Yale University

This study tested whether adding reminders to electronic health records helps doctors follow guidelines for managing overweight and obesity in children. Over 58,000 children and their doctors took part across multiple primary care practices. The goal was to improve care and help …

This study tested a telehealth platform designed to help people with opioid use disorder start medication treatment and reduce overdose events. 33 adults with a history of opioid overdose and moderate to severe opioid use disorder participated. The platform aimed to connect them …

This early-phase study tested a new drug (APX005M) added to two existing immunotherapy drugs (nivolumab and ipilimumab) in 26 people with advanced melanoma or kidney cancer who had not received prior immunotherapy. The main goals were to check safety and find the best dose. The s…

This study tested two different ways to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which approach worked better for starting and staying on treatment o…

This study looked at whether a community health worker (a kind of health coach) could help people with type 2 diabetes and low income use a program that gives them free money to buy fruits and vegetables. 104 Hispanic adults in Connecticut took part. The goal was to see if the he…

This study tested a web-based program that combines cognitive behavioral therapy with pain self-management for 160 adults who have both opioid use disorder and chronic pain. Participants were already taking methadone or buprenorphine. The program taught coping skills and used dai…

This study tested whether the drug Taltz can slow scar tissue growth in the throat, potentially reducing the need for repeat surgeries in people with idiopathic subglottic stenosis. Ten participants received the drug, and researchers measured how long they could go between surger…

This study tested a combination of two targeted drugs, afatinib and cetuximab, in 50 adults with advanced head and neck cancer that had already been treated with chemotherapy or immunotherapy. The goal was to see if the drug pair could shrink tumors. While the treatment aims to c…

This study tested a combination of chemotherapy drugs given both before and after surgery for people with early-stage pancreatic cancer. The goal was to shrink the tumor before surgery and kill any remaining cancer cells afterward. 46 participants were enrolled to see if this app…

This study tested a program called Bright Bodies for children ages 7 to 13 with obesity and their parents. The goal was to help kids lower their body mass index (BMI) through healthy eating, physical activity, and family support. The program was offered in three different communi…

This study looked at whether a special primary care program (Transitions Clinic Network) helps people recently released from jail stay in treatment for opioid addiction. About 400 participants were randomly assigned to either standard primary care or the special program. Research…

This study looked at whether the medication lisdexamfetamine (LDX) can help adults with binge-eating disorder and obesity avoid relapsing. About 61 people who first responded to treatment were randomly assigned to continue LDX or switch to a placebo. The goal was to see if LDX ke…

This study tested a program that gave low-income pregnant Latina women money each month to buy fruits and vegetables, along with nutrition education and text reminders. Over 10 months, the goal was to see if women bought and ate more produce and felt less food insecurity. The pro…

This study tested a virtual reality video game called Invite Only VR to help prevent e-cigarette and cannabis vaping in middle school students. 62 students in 6th to 8th grade from three Connecticut schools played the game and reported on their experience. Researchers measured wh…

This study compared a new pain education and self-management program (COPES) to standard cognitive behavioral therapy for chronic pain in 764 veterans. The goal was to see if COPES could better reduce how much pain interferes with daily life. Participants had chronic musculoskele…

This study tested a mobile app designed to help middle-aged adults with type 1 diabetes exercise more safely and confidently. The app uses data from blood sugar monitors, activity, mood, and sleep to give personalized tips and encouragement. 24 people took part to see if the app …

This study tested two online treatments for teenagers who have bulimia nervosa (binge eating and purging) and are overweight. The goal was to see if these therapies are practical and helpful for reducing binge eating and purging. Twenty-five teens participated, and the study meas…

This study tested a digital neurotherapy (a brain training program) in 36 adults who were either cancer survivors or on dialysis for kidney failure. The goal was to see if it could help with depression, thinking skills, and quality of life. Participants used the program and compl…

This study tested a new behavior therapy for teens with autism who struggle with irritability and aggression. The therapy teaches emotion regulation and coping skills for the challenges of growing up. 65 adolescents participated, and researchers measured changes in aggressive beh…

This study tested an online version of a proven psychological treatment for children with serious behavior problems like aggression and defiance. 86 children and their parents in Connecticut took part. The goal was to see if online therapy could help families who can't get in-per…

This study tested different ways to help people living with HIV quit smoking. It used stop-smoking medications and paid participants for staying smoke-free. The goal was to see if these methods could reduce the number of cigarettes smoked per day. 323 adults with HIV who smoked a…

This study tested a therapy called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-directed strategies to regularize sleep and daily routines, aiming to reduce suicide risk. Re…

This study looked at whether cannabidiol (CBD) can safely help people who are being treated for opioid addiction and also have chronic pain. Seven adults on methadone or buprenorphine received different doses of CBD or a placebo in a controlled setting. Researchers measured safet…

This study looked at whether a combination of two medications, naltrexone and bupropion, can help reduce binge-eating episodes in people with obesity. Researchers compared the medication to a placebo in adults aged 18 to 64 who have binge-eating disorder and a BMI of 30 or higher…

This study tested a new way to help people with temporal lobe epilepsy who still have seizures despite medications or other treatments. Instead of trying to stop the seizures, researchers used electrical stimulation in the thalamus (a deep brain area) to try to keep people consci…

This study tested a brief, self-guided online program designed to increase hope in women currently experiencing intimate partner violence. Researchers enrolled 97 women and measured whether the program was easy to use, safe, and actually boosted feelings of hope, self-worth, and …

This study looked at whether quitting cigarettes and e-cigarettes at the same time or quitting cigarettes first then e-cigarettes works better. Nineteen adults who used both products daily took part. All received a medication called varenicline, counseling, and support tools to h…

This study tested a GLP-1 drug (similar to popular weight-loss medications) in 96 adults with obesity but no diabetes. Participants received either the drug or a placebo. Researchers measured changes in food cravings, hunger, stress, and actual food intake. The goal was to see if…

This study tested whether combining two medications, varenicline and guanfacine, helps people quit smoking. 167 adult smokers took part in a 12-week treatment program. Researchers measured how long participants could delay their first cigarette and how stress affected their smoki…

This study tested whether repeated doses of ketamine, given through an IV, can safely and effectively reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers compared ketamine to a placebo and used brain scans to expl…

This study tested two bowel-cleansing drinks in 520 hospitalized adults needing a colonoscopy. One drink (MoviPrep) uses a smaller volume than the standard (GoLYTELY). The goal was to see if the lower-volume option works just as well and is easier to tolerate. Results could help …

This small pilot study tested an online guided self-help program for teenagers aged 12 to 17 who struggle with binge eating and are above a healthy weight. The program used cognitive behavioral therapy (CBT) techniques over four months. The main goals were to see if teens would a…

This study tested whether giving a single 5 mg dose of olanzapine before outpatient surgery improves how patients feel the day after. 384 women aged 18-50 took either the drug or a placebo. The goal was to see if it helps with nausea, pain, and overall recovery quality.

This study tested whether a web-based social support program is practical and helpful for people who drink heavily and want to cut down. Thirty adults in Connecticut used the online tool for 28 days. The goal was to see if people would use it and find it supportive, not to measur…

This study tested a phone-based counseling program for veterans with chronic pain who were at risk for substance misuse. Over 1,100 veterans took part. The program aimed to reduce pain and risky substance use by helping them get better pain treatment.

This study tested a new device called Miraπ that physically moves a stroke patient's affected hand during mirror therapy. It compared this device to standard mirror therapy in 24 stroke patients with one-sided hand paralysis and pain. The goal was to see if the device could impro…

This study looked at whether women recovering from a midurethral sling procedure for stress urinary incontinence need to restrict heavy lifting for 3 weeks or 6 weeks. Researchers compared symptom distress and patient satisfaction between the two groups. The goal is to find the b…

This study tested whether a numbing injection (nerve block) given before thyroid surgery helps people feel better the day after. 160 adults having thyroid surgery were randomly assigned to get either the numbing medicine or a saltwater placebo. They filled out surveys about their…

This study tested a portable device that gently moves the hand to reduce muscle tightness (spasticity). Ten adults with hand paralysis or motor problems used the device for one 20-minute session. Researchers measured changes in muscle tone and asked participants about the device'…

This study aimed to create a large collection of medical information and blood samples from 311 people with myasthenia gravis. Researchers hope this resource will help them learn more about the disease. Participants were adults recently diagnosed with myasthenia gravis. The study…

This study looked at how giving extra chloride (without sodium) affects fluid balance in people with stable heart failure. Twenty participants were closely monitored over a week. The goal was to learn more about how chloride impacts the body's handling of fluids and salt, which c…

This study looked at whether a substance called endotoxin, which comes from certain bacteria, can increase alcohol consumption in people with alcohol use disorder. Researchers gave 27 adults either endotoxin or a placebo and measured how much alcohol they drank during a 120-minut…

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid use disorder. Researchers looked at whether the tool increased the use of standard assessments and buprenorphine treatment. The study involved 267 adults with moder…

This study tested a program where a patient navigator helped people with diabetes who had not had an eye exam in the past year schedule one. The goal was to see if this approach was practical and acceptable, so it could be tested in a larger trial. 35 adults at high risk for diab…

This study aims to confirm that certain brain and eye measurements can serve as reliable biomarkers for autism. Researchers will compare 200 children with autism and 200 typically developing children, ages 6 to 11. The goal is to provide better tools for future clinical trials, n…

This study tested whether a virtual reality program (DeepDream) can produce experiences similar to psychedelic drugs. Ten healthy volunteers took part at Yale University. Researchers measured changes in consciousness, mystical feelings, and sense of self. The goal was to see if V…

This study looked at 30 people who recently had a stroke caused by narrowing of arteries in the brain. Researchers used two types of MRI contrast agents to see if inflammation in the artery walls could be detected. The goal was to better understand why some strokes come back even…

This study tested whether combining MRI and ultrasound imaging during prostate biopsy with single-cell analysis can better predict how prostate cancer will progress. Researchers collected samples from 600 men scheduled for biopsy and tried to grow cancer cells in the lab to study…

This early-phase study at Yale University looked at how cannabidiol (CBD) affects brain inflammation and pain sensitivity in 28 healthy adults. Participants received either CBD or a placebo before undergoing brain scans and a capsaicin pain test. The goal was to understand how CB…

This study looked at how short-term stress changes the way we learn and remember. Researchers used brain scans (fMRI) to watch brain activity in 106 healthy adults while they performed learning tasks. The goal was to understand the brain mechanisms behind stress effects, not to t…

This study tested a digital program called Be There Certificate among 102 college students living in dorms. The goal was to see if students would use the program and if it improved their mental health knowledge and ability to support peers. Researchers measured completion rates, …

This study looked at how the amount of nicotine and how fast it enters the body affects a person's desire to smoke and the pleasurable feelings from nicotine. Twenty daily smokers received nicotine through an IV to mimic smoking. The goal was to understand nicotine's effects, not…

This study used special brain scans (PET imaging) to compare the brains of 40 people: experienced meditators with at least 10 years of practice and non-meditators. The goal was to see if meditation is linked to differences in brain synapses, which are the connections between brai…

This study tested whether using a special computer model to send kidney injury alerts only to patients who would benefit most could reduce worsening kidney damage, need for dialysis, or death. Over 2,000 hospitalized adults with acute kidney injury took part. The goal was to see …

This study tested whether instant computer feedback helps community health workers in Nigerian clinics improve patient care. Researchers compared treatment plans written before and after the computer gave advice, with a doctor reviewing the plans. The goal was to see if the tool …

This study looked at whether telling older women about overdiagnosis (finding cancers that would never cause harm) changes their desire to get mammograms. Over 300 women aged 70 and older watched a video explaining overdiagnosis and answered surveys about their screening intentio…

This study looked at how to best prevent tuberculosis (TB) in Malaysian prisons. Researchers compared a standard 40-week daily TB prevention treatment to a shorter 12-week weekly treatment in 316 inmates, some with HIV or opioid dependence. The goal was to see which approach work…

This study looked at whether a treatment that focuses on parents can change brain activity in children with anxiety disorders. Researchers measured anxiety levels and brain responses in 214 children before and after 12 weeks of parent-based therapy. The goal was to see if changes…

This study tested a computer tool that helps emergency doctors start buprenorphine treatment for people with opioid use disorder. The tool guides doctors through diagnosis, withdrawal assessment, and treatment steps. Over 1,100 patients took part, and the study measured how often…

This study looked at how smoking marijuana affects thinking and driving skills in 41 adults aged 18-55 who use cannabis regularly. Researchers tested memory, coordination, and simulated driving at different times after use. The goal was to see if a simple field test could reliabl…

This study tested a new way to find people exposed to tuberculosis (TB) in Cali, Colombia. Researchers used a mobile phone chatbot and a simple oral (mouth) sample test to make contact tracing easier and more accessible at home. The goal was to see if this approach was practical …

This study looked at how men and women differ in their sensory experience and appeal of sweet and cooling e-cigarette flavors. 66 adult smokers who also used e-cigarettes took part. Researchers measured how much participants liked each flavor and how much they valued it compared …

This study tested an experimental drug called CVL-562 in 112 people with early schizophrenia to see how it affects brain activity during memory tasks. Participants had five brain scans (fMRI) while doing a spatial memory exercise. The goal was to find brain markers that could hel…

This study looked at whether doctors trust and find useful an artificial intelligence (AI) tool that predicts the risk of serious stomach bleeding. 108 medical residents used the tool in simulated emergency scenarios. The goal was to see if adding a chat-like AI interface made th…

This study looked at how flavors in e-cigarettes affect how much adult smokers like and want them. It included 130 smokers aged 21-50 who used only e-cigarettes for two weeks. The goal was to measure their reactions, not to treat or cure any condition.

This study tested a special imaging method (SPECT/CT) to see how well blood flows to leg muscles in people with peripheral artery disease (PAD) and diabetes. Researchers compared these images to those from healthy volunteers and also looked at changes after artery-opening treatme…

This study looked at 165 emergency room patients with high blood pressure to see how many had undiagnosed left ventricular hypertrophy (a thickening of the heart muscle). Researchers used a portable ultrasound to detect the condition and then measured how often patients followed …

This study worked with healthcare workers, ministry officials, and community members to understand what helps or hinders breast cancer screening using clinical breast exams in primary health centers in Abuja, Nigeria. The goal was to create practical strategies to make screening …

This study tested a new, portable low-field MRI to measure white matter hyperintensities (WMH)—tiny brain changes linked to aging and vascular risk. Researchers enrolled 100 adults with at least one risk factor like high blood pressure or diabetes. They developed a simple grading…

This study looked at how the heart failure medication Entresto (LCZ696) lowers blood pressure and affects sodium excretion. 46 stable heart failure patients participated in a crossover trial where they received either a placebo or a drug called aprepitant alongside Entresto. The …

This study looked at how vitamin D (calcitriol) affects dopamine receptors in the brains of people with opioid use disorder. Five participants completed brain scans to measure dopamine activity. The goal was to understand if vitamin D could help with treatment, but this was an ea…

This study looked at whether a blood test called DiviTum-TKa can help doctors check if patients with metastatic breast cancer are taking their CDK4/6 inhibitor medication correctly and if other drugs are interfering. The test measures a marker of cell growth to see if the treatme…

This study looked at how two cooling ingredients, WS-3 and menthol, affect the sensation of e-cigarettes. 31 adults who use e-cigarettes rated the coolness, flavor, sweetness, and harshness of different e-cigarette mixes. The goal was to find the right levels of these ingredients…

This study explored how a very low carbohydrate diet impacts blood sugar levels and brain function in 19 adolescents with type 1 diabetes. Researchers measured time spent in the optimal glucose range and episodes of low blood sugar over two weeks. The goal is to understand the sa…

This study looked at how a single dose of THC (the active ingredient in cannabis) changes immune-related genes and proteins in the blood. Researchers compared 56 adults with and without HIV to see if the effects differ. The goal was to understand THC's impact on the immune system…

This study looked at how gut bacteria might influence fat metabolism in young people aged 15 to 21. Researchers gave a special sugar drink to 38 healthy and obese participants to measure changes in fat production in the liver. The goal was to understand the role of gut bacteria i…

This study looked at how the brain changes in people who use cannabis heavily after they stop. Researchers used brain scans and EEG to measure brain activity and thinking skills at the start, after 48 hours, and after four weeks of not using cannabis. The goal was to understand h…

This study looked at whether letting children start preschool at age 3 (instead of age 4) helps them learn better and also helps their mothers find work and earn more money. Over 2,000 children and their families in rural Kenya took part. The goal is to see if this change is good…

This study worked with healthcare workers and community members in Soweto, South Africa, to find the best ways to offer breast cancer screening using simple physical exams in local clinics. Researchers observed clinic workflows and held group discussions with 80 participants to u…

This study looked at how people with autoimmune diseases like multiple sclerosis or blistering skin conditions respond to COVID-19 vaccines while on B-cell depleting therapies. Researchers measured antibody levels and T-cell activity over time to understand vaccine effectiveness …

This study tested whether a portable MRI machine can start scans faster than a standard MRI in the emergency department. 100 adults who needed a brain MRI were randomly assigned to get either a portable MRI plus usual care or usual care alone. Researchers measured the time from w…

This study tested whether a Suicide Prevention Package (SuPP) could be added to an existing depression program in rural Pakistan. Fifty women with young children or who were pregnant took part. The goal was to see if the program was practical and well-received, not to prove it wo…

This study looked at how the strength and form of nicotine in e-cigarettes affect how fast and how much nicotine gets into the blood. Thirty-six adults who vape regularly took puffs from different e-cigarette setups while their blood was sampled through a small tube in their arm.…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…