bypass—in severely obese teenagers aged 14 to 19. It tracks changes in weight, blood sugar, and nutrition over time to find out which surgery is safest and most effective. The goa…

This study tests two telemedicine programs for adults with chronic pain and opioid use disorder. One program uses standard collaborative care, while the other adds a self-management tool. The goal is to see which approach better reduces pain interference and opioid misuse. About …

This study aimed to see if adding etrasimod to standard steroid treatment could reduce the need for steroids in people with moderate to severe diarrhea and colon inflammation caused by immune checkpoint inhibitors (cancer immunotherapies). The trial was planned for adults with ad…

This study tests a community program to improve asthma care for 50 children in New Haven. It pairs an online decision-support tool for doctors with home visits from Promotora health workers who provide culturally tailored asthma education and connect families to legal and medical…

This study looks at whether adding behavioral therapy, medication, or both can help people lose more weight after bariatric surgery. About 84 adults who had gastric bypass or sleeve gastrectomy but didn't lose enough weight will take part. The goal is to find better ways to manag…

This study tests whether starting alcohol use disorder treatment while still in the hospital helps patients stay engaged in care and drink less after they go home. 450 hospitalized adults with moderate to severe alcohol problems will receive either a brief counseling session alon…

This study tests whether combining two approved multiple myeloma drugs, belantamab mafodotin and elotuzumab, is safe and works better together. It includes 24 adults whose myeloma has returned or not responded after at least three prior treatments. The goal is to find the best do…

This early-stage study tested whether briefly raising blood pressure in stroke patients undergoing a clot-removal procedure could slow brain damage. It involved 40 adults with large-vessel blockage strokes treated within 24 hours. The main goals were to see if the blood pressure …

This study tests whether a medication not originally approved for alcohol use disorder can help people with HIV reduce their drinking. Researchers will enroll 30 adults with HIV and alcohol use disorder to see if the treatment is practical, safe, and acceptable. The approach comb…

This study tests a pharmacist-led program that uses telehealth to help women with HIV who also face challenges like housing or food insecurity. The program supports them in switching from daily pills to a long-acting injectable treatment (shots every two months). The goal is to s…

This study tests a drug called sacituzumab govitecan in 20 people with ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to platinum-based chemotherapy. The drug works like a guided missile, delivering chemotherapy directly to cancer cells. The mai…

This early-phase study tested a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The goal was to see if the drug reduces abnormal electrical activity linked to seizures. Participants took the drug for 4 weeks, and thei…

This study tests whether a low-caffeine green tea extract (EGCG) can shrink uterine fibroids and improve pregnancy and live birth rates in women aged 18-40 with infertility. About 33 participants will take the extract and be monitored for conception, miscarriage, and fibroid chan…

This study tests a drug called sacituzumab govitecan in 50 people with endometrial cancer that has returned or not responded to platinum chemotherapy. The drug works by delivering chemotherapy directly to cancer cells. The main goal is to see how many patients' tumors shrink or d…

This study looks at whether adding spironolactone to standard blood pressure treatment works better than standard treatment alone for people who have had a stroke. About 160 adults who survived a stroke will take part. The main goal is to see if home blood pressure readings are l…

This study tests whether a weekly injection of semaglutide can help preserve the pancreas's ability to make insulin and reduce fat buildup in the liver. It involves 60 obese teenagers with prediabetes or early type 2 diabetes who also have fatty liver disease. Participants receiv…

This study tests a new way to help people with heart failure in Uganda manage their condition. It combines a standard care package with a mobile app that tracks symptoms and gives advice. About 576 adults with moderate heart failure will take part across six hospitals. The goal i…

This study tests whether artificial intelligence (AI) can spot a serious heart valve condition called aortic stenosis using portable, non-invasive devices. Researchers will enroll 410 adults aged 70 and older during routine primary care visits. The goal is to see if AI-powered an…

This study aimed to see if a computer program could correctly identify patients with a rare condition called ATTR amyloidosis from medical records. The plan was to test the program's accuracy by comparing it to actual diagnoses. However, the study was withdrawn before any partici…

This study tests a 24-week program that uses rewards and support services to help people with opioid use disorder who inject drugs stay on PrEP, a daily pill that prevents HIV. About 526 participants will be followed for a year to see if the program improves medication adherence …

This study is testing a new augmented reality video game called 'No Time Wasted' to help teens aged 16-18 learn about alcohol risks and reduce dangerous drinking. About 20 high school students will play the game and answer surveys to see if it improves their knowledge and encoura…

This study tests a new virtual reality program for 8th graders to prevent e-cigarette use and teach emotion regulation skills. Researchers will work with about 40 students and school staff to see if the VR game is acceptable, usable, and practical in real classrooms. The goal is …

This pilot study tested whether propranolol, a beta-blocker, reduces alcohol drinking in stressed adults with alcohol use disorder. Twenty participants took either propranolol or a placebo for two weeks, then completed two lab sessions where they were exposed to stress or relaxat…

This study tests a new approach called ED-TREAT that helps emergency room staff spot and treat agitation early. About 26 adults at risk of agitation will take part to see if the tool is easy to use and works well. The goal is to improve patient care and reduce the need for physic…

This early study tests whether brexanolone is safe and feasible for people who have both PTSD and alcohol use disorder. Researchers want to see if the drug can reduce stress-induced drinking. The study involves 25 adults aged 21-55 who drink heavily. It is a small, first-step tri…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can change brain connections to improve depression. 18 adults with major depression who didn't get better with standard treatments will receive psilocybin in a controlled setting. Researche…

This study aimed to see if Botulinum Toxin-A (Botox) could help people with hidradenitis suppurativa, a painful skin condition. It planned to enroll adults with active armpit lesions of similar severity on both sides. However, the study was withdrawn before any participants were …

This study looks at whether joining community drum circles and mindfulness programs can help reduce anxiety and depression in Black and other marginalized groups who faced extra stress during COVID-19. About 90 people aged 16 and older will take part. Researchers will measure how…

This study tests whether a wearable device called UpRight Go can reduce pain, numbness, and weakness in people with cubital tunnel syndrome who haven't had surgery. About 40 adults will use the posture trainer and report their symptoms. The goal is to see if improving posture can…

This study aimed to see if using virtual reality (VR) before transcranial magnetic stimulation (TMS) could help people with obsessive-compulsive disorder (OCD). It planned to enroll adults already approved for TMS treatment. However, the study was withdrawn before any participant…

This study tests a smartphone-based program called LDART that uses social support to help adults with alcohol use disorder drink less. Researchers will enroll 80 people in Connecticut to see if the program is easy to use and helps reduce heavy drinking days. The goal is to gather…

This small pilot study tests a modified cognitive-behavioral therapy (CBT) for children with autism and intellectual disability who have disruptive behaviors like irritability and aggression. Up to 6 children will receive CBT sessions, and researchers will measure changes in beha…

This study tests whether the medication lisdexamfetamine can help people who struggle with loss-of-control eating after bariatric surgery and did not improve with earlier treatments. About 60 adults who had gastric bypass or sleeve gastrectomy will receive either the drug or a pl…

This early-stage study tests whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). About 28 adults with severe OCD who haven't improved with standard treatments will receive psilocybin or be pla…

This study tests a digital mindfulness app called Calm Health in 26 adults with chronic kidney disease. Participants use the app for 6 weeks while wearing a wrist sensor to track sleep, activity, and heart rate. The goal is to see if the app is easy to use and if it helps reduce …

This study planned to test whether a small electrical device (TENS) could reduce pain when placing an IUD. It was designed for adults getting a new or replacement IUD. The study was withdrawn before enrolling anyone, so no results are available.

This study is testing a digital program called LDART to see if it helps adults who use stimulants like cocaine or methamphetamine. Researchers want to know if people find it easy to use and if it helps reduce how often they use these drugs. The study involves 80 participants in C…

This study looks at whether applying a silicone ointment to the skin before head and neck surgery can improve how scars heal. Researchers will compare scar appearance and symptoms like pain and itching in 60 adults who use the ointment versus those who don't. The goal is to find …

This study looks at whether a virtual, community-based program combining music and mindfulness can help people of African descent manage stress, anxiety, and depression during COVID-19. About 300 participants aged 16 and older will take part. The goal is to see if these culturall…

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study looks at whether a family-centered approach helps caregivers affected by intimate partner violence (IPV) engage more with support services compared to a child-centered approach. About 95 caregivers with children under 5 who were reported to child protective services fo…

This study looks at whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard care can help people with acute heart failure and kidney injury recover faster. It involves 30 adults aged 18-85 with heart failure and high NT-proBNP levels. The main goal is to see i…

This study looks at 500 women with suspected heart problems to compare two common tests used during heart catheterization: FFR and iFR. The goal is to see which test better predicts future heart attacks, strokes, or the need for another procedure over 5 years. Participants will h…

This study looks at whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help adult education students manage behavioral health challenges like depression, anxiety, and substance use. About 340 students and staff from New Haven Adult Educa…

This study aims to find the genes that cause aortic aneurysms (bulges in the main artery) and heart valve problems. Researchers will collect blood and tissue samples from 3000 people with these conditions and their family members. The goal is to better understand why these diseas…

This study looks at whether giving doctors feedback about their prescribing habits can reduce the number of potentially harmful medications given to older adults when they leave the emergency department. About 200 clinicians from Yale New Haven Health System are taking part. The …

This study looks at whether a virtual, community-based music and mindfulness program can help People of African Descent (PADs) manage stress, anxiety, and depression during COVID-19. Researchers will measure feelings of connection and synchrony when participants listen to drum ci…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking in a safe, simulated setting. About 40 occasional users aged 21 to 55 will take part. The goal is to better understand the risks of driving under the influence.

This study aimed to see if a structured reflective writing program could reduce burnout in physician assistant students at Yale. It was designed to track changes in burnout scores over time using a questionnaire. However, the study was withdrawn before enrolling any participants,…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking in a safe, simulated setting. About 40 adults aged 21–55 who have used both substances before will take part. Researchers measure things like steering accuracy and self-reported f…

This study aimed to see if a simple blood test could find blockages in the tiny blood vessels of the heart in people who had a heart transplant. Researchers planned to take blood samples every three months for a year and check medical records for three years. However, the study w…

This study looks at how alcohol and cannabis, alone or together, affect simulated driving and thinking. About 40 occasional users aged 21–55 will take part. The goal is to understand the risks, not to treat any condition.

This study looks at how alcohol and cannabis (THC) affect driving ability and thinking in a driving simulator. About 40 adults aged 21–55 who have used both substances before will take part. The goal is to understand the risks of driving under the influence.

This study looks at how a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) changes brain activity and social thinking in adults with autism. About 100 participants, both with and without autism, will have their brain waves and ey…

This study aimed to see how MDMA changes brain activity in people with PTSD, especially in areas that handle emotions. Researchers planned to give MDMA to a small group and measure brain scans and PTSD symptoms. However, the study was withdrawn before any participants were enroll…

This study looks at how cannabinoids (compounds found in cannabis) affect short-term and long-term memory in adults aged 18 to 55 who have used cannabis at least once. Researchers will measure memory using word recall and attention tasks. No treatment is given—this is purely an o…

This study looks at how cannabis (specifically the drug Dronabinol) changes the immune system and genes in people with HIV. Researchers will take blood samples before and after giving Dronabinol to 160 participants. The goal is to understand these changes better, which could help…

This study looks at what might happen if menthol cigarettes are banned. Researchers want to see if offering menthol or tobacco-flavored e-cigarettes helps adults who smoke menthol cigarettes smoke less or switch completely. About 150 current menthol smokers will take part over 8 …

This study gathers information from 8,000 stroke patients worldwide to learn more about seizures that happen after a stroke. Researchers will analyze the data to see how well patients recover and to create a tool that can predict who might develop epilepsy. The goal is to improve…

This study looks at how a newer, more sensitive type of PET scan (PSMA PET) affects the anxiety, decision-making, and quality of life of 350 men with prostate cancer. Participants will complete surveys about their feelings and experiences over a year. The goal is to understand th…

This study looks at brain changes in people with major depression or PTSD using special PET scans. Researchers want to see if a single dose of ketamine can reverse the loss of brain connections (synapses) linked to these conditions. The study involves 130 adults who will have MRI…

This study looks back at the medical records of 150 children with biliary atresia, a rare liver disease, treated between 2012 and 2021. Researchers want to find out which treatments and factors lead to better survival and fewer liver transplants. The goal is to use this informati…

This study involves 500 people who have chest pain or other signs of heart trouble, but whose main heart arteries are not blocked. Researchers use special tools during a heart catheterization to measure tiny blood vessel function and look for hidden causes like microvascular dise…

This study follows 458 people with critical limb ischemia, a severe form of peripheral artery disease that can lead to amputation. Researchers are collecting data on symptoms, treatments, and outcomes to set new standards for diagnosis and care. The goal is to better understand w…

This study looks at how live music changes brain activity, heart rate, and anxiety in people with early Alzheimer's or mild memory problems, and their caregivers. Researchers will measure brain waves and heart signals while participants listen to live or recorded music. The goal …

This study looks at whether using synthetic cannabinoids lowers the number of CB1 receptors in the brain. Researchers will use brain scans and thinking tests in 15 current users. The goal is to better understand how these drugs affect the brain, not to test a treatment.

This study tests a digital score to monitor aortic stenosis, a heart valve condition, in 210 adults aged 65 and older with early signs of the disease. Researchers will track changes in heart function over time using data from routine tests. The goal is to improve risk prediction,…