Mucositis

This early-stage study tests a new vaccine called PollenVax for people with moderate to severe mugwort pollen allergy. The main goal is to see if the vaccine is safe and tolerable in 30 adults aged 18 to 65. Participants receive four shots of either the vaccine or a placebo, and …

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This phase 2 trial tested the oral cholera vaccine Vaxchora in 34 healthy adults to see how well it triggers protective antibodies and immune cells. Participants received a single dose, and researchers measured antibody levels, B cells, and T cell responses. The goal is to unders…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This study tested a new Shigella vaccine in 200 healthy African infants to see if it can prevent severe diarrhea. The vaccine was given in two doses, and researchers measured immune responses and safety. The trial is now complete, and results will show whether this approach is pr…

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study compares a new probiotic gel to a standard steroid gel for treating minor recurrent canker sores—painful mouth ulcers that make eating and talking difficult. Adults with these sores will apply either the probiotic or steroid gel four times daily for up to two weeks. Re…

This study looked at 40 adults aged 35–55 with a history of periodontitis (gum disease) who needed a dental implant. Each received one of two implant surface types: sandblasted acid-etched or plasma-sprayed. Researchers measured bone loss around the implant and gum health over on…

This study tested whether a daily dose of Travelan (IMM-124E) tablets could prevent moderate-to-severe diarrhea in healthy adults deliberately infected with ETEC bacteria, a common cause of travelers' diarrhea. Sixty-three volunteers took either Travelan or a placebo for 7 days. …

This study tested whether a stannous fluoride toothpaste can reduce gum inflammation, bleeding, and plaque better than a standard fluoride toothpaste. Over 12 weeks, 133 adults brushed with one of the two toothpastes and had their gums checked at several visits. The goal was to s…

This study tested whether a hands-on teaching method called Touch-to-Teach helps people with dental crowns clean between their teeth better than standard advice. 36 adults with at least one crown took part and were split into two groups: one got personalized brush training, the o…

This study tested a new drug called VR-AD-1005 for treating severe diarrhea caused by cholera. The drug aims to reduce fluid loss and the need for antibiotics, which could help fight antibiotic resistance. 150 adults with cholera took part, and researchers measured stool output a…

This study tested whether using a stannous fluoride toothpaste, a cetylpyridinium chloride mouthwash, and a battery-powered toothbrush together can reduce dental plaque and gingivitis (gum inflammation). 134 adults with at least 20 teeth and signs of gum disease used the regimen …

This study looked at 84 people with severe allergic rhinitis (constant sneezing, runny nose, itching, stuffiness) that didn't improve with usual treatments. Researchers compared three procedures that target the nerve in the nose: surgical cutting, radiofrequency, and surface cobl…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested a device called NEUROMARK in 80 adults with chronic rhinitis (long-term stuffy or runny nose). The device uses radiofrequency energy to disrupt nerves in the nose that trigger symptoms. The goal was to see if it safely reduces nasal symptoms like congestion and …

This study tested whether a mouthrinse with benzydamine hydrochloride could reduce plaque buildup when people stopped brushing for three days. Fifty healthy women with no gum disease used either the active mouthrinse or a placebo. The results showed no significant difference in p…

This study tested whether toothpaste containing hops extract can reduce gum inflammation (gingivitis) better than standard fluoride toothpaste. 120 adults brushed twice daily for 3 months with one of four toothpastes. Researchers measured bleeding and gum health to see if the hop…

This study tested whether pulsed electromagnetic fields (PEMF) can reduce harmful bacteria and improve healing around dental implants. 35 healthy adults with at least two missing teeth took part. Researchers measured changes in bacteria types and gum tissue volume to see if PEMF …

This study tested whether a new mouthwash called MicroRepair ABX works as well as the standard chlorhexidine mouthwash for treating plaque-induced gingivitis (gum inflammation). Forty adults with gum disease used one of the two mouthwashes twice daily for 14 days after a professi…

This study tested four different mouthwashes—hydrogen peroxide with hyaluronic acid, hyaluronic acid alone, chlorhexidine, and a placebo—in 80 healthy adults aged 18 to 35 with mild gum inflammation. Participants used their assigned rinse twice daily for three weeks. The goal was…

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a …

This study tested two daily-use mouth rinses containing chlorhexidine (CHX) plus either hydrogen peroxide or cetylpyridinium chloride against a placebo rinse. Over 3 months, 81 adults used the rinse twice daily alongside normal brushing. Researchers measured plaque buildup, gum i…

This study tested whether a probiotic called Lactobacillus rhamnosus Lcr35® can reduce the number of painful canker sores in people who get them often. Twenty adults with frequent outbreaks took either the probiotic or a placebo daily for 3 months, then were monitored for another…

This study tested whether a new Colgate toothpaste with dual zinc can better control plaque and gingivitis (gum inflammation) compared to a standard cavity protection toothpaste. 86 adults with mild to moderate plaque and gum issues used one of the two toothpastes for three month…

This study compared a stannous fluoride toothpaste paired with a newly designed toothbrush to a standard toothpaste and brush for reducing plaque and gingivitis (gum inflammation). 95 adults with mild to moderate gum issues used their assigned products for 3 months. Researchers m…

This study tested whether a special dental care routine (PerioGard) works better than standard products for reducing plaque and gum inflammation. Eighty adults with mild to moderate gingivitis used either the PerioGard regimen or a regular fluoride toothpaste and mouthwash for th…

This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash and a manual toothbrush reduces dental plaque and gingivitis better than using regular fluoride toothpaste with a standard toothbrush. Eighty-two adults with mild gum di…

This completed Phase 2 study enrolled 84 adults with mild to moderate plaque and gingivitis. Participants were randomly assigned to use one of two manual toothbrush and toothpaste regimens at home for 6 weeks. Dentists measured plaque and gum inflammation at 1, 3, and 6 weeks to …

This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash can improve gum health and reduce plaque buildup better than using regular fluoride toothpaste alone. About 199 adults with mild gum disease (gingivitis) took part. Rese…

This study looked at whether a toothpaste made from black seed (Nigella sativa) can lower signs of gum inflammation in 100 Indonesian soldiers with gingivitis. Researchers measured certain proteins in saliva that are linked to gum disease. The goal was to see if this toothpaste c…

This study tested whether a mouthwash made from Triphala, an Ayurvedic herbal formula, works as well as the standard chlorhexidine mouthwash for reducing plaque and gum inflammation. 220 adults with mild to moderate gingivitis used one of the two mouthwashes twice daily for 30 da…

This study tested a type of allergy immunotherapy (Clustoid® Max Forte) in 140 people aged 5 to 65 with dust mite allergies. The goal was to see if it reduces allergy and asthma symptoms and the need for medication over one year. Results were measured by symptom scores and medica…

This study tested a dietary supplement containing immune-supporting nutrients and postbiotics in 40 children aged 5–12 with asthma and/or allergic rhinitis. The goal was to see if the supplement could improve symptom control over 6 months. Researchers also looked at changes in im…

This study tested whether a mouthwash made from guava leaf extract can reduce plaque and gum inflammation as well as a standard chlorhexidine mouthwash. 160 adults with chronic gingivitis rinsed twice daily for up to 90 days. Researchers measured plaque buildup and gum health to …

This study tested whether using a special toothpaste and mouthwash together with a manual toothbrush works better than regular fluoride toothpaste alone for reducing plaque and improving gum health. 90 adults with mild to moderate gum problems brushed twice daily for 12 weeks. Re…

This completed Phase 3 study tested whether a battery toothbrush paired with a stannous fluoride toothpaste is more effective at reducing plaque and gingivitis than a regular fluoride toothpaste with a manual toothbrush. 130 adults with mild gum disease brushed twice daily for 12…

This study tested whether adding hyaluronic acid to a standard chlorhexidine mouthwash helps treat gingivitis (gum inflammation). Sixteen adults with gingivitis used two different mouthwashes after a professional teeth cleaning. Researchers measured bleeding and plaque levels to …

This study tested whether a special light device used at home can improve oral health in teenagers with braces. Forty teens used the device daily for two months, while others received standard brushing instructions. The goal was to see if the device reduces plaque and gum bleedin…

This study tested whether an experimental toothpaste with stannous fluoride, zinc chloride, and alumina can improve gum health better than a regular fluoride toothpaste. 175 adults with mild to moderate gingivitis used the toothpaste for 4 weeks. Researchers measured gum bleeding…

This study tested whether a toothpaste with stannous fluoride can improve gum health better than a regular fluoride toothpaste. 154 adults with mild gum inflammation (gingivitis) used one of the two toothpastes for 12 weeks. Researchers measured gum bleeding and plaque to see whi…

This study tested a cream containing acyclovir and penciclovir against an over-the-counter cream (Abreva) for preventing cold sores caused by UV light. Forty adults with a history of cold sores were exposed to UV light to trigger an outbreak, then treated with one of the creams. …

This study tested whether adding two special gels to standard cleaning helps treat gum inflammation around dental implants. 92 adults with at least one inflamed implant received either standard cleaning alone or cleaning plus the gels. The gels aim to reduce bleeding and plaque. …

This study tested whether an AI-powered chatbot could help people with dental implants take better care of their teeth and gums. 110 adults with implants were split into two groups: one used the chatbot for personalized oral hygiene tips, while the other received standard printed…

This completed study tested whether a new herbal mouthwash and gel (StellaLife) works as well as the standard chlorhexidine mouthwash for treating gingivitis (early gum disease). 34 healthy adults without gum disease took part. The goal was to see if StellaLife can control plaque…

This study tested a new mouthwash containing CPC, hyaluronic acid, and zinc lactate against a standard fluoride mouthwash. The goal was to see if it reduces plaque and prevents gum problems in adults with at least two dental implants. Eighty participants used the mouthwash for si…

This study tested two mouthwashes—one with 0.12% chlorhexidine and another with a lower dose of chlorhexidine plus cetylpyridinium chloride—to see which better controls gum inflammation and bacteria in people with gum disease. 72 adults used one of the rinses for a month after a …

This study tested how well floss and three different mouthwashes (one with essential oils and alcohol, one with essential oils but no alcohol, and one with CPC+Zn and no alcohol) reduce plaque and gum inflammation. 228 adults with mild to moderate gum disease took part. The goal …

This study tested whether EDTA eye drops can shorten cold sore outbreaks compared to the over-the-counter cream Abreva. Ten adults with a history of sun-triggered cold sores were randomly assigned to one of the two treatments. Researchers tracked how many days it took for each co…

This study looked at how well the antibiotic Klacid SR works for adults with respiratory infections like bronchitis and mild pneumonia, especially in those who had taken it before. Over 3,000 participants were treated in regular doctor visits, and doctors checked if symptoms impr…

This study tested whether taking a daily probiotic (Bifidobacterium Lactis HN019) can reduce plaque buildup and gum bleeding in people undergoing orthodontic treatment with braces or clear aligners. Sixty participants, aged 10 to 30, took the probiotic or a placebo for a period w…

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo…

This study tested whether lozenges made from propolis (a substance bees produce) can improve gum health in 100 young adults with mild to moderate gingivitis. Participants chewed the lozenges twice daily for a week while keeping their normal brushing routine. Researchers measured …

This study tested whether using a mouthwash with cetylpyridinium chloride (CPC) along with regular brushing improves gum health and reduces plaque more than brushing alone. 136 adults with mild to moderate gingivitis used either the CPC mouthwash or just brushed with fluoride too…

This study compared interdental brushes and rubber bristle cleaners in 40 adults with gingivitis (early gum disease). Participants used one of the two tools for four weeks. Researchers measured plaque removal and gum bleeding, and also asked about satisfaction. The goal was to se…

This study looked at whether smokers who switch to combustion-free nicotine products (like e-cigarettes or heated tobacco) see improvements in their gum health and tooth appearance. 460 smokers with mild gum disease were randomly assigned to keep smoking, switch to these products…

This study tested a special dental floss coated with a probiotic (good bacteria) to see if it could reduce harmful mouth germs and improve gum health. Thirty-three healthy men used the probiotic floss and a placebo floss for two weeks each, with a break in between. Researchers me…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a non-invasive optical device that uses different types of light to detect and diagnose various mouth conditions, including oral cancer, gum disease, and dry mouth. Over 1,000 participants with and without oral lesions were imaged, and the results were compared …

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This completed study tested whether facial images and voice recordings can help screen for allergic rhinitis (hay fever). Researchers collected photos and voice samples from 1500 people with chronic rhinitis, then compared them to standard allergy tests. The goal was to build a p…

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This study tested whether adding thalidomide to glutamine can delay the onset of severe mouth sores caused by radiation therapy. 138 oral cancer patients were randomly assigned to receive either the combination or glutamine alone during their radiation treatment. The main goal wa…

This study tests whether a probiotic gummy containing Weizmannia coagulans BC99 can reduce symptoms of allergic rhinitis (hay fever) in children aged 4 to 14. Over 8 weeks, half the children receive the probiotic gummy and half receive a placebo. Researchers track changes in nasa…

This study looked back at medical records of 58 adult cancer patients who developed painful mouth sores from chemotherapy or radiation. They had been treated with a combination of ozone applied in the dentist's chair and ozone-based gels, toothpaste, and mouthwash at home. The go…

This study tested two methods to help gums heal after a gingivectomy (removing excess gum tissue). Sixty-four healthy adults received either a hyaluronic acid spray (applied twice daily for 7 days) or low-level laser therapy (applied 4 times over 7 days). Researchers measured wou…

This study tested whether adding thread embedding acupuncture (TEA) to standard steroid nasal spray helps people with allergic rhinitis. 64 adults took part. The goal was to see if the combination reduces symptoms like sneezing and stuffy nose better than the spray alone, and whe…

This study tested a device called NEUROMARK that uses radiofrequency energy to disrupt nerves in the nose. It included 36 adults with moderate to severe chronic rhinitis. The goal was to see if the procedure safely reduces symptoms like runny nose and congestion over 3 months.

This study tested whether a new mouthwash can reduce dental plaque and help prevent gum problems better than a control mouthwash. 80 adults with mild to moderate gum inflammation and plaque used the product for three months. Researchers measured gum health and plaque levels at 2 …

This study tested whether a home-use light device (rhinophototherapy) can reduce nasal inflammation and allergy symptoms as well as a standard steroid spray. Thirty-five adults with allergic rhinitis used either the light device for 4.5 minutes three times daily or a steroid spra…

This study tested whether a propolis mouth rinse could delay or prevent severe oral mucositis (painful mouth sores) in 140 head and neck cancer patients undergoing radiation. Participants used either a 15% propolis solution or a placebo four times daily alongside standard oral ca…

This study tested whether adding a decongestant nasal spray for the first 5 days to standard steroid spray treatment helps children with persistent allergic rhinitis feel better faster. 76 children aged 4-18 were randomly assigned to receive either steroid spray alone for 4 weeks…

This study tested whether a mouth rinse made from sumac, a common spice, can help heal painful canker sores and reduce pain. Thirty-eight healthy adults with minor mouth ulcers used the rinse and were monitored for healing and pain levels. Researchers also measured inflammation m…

This phase 3 trial tested whether ulinastatin, a drug that blocks certain enzymes, can reduce severe mouth sores caused by chemoradiotherapy in 179 patients with advanced nasopharyngeal cancer. Patients received either standard care or ulinastatin alongside their cancer treatment…

This study tested if zinc oxide ointment can help heal painful canker sores. One hundred people with canker sores used either the zinc ointment or a placebo three times a day for six days. Researchers measured pain and how the sores affected daily life to see if the ointment made…

This completed trial tested whether a probiotic called Bifidobacterium longum ES1, or its heat-treated version, could reduce symptoms of allergic rhinitis (hay fever) in 72 adults with moderate-to-severe dust mite allergies. Participants took daily capsules for several weeks and …

This study tested an investigational treatment called PQ Grass 27600 SU in 119 adults with seasonal grass pollen allergies (hay fever). The goal was to see if it could reduce allergy symptoms and the need for relief medications during peak grass pollen season. Participants receiv…

This study tested an experimental nasal spray called INI-2004 in 78 adults with ragweed allergies. Participants received either the spray or a placebo once a week for four weeks, then spent time in a room filled with ragweed pollen to see if symptoms improved. The goal was to che…

This study looked at whether taking a grass pollen tablet (SLIT) together with the drug dupilumab for 2 years can help adults with moderate to severe hay fever tolerate grass pollen better, even after stopping treatment. About 199 participants were involved. The main goal was to …

This study tested whether taking a specific probiotic (Limosilactobacillus reuteri) can improve gum health in adults with braces who also have gingivitis (gum inflammation). One hundred participants either received the probiotic or no supplement. Researchers measured gum bleeding…

This study tested a nasal spray made from pistacia lentiscus oil (Bactorinol) in 120 adults with vasomotor rhinitis, a chronic condition causing nasal congestion and runny nose. Participants used the spray or a saline placebo for 20 days. The goal was to see if the oil spray impr…

This study tested two mouthwashes—a standard antiseptic (chlorhexidine) and a new one (MicroRepair ABX)—in 40 adults with gingivitis (gum inflammation). After a professional cleaning, participants used their assigned mouthwash twice daily for 14 days. Researchers measured gum ble…

This study tested a new device called Mucopad HA in 50 adults who had painful mouth sores (oral mucositis) after radiation therapy. The goal was to see if the pad is safe and helps the sores heal. Researchers measured healing time, pain levels, and dry mouth.

This study tested whether placing orange blossom essential oil inside a stoma bag can reduce odor, lessen social isolation, and help people adapt to life with a stoma. Sixty adults with a stoma took part. Researchers measured changes using a stoma adaptation scale and a social is…

This study tested two ways to teach people with gingivitis (early gum disease) how to clean their teeth better. One group watched a video, the other practiced on a dental model. After one month, both groups showed improved gum health and awareness, with no major difference betwee…

This completed trial tested the NEUROMARK device, which uses radiofrequency to disrupt nerves in the nose, against a sham (fake) procedure in 132 adults with chronic rhinitis. The goal was to see if the device could reduce symptoms like runny nose and congestion by at least 30% a…

This study tested whether shining a red LED light on mouth sores caused by radiation therapy can help them heal. 28 people with head or neck cancer who already had mild sores received a 7-minute light treatment before each radiation session. The main goal was to see if the sores …

This study tested whether a benzydamine hydrochloride (Difflam) oral spray can reduce the severity of mouth sores caused by high-dose radiation in head and neck cancer patients. Thirty-five adults receiving radiation without chemotherapy were randomly assigned to standard mouth c…

This study tested Xolair (omalizumab) in 50 teenagers aged 12 to 17 with severe seasonal allergic rhinitis (hay fever) that standard treatments couldn't control. Researchers tracked side effects and how much symptoms improved. The goal was to see if Xolair is safe and effective i…

This small study tested whether acupuncture can relieve nasal congestion in people with allergic rhinitis. Eleven adults received either acupuncture or a standard nasal spray for 6 weeks. The goal was to see if acupuncture offers a safe, side-effect-free option for stuffy noses.

This study tested whether a supplement called M-Gard can help relieve symptoms of seasonal grass pollen allergies (hay fever). Twenty healthy adults with a history of grass allergies took M-Gard or a placebo in a crossover design. Researchers measured symptom severity like nasal …

This study tested whether vitamin B12 tablets can ease painful mouth ulcers caused by braces, comparing them to a standard steroid gel (Kenalog). 82 adults with traumatic ulcers were split into two groups. Researchers measured pain and ulcer size after 4 and 8 days to see which t…

This study tested whether adding a propolis mouth rinse to standard oral care could prevent or reduce mouth sores in 60 COPD patients in the intensive care unit. Half the patients received propolis care for 15 days, while the other half got standard care only. Researchers checked…

This study tested the safety and effectiveness of Allegra D (fexofenadine plus pseudoephedrine) in 203 people aged 12 and older with allergic rhinitis. Participants took the medication for up to 13 days, and researchers tracked side effects and symptom improvement using nasal and…

This study tested a new drug called BLU-808 in 21 adults with ragweed allergies. The goal was to see if it is safe and helps reduce sneezing, runny nose, and itchy eyes caused by ragweed pollen. Participants were exposed to ragweed in a special chamber to measure the drug's effec…

This Phase 2 trial tested an injection called TQC2938, a humanized monoclonal antibody, in 136 adults with seasonal allergic rhinitis. All participants also used a standard nasal spray. The study measured how well the injection reduced nasal symptoms like sneezing and congestion …

This study tested whether apple fruit extract, which has antioxidant and anti-inflammatory properties, could improve symptoms of allergic rhinitis (hay fever). Forty adults with persistent allergies received either standard treatment plus apple extract or standard treatment alone…

This study tested whether Ectoin allergy nasal spray and eye drops can relieve symptoms of hay fever (runny nose, sneezing, itchy eyes) better than a placebo. 46 adults with ragweed allergies were exposed to pollen in a special chamber. Researchers measured symptom scores and nas…

This study tested whether mouth rinses containing the amino acids arginine or glutamine could reduce the severity of painful mouth sores caused by radiation therapy in head and neck cancer patients. 69 participants swished and swallowed these supplements three times daily during …

This study looked at 200 children aged 2 to 12 with mild to moderate croup, a viral infection that causes a barking cough and breathing trouble. Researchers compared giving the steroid dexamethasone as a pill versus an injection to see which works better for easing symptoms. The …

This study tested whether an ectoine nasal spray works better than a cromoglycic acid spray for easing allergic rhinitis symptoms like a stuffy nose, runny nose, and sneezing. Fifty adults with proven allergies used one of the two sprays for 14 days. Doctors and patients rated ho…

This study tested whether ozone therapy can help treat oral mucositis—painful mouth sores—in 38 patients receiving radiation and chemotherapy for head and neck cancer. Patients received in-office ozone gas treatment plus at-home ozonated oil products. The researchers measured cha…

This study tested two ways to protect gums during in-office teeth whitening: relative isolation (using a tray) and absolute isolation (covering gums completely). Thirty healthy adults with no cavities or gum disease took part. Researchers checked for gum irritation, tooth sensiti…

This study looked at 30 adults with braces and gum inflammation (gingivitis). Each person received two different cleanings—one side of the mouth got a newer method called Guided Biofilm Therapy (using air and powder), and the other side got the standard ultrasonic cleaning and po…

This early-stage study tested a new drug called INI-2004 in 68 healthy people and those with ragweed allergies. The goal was to check safety and how well it reduces nasal symptoms like sneezing and congestion. Researchers gave single or multiple doses and monitored side effects a…

This early-stage trial tested the safety and tolerability of a new corticosteroid nasal spray called PA9159 in 36 healthy Chinese adults. Participants received either a single dose or seven daily doses of the spray, or a placebo. The goal was to find the maximum safe dose and see…

This study tested whether a mix of two probiotics (Lactobacillus acidophilus and Limosilactobacillus reuteri) could shorten diarrhea in children aged 1 to 6 with acute infectious diarrhea. 145 children were randomly assigned to receive the probiotics or a placebo. Researchers mea…

This study tested a drug called omalizumab in 337 adults and teens with severe Japanese cedar pollen allergy (hay fever) that standard medicines couldn't control. Participants received either omalizumab or a placebo on top of their usual allergy treatments for 12 weeks. The goal …

This study tested whether the drug TAU-284 (bepotastine besilate) can reduce sneezing, runny nose, and congestion in children aged 7 to 15 with perennial allergic rhinitis (year-round nasal allergies). In a double-blind, placebo-controlled design, 473 children took either the dru…

This pilot study tested a new treatment called non-thermal plasma (NTP) for painful mouth ulcers in 50 adults. The goal was to see if NTP could speed up healing and reduce pain better than standard laser therapy or a placebo. Participants were randomly assigned to one of three gr…

This study tested a medicine called TAU-284 in 490 children aged 7 to 15 who have year-round nasal allergies. The goal was to see if it reduces sneezing, runny nose, and congestion better than a placebo. The trial was completed and focused on symptom relief, not a cure.

This study tested the long-term safety and effectiveness of TAU-284 (bepotastine besilate) in 58 children aged 7 to 15 with perennial allergic rhinitis (year-round nasal allergies). Over 12 weeks, researchers tracked side effects and changes in sneezing, runny nose, and congestio…

This study aimed to create a better nursing plan for mouth sores caused by cancer treatments like chemo and radiation. Researchers worked with 54 cancer patients to test a new care routine based on the best available evidence. The goal was to reduce mouth soreness and improve dai…

This study tested a full-mouth electronic toothbrush (FMET) to see if it reduces gum inflammation and plaque better than a regular electronic toothbrush. 94 adults with mild to moderate gingivitis used either the FMET, a conventional electronic toothbrush, or the FMET with a spec…

This study tested a new drug called LP-003 in 180 adults with moderate to severe seasonal allergic rhinitis (hay fever) that wasn't well controlled by usual treatments like antihistamines or nasal sprays. LP-003 is an antibody that blocks IgE, a key driver of allergic reactions, …

This study tested whether low level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health in people getting braces. 108 Pakistani patients aged 18-30 received either standard braces or braces plus laser treatment on their front teeth every three we…

This study tested whether a water flosser is better than an interdental brush at removing plaque and reducing gum inflammation in people with braces. 75 adults with braces used both tools on different sides of their mouth for 3 months. The goal was to see which tool cleans better…

This study tested whether a low-level laser can be used to treat painful mouth sores caused by chemotherapy or radiation in children with cancer. The laser was applied to the inside of the mouth every two days while sores were present. The main goal was to see if the treatment co…

This early-stage study tested a single dose of the investigational drug MT-2990 in 75 adults with seasonal allergic rhinitis triggered by Japanese cedar pollen. The main goals were to check the drug's safety, how the body processes it, and whether it can reduce allergy symptoms w…

This study tested a medication called STALORAL Birch 300 IR in 553 children aged 5 to 17 with birch pollen allergies. The goal was to see if it safely reduces symptoms like sneezing, runny nose, and itchy eyes during pollen season. Participants received the treatment or a placebo…

This study tested ozone therapy to treat painful mouth sores caused by radiation and chemotherapy in 58 head and neck cancer patients. Patients received professional ozone treatments at the dental clinic plus ozone-based toothpaste, mouthrinse, and gel to use at home for 15 days.…

This study tested two treatments—laser therapy and ozone gas—to relieve painful mouth sores caused by cancer treatment. Forty adults with head and neck or blood cancers took part. Each received one treatment daily for five days. The goal was to see which therapy better reduced so…

This study looked at whether children with year-round allergic rhinitis can use a nasal steroid spray only when symptoms bother them, instead of every day. Sixty-eight children aged 6 to 18 were randomly assigned to either daily use or as-needed use of fluticasone furoate spray. …

This study tested whether gargling with hawthorn vinegar, black mulberry syrup, or green tea could improve oral health and quality of life in 120 adults with diabetes who had mouth sores (mucositis). Participants used one of the three gargles three times a day for 14 days alongsi…

This study looked at how satisfied people were with at-home tooth bleaching using two different types of orthodontic retainers. Forty adults who had finished Invisalign treatment used both retainer designs and rated their experience. The goal was to see if one design caused less …

This study tested whether a specific routine—using a power toothbrush and mouth rinse twice daily—reduces gum bleeding and inflammation better than a manual toothbrush alone. 69 adults with gingivitis participated for 6 weeks. Researchers measured gum health at the start and afte…

This completed study tested whether probiotic gummies can relieve allergic rhinitis symptoms in children aged 4 to 14. Over 56 days, 72 kids took either the probiotic or a placebo, and researchers tracked nasal symptoms, quality of life, and gut health. The goal was to see if pro…

This study tested how satisfied people are with at-home teeth whitening using two different types of trays: Vivera and Essix. Forty adults with healthy teeth used a 10% carbamide peroxide gel for 2 hours a day, 3 days a week, for 4 weeks with each tray. Researchers measured satis…

This study tested two treatments for painful mouth sores caused by radiation therapy: MEBO ointment and Tantum Verde mouthwash. 36 adults with moderate to severe sores were randomly assigned to one treatment for two weeks. Researchers measured soreness and healing at the start, a…

This study tested whether a low dose of IL-2 (a protein that helps regulate the immune system) could reduce nasal symptoms in people with birch pollen allergy. Twenty-four adults with a history of seasonal allergies received either the drug or a placebo over several months. The g…

This study tested a nasal spray called AD17002 in 48 adults with house dust mite allergic rhinitis. The goal was to see if it is safe and can reduce symptoms like sneezing, runny nose, and congestion. Participants received either the spray or a placebo, and researchers monitored …

This completed trial tested a wearable headband called Sonu that uses sound waves to relieve moderate to severe nasal congestion in children aged 12 to 21. The device works by sending gentle vibrations through the skull to clear the nasal passages. Researchers measured safety and…

This study tested whether taking the allergy drug fexofenadine for two days before ragweed season can reduce symptoms like sneezing and runny nose. 95 adults with ragweed allergies were randomly given either fexofenadine or a placebo. Researchers measured nasal symptoms over six …

This study tested whether a 25% lower dose of dexamethasone (0.15 mg/kg) works as well as the standard dose (0.6 mg/kg) for treating croup in children. Croup is a viral infection that causes airway swelling and breathing trouble. The trial involved 50 children and tracked return …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…

This completed study looked at how oral health problems like cavities and gum issues affect the daily lives of 454 preschool children in Portugal. Researchers asked parents about their child's oral health and its impact on the child and family. The goal was to understand which so…

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This study looked at how bacteria in our gut change foods like leafy greens, berries, oats, and plant proteins into substances that might help prevent cancer. Seven healthy adults ate a diet rich in these foods, and researchers measured the compounds produced in their stool, bloo…

This study tested whether custom-made orthodontic molar bands, created using digital scans and 3D printing, lead to better gum health than standard pre-made metal bands. 180 teenagers getting braces were randomly assigned to one type of band. Researchers checked plaque buildup, g…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study measured levels of a protein called IL-36α in saliva and gum fluid from 80 people with gum disease, gingivitis, or healthy gums. The goal was to see if this protein is linked to gum inflammation and damage. No treatment was given; it was purely an observational study t…

This study examined how standard non-surgical gum disease treatment changes the jaw bone structure in 69 people with gingivitis or periodontitis. Researchers used fractal analysis of dental X-rays taken before and 6 months after treatment to detect subtle bone changes. The goal i…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study looked at gene activity in cells from the nose and lungs of 44 healthy and allergic adults. The goal was to understand how allergies change these cells and why the nose and lungs react differently. Researchers hope this knowledge will lead to better treatments for alle…

This study surveyed 500 parents of children with asthma or allergic rhinitis to see how much they know about air quality and pollution. The goal was to understand their awareness, knowledge, and protective behaviors. The results will help design better education and prevention pr…

This study measured two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 people with healthy gums, gingivitis, or periodontitis. Researchers collected samples before and after non-surgical periodontal treatment (deep cleaning) to see if these proteins change with treatment. The …

This completed study from Saudi Arabia surveyed 100 adult denture wearers about their knowledge of denture care and oral probiotics. Participants also had a dental exam and provided plaque samples to check for bacteria and fungi. The goal was to see how awareness and practices re…

This study looked at how a toothpaste with sodium bicarbonate (baking soda) affects the bacteria living in the mouth over 12 weeks. Seventy-four adults with mild gum inflammation (gingivitis) used either the baking soda toothpaste or a regular fluoride toothpaste. Researchers che…

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study looked at whether a home visit by an environmental counselor can improve the quality of life for children with asthma or allergic rhinitis. Researchers checked the children's health at the start and again six months after the visit using standard questionnaires. The st…

This study looked at whether gum inflammation affects the genes that control the body's daily (circadian) clock. Researchers collected gum tissue from 60 healthy adults with similar sleep habits, comparing those with healthy gums, gingivitis, or advanced gum disease. They measure…

This completed Phase 1 study tested whether two substances in the blood (sST2 and miR-223) can help predict how well patients with dust mite allergies respond to a six-month course of under-the-tongue immunotherapy (SLIT). Fifty-four patients with moderate-to-severe allergic rhin…

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This study looked at the oral health of 61 obese adults, comparing those who had bariatric surgery to those who did not. Researchers measured tooth wear, cavities, and gum disease to understand how surgery might affect the mouth. The goal was to gather information, not to test a …

This study looked at how the body naturally stops allergic inflammation after being exposed to grass pollen. Researchers measured specific molecules in the nose that help control and resolve the allergic response. Twenty adults with grass pollen allergies participated. The goal w…

This study followed 163 people who got dental implants between 1999 and 2005 to see how well the implants held up over time. Researchers checked patient satisfaction, implant survival, bone loss, and signs of inflammation. They also looked for risk factors that might lead to prob…

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This completed study checked the gum health of 226 adults with hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. Researchers measured gum pockets, bleeding, and plaque, and compared them to healthy people. The goal was to see if HS inflammation might …

This study looked at levels of two immune-related substances, fractalkine and CX3CR1, in the gum fluid of people with gingivitis or periodontitis. Researchers measured these before and after standard non-surgical gum treatment, like deep cleaning and oral hygiene advice. The goal…

This study looked at whether having better sanitation helps the oral rotavirus vaccine work better in babies. Researchers followed 261 infants in low-income areas of Maputo, Mozambique, comparing those with improved sanitation to those without. They measured immune response and c…

This completed study looked at how smoking affects gum health in 484 adults. Researchers compared current smokers to non-smokers by measuring plaque, gum bleeding, pocket depth, and gum recession. The goal was to better understand the link between smoking and periodontal disease.

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study looked at three proteins in saliva—IL-6, IL-8, and LIGHT—to see if they can tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers measured these proteins in 60 non-smoking, healthy adults (20 …

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study observed how private pediatricians in France manage allergic rhinitis (hay fever) in children under 18. Over 1,000 children participated, and researchers collected data on current treatment practices, including how many kids might be eligible for allergy immunotherapy.…

This study aimed to find the right strength of two grass allergen extracts (timothy and orchard grass) to cause a skin reaction similar to histamine. Thirty-one adults with grass pollen allergies received skin prick tests with different concentrations. The goal was to improve all…

This study looked at the free amino acids in saliva from 120 people with healthy gums, gingivitis, periodontitis, healthy implants, implant mucositis, or implantitis. Researchers wanted to see if different amino acid patterns could help tell these conditions apart. The goal is to…

This study examined 69 children aged 6 to 14 to see if a deviated nasal septum (a crooked wall inside the nose) is linked to allergic rhinitis (hay fever). Researchers compared kids with and without the deviation using allergy tests, nasal samples, and quality-of-life questionnai…

This completed study tested whether a dissolved allergy tablet (Itulazax) can be used as a nasal spray to diagnose birch pollen allergy. 89 participants received either the dissolved tablet or a saltwater spray, and their nasal symptoms and airflow were measured. The goal was to …