Cleaner toilets, stronger vaccine? study tests Sanitation's role

NCT ID NCT03313128

Completed Knowledge-focused Sponsor: London School of Hygiene and Tropical Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether having better sanitation helps the oral rotavirus vaccine work better in babies. Researchers followed 261 infants in low-income areas of Maputo, Mozambique, comparing those with improved sanitation to those without. They measured immune response and checked for gut infections and inflammation that might interfere with the vaccine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could show that improving sanitation helps rotavirus vaccines work better in low-income settings.
What could go wrong: This is an observational study, not a treatment trial. Results may not prove cause and effect, and findings may not apply to other regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intestinal infectious disease Rotavirus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENTERIC INFECTIONS ENVIRONMENTAL ENTERIC DYSFUNCTION ROTAVIRUS INFECTIONS

Contacts and locations

Locations

Centro de Investigação em Saúde da Polana Caniço (CISPOC)

Maputo, 264, Mozambique

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