Mucositis

This trial tests a new oral cholera vaccine called PanChol in healthy adults aged 18 to 55 in Zambia. The vaccine is designed to be safer and more effective than current options. Researchers will monitor participants for side effects and measure their immune response after vaccin…

This study tests a new cholera vaccine (OSP:rTTHc CCV) in 390 healthy adults and children aged 1 to 45 in a region where cholera is common. The goal is to see if the vaccine is safe and triggers a strong immune response. Some participants get the vaccine with or without an adjuva…

This study in Nairobi, Kenya, is testing whether giving the oral cholera vaccine Euvichol-S at longer intervals (3 months or 12 months) works as well as the standard 2-week schedule. Over 1,000 healthy participants aged 1 year and older will be randomly assigned to one of three d…

This study tests a new oral cholera vaccine (Biovac OCV-S) to see if it works as well as a currently approved vaccine (Euvichol-Plus). About 2,824 healthy people aged 1 to 45, including some adults living with HIV, will receive two doses. Researchers will check immune responses a…

This early-stage study tests a new vaccine called IVT Shigella-04 to see if it is safe and helps the immune system fight Shigella bacteria, a major cause of severe diarrhea. About 60 healthy adults aged 18 to 49 will receive two shots of either the vaccine or a placebo. Researche…

This study tests whether a chlorhexidine mouthwash with an anti-discoloration system (ADS) can prevent gum inflammation better than a placebo. Healthy volunteers will stop brushing for three weeks and use only the mouthwash to see how well it controls plaque and gingivitis. The g…

This study tests whether an experimental toothpaste containing stannous fluoride can reduce gum inflammation and plaque buildup better than a standard fluoride toothpaste. About 110 adults with mild to moderate gingivitis will brush twice daily for 8 weeks. Researchers will measu…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This trial tests whether spirulina, a dietary supplement made from blue-green algae, can reduce the severity and pain of recurrent aphthous ulcers (canker sores). Forty adults with active mouth ulcers will receive either spirulina tablets or a placebo for a set period. Researcher…

This study tests whether an oil pulling mouthwash can reduce dental plaque, gum inflammation, and harmful bacteria better than a standard mouthwash or a placebo rinse. Healthy adults aged 18 to 70 with mild to moderate gum inflammation will use one of three rinses for a period. R…

This trial investigates whether the antiviral drug ganciclovir can help people with moderate-to-severe allergic rhinitis that doesn't improve with standard treatments. Participants receive either ganciclovir capsules or a placebo for two weeks, alongside a nasal steroid spray. Re…

This study tests a dog allergy immunotherapy called Alutard SQ Dog in 40 adults with moderate-to-severe dog allergy. Participants receive increasing doses over 13 weeks, then maintenance shots every 6-8 weeks for a year. Their symptoms and lung function are measured before and af…

This Phase 2 trial tests PollenVax, a new immunotherapy for people with moderate-to-severe allergic rhinitis caused by mugwort pollen. The treatment is given as four weekly shots before the pollen season. Researchers will compare symptom scores and medication use between the Poll…

This study tests the drug lenalidomide in 42 adults with Behçet's syndrome who have stubborn mouth ulcers. Participants take 10 mg of lenalidomide daily for 12 weeks, then stop for 4 weeks of observation. The main goal is to see if the ulcers completely disappear by week 12.

This study looks at whether vitamin D levels and supplements can reduce inflammation in people with gum disease (periodontitis or gingivitis). Researchers will measure markers of inflammation in blood and gum fluid before and after treatment. The study involves 120 adults with di…

This study looks at 100 women with infertility to see how common chronic endometritis (a long-term inflammation of the womb lining) is and whether antibiotic treatment can improve their chances of getting pregnant and having a healthy baby. Participants will have a camera test an…

This study tests a new cleaning method (air-polishing with erythritol) against standard cleaning (ultrasound) to prevent white spots on teeth and gum inflammation in 60 teens aged 12-16 who are getting braces. Participants will be followed for 2 years to see which method works be…

This study looks at whether a toothpaste with a special gum-health ingredient can improve gum health in people with gingivitis. 150 adults will use the test toothpaste for 13 weeks, then switch to a regular fluoride toothpaste for 4 weeks. Researchers will measure gum inflammatio…

This study tests whether using a smart electric toothbrush with an app and flossing can control gum inflammation as well as getting a professional dental cleaning. 92 adults with mild gum disease will be split into two groups: one uses the smart toothbrush alone, the other gets a…

This study tests whether a mouthwash made from black mulberry extract can improve gum health when used along with standard dental cleaning (scaling and root planing). Thirty adults with gingivitis will be split into two groups: one gets cleaning alone, the other adds the mulberry…

This 8-week study tests whether using a compact water flosser (Bixdo A30 Pro) along with regular toothbrushing reduces gum inflammation and plaque better than brushing alone. About 165 adults with plaque-induced gingivitis will be randomly assigned to either use the water flosser…

This study looks at whether giving antibiotics to children with a certain type of Shigella infection (non-dysentery watery diarrhea) helps them recover faster and grow better. About 700 children in Bangladesh and Zambia will receive either azithromycin or a placebo. Researchers w…

This study tests whether a special delayed-connection surgery (Turnbull-Cutait) can help people with low rectal cancer avoid a permanent colostomy bag better than the standard surgery with a temporary stoma. About 520 adults aged 18-75 with rectal cancer will be randomly assigned…

This study is testing whether adding medroxyprogesterone acetate to standard doxycycline treatment can better cure chronic endometritis and improve pregnancy outcomes in women with recurrent reproductive failure. One thousand women aged 20-45 will be randomly assigned to receive …

This study tests whether adding a daily probiotic tablet and a coenzyme Q10 toothpaste to standard gum cleaning can improve oral health in pregnant women. Forty pregnant women will be split into two groups: one gets the probiotic plus Q10 toothpaste, the other gets only the Q10 t…

This 6-month study tests whether a special antimicrobial mouthrinse can reduce plaque buildup and improve gum health in adults with gingivitis. Participants will brush and rinse twice daily and visit the clinic every 3 months. The goal is to see if the rinse helps control gum inf…

This Phase 3 trial tests whether the drug apremilast can completely clear painful mouth ulcers in people with severe recurrent aphthous stomatitis (RAS) that hasn't responded to colchicine. About 134 adults will receive either apremilast or a placebo twice daily for 12 weeks, fol…

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. One hundred survivors who finished cancer treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the pro…

This study tests whether a special dental gel (Livfresh) can improve gum health when used alongside standard deep cleaning. About 76 adults with moderate gum disease will brush with the gel twice daily for 6 months. Researchers will measure changes in gum pocket depth and bleedin…

This study tests whether a daily probiotic lozenge (SALI-10) can prevent gingivitis, a common gum disease that causes bleeding and inflammation. About 60 healthy adults will stop brushing for a short period to allow plaque buildup, then take either the probiotic or a placebo. The…

This study tests whether a gel made from enamel proteins can thicken gum tissue around dental implants. Researchers will measure gum thickness in 32 adults who need implant uncovering surgery. The goal is to see if this treatment improves gum health and implant stability.

This study tests whether adding berberine (a natural compound) to the standard antibiotic doxycycline works better than doxycycline alone for chronic endometritis, an inflammation of the uterine lining that can cause infertility. About 206 women with the condition will take eithe…

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing whether a simple online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to see if …

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

This study tests whether whole genome sequencing (looking at all DNA) finds more answers than whole exome sequencing (looking at just the protein-making parts) for children with long-lasting diarrhea and gut problems. About 180 children will be randomly assigned to one test or th…

This trial investigates whether a professional dental cleaning and instruction on proper brushing and flossing can reduce the amount of bacteria that enter the bloodstream during tooth brushing. Such bacteria can sometimes lead to infective endocarditis, a serious infection of th…

This study tests if rinsing with virgin coconut oil can prevent severe mouth sores in children and young adults (ages 7-26) getting a bone marrow transplant. About 60 participants will either use standard mouth rinses or add coconut oil to their routine. Researchers will compare …

This study tests a targeted approach to stop cholera spread in Dhaka, Bangladesh. When someone tests positive for cholera, their household and nearby neighbors (within about 20–40 meters) are offered an oral cholera vaccine. The goal is to see if this ring vaccination reduces the…

This study tests whether a dexamethasone mouthwash can prevent moderate to severe mouth sores caused by chemotherapy in adults with cancer. Participants use the mouthwash four times daily during chemo for up to 8 weeks. Researchers compare their outcomes to a historical group to …

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study tests a program called CHoBI7, which teaches handwashing, water treatment, and safe water storage to diarrhea patients and their families in Bangladesh hospitals. Researchers want to see if this program reduces diarrhea and improves hygiene behaviors compared to standa…

This study tests whether a one-time infusion of amimestrocel, made from donated umbilical cord cells, can prevent severe mouth and gut sores in people receiving a stem cell transplant. About 22 adults will get the infusion before their transplant, and researchers will monitor for…

This study tests whether a zinc-based spray (Gel X) can prevent painful mouth sores caused by radiation therapy for head and neck cancer. About 130 adults receiving radiation will use either the zinc spray or a sodium bicarbonate rinse. The goal is to see if the spray reduces how…

This study tests whether using a lactoferrin-based toothpaste and mouthwash twice daily, along with regular professional cleanings, can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one using both the toothpas…

This study tests whether low-level laser therapy can prevent severe mouth sores (mucositis) caused by chemotherapy in children and young adults aged 4 to 25. The laser is a painless, non-heating light applied to the mouth before chemotherapy. The trial is double-blind and placebo…

This study tests a daily light therapy device placed inside the mouth to prevent severe mouth sores in people receiving a stem cell transplant. Twenty adults will use the device for about 2-3 minutes each day from the start of their conditioning chemotherapy through day 20 after …

This study tests whether providing targeted water, sanitation, and hygiene (WASH) supplies and education to households of cholera patients can reduce the spread of diarrhea. About 2,900 people in South Kivu, DRC, will take part. The goal is to see if these simple measures can pre…

This study aims to see if a 7-day water, sanitation, and hygiene program can reduce cholera infections in neighborhoods where a cholera patient lives. About 3,140 people will take part, focusing on homes without running water. The program provides practical tools and education to…

This study is testing whether taking high-dose fish oil supplements during pregnancy can prevent asthma and persistent wheezing in early childhood. The trial will enroll 2000 pregnant Danish women with low blood levels of omega-3s. Participants take fish oil or placebo capsules d…

This study is testing whether taking a higher dose of vitamin D during pregnancy can prevent asthma and persistent wheezing in children up to age 3. Researchers will give 2000 pregnant women either vitamin D or a placebo daily from week 22-26 of pregnancy until one week after del…

This phase II trial tests whether adding BMX-001 to standard symptom management can reduce severe mouth sores in head and neck cancer patients receiving chemoradiation. About 98 participants will receive either BMX-001 or a placebo alongside usual care. The goal is to see if BMX-…

This study tests if Dymista nasal spray safely eases allergy symptoms like sneezing, stuffy nose, and itchy eyes in Chinese teenagers aged 12 to 17. About 100 participants will use the spray twice daily for two weeks. The goal is to see if symptoms improve, not to cure allergies.

This Phase 3 trial tests an investigational injection called SHR-1819 in adults aged 18 to 75 with seasonal allergic rhinitis (hay fever) who haven't gotten enough relief from standard treatments like nasal sprays or antihistamines. The study compares the drug to a placebo to see…

This study compares two types of stitches (NOVOSYN quick and MONOSYN quick) used in gum surgery to see if they heal equally well. About 84 adults having gum surgery will be randomly assigned one of the two stitches. The main goal is to check early healing signs like skin regrowth…

This study tests if a steroid mouthwash can prevent or reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 100 adults with advanced breast or lung cancer will use the mouthwash and be monitored for 12 weeks. The goal is to see if this simple step…

This trial tests whether alpha-lipoic acid, a powerful antioxidant, can prevent oral mucositis—painful mouth sores—caused by the chemotherapy drug 5-fluorouracil in colorectal cancer patients. Half of the 50 participants will take alpha-lipoic acid twice daily for six months, whi…

This phase II trial tests whether a plant-derived supplement called chlorophyllin can reduce severe mouth sores caused by high-dose radiation given before a stem cell transplant. People aged 12 to 65 with blood cancers who need total body irradiation as part of their transplant p…

This trial investigates whether Yupingfeng Powder, a traditional Chinese herbal formula, can improve symptoms and quality of life in adults with allergic rhinitis (hay fever). Participants will take the herbal granules or a placebo twice daily for 8 weeks, with follow-up for anot…

This early-stage trial tests an experimental RNA immunotherapy called ITI-9001 in adults with Japanese cedar pollen allergy. The treatment aims to retrain the immune system to reduce allergic reactions. Researchers are primarily checking safety and how well people tolerate the sh…

This study tests whether taking taurine granules before daily radiation can reduce painful mouth sores and skin burns in 160 head and neck cancer patients. Half get taurine, half get a placebo, and researchers track side effect severity. If effective, it could offer a simple, low…

This study tests a mouth rinse called MucoLock for people with ongoing mouth pain or burning sensation (stomatitis). About 25 adults will swish the rinse for 5 minutes, three times a day, for 28 days. Researchers will measure changes in pain scores and quality of life to see if t…

This phase 3 trial tests whether a lozenge called BupiZenge, which contains the long-acting painkiller bupivacaine, can relieve mouth pain from radiation therapy better than the standard lidocaine rinse. About 150 adults with head and neck cancer will be randomly assigned to one …

This clinical trial tests whether a doxepin solution spray can relieve severe breakthrough pain when swallowing, a common side effect of radiation therapy for nasopharyngeal carcinoma. About 178 patients will be randomly assigned to receive either the doxepin spray or a placebo s…

This study is testing four medical devices (PIR, NS, NHE, NHG) in 150 adults with acute viral rhinitis, rhinosinusitis, or rhinopharyngitis (common cold). The goal is to see if they are safe and help reduce symptoms like sneezing, runny nose, and sore throat. Participants use the…

This study is testing an oral spray called OROSEDAL to see if it helps relieve pain from sore throats, canker sores, and other minor mouth lesions. About 124 children and adults will use the spray as prescribed and report their pain levels over 6 days. The spray works by forming …

This study is testing a serious video game designed to improve emotional well-being in teenagers aged 12 to 16, both with and without chronic conditions like type 1 diabetes, asthma, and allergies. The game uses artificial intelligence to personalize activities that build coping …

This study tests whether a special toothpaste can improve gum inflammation (gingivitis) in adults. Sixty participants with moderate gum inflammation will use either the test toothpaste or a regular one for 4 weeks. Dentists will check gum health at the start and end to see if the…

This study tests whether a daily probiotic supplement called BioAmicus Complete can help infants with colic, constipation, diarrhea, and eczema. 140 babies will receive either the probiotic drops or a placebo (sunflower oil) for 25 days. Researchers will track changes in stool, c…

This phase 3 trial tests whether Houyanqing Oral Liquid, a Chinese herbal mix, can prevent or reduce severe mouth sores caused by radiation therapy in 386 nasopharyngeal cancer patients. Participants take the liquid four times daily during radiation, alongside standard care. The …

This study tests whether folic acid supplements can reduce mucositis (painful sores in the mouth, nose, throat, or other areas) in people with advanced kidney cancer who are on targeted therapy or immunotherapy. About 100 participants will receive either folic acid or a placebo, …

This study tests a device called NOVOCLEAR™ that uses pulsed energy to treat chronic rhinitis, a condition causing long-term runny nose, congestion, itching, and sneezing. The treatment targets nerves in the nose to reduce symptoms. Researchers will enroll 30 adults who haven't g…

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study tests whether a mobile app that sends daily push notifications can help teenagers wearing braces improve their oral hygiene. Braces make it harder to clean teeth, leading to plaque buildup and gum problems. Researchers will compare three groups: app with reminders, app…

This study tests whether a diet low in saturated fats and rich in whole grains, fruits, and vegetables can reduce the severity of atopic dermatitis (eczema) in young adults. Researchers will track changes in skin symptoms and barrier function over two months. The goal is to see i…

This study tests an injection called TQH2722 in 300 adults with seasonal allergic rhinitis (hay fever). The goal is to see if it safely eases symptoms like sneezing, stuffy nose, and itchy eyes when added to standard allergy treatments. Participants will receive the injection and…

This study tests a traditional Chinese herbal oral solution and mouthwash to see if they can shorten the time head and neck cancer patients suffer from severe mouth sores caused by radiation therapy. About 128 adults aged 18-65 with non-metastatic head and neck cancers will recei…

This phase 2 trial tests whether a traditional Chinese medicine oral liquid and mouthwash can prevent or reduce severe mouth sores caused by radiation therapy in head and neck cancer patients. About 118 adults aged 18-65 will receive either the herbal treatment or a placebo along…

This study tests whether applying medical ozone gas to mouth sores can reduce pain and severity in people undergoing radiation or chemotherapy for head and neck cancer. Fifty participants will receive ozone therapy, and half will also use a special toothpaste and mouthwash at hom…

This study tests whether a mobile app can help people with allergic rhinitis (hay fever) stay on their allergy immunotherapy (allergy shots or under-the-tongue drops) for the full 3 years. Many people stop early, reducing the treatment's effectiveness. The app provides reminders …

This study tracks how adults with grass pollen allergy use Grassmuno® in everyday medical practice. Researchers will monitor treatment adherence and injection schedules over two years. The goal is to understand how well patients stick with the therapy and how it controls their sy…

This study tests whether high-level laser therapy can help manage oral mucositis—painful mouth sores—in children under 18 who are having a bone marrow transplant. Fourteen participants will receive either laser treatment or standard mouth care (chlorhexidine and sodium bicarbonat…

This study tests a new method for treating cat allergies called intralymphatic immunotherapy (ILIT), where allergen extracts are injected directly into a lymph node. Thirty-six adults with cat-triggered allergic rhinitis and asthma will receive 3-4 ultrasound-guided injections. T…

This study tests whether toothbrushes with tapered bristles are better at removing plaque and reducing gum bleeding than regular round bristles, without causing scratches. About 70 adults with gum disease will use one of two toothbrushes at home for 4 weeks. Researchers will chec…

This study tests whether adding amino acids to the standard rehydration drink can help children aged 6 months to 5 years recover faster from acute gastroenteritis (stomach flu). About 72 kids with mild to moderate diarrhea will receive either the fortified drink or standard oral …

This study tests if a special light treatment, called photobiomodulation, can reduce the severity and frequency of painful mouth sores in oral cancer patients receiving radiation therapy. About 30 adults who have had surgery for oral cancer will receive the light treatment five t…

This study tests whether a pure green tea mouthwash can reduce dental plaque and gum inflammation better than a placebo or essential oils mouthwashes like Listerine. About 44 healthy adults will rinse with their assigned mouthwash twice daily for 3 weeks, avoiding all other oral …

This study tests a new under-the-tongue treatment (MM09) for people with rhinitis or rhinoconjunctivitis caused by house mite allergy, with or without mild asthma. About 736 participants aged 12 to 65 will receive either MM09 or a placebo to see if it reduces allergy symptoms and…

This study tests whether smelling lavender essential oil during awake ear, nose, and throat procedures can lower anxiety and pain. About 184 adults will be randomly assigned to receive either lavender aromatherapy or a placebo (odorless liquid). Participants will rate their anxie…

This study tests whether gargling with olive oil can reduce painful mouth sores caused by radiation or chemotherapy in head and neck cancer patients. About 120 adults will either use olive oil mouthwash or receive standard care for 12 weeks. Researchers will track soreness, dry m…

This study tests whether a hydrogen peroxide mouth rinse called OROXID can help treat gingivitis, a common gum inflammation. About 90 adults with mild gum disease will use the rinse twice daily for 4 weeks, alongside regular brushing. Researchers will measure changes in gum infla…

This study looks at how well seawater nasal sprays work in everyday life for people with nasal and sinus issues like colds, allergies, or after surgery. About 1065 people of all ages, including pregnant women, will use the sprays and report their symptoms. The goal is to see if t…

This study tests whether a daily probiotic blend can improve quality of life for adults with persistent allergies to dust mites, cats, or dogs. For 12 weeks, 98 participants will take either the probiotic or a placebo and track their symptoms and antihistamine use. The goal is to…

This study is testing a seawater spray mixed with essential oils to see how well it relieves nasal congestion from colds, sinus infections, or allergies. About 114 people aged 12 and older will use the spray for 7 days. The main goal is to see if nasal blockage improves after 3 d…

This study tests whether taking rice bran supplements can reduce severe mouth sores caused by radiation therapy in head and neck cancer patients. About 80 adults receiving radiation will take rice bran during treatment to see if it lessens pain and improves quality of life. The g…

This study tests whether applying low-level laser light to the gums after tooth extraction and socket preservation can improve healing and reduce pain. About 39 adults will receive either standard care or standard care plus laser treatment on days 1, 3, and 7 after surgery. Resea…

This study tests a new nasal spray called ALDP001 for people with seasonal allergic rhinitis (hay fever). Researchers want to find the best dose and how often to use it to reduce symptoms like sneezing, stuffy nose, and runny nose. About 164 adults will take part, and their sympt…

This study is testing a new seawater spray with essential oils to see if it safely relieves nasal congestion from colds, sinus infections, or allergies. About 101 people aged 12 and older will use the spray for 8 days. The main goal is to check if nasal stuffiness improves by at …

This study tests a new antibody drug for people whose seasonal allergies (hay fever) are not controlled by standard treatments. The drug targets a protein involved in allergic inflammation. About 120 adults will receive either the antibody or a placebo, and researchers will measu…

This study tests whether an oxygenated gel can reduce pain and speed up healing of canker sores (aphthous ulcers) compared to a standard steroid gel. Thirty adults with a single small ulcer will apply the gel twice daily for 7 days. Researchers will check pain levels and ulcer si…

This phase 3 trial tests whether a new drug called DW1807 works better than another drug (DW1807-R2) for people with year-round allergic rhinitis who also have asthma. About 274 adults will take one of the two drugs daily for 4 weeks. The main goal is to see if DW1807 improves na…

This Phase 3 trial tests an injection called GR1802 for people with seasonal allergic rhinitis (hay fever) that is not well controlled by standard treatments. The drug is a lab-made antibody that blocks a key inflammation signal. About 150 adults will receive either GR1802 or a p…

This study tests an injection called SHR-1819 in 100 adults with seasonal allergic rhinitis (hay fever). Participants will receive either the drug or a placebo to see if it reduces daily nasal symptoms like sneezing and stuffiness. The trial is double-blind, meaning neither patie…

This study looks at how fixed versus removable orthodontic retainers influence the types of bacteria living in the gum pockets and overall gum health. Ten adults who have finished braces will be split into two groups: one gets a fixed retainer bonded to the back of the teeth, the…

This study examines a possible connection between gum disease and chronic neck pain. Researchers will compare neck pain intensity and daily disability among adults aged 30-55 with healthy gums, gingivitis, or periodontitis. Participants complete pain scales and questionnaires to …

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This study follows 100 adults with healthy gums or various stages of gum disease over two years. Researchers will collect saliva and plaque samples at yearly visits to measure specific biomarkers. The goal is to see if these markers can predict who will develop or worsen gum dise…

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study looks at fluid from the gums of 80 people with gingivitis—half children aged 8-12, half young adults aged 15-24. Researchers will measure inflammation markers to see if they differ by age. The goal is to understand how gum disease develops during growth and puberty.

This study collects dental plaque and checks oral health in 100 adults with high plaque levels. Half have mild gum inflammation, half have moderate-to-severe gingivitis. Researchers will compare the types of bacteria in plaque to understand why some people develop gum disease and…

This study tests a printed decision aid that helps people with chronic hypertrophic rhinitis compare five surgical options. About 158 participants will either get standard counseling or the extra aid. Researchers will measure how certain patients feel about their choice and wheth…

This study in Bauchi, Nigeria, is testing whether giving free Oral Rehydration Salts (ORS) and zinc directly to homes can increase how often these treatments are used for children under 5 with diarrhea. Over 100,000 children are taking part, with some areas receiving the medicine…

This study looks at 1,000 women undergoing IVF to understand how tiny organisms in the womb (the microbiome) may cause chronic endometritis, a condition that can harm fertility. Researchers will collect samples from the vagina and womb to compare the microbes in women with and wi…

This study checks how often two tiny parasites (Entamoeba gingivalis and Trichomonas tenax) are found in the mouths of people with and without gum disease. Researchers will collect spit and plaque samples from 120 adults and look at them under a microscope. The goal is to learn i…

This study is looking for 530 adults with hay fever in South-Eastern Australia to help create a tool that predicts thunderstorm asthma. Participants will have allergy and lung function tests, then track their symptoms during spring for two years. The goal is to find warning signs…

This study is testing whether a nasal allergen provocation test (NAPT) can help doctors start and monitor allergy immunotherapy more effectively. Researchers will follow 200 adults with allergic rhinitis who are beginning immunotherapy, using the NAPT along with blood tests and s…

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study aims to find biological markers in saliva, gum fluid, and tissue that can predict which people with mild gum inflammation will develop serious periodontitis. Researchers will use advanced techniques to analyze samples from 228 adults aged 18-40 with gingivitis or early…

This study looks at two proteins, Gas6 and sMerTK, in the fluid around teeth to see if they differ between healthy gums, gingivitis, and periodontitis. Researchers will collect samples from 90 adults and measure these proteins. The goal is to better understand the biology of gum …

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth sores in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal i…

This study looks for immune markers that show whether a person is protected from cholera after vaccination or natural infection. About 1,200 people will receive either a cholera vaccine or a typhoid vaccine (as a comparison) and give blood samples over two years. The goal is to f…

This study uses a special high-frequency ultrasound to take detailed images of gum tissue. Researchers will compare healthy gums to gums with gingivitis (early gum disease) to see if the ultrasound can detect inflammation. About 40 adults will participate, and the goal is to find…

This study looks at how different oral hygiene routines (including mouthwash) affect gum health, mouth bacteria, and inflammation in people with gingivitis. About 250 adults will use assigned products twice daily for 4 weeks, then stop for 2 weeks to see how their gums and microb…

This study looks at how standard gum disease treatments—deep cleaning with or without a special mouthwash—change proteins in your saliva and affect blood vessel health. Researchers will study 30 adults with gum disease to see if these treatments help or harm the good bacteria tha…

This study looks at 1,000 children (ages 5-18) with dust mite allergies to see if customizing allergy shots based on their specific mite protein sensitivities leads to better symptom control. Participants get a detailed blood test to map their allergy profile and are followed for…

This study explores whether people who seek help for both their allergies and their mental health (like anxiety or depression) have better control over their symptoms. Researchers will look at health records from 200,000 adults over several years. The goal is to understand if com…

This study looks at how indoor air and dust pollutants in classrooms impact children's allergies and lung function. Researchers will monitor 100 children, comparing those with allergies to those without, using questionnaires, allergy tests, and breathing tests. The goal is to ide…

This long-term study follows 1,000 people with eczema and related allergies, plus healthy volunteers, to see what factors help the disease go into remission. Researchers will collect medical and lifestyle data to find patterns and possible biomarkers. The goal is to better unders…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study observes 100 adults aged 20–40 who are having nose surgery (septorhinoplasty) to see if the length of time nasal packing is left in place affects the development of sore throat or pharyngitis. Participants will have their sore throat, swallowing difficulty, and throat …

This study is testing whether a simple symptom score questionnaire (SCST) is acceptable and useful for patients with allergic rhinitis during ENT check-ups. The goal is to see if this tool helps doctors monitor severity and response to treatment consistently. Thirty adults will p…

This study is looking at whether certain markers in blood and saliva can predict how well people with gum disease heal after non-surgical treatment. Researchers will measure these markers in 180 adults with healthy gums, gingivitis, or advanced periodontitis before and after trea…

This study aims to develop a better way to measure oral health using photographs and imaging software, rather than traditional dental exams. About 275 adults will use different toothpastes or mouthwashes for up to 6 months, and researchers will track plaque levels, gum health, an…

This study looks at how inflammation in the gums affects the body's immune response during wound healing after a tooth is pulled. Researchers will measure gum health before extraction, take small tissue samples right after and again two weeks later, and check healing at three mon…

This study looks at how the natural bacteria in your mouth might influence the effectiveness of radiation therapy for head and neck cancer. Researchers will collect saliva samples from 100 patients before, during, and after treatment to analyze the bacteria and viruses present. T…

This study looks at why people's gums respond differently to the buildup of dental plaque. Researchers will monitor 80 healthy adults aged 18-35 as they stop brushing for a period to allow plaque to grow naturally. The goal is to identify the biological reasons behind varying lev…

This study follows 368 mothers and their babies in Zimbabwe from pregnancy until the child turns 3. Researchers want to understand how malnutrition, poor water and sanitation, and gut problems affect child growth, infections, and development. They will measure gut bacteria, immun…

This study looks at 60 children with congenital diarrhea and enteropathy (CODE) in China. Researchers will collect medical history, blood, and stool samples to find biological markers and build a risk prediction model. No new treatment is being tested; the goal is to better under…