Ulcerative colitis

This study tests whether combining risankizumab with either trosunilimab or ABBV-701 can safely reduce inflammation and improve symptoms in adults with moderately to severely active Crohn's disease or ulcerative colitis. Participants are randomly assigned to one of the combinatio…

This study tests whether combining two drugs—vedolizumab and tofacitinib—can quickly bring moderate to severe ulcerative colitis under control. About 65 adults will receive both drugs for 8 weeks, and those who respond will continue on vedolizumab alone for nearly a year. The goa…

This study tests an experimental drug called ATH-063 in 120 adults with moderate to severe ulcerative colitis who have not responded to or can no longer use biologic therapies. Participants will receive either the drug or a placebo for 12 weeks to see if it can reduce symptoms an…

This study tests whether MK-8690, a drug given as a shot, can help people with moderate-to-severe ulcerative colitis achieve remission. About 100 adults who haven't responded well to other treatments will receive either MK-8690 or a placebo. The main goal is to see if more people…

This phase 3 study tests the drug risankizumab in about 120 children aged 2 to 18 with moderate to severe ulcerative colitis. The trial has three parts: an initial 12-week IV treatment period, a 52-week maintenance phase where patients get one of two doses by injection, and a lon…

This trial is testing whether adding a Lactobacillus probiotic or a trace element supplement to standard ulcerative colitis treatment can help keep the disease in remission. About 132 adults with mild to moderate ulcerative colitis will be randomly assigned to one of three groups…

This study tests a new antibody drug called XmAb942 for moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. First, healthy volunteers will receive the drug to check safety. Then, about 270 people with ulcerative colitis will get either XmAb942 or a placeb…

Researchers are testing fecal microbiota transplantation (FMT) for ulcerative colitis, a chronic inflammatory bowel disease. They will compare stool from healthy Han donors with stool from healthy Dai donors, a Yunnan ethnic group with distinct diets, to see if donor background a…

This study tests an investigational drug called duvakitug in people with moderate-to-severe ulcerative colitis who have already responded to treatment. The goal is to see if duvakitug can help maintain remission better than a placebo over 40 weeks, with an optional long-term exte…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study is testing the drug vedolizumab (Entyvio) in 400 adults with moderate to severe ulcerative colitis or Crohn's disease. Participants first receive the drug through an IV for 6 weeks, then switch to injections under the skin for the rest of the year. The main goal is to …

This study tests whether a supplement called palmitoylethanolamide (PEA) can help people with mild-to-moderate ulcerative colitis. Researchers will measure changes in disease activity, quality of life, and inflammation markers in 60 participants. The goal is to see if adding PEA …

This study will test whether a diet rich in protein and fiber can reduce harmful gas-producing bacteria in the gut of people with ulcerative colitis. Forty adults with mild to moderate disease will eat specially prepared frozen meals for two separate week-long periods. Researcher…

This study looks at the long-term safety of a medicine called tulisokibart for people with moderate to severe Crohn's disease or ulcerative colitis. It is an extension study, meaning participants must have already taken tulisokibart in a previous study. The main goal is to see ho…

This early-stage trial evaluates an investigational oral drug called ONO-6414 in healthy adults and in people with active ulcerative colitis. The main goals are to assess the drug's safety, tolerability, and how the body processes it. The study includes single and multiple doses,…

This study tests a new medicine called MH002, which contains live bacteria meant to restore gut health in people with mild-to-moderate ulcerative colitis. About 204 adults whose current treatment isn't working well enough will receive either a low dose, high dose, or placebo caps…

This study tests an oral drug called LY4268989 (MORF-057) in adults with moderate-to-severe ulcerative colitis. About 1,431 participants will receive either the drug or a placebo for up to 108 weeks. The goal is to see if the drug can safely help control the disease and improve s…

This study tests a new medicine called afimkibart in children aged 2 to 17 with moderate to severe ulcerative colitis, a disease that causes inflammation and sores in the colon. The goal is to see if the drug can safely help children feel better and achieve remission (no symptoms…

This phase 2 study is testing two new drugs — mirikizumab (given by IV or injection) and LY4395089 (a pill) — in 60 adults with moderately to severely active ulcerative colitis or Crohn's disease. The goal is to see if these treatments are safe and can help control the disease. T…

This study tests whether adding a new oral drug, LY4268989, to the existing treatment mirikizumab works better than mirikizumab alone for adults with moderate-to-severe ulcerative colitis. About 252 participants will receive either the combination or mirikizumab plus a placebo fo…

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This Canadian study is testing whether switching to the drug guselkumab (Tremfya) can help people with inflammatory bowel disease (IBD) who didn't respond well enough to ustekinumab. Researchers will track symptoms, test results, and overall health in 200 participants over one ye…

This study observes 35 adults with moderate-to-severe Crohn's disease or ulcerative colitis to see how long they continue taking guselkumab in everyday medical practice. Researchers will track treatment persistence and early symptom relief, like reduced bowel urgency. No experime…

This study tests an oral medication called icotrokinra for people with moderate to severe ulcerative colitis, a chronic condition that causes inflammation and ulcers in the colon. About 882 adults and adolescents will receive either the drug or a placebo to see if it can bring ab…

This study will follow 500 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission and how the treatment affects daily life, including fatigue and work productivity. The goal is to underst…

This phase 3 trial tests whether the experimental drug JNJ-78934804 can help people with moderate to severe ulcerative colitis achieve remission better than the existing drug guselkumab. About 644 participants will receive either the new drug or guselkumab, and researchers will c…

This study follows 200 Chinese patients with moderate-to-severe ulcerative colitis who have never taken biologic drugs. They will receive guselkumab as part of their normal care. Researchers will measure changes in symptoms and quality of life over 48 weeks to see how well the dr…

This study tracks 220 adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting guselkumab, a biologic drug. Researchers will measure how many achieve remission (symptom control) and whether they can stop steroids. The goal is to see how well the drug …

This study is checking the long-term safety of guselkumab, a biologic drug given as a shot, in children with moderate to severe Crohn's disease, ulcerative colitis, or juvenile psoriatic arthritis. About 196 kids who already completed a prior guselkumab study and benefited from i…

This study tests a new drug called RO7837195 for people with moderate to severe ulcerative colitis who haven't gotten better with other treatments. About 224 participants will receive either the drug or a placebo for 12 weeks to see if it can bring about remission. The goal is to…

This study tests if the drug vorinostat is safe and can help people with moderate-to-severe Crohn's disease by reducing gut inflammation. Participants who respond well may then receive a maintenance treatment with ustekinumab for up to two years. The goal is to control symptoms a…

This study tests whether adding acupuncture to the standard drug mesalazine helps people with mild-to-moderate ulcerative colitis achieve and stay in remission. Eighty adults will receive either real acupuncture or sham patches alongside mesalazine for 12 weeks. The goal is to se…

This Phase 2 trial is testing three long-acting antibodies, alone or in combination, for people with moderate-to-severe ulcerative colitis. The study will enroll 645 adults to see if these treatments can reduce inflammation and lead to remission. Participants receive the antibodi…

This study tests a daily pill called etrasimod in 24 children aged 2 to 12 with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The goal is to see if the drug can safely help children reach remission (few or no symptoms) over 52 weeks. Participants wh…

This study tests the long-term safety and effectiveness of mirikizumab in 150 children and adolescents with moderate-to-severe ulcerative colitis or Crohn's disease. Participants who completed earlier mirikizumab studies can join. The trial lasts about 172 weeks and aims to see i…

This study tests a new drug called BI 3032950 in 80 adults with moderate to severe ulcerative colitis who haven't improved on other treatments. In the first part, the drug is given by IV every 4 weeks for 12 weeks. Those who respond then receive injections under the skin every 4 …

This program offers early access to upadacitinib (Rinvoq) for people with Crohn's disease, ulcerative colitis, certain types of arthritis, or atopic dermatitis who have no other suitable treatments and cannot join ongoing clinical trials. A doctor must decide if the potential ben…

This study tests a new drug called duvakitug in about 980 people with moderate-to-severe ulcerative colitis. Participants receive either duvakitug or a placebo as an injection under the skin for up to 12 weeks. The goal is to see if the drug can help achieve remission, meaning le…

This study is testing whether guselkumab, a biologic drug, can help people with moderate-to-severe ulcerative colitis achieve remission. Participants receive IV infusions followed by maintenance injections. The trial tracks clinical, endoscopic, and histological healing over 48 w…

This trial tests whether the oral drug ponesimod can help people with moderately to severely active ulcerative colitis achieve remission. Participants receive either ponesimod or a placebo daily for 16 weeks, with an option to continue on ponesimod for another 36 weeks. The study…

This early-stage trial explores whether adding two experimental capsules, ND-12 and H-6, to standard mesalazine treatment can better control chronic inflammatory diarrhea in adults, including those with active ulcerative colitis. Participants will take the combination or a placeb…

This study follows 200 adults in Japan with moderate to severe ulcerative colitis who are already prescribed risankizumab by their doctor. Researchers will track how well the drug controls symptoms like diarrhea and rectal bleeding over up to 156 weeks. The goal is to see if the …

This study tests a daily pill called filgotinib in 80 children aged 8 to 17 with moderate to severe ulcerative colitis, a chronic gut disease. The goal is to see if the drug can reduce inflammation and help children feel better. All participants receive the drug, and the study tr…

This trial is testing whether personalized, adaptive treatment strategies can help people hospitalized with acute severe ulcerative colitis. The approach adjusts medication based on how each patient responds, aiming to improve outcomes and reduce the need for colon removal. The s…

This study looks at people with inflammatory bowel disease (Crohn's or ulcerative colitis) who feel fine but still have moderate to severe inflammation inside their gut. It compares two approaches: switching to a different targeted medication versus staying on the current one. Th…

This trial tests whether a 12-week dietary intervention can improve gut health, reduce inflammation, and enhance quality of life in adults with ulcerative colitis who are in remission. Participants are randomly assigned to a Mediterranean diet, a Mediterranean diet combined with …

This study tests a new drug called RO7790121 for people with moderate to severe ulcerative colitis, a condition that causes inflammation in the colon. About 350 adults who haven't responded well to other treatments will receive either the drug or a placebo. The main goal is to se…

This study follows 200 adults with Crohn's disease or ulcerative colitis who are prescribed Zymfentra as part of their regular care. Participants answer online surveys about their bowel habits for one year to see if symptoms improve. The goal is to understand how effective this m…

This study looks at how children and teenagers with moderate to severe ulcerative colitis or Crohn's disease process a drug called vedolizumab when given as a shot under the skin. About 70 participants who already responded to vedolizumab given through a vein will receive the sho…

This study looks at whether using two drugs together (upadacitinib and vedolizumab) works better than just one drug (upadacitinib alone) for people with moderate-to-severe ulcerative colitis, a chronic bowel disease. Researchers will review medical records from 150 adults across …

This study tests two drugs, eltrekibart and mirikizumab, alone or together, in 140 adults with moderate-to-severe ulcerative colitis. The goal is to see if they can safely reduce inflammation and help patients achieve remission. Participants must have tried other treatments witho…

This study tests a new drug called SSGJ-627 in 288 adults with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if it safely controls symptoms like bleeding and diarrhea. Participants must have tried other treatments without success.

This pilot study tests whether a specific probiotic, given as a rectal enema, can improve gut health in people with mild-to-moderate ulcerative colitis. Researchers will measure changes in the gut microbiome and signs of rectal healing. The trial enrolls 20 adults aged 18 to 80 w…

This study tests an oral medication called ozanimod in children aged 12-17 with moderate-to-severe ulcerative colitis who haven't responded to standard treatments. The goal is to see if the drug can safely bring the disease into remission. About 120 participants will receive eith…

This trial tests an experimental oral drug called BRS201 in people with active mild ulcerative colitis. Participants take the drug or a placebo for four weeks each in a crossover design, and researchers measure changes in gut inflammation markers and symptoms. The study involves …

This study is testing a new oral drug called etrasimod in 30 elderly patients with active ulcerative colitis. Researchers will track how many patients achieve remission after 4 weeks and look for improvements in the gut lining after a year. The goal is to see if the drug is safe …

This study tests whether giving children with active ulcerative colitis a series of fecal microbiota transplants (FMT) along with a special liquid diet (partial enteral nutrition) can help control the disease. The trial includes children aged 2 to 16 who either have not responded…

This study watches 300 adults with moderate to severe ulcerative colitis who are prescribed etrasimod by their doctor. Researchers track symptoms like stool frequency and rectal bleeding over 52 weeks using health questionnaires. The goal is to see how well the drug works outside…

This study tests an experimental oral drug called INT-210 in adults with active ulcerative colitis, a chronic inflammatory bowel disease. Participants take either 200 mg or 400 mg of INT-210 twice daily for 12 weeks. The main goals are to check the drug's safety and how the body …

This study explores whether people with inactive inflammatory bowel disease (IBD) can safely stop taking proton pump inhibitors (PPIs), a common acid-reducing medication. Evidence suggests PPIs may make IBD treatments less effective and increase hospital visits. The trial will re…

This study tests a daily medication called etrasimod in 36 adolescents aged 12 to 17 with moderate-to-severe ulcerative colitis. The goal is to see if the drug can safely help control the disease and reduce inflammation over a year, with an option to continue treatment for up to …

This study is monitoring the safety and effectiveness of the drug Jyseleca (filgotinib) in Korean patients with rheumatoid arthritis or ulcerative colitis. Researchers will track side effects and disease activity over 24 weeks. About 2,040 participants are being observed during r…

This study will follow 100 people in Saudi Arabia with moderate to severe Crohn's disease or ulcerative colitis who are starting guselkumab. Researchers will measure how long patients continue the treatment in real-world clinics, along with early symptom improvements. No new drug…

This study tests an experimental pill called ISM5411 (Garutadustat) in 80 adults with active ulcerative colitis. Half receive the drug, half a placebo, and neither patients nor doctors know who gets what. The goal is to check if the drug is safe and helps control the disease.

This study follows 40 children with Crohn's disease or ulcerative colitis who developed severe psoriasis from anti-TNF drugs and switched to ustekinumab. Researchers will check if their digestive symptoms stay controlled and if their skin improves after 3-6 months. The goal is to…

This study tests whether a special medical food called LH VIOLA, taken as a partial replacement for regular meals, can help people with Crohn's disease or ulcerative colitis who are at risk of malnutrition maintain or regain weight and muscle strength. About 146 participants will…

This study looks at the long-term safety of a drug called vedolizumab given as a shot under the skin to children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who did well on the drug in an earlier study will keep getting it, while those who didn…

This study looks at how well risankizumab works for people with moderate to severe ulcerative colitis in real-world settings. About 200 adults in Germany and Austria will take the drug as prescribed by their doctor and be followed for up to 52 weeks. The goal is to see if symptom…

This study tests if upadacitinib, a newer pill, works as well as standard steroid injections for treating sudden, severe flare-ups of ulcerative colitis. About 46 adults with acute severe colitis will receive either upadacitinib or steroids for 3 months, with frequent checkups. T…

This study follows 50 people with moderate to severe Crohn's disease or ulcerative colitis to see how long they stay on guselkumab in real-world settings. Researchers will measure treatment persistence and early symptom improvements using patient diaries. The goal is to understan…

This study tests a special form of vitamin B3 (nicotinamide) that releases in the lower gut to treat mild to moderate ulcerative colitis. About 459 adults will receive either a low or high dose of the vitamin or a placebo. The goal is to see if it can reduce symptoms and improve …

This early-stage study is testing whether an oral probiotic called R-3750 is safe and tolerable for people with mild to moderate ulcerative colitis. About 36 adults will take the probiotic and be monitored for side effects, inflammation, and symptom changes. The goal is to see if…

This study tests a once-daily food supplement designed to improve gut bacteria in people with mild-to-moderate ulcerative colitis. About 162 adults will take either the supplement or a placebo for 24 weeks, alongside their usual treatment. The goal is to see if the supplement hel…

This early-stage trial tests BDHK-2009, an experimental tablet for inflammatory bowel diseases like ulcerative colitis and Crohn's disease. The study involves 68 healthy adults aged 18 to 55 to see if the drug is safe and how the body handles it. Participants receive either a sin…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This study tests whether butyrate enemas can help Hispanic children aged 7-21 with mild-to-moderate ulcerative colitis. Butyrate is a natural substance made by gut bacteria that may reduce inflammation. The goal is to see if it can lower disease activity scores and improve marker…

This study tests whether two types of fibre supplements—acacia gum and microcrystalline cellulose—can reduce gut inflammation in people with ulcerative colitis. Sixty-nine participants will add one of the fibres or a placebo to their usual diet for six weeks. Researchers will mea…

This phase 2 trial tests an experimental pill called HRS-7085 in 48 adults with moderate to severe ulcerative colitis. Participants receive either a low dose, high dose, or placebo for several weeks. The study checks for safety, symptom improvement, and how the drug moves through…

This study tests the long-term safety of an oral drug called zasocitinib (TAK-279) in adults with moderate to severe Crohn's disease or ulcerative colitis. Participants who responded to the drug in earlier studies can continue treatment for up to 3 years. The main goal is to see …

This study tests whether adding selenium supplements to standard advanced therapies (like biologics) helps people with moderate to severe ulcerative colitis achieve remission. About 180 participants will receive either selenium or a placebo for a set period. The goal is to see if…

This study looks at how well ozanimod works compared to azathioprine for people with steroid-dependent ulcerative colitis in Japan. Researchers will review medical records of 150 adults to see which drug helps patients stop steroids and stay symptom-free. The goal is to find a be…

This study tests a dietary supplement called ButyMixx in 40 adults with ulcerative colitis who are in remission. ButyMixx contains sodium butyrate and a beneficial yeast to support gut health. Participants take two sachets daily for 8 weeks, and researchers check for symptom chan…

This study tests an experimental drug called TQH3906 in adults with moderate-to-severe ulcerative colitis or Crohn's disease. About 135 participants will receive either the drug or a placebo for 12 weeks to see if it safely reduces inflammation and improves symptoms. The goal is …

This study is for children with ulcerative colitis or Crohn's disease who already completed a previous vedolizumab trial. It aims to see how safe the drug is over a longer period. About 240 kids will receive vedolizumab infusions or be observed without treatment. Researchers will…

This phase 2 trial tests whether adding a freeze-dried fecal microbiota transplant (FMT) to standard biologic drugs (vedolizumab or ustekinumab) helps people with ulcerative colitis reach remission more safely and effectively. About 40 adults with active UC will receive either FM…

This study tests a sequential treatment for moderate to severe ulcerative colitis. First, patients take upadacitinib (a fast-acting pill) along with vedolizumab (a slow but safe infusion) for 8 weeks to quickly reduce inflammation. Then, they continue with vedolizumab alone for l…

This study is testing whether a Mediterranean-like diet called Nordiet can improve gut health and reduce inflammation in 160 teens and adults with Crohn's disease or ulcerative colitis. Participants will follow the diet for four weeks while researchers check changes in gut bacter…

This study is testing an interleukin-23 monoclonal antibody, a drug that blocks a key inflammatory protein, in 200 adults with moderate to severe Crohn's disease or ulcerative colitis. Participants receive the drug and are followed for 54 weeks to see if they can achieve remissio…

This study compares two drugs—upadacitinib (a pill) and infliximab (an infusion)—as second-line treatments for acute severe ulcerative colitis. About 226 adults will be randomly assigned to one of the two drugs for 3 months. The main goal is to see if upadacitinib can reduce symp…

This study tests a new drug called SAR442970 for people with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. About 99 adults will receive either the drug or a placebo to see if it can help control the disease and reduce symptoms…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous anti-TNF treatment stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and health ove…

This study tests an oral biologic called MB-001 in 100 adults with moderate-to-severe ulcerative colitis. Participants take either MB-001 or a placebo daily for 12 weeks, then may continue in an open-label phase. Researchers will check for side effects and measure improvements in…

This study tests whether a diet made from common American foods like sandwiches, grilled meats, and oatmeal can reduce inflammation and improve symptoms in people with ulcerative colitis. Over 8 weeks, 122 participants will receive catered meals and guidance from a dietitian. The…

This study looks at whether a drug called guselkumab can help people with moderate to severe Crohn's disease who did not improve or could not tolerate another drug called ustekinumab. About 60 adults will receive guselkumab and be followed for 52 weeks. The main goal is to see ho…

This study tests whether giving several fecal transplants (instead of just one) works better to clear repeat C. diff infections in people with ulcerative colitis. About 64 adults with active colitis and repeat C. diff will receive either one or multiple infusions of healthy donor…

This study tests whether fecal transplants from carefully selected 'superdonors' can help people with mild-to-moderate ulcerative colitis achieve remission. 42 adults with a recent diagnosis will receive either superdonor FMT or a placebo via colonoscopy and capsules. The main go…

This Phase 2 study is testing two new drugs, MT-501 and MT-201, in 140 adults with moderate-to-severe Crohn's disease or ulcerative colitis. The goal is to see if these treatments are safe and can improve symptoms and gut healing. Researchers will monitor side effects and measure…

This study tests whether taking freeze-dried fecal transplant capsules (PRIM-DJ2727) can help adults with ulcerative colitis stay in remission and avoid flare-ups. About 58 participants will take the capsules or a placebo for 12 weeks alongside their usual treatment. The goal is …

This study tests an experimental drug called HSK47388 in 150 adults with moderately to severely active ulcerative colitis, a chronic bowel disease causing inflammation and sores. Participants will receive either the drug or a placebo to see if it improves symptoms and helps heal …

This early-phase trial tests whether a patient's own immune cells, engineered to target BCMA and/or CD19, can calm severe ulcerative colitis that hasn't responded to other treatments. Twelve adults with moderate-to-severe active disease will receive a single infusion of these CAR…

This program provides children and teenagers with moderate to severe ulcerative colitis or Crohn's disease continued access to vedolizumab, a medication given through a vein, after they finish a related study. It is for those who still benefit from the treatment and have no good …

This study tests whether taking a daily prebiotic supplement for 8 weeks can improve gut health and reduce inflammation in people with ulcerative colitis. Researchers will collect stool samples and track symptoms in 70 adults. The goal is to see if prebiotics can help manage the …

This study tests a new drug called OD-07656 in people with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if it safely reduces symptoms like bleeding and diarrhea, and if it can make a follow-up treatment (vedolizumab) work better. About 57 adu…

This study tests whether adding mebendazole, a common deworming medication, to standard mesalamine therapy can improve symptoms in people with mild-to-moderate ulcerative colitis. 46 adults will take mebendazole or a placebo twice daily for 6 months. Researchers will measure chan…

This study tests whether adding upadacitinib (Rinvoq) to standard steroid treatment helps people with a severe ulcerative colitis flare-up recover faster and avoid emergency care or surgery. About 110 adults with acute severe ulcerative colitis will be randomly assigned to get ei…

This study is testing whether adding the allergy medicine desloratadine to standard ulcerative colitis treatment can better control inflammation and symptoms. About 44 adults with mild to moderate ulcerative colitis will take either desloratadine plus mesalamine or mesalamine alo…

This study follows 500 people with ulcerative colitis who have already tried at least two advanced medications without success. Participants choose either to continue trying different medications or to have their colon removed (colectomy). Researchers will compare quality of life…

This study tests whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to standard anti-TNF therapy can improve outcomes for people with active Crohn's disease or ulcerative colitis. Eighty adults starting anti-TNF drugs will be randomly assigned to eithe…

This study looks at whether removing certain food additives (like carrageenan and polysorbates) from the diet can improve symptoms and gut health in people with moderately active ulcerative colitis. About 70 participants will be randomly assigned to either a normal healthy diet o…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with moderate to severe ulcerative colitis flares. The goal is to see if this treatment can stop symptoms like rectal bleeding and frequent stools, and…

This study is testing whether people with Crohn's disease or ulcerative colitis who are in deep remission can safely reduce their dose of the biologic drug ustekinumab. Participants will either switch from injections every 4 weeks to every 8 weeks, or from every 8 weeks to every …

This study tests whether taking vitamin D3 supplements can lower inflammation in people with moderate ulcerative colitis. Sixty adults aged 20-40 will either get standard care plus a placebo or standard care plus a high dose of vitamin D3 every two weeks for 12 weeks. Researchers…

This study compares two treatment approaches for people newly diagnosed with moderate-to-severe ulcerative colitis (UC). One group gets early treatment with mirikizumab, a biologic drug, while the other starts with standard azathioprine pills and can switch to mirikizumab later i…

This pilot study is testing whether drinking 8 ounces of pomegranate juice daily for 8 weeks can reduce gut inflammation and improve quality of life in people with mild-to-moderate ulcerative colitis. Researchers will also look at how the juice affects gut bacteria. The study inv…

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This early trial tests whether a device that sends mild electrical pulses to the sacral nerve can safely help control symptoms of ulcerative colitis. The study will enroll 15 adults whose disease has not responded well to standard medications. Researchers will track changes in di…

This study will follow about 4,000 people who have received a fecal microbiota transplant (FMT) — a procedure that transfers gut bacteria from a healthy donor to restore balance in the gut. It aims to see how well FMT works over 3 months, 1 year, and 5 years for conditions like r…

This study follows 80 Chinese adults with moderate to severe ulcerative colitis who are already prescribed upadacitinib by their doctor. Researchers will collect routine medical data over one year to see if the drug improves symptoms like bloody diarrhea. No extra tests or visits…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) remember to take their medications and manage their symptoms. About 70 teens aged 13-17 will either use the full app with reminders and challenges or just a si…

This program provides early access to the drug etrasimod for people with ulcerative colitis who have tried at least three other treatments without success or cannot use them. The goal is to offer a potential treatment option when no standard therapies are left. Patients must meet…

This phase 2 trial tests whether rupatadine, an allergy medicine, can help control inflammation in people with mild-to-moderate ulcerative colitis. About 60 adults will take rupatadine or a standard treatment (mesalamine) for several weeks. The goal is to see if rupatadine reduce…

This study tests whether adding diet advice and stress management sessions to standard advanced therapy helps people with Crohn's disease or ulcerative colitis reach remission. About 160 adults with active IBD will be split into four groups, each receiving different combinations …

This study tests a new oral drug called BRS201 in 20 adults with severe ulcerative colitis who have not improved with standard treatments. Participants take the drug twice daily for 4 weeks and attend 8 clinic visits for blood, stool, and urine tests. The goal is to see if BRS201…

This study tests whether a carefully designed diet can change the gut bacteria in people with active ulcerative colitis and reduce disease activity. Twenty adults with mild to moderate colitis will follow the diet and have their gut bacteria and inflammation levels measured. The …

This study is testing whether a remote monitoring app can help people with active inflammatory bowel disease (Crohn's or ulcerative colitis) spend more time in remission. About 290 adults whose disease is flaring will use the app to track symptoms and health data. The goal is to …

This study tests a new drug, BCD-261, in 198 adults with moderate to severe ulcerative colitis who haven't improved with standard treatments. Participants receive one of three doses of BCD-261 or a placebo as an injection. The goal is to see if the drug can reduce inflammation an…

This study tests whether budesonide extended-release tablets can safely help children aged 5 to 17 with mild to moderate ulcerative colitis achieve remission. About 70 participants will receive either a low dose, high dose, or placebo for 56 days. The goal is to reduce symptoms l…

This trial asks whether adding a quick, painless intestinal ultrasound to standard check-ups can change how doctors treat inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Adults with IBD who are already scheduled for a colonoscopy are randomly a…

This study is testing whether two simple stool tests—fecal calprotectin and a fecal immunochemical test (FIT)—can predict early on if biologic therapy will help people with moderate-to-severe ulcerative colitis. Researchers will measure these markers at weeks 2 and 4 after starti…

This study is testing a new stool test that measures calprotectin, a protein that signals inflammation in the gut. The goal is to see if the test can help doctors diagnose Crohn's disease or ulcerative colitis and tell them apart from irritable bowel syndrome. About 220 adults wi…

This study compares a new imaging technique called Texture and Colour Enhancement Imaging (TXI) with standard white light during colonoscopy in 219 people with inflammatory bowel disease (IBD). The goal is to see if TXI finds more dysplastic (precancerous) lesions. Each patient w…

This study is developing an artificial intelligence system that analyzes CT and MRI scans to diagnose and predict outcomes for digestive diseases like Crohn's disease, ulcerative colitis, and intestinal tuberculosis. Researchers are using data from 21 hospitals in China to train …

This study is testing a device called the AlgometRx Nociometer to see if it can measure inflammation in children with inflammatory bowel disease (IBD). The device checks how different nerve fibers respond, which may give doctors a clearer picture of disease activity. Researchers …

This study tests whether the drug etrasimod can prevent pouchitis, a common inflammation of the internal pouch created after colon removal surgery. Researchers will give either etrasimod or a placebo to 40 high-risk patients for 48 weeks and track how many develop pouchitis. The …

This study tests whether Aquamin, a natural mineral supplement from seaweed, can prevent pouchitis—a painful inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take Aquamin or a placebo for up to 8 months. Th…

This study tests whether modafinil, a drug used for sleep disorders, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, starting at 100 mg daily with possible dose increases. …

Adults with inflammatory bowel disease often face psychological distress, especially during transitions like a new diagnosis, a flare, or surgery. Researchers are testing IBD Strong Peer, a program where trained peer mentors provide emotional support through up to 10 virtual call…

This study tests whether a special online therapy for insomnia, adapted for people with ulcerative colitis (UC), is helpful and practical. About 20 adults with active UC and insomnia will take part. They will complete online questionnaires, keep a daily sleep diary, and attend 5 …

This trial tests whether a supervised moderate-intensity exercise program, done at least 30 minutes three times a week, can improve quality of life in adults with inflammatory bowel disease (IBD) that is currently in remission. Over six months, researchers will compare those who …

This study tests whether a special chair that delivers high-intensity electromagnetic stimulation can improve bowel leakage (fecal incontinence) and quality of life in people who have a J-pouch after surgery for ulcerative colitis. Participants will sit on the Emsella chair for 2…

This study tests a small device placed under the skin near the tailbone that sends mild signals to a nerve, aiming to reduce sudden bowel urgency in people with ulcerative colitis. About 137 adults with the condition will take part. The device is implanted in a same-day procedure…

This phase 4 trial tests whether taking a 2 mg prolonged-release melatonin tablet before bed can improve sleep quality in adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) whose disease is in remission. Participants must have poor sleep (PSQI score >5…

This pilot study will test a 24-week digital self-management program designed to help people with inflammatory bowel disease (IBD) manage their symptoms and build long-term healthy habits. The program is accessed via web or mobile device and is used alongside standard care. The s…

This study tests whether morning bright light therapy can help people with Crohn's disease or ulcerative colitis by reducing gut leaks and inflammation. About 30 adults with stable medication will use a light box each morning for 8 weeks. Researchers will check changes in gut bar…

This pilot study tests whether the MyIBDDiet app helps people with inflammatory bowel disease (IBD) learn about and follow an anti-inflammatory diet. Forty adults with IBD who are not in a flare will use the app for 30 to 60 days and complete surveys about its ease of use and the…

This study tests whether a ketogenic (low-carb, high-fat) or carnivore (all meat) diet can improve quality of life and reduce symptoms in adults with inflammatory bowel disease (Crohn's or ulcerative colitis) or rheumatoid arthritis. Participants are randomly assigned to one of t…

This study tests if pentoxifylline, a drug already used for other conditions, can safely reduce symptoms of mild to moderate ulcerative colitis. About 60 adults will take the drug and be monitored for changes in bowel symptoms and quality of life. The goal is to see if this offer…

This study looks at whether people with certain cancers prefer getting their immune therapy as a shot under the skin (subcutaneous) or through a needle in a vein (intravenous). About 880 adults who are already eligible for standard treatments like nivolumab or pembrolizumab will …

This study tests whether one hour of morning light therapy each day for four weeks can improve sleep quality and reduce inflammation in adults with ulcerative colitis who have active inflammation and poor sleep. Thirty participants will wear a sleep tracker, complete surveys, and…

This study tests whether a special 5-day diet that mimics fasting can lower inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Participants will follow the diet for three cycles while researchers track symptom changes. The goal is to see …

This study tests whether adding fermented foods like kimchi, sauerkraut, yogurt, and kefir to the diet can reduce inflammation and improve quality of life in people with mild to moderate ulcerative colitis. Researchers will measure changes in a stool marker of inflammation and tr…

This study looks at whether a single educational session about the benefits of exercise can help people with Crohn's disease or ulcerative colitis (IBD) become more physically active. The goal is to reduce fatigue, improve digestion, and enhance quality of life. About 71 adults w…

This study looks at whether people with moderate-to-severe inflammatory bowel disease (IBD) need to take a steroid (dexamethasone) before each infliximab infusion to prevent allergic reactions. Researchers will compare those who get the steroid routinely with those who only get i…

This study tests whether a 12-week personalized aerobic exercise program, done at home with telemedicine guidance, can improve fitness, disease control, and quality of life in adults with inactive or mildly active inflammatory bowel disease (IBD). Twenty-eight participants will e…

This study looks at whether a 12-week remote exercise program can improve quality of life for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 72 adults with IBD will use a smartphone app to follow guided physical activities at…

Researchers collect small tissue samples from the inflamed and non-inflamed intestines of people with Crohn's disease or ulcerative colitis, as well as from people without inflammatory bowel disease. They grow these cells into tiny three-dimensional structures called organoids th…

This early-phase study is testing whether afimkibart, an experimental drug for ulcerative colitis, changes how the body processes common medications like caffeine, warfarin, and omeprazole. About 25 people with moderate to severe active ulcerative colitis will receive afimkibart …

This study aims to learn how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants aged 0 to 75 will receive standard medical care and may provide blood, tissue, or white blood cell samples. No experimen…

This study follows 7,000 healthy relatives of people with inflammatory bowel disease, including siblings and children, to find early clues that might predict who will later develop Crohn's disease or ulcerative colitis. Researchers collect blood, urine, stool, saliva, and tissue …

This study looks at the long-term safety of the drug ustekinumab compared to other biologic treatments in adults with Crohn's disease or ulcerative colitis. Researchers will use health records from the Department of Defense to track rates of cancer, serious infections, and other …

This study uses health insurance claims data from Korea to count how many children under 18 have Crohn's disease or ulcerative colitis, and how their treatment changes as they grow. Researchers will look at patterns of medication use, hospital visits, and costs over several years…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study asks whether modern fermented vegan products—like plant-based yogurt and meat substitutes—are healthier for the gut than the dairy and meat they replace. Researchers will compare these diets in healthy volunteers and in people with inflammatory bowel disease (IBD), loo…

This study is testing whether a blood test measuring a protein called LRG can tell if the gut lining has healed in people with ulcerative colitis. Researchers will compare blood LRG levels with colonoscopy and tissue samples in 100 patients. If the blood test works, it could offe…

This study is building a registry of medical information from people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal is to use this data to better understand how IBD develops and progresses, which could help improve future treatme…

This study follows 1,500 children newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, to understand why some respond well to treatments while others develop complications. Researchers will collect medical data and biological sa…

This study surveys 400 adults with inflammatory bowel disease (IBD) from two medical centers to understand how social factors like insurance, income, and support affect medication adherence and quality of life. Researchers focus on Hispanic and Black patients, who often have wors…

This study is testing whether changes in two stool markers — a fecal immunochemical test (qFIT) and calprotectin (FC) — measured two weeks after starting standard therapy can predict whether people with ulcerative colitis will relapse or need stronger medication within a year. Re…

This study tests whether a new laboratory method—staining for a protein called claudin 2—can more accurately measure healing in the gut of people with ulcerative colitis or Crohn's disease. Researchers will compare this method with standard scoring systems and track whether it pr…

This study looks at whether teaching children and teens with inflammatory bowel disease (IBD) about ultra-processed foods (like packaged snacks and sugary drinks) can help them eat less of them. About 120 participants will complete online food diaries and receive either nutrition…

This observational study compares inflammatory markers in the blood and tissue of people with active Crohn's disease or ulcerative colitis versus healthy volunteers. Researchers aim to identify differences in the IL-23/Th17 inflammatory pathway and other immune signals. The study…

This observational study is collecting blood, stool, and tissue samples from 6,000 people with inflammatory bowel disease (Crohn's disease or ulcerative colitis), along with their relatives and healthy volunteers. Researchers aim to identify biomarkers that can assess intestinal …

This study looks at how children with Crohn's disease or ulcerative colitis burn energy at rest. Researchers will measure resting energy expenditure using a special breathing test and compare it to standard formulas. The goal is to see if energy use is linked to disease activity …

This study looks at bile acid profiles in children with ulcerative colitis (UC) who also have a C. difficile infection. Researchers want to see if changes in bile acids and gut bacteria make these children more vulnerable. They will compare three groups: children with UC flare-up…

This study collects small tissue samples (biopsies) from people undergoing routine endoscopy and grows them into mini-organs called organoids in the lab. These organoids mimic the real intestine and help researchers understand diseases like Crohn's and ulcerative colitis. The goa…

This study follows about 1,182 pregnant women with ulcerative colitis who are taking or have taken ozanimod. Researchers will watch for any health problems in the mothers and their babies, such as birth defects or pregnancy complications. The goal is to learn whether the drug is …

This study is looking for genetic clues that might predict how well people with inflammatory bowel disease (IBD) will respond to a common treatment called anti-TNF therapy. Researchers will collect blood samples from 40 patients who have not used anti-TNF before and track their r…

This study looks at whether a protein in the blood called LRG can accurately show how active Crohn's disease or ulcerative colitis is in the gut. Researchers will compare LRG levels with standard endoscopic and symptom scores in 100 European adults. If successful, LRG could becom…

This study is tracking over 25,000 people with inflammatory bowel disease (IBD) to understand why many continue to have abdominal pain even when their disease is in remission. Researchers will use questionnaires, blood and stool samples, heart rate recordings, and genetic data to…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study will compare kidney function in 3,000 adults with Crohn's disease or ulcerative colitis to 3,000 adults without these conditions. Participants will provide blood and urine samples and have a kidney ultrasound. The goal is to learn how common kidney problems are in IBD …

This study looks at how much energy, water, and waste are used during different types of bowel imaging tests for people with ulcerative colitis or Crohn's disease. The goal is to see if a simple, non-invasive ultrasound can be a greener alternative to colonoscopy and CT scans. Ab…

This study follows 153 people aged 60 and older with inflammatory bowel disease (IBD) to see how disease activity affects frailty. Researchers will also check whether frailty raises the risk of hospitalization or death. Participants will have their frailty, IBD symptoms, and over…

This study aims to identify biological markers that can predict how patients with inflammatory bowel disease (IBD) will respond to a type of medication called TNF-alpha inhibitors. Researchers will collect blood and tissue samples from 100 adults, including healthy controls and I…

This study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) or other gut disorders. Researchers will use a cutting-edge technique called spatial transcriptomics to map gene activity directly inside gut tissue. The goal is to better…

This study follows 450 adults who have early signs of inflammatory bowel disease (Crohn's or ulcerative colitis) found during routine colon cancer screening, but who have no symptoms yet. Researchers will collect blood, stool, and tissue samples over time to see how the disease p…

This study looks at whether people with ulcerative colitis (UC) who are in deep remission (no signs of inflammation) can safely reduce or stop their medication. Researchers will compare two groups: those who continue their current therapy and those who decrease or stop it. The go…

This study looks at how the bacteria and diet of pregnant women with inflammatory bowel disease (IBD) may influence gut inflammation in their babies. Researchers will collect samples from 80 mothers and infants over a year to track gut microbes and diet. The goal is to find patte…

This study observes how doctors use a treat-to-target strategy for people with Crohn's disease or ulcerative colitis in routine care. Researchers will review medical records of 2000 adults over 24 months to see if adjusting treatment based on disease activity improves outcomes. N…

This study looks at how gut bacteria change the energy use of immune cells in people with inflammatory bowel disease (IBD) and healthy adults. Researchers will give healthy volunteers a short course of antibiotics to alter their gut bacteria, then measure immune cell metabolism u…

This study looks at whether measuring infliximab levels in saliva is as good as measuring it in blood for children with inflammatory bowel disease (IBD). Fifteen children starting infliximab will provide saliva and blood samples during routine visits. The goal is purely to gather…

This study is testing whether a simple ultrasound can accurately measure muscle loss in people with inflammatory bowel disease (Crohn's or colitis). Currently, doctors use CT scans to check for muscle wasting, but CT involves radiation and is not always available. Researchers wil…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study follows 945 women with Crohn's disease or ulcerative colitis to see how pregnancy affects their condition. Researchers will track disease flares during pregnancy, after childbirth, and during breastfeeding. The goal is to better understand the link between IBD and preg…

This study interviews 60 children aged 10-17 with inflammatory bowel disease (Crohn's or colitis) to learn what makes it easier or harder for them to be physically active. Participants fill out two questionnaires and talk one-on-one with a researcher. No treatment or exercise pro…

This study aims to find new markers in the blood that can detect an imbalance of gut bacteria linked to inflammatory bowel disease (IBD). Researchers will compare 60 people with IBD and 60 people without IBD by collecting stool, blood, and tissue samples. The goal is to develop a…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study from Aarhus University is looking at how common magnesium deficiency is in people with Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhea. Magnesium is important for muscles, nerves, and heart health, but standard blood tests may miss a deficiency. T…

This study explores whether ultrasound and elastography can detect fibrosis (scarring) in the gut of people with ulcerative colitis. Researchers will compare ultrasound images with tissue samples from biopsies to find new biomarkers. The goal is to develop a non-invasive method t…

This study is a large registry that will follow 10,000 people with inflammatory bowel disease (IBD) in Germany over many years. Its goal is to collect real-world information on how well treatments work, how the disease changes over time, and how it affects patients' daily lives. …

This study explores how traditional Chinese medicine tools, such as tongue and pulse diagnosis, can help identify unique features of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare 30 people with IBD to 30 healthy volun…

This study looks at how sleep problems affect people with ulcerative colitis, a type of inflammatory bowel disease. Researchers will study 152 participants to see how sleep quality relates to gut bacteria, nerve function, and disease activity. The goal is to understand the connec…

This study is testing whether robotic surgery is a practical option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to standard laparoscopic surgery in 100 adults to see which approach wo…

This study follows 216 adults with inflammatory bowel disease (IBD) who are in remission. They wear a wrist monitor and fill out sleep questionnaires for one year to see if changes in sleep quality can predict when a flare-up will happen. The goal is to find early warning signs o…

This study is for adults in South Korea with ulcerative colitis or Crohn's disease who are already taking vedolizumab injections. Researchers will look at medical records to track side effects and how well the treatment works. No new medicine or treatment is given—this is just an…

This study looks at whether microplastics are found more often in children with inflammatory bowel disease (IBD) compared to healthy children. Researchers will collect samples of tissue, blood, urine, and stool from 40 children during routine endoscopy. No treatment is given—the …

This study is a large registry that will collect information from over 4,000 people with Crohn's disease or ulcerative colitis in Argentina. Doctors will record details about patients' diagnosis, treatments, and any safety issues like infections. The goal is to better understand …

This study is collecting health data, voice recordings, and biological samples from 100 IBD patients in Luxembourg (part of a larger 800-person study across Europe). Researchers hope to find patterns that can predict when a patient's treatment needs to change. The goal is to use …

This study aims to find out how often men with inflammatory bowel disease (IBD) have HPV infection in their mouth and anal area. Researchers will collect swab samples from 384 men with Crohn's disease or ulcerative colitis and test for HPV and abnormal cell changes. The goal is t…

This study follows 48 adults with active Crohn's disease or ulcerative colitis who are starting biologic or JAK inhibitor therapy. Researchers use a quick, painless bioelectrical impedance scan to measure muscle mass and other body composition changes at the start, 24 weeks, and …