COLORECTAL CANCER

This study tests whether adding TAS-102 to fruquintinib helps people with advanced colorectal cancer live longer without their disease getting worse. About 120 adults whose cancer has not responded to standard treatments will be randomly assigned to receive either the drug combo …

This study tests whether a combination of two chemotherapy drugs (trifluridine/tipiracil and irinotecan) can clear leftover cancer DNA from the blood of people with colon cancer after surgery. About 22 adults whose blood still shows signs of cancer after standard treatment will r…

This study tests a new drug called BOLD-100 combined with standard FOLFOX chemotherapy in people with advanced colorectal, pancreatic, stomach, or bile duct cancers. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. About 220 adults whose …

This study tests whether using chlorhexidine (an antiseptic) to flush the surgical area during colorectal cancer surgery works better than using saline (salt water) to prevent infections and other complications. About 532 adults aged 18-85 with operable colorectal cancer will tak…

This early-phase study tests a new drug called PT0511 in adults with advanced solid tumors that have a KRAS mutation or amplification, including colorectal, pancreatic, and lung cancers. The main goals are to check safety, find the best dose, and see how the drug works alone or w…

This study tests a combination of two or three drugs (cabozantinib, durvalumab, and possibly tremelimumab) in people with advanced stomach, esophageal, liver, or colorectal cancer that cannot be removed by surgery. The goal is to find the safest dose and see if the treatment can …

This study tests a new vaccine made from engineered bacteria that targets KRAS mutations in colorectal and pancreatic cancer. It is given after surgery and chemotherapy to patients at high risk of recurrence. The goal is to see if the vaccine is safe and can help prevent the canc…

This study tests whether adding a combination of two antibiotics and aspirin to standard chemotherapy can help people with stage IV colorectal cancer. About 97 participants will receive either chemo alone or chemo plus the microbiome therapy. The goal is to see if the added treat…

This early-phase study tests an experimental drug called MRG007 in people with advanced solid tumors (like colorectal, gastric, or pancreatic cancer) that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects, while also seei…

This study tests two experimental drugs, elironrasib and daraxonrasib, alone or together, in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if these drugs are safe and can shrink or control tumors. About 534 adults with lung, colorec…

This study tests a new drug, APL-5125, in about 100 adults with advanced solid tumors like colorectal, pancreatic, and breast cancer that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink or control tumors. The trial has two pha…

This study tests whether adding radiotherapy to a drug combination (fruquintinib and sintilimab) can help control colorectal cancer that has spread to the liver and hasn't responded to two prior treatments. About 62 adults with a specific cancer subtype (MSS/pMMR) will be randoml…

This study is testing several new experimental drugs called RAS(ON) inhibitors, alone or with standard chemotherapy, in people with advanced colorectal or pancreatic cancer that has spread. About 1,130 adults will participate to see if these combinations are safe and can shrink t…

This early-stage trial tests an investigational drug called JR8603 in about 94 adults with advanced solid tumors (including stomach, junction, and colorectal cancers) whose prior treatments have stopped working. The main goals are to check safety, find the best dose, and see if t…

This study tests a new drug, MGC026, in 250 adults with advanced solid tumors that have not responded to other treatments. The goal is to check the drug's safety, find the right dose, and see if it can shrink tumors. Participants receive the drug by IV and are closely monitored f…

This study tests whether two drugs, fruquintinib and tislelizumab, can control colorectal cancer in people who still have signs of cancer cells in their blood after finishing chemotherapy. About 20 adults with stable disease will receive the combination to see if it is safe and c…

This study looks at people with colorectal cancer that spread to the liver. After successful liver surgery and a good response to initial chemotherapy, half the participants will restart chemotherapy (FOLFIRI) and half will receive no further treatment. The goal is to see if rest…

This early-stage study tests a new treatment called IVX037, a virus injected directly into tumors, for people with advanced colorectal, stomach, or ovarian cancers that have stopped responding to standard treatments. The study has two parts: first, testing IVX037 alone, then comb…

This study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer). The goal is to find a safe dose and see if it can shrink tumors. About 216 adults with tumors that have sp…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy and targeted therapy can help people with a specific type of advanced colorectal cancer live longer without their disease getting worse. The trial enrolls 238 adults whose cancer has spre…

This early-phase study tests a new drug called BL-M17D1 in about 20 people with advanced HER2-positive or low-HER2 cancers of the digestive tract (esophagus, stomach, pancreas, colon) and other solid tumors. The main goals are to check safety, find the best dose, and see if the d…

This phase 3 study tests whether a combination of three drugs (tucidinostat, sintilimab, and bevacizumab) can help people with a specific type of advanced colorectal cancer (MSS/pMMR) live longer. Participants must have already tried at least two standard treatments without succe…

This early-phase study tests a new treatment called GCC19CART for people with advanced colorectal cancer that has come back or not responded to standard therapies. The treatment uses a patient's own immune cells, modified to target a protein found on cancer cells. The main goals …

This study tests a new drug called SHR-8068 combined with other cancer treatments for people with colorectal cancer. The goal is to see if the combination is safe and helps shrink or control tumors. About 200 adults aged 18 to 75 with good performance status are being recruited.

This study tests whether adding an experimental drug (ONO-4578) to a standard chemotherapy and immunotherapy regimen can shrink tumors better than current treatment in people with advanced colorectal cancer that has not spread widely. About 144 adults whose tumors show a specific…

This study tests whether adding an immune-boosting drug (PDS01ADC) to standard liver-directed chemotherapy can help people with certain cancers that have spread to the liver. About 70 adults with colorectal, bile duct, or adrenal cancer will receive treatment through a pump place…

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two immunotherapy drugs (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if…

This study tests whether a single, high-dose session of MRI-guided radiation can control colorectal cancer that has spread to the liver. About 32 adults with up to 3 small liver tumors will receive this treatment. Researchers will track tumor growth, side effects, and look for MR…

This early-stage study tests a new oral medication, PF-08032562, in people with advanced breast or colorectal cancer that has spread. The goal is to find the safest dose and see if it works alone or with other cancer treatments. About 260 adults will take the pill daily in 28-day…

This study tests a drug called tislelizumab in 40 people in Nigeria who have a specific type of colorectal cancer (mismatch repair deficient) and have not had treatment before. The goal is to see if the drug can shrink tumors and is safe. It is a phase 2 trial, meaning it is stil…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment will take the drug al…

This study tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers (like breast, stomach, lung, or ovarian cancer) that have worsened after at least one prior treatment. The goal is to see if the drug can shrink tumors and how long that effect last…

This study is for people with colorectal cancer that has spread to the lining of the abdomen and has not responded to first-line treatment. It compares standard second-line therapy alone versus standard therapy plus a special type of radiotherapy guided by a PET scan and an immun…

This study tests a cancer drug (PD-1 antibody) given before surgery to people who have two or more colorectal cancers at the same time. Some participants will also get chemotherapy. The goal is to see if the drug can shrink or eliminate the tumors, making surgery more effective. …

This early-phase study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. AGX101 is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to find the safest dose and to check for sid…

This study tests different combinations of immunotherapy drugs (with or without radiation) in 24 people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these combinations can change the immune environment inside the liv…

This study tests a drug called futibatinib combined with other cancer treatments (like immunotherapy or chemotherapy) in people with advanced colorectal cancer that cannot be removed by surgery. The goal is to see if the combination can shrink tumors and how safe it is. About 33 …

This study looks at whether adding an immunomodulator (a drug that helps the immune system) to standard cancer treatments can improve survival for people with colorectal cancer. Researchers will review medical records of 250 adults who started treatment between 2020 and 2024. The…

This early-phase study tests a new drug called 177LuBetaBart in people with advanced solid tumors that have stopped responding to standard treatments. The drug is a radioactive antibody designed to seek out and destroy cancer cells. The study will check for safety and side effect…

This study compares two ways to remove large, flat colon growths (LST-G type) that can turn into cancer. About 282 adults will be randomly assigned to get either standard snare removal (EMR) or a more precise dissection (ESD). The goal is to see which method better prevents the g…

This study looks at whether giving chemotherapy after all visible tumors have been removed or destroyed can help people with metastatic colorectal cancer live longer without the cancer coming back. About 507 adults whose cancer has spread but has been fully treated will be random…

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another c…

This study tests an experimental drug, LY3962673, in people with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a specific genetic change called KRAS G12D. The main goals are to check the drug's safety and see if it can shrink tumors, both alone and…

This study tests whether a blood test that detects tumor DNA can help doctors decide how long chemotherapy should last for people with certain types of colorectal cancer. About 340 adults with stage II or low-risk stage III colorectal cancer will be randomly assigned to standard …

This early-phase study tests a new treatment called Anti-CEA CAR-T for people with advanced solid tumors (like colorectal or stomach cancer) that have not responded to standard therapies. The treatment uses a patient's own immune cells, modified to target a protein called CEA fou…

This study is for people with colorectal cancer that can be removed by surgery. Before surgery, participants will receive a short course of targeted drugs chosen based on their tumor's specific genetic makeup. The goal is to see if this approach can shrink or eliminate the cancer…

This early-phase study tests a new treatment called PeptiCRAd-1, a virus designed to train the immune system to attack cancer cells, combined with the immunotherapy drug pembrolizumab. About 15 adults with certain advanced solid tumors (like melanoma, lung cancer, or sarcoma) wil…

This study tests an experimental drug called MCLA-129 in people with advanced solid tumors, including lung, head and neck, and colorectal cancers that have stopped responding to standard treatments. The drug is a bispecific antibody designed to target two cancer-related proteins …

This study tests a combination of two treatments (fruquintinib plus FOLFIRI) in people with metastatic colorectal cancer whose disease has worsened after first-line therapy. About 60 participants will receive the drug combo to see if it can stop or slow cancer growth. The goal is…

This study tests a combination of two approved drugs, anlotinib and sintilimab, as a first treatment for people with advanced colorectal cancer that has spread but not to the liver. The goal is to shrink or control the cancer while avoiding standard chemotherapy. The trial enroll…

This study looks at whether drinking instant coffee every day for 6 weeks can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. About 80 adults who completed surgery, chemo, or radiation at least 2 months ago will par…

This study tests whether adding celecoxib to TAS-102 can clear tiny amounts of cancer DNA left in the blood after standard chemotherapy for colorectal cancer. About 25 adults who have finished initial treatment but still have signs of cancer in their blood will take part. The goa…

This study tests a new surgical technique called Q-ISR that tailors the removal of rectal cancer based on where the tumor is located. It involves 100 adults with ultra-low rectal cancer who will be randomly assigned to receive Q-ISR, a partial removal, or a total removal of the a…

This study tests whether adding a GSL synthetase inhibitor (eliglustat) to standard immunotherapy and/or regorafenib can shrink tumors or slow cancer growth in people with advanced colorectal cancer that has not responded to at least two prior treatments. About 120 adults with a …

This early-stage trial tests a combination of specially engineered immune cells (TROP2-CAR-NK cells) and a targeted drug (cetuximab) in people with colorectal cancer who have minimal residual disease—tiny amounts of cancer left after treatment. The goal is to find the safest dose…

This study compares robot-assisted surgery to traditional open surgery for people with colon cancer on the right side of the colon. The goal is to see if the robot approach can remove the cancer just as completely, while possibly causing fewer complications and shortening hospita…

This study tests an experimental pill, VVD-133214, in people with advanced solid tumors that have a specific genetic feature called MSI or dMMR. The drug targets a protein (Werner) that helps these cancers grow. The main goal is to check safety and find the right dose, with up to…

This study tests a procedure called pulmonary suffusion, which delivers chemotherapy drugs like cisplatin directly to the lungs through a minimally invasive method. The goal is to control any remaining cancer cells after surgery or ablation in patients with sarcoma or colorectal …

This early-stage study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells and boost the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatments.…

This study tests three experimental treatments for people with advanced esophageal, stomach, or colorectal cancers that have spread. The goal is to see if these drug combinations can shrink tumors and how safe they are. About 376 adults aged 18 to 75 will participate. The treatme…

This study tests a combination of two drugs, fruquintinib and serplulimab, in people with advanced colorectal cancer that has spread to areas other than the liver and has not responded to standard treatments. The goal is to see if this combination can shrink tumors or slow the di…

This early-phase study tests a new drug called IBI3028 in people with advanced solid tumors that cannot be removed by surgery or have spread. The main goals are to find a safe dose and understand side effects. About 493 adults with certain cancers like colorectal, lung, or pancre…

This study tests a new drug called MK-2870, alone or with other cancer treatments, in people with advanced colorectal, pancreatic, or bile duct cancers that have spread or can't be removed by surgery. The main goals are to check the drug's safety and see if it can shrink tumors. …

This study tests a new drug, telisotuzumab adizutecan, against standard treatments in about 140 adults with colorectal cancer who have completed initial chemotherapy and show no visible tumors, but still have cancer DNA in their blood. The goal is to see if the new drug can delay…

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 80 participants will receive the drug through an IV, and r…

This early-stage study tests a new drug called IDE034 in about 150 adults with advanced solid tumors (like lung, ovarian, or colon cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink …

This early-stage study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, or related mutations). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. …

This study tests a new device called ColoSeal ICD that is placed inside the colon after surgery for rectal or rectosigmoid cancer. The device is designed to protect the surgical connection from stool for up to 21 days, helping it heal and reducing the risk of leaks. About 15 adul…

This early-stage study tests a new drug called RGT-61159 in people with adenoid cystic carcinoma or colorectal cancer that has returned or stopped responding to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors…

This study tests a new technique called In Vivo Lung Perfusion (IVLP) that delivers chemotherapy directly into one lung during surgery to remove lung tumors. The goal is to kill any remaining cancer cells while reducing side effects on the rest of the body. About 10 adults with c…

This early-phase trial tests a combination of immune cells (DC-CIK), a bispecific antibody, and a targeted drug as a third-line treatment for advanced colorectal cancer. It enrolls 14 adults who have failed standard therapies. The goal is to see if this triple therapy can shrink …

This study tests whether a combination of two drugs (botensilimab and balstilimab) can clear leftover cancer DNA in people with colorectal cancer who still have signs of disease after surgery and chemotherapy. About 284 adults with a specific type of colorectal cancer (MSS) will …

This study tests whether a 6-month diet change can reduce inflammation and improve metabolism in obese adults who have had colon polyps. Participants and their household partners will follow a special diet and provide blood and stool samples. The goal is to see if diet can lower …

This study tests whether giving two targeted drugs (encorafenib and cetuximab) before surgery can shrink tumors in people with a specific genetic mutation (BRAF V600E) in localized colon or upper rectal cancer. About 30 participants will receive the drug combination for a short t…

This study tests a device called xBar that monitors healing after colorectal cancer surgery. About 80 adults having low anterior resection will use the system, which tracks recovery in real time. The goal is to see if it reduces complications and helps more patients avoid a tempo…

This early-stage study tests a new radioactive drug, [177Lu]Lu-NNS309, in adults with advanced pancreatic, lung, breast, or colorectal cancers that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink t…

This study tests an experimental drug called YL202 in about 100 people with advanced solid tumors, including lung, colorectal, and cervical cancers that have not responded to other treatments. The main goal is to see if the drug can shrink tumors, while also checking for side eff…

This early-stage study tests a new drug called M9140 in people with advanced colorectal cancer that has not responded to standard treatments. The drug works by attaching a chemotherapy agent to an antibody that seeks out cancer cells. The study aims to find the safest dose and se…

This study tests a new way of giving chemotherapy to people with certain gastrointestinal cancers, like colorectal or stomach cancer. The approach adjusts the dose of one chemotherapy drug (5-FU) based on how well each person tolerates the starting dose. The goal is to see if thi…

This early-phase trial tests whether adding low-dose radiotherapy to standard immunotherapy and chemotherapy is safe for people with colorectal cancer that has spread only to the liver. About 9 to 18 adults who have not had prior treatment will receive the combination. The main g…

This study tests a new drug, ALE.P03, that delivers a cancer-killing agent directly to tumor cells with a specific marker (CLDN1). It is for adults with advanced or metastatic cancers of the cervix, lung, colon, bile duct, or bladder that have not responded to standard treatments…

This study tests a chemotherapy-free treatment for people with a specific genetic form of colorectal cancer (KRAS G12C mutation) that has spread locally or to a few spots that can be removed. About 40 participants will take two drugs (fulzerasib pills and cetuximab shots) for two…

This study tests a new combination of three drugs (trastuzumab-deruxtecan, capecitabine, and bevacizumab) as a first treatment for people with HER-2 positive colorectal cancer that has spread or cannot be removed by surgery. The goal is to see how many patients' tumors shrink or …

This study tests whether a blood test that detects cancer DNA can help doctors decide on the best chemotherapy for people with high-risk stage II colorectal cancer. About 340 patients who still have cancer DNA in their blood one month after surgery will receive different chemothe…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This early-stage study tests a new drug, enzelkitug, given alone or with standard immunotherapy drugs, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety and find the right dose. About 450 adults with cancers like lung, …

This study tests whether two immunotherapy drugs, cemiplimab alone or combined with fianlimab, can eliminate tumors in older adults (age 70+) or those unfit for surgery with a specific genetic type of colorectal cancer (MSI-H). The goal is to achieve a complete response, meaning …

This study tests a new drug called SIM0610 in adults with advanced solid tumors (cancers that have spread). The main goals are to check safety and find the right dose. About 260 people with certain cancers like lung, colon, head and neck, or liver cancer can join. The study has t…

This early-phase study tests a new treatment called PTC13, which uses a patient's own immune cells (T-cells) engineered to attack cancer cells that have a protein called CEA. The study includes adults with advanced colorectal, stomach, pancreatic, or other solid tumors that have …

This study tests an experimental oral drug called NEO212 in adults with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it can slow tumor growth. About 134 participants will receive NEO212 a…

This study tests a vaccine called PD1-Vaxx given before surgery for people with a specific type of colorectal cancer (MSI-high). The goal is to see if the vaccine can shrink or eliminate the tumor before it is removed. 44 participants will receive three doses of the vaccine befor…

This early-phase study tests a new oral drug, MOMA-341, alone or with other treatments, in people with advanced solid tumors that have specific genetic markers (MSI-H or dMMR). The main goal is to check safety and find the best dose. About 132 adults whose cancer has not responde…

This early-phase study tests a new drug, KIVU-107, in about 76 adults with advanced solid tumors that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to deliver a cancer-killing agent directly to tumor cells. The main goal is to find the…

This study tests an experimental oral drug called zongertinib, which blocks HER2 (a protein that fuels cancer growth). It is given alone or with other standard treatments to adults with advanced HER2+ breast, stomach, or colorectal cancer that has spread and no longer responds to…

This early-stage trial tests a two-step vaccine strategy in adults with advanced colorectal or small bowel cancer that has not responded to standard treatments. Participants first receive one vaccine injection, followed by two doses of a second vaccine four weeks apart. The goal …

This study looks at how safe and effective the oral drug fruquintinib is for treating advanced colon cancer that hasn't responded to other treatments. It focuses on Black/African American and Hispanic/Latino patients, who were not well-studied in earlier trials. The main goal is …

This early-stage study tests a new treatment called DISP-10, which combines a virus and specially engineered immune cells, for people with advanced stomach, esophageal, or colorectal cancers that have spread. The goal is to find a safe dose and see if it shrinks tumors. About 66 …

This study is for people with high-risk stage III colorectal cancer. It uses a blood test (ctDNA) to see if adding a targeted drug (bevacizumab) to standard chemotherapy works better than chemo alone. About 100 participants will be randomly assigned to one of two treatment groups…

This study tests a new treatment called EBNK-001, which uses donor immune cells (natural killer cells) to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive these cells alon…

This study tests if adding a non-invasive sound wave treatment called histotripsy to standard chemotherapy can help people with colorectal cancer that has spread to the liver. About 100 adults whose liver tumors cannot be removed by surgery will receive both treatments. The goal …

This study looks at whether using a person's genetic information to decide the dose of chemotherapy can lower the risk of serious side effects. It involves 178 adults with colorectal or pancreatic cancer who have certain gene types. Participants are randomly assigned to receive e…

This study compares a new technique called total underwater colonoscopy (using water instead of gas to open the colon) with the standard method in over 1,000 people who had a positive stool test. The goal is to see if the water method finds more flat, hard-to-see polyps that can …

This study tests whether adding hydroxychloroquine (a drug used for malaria) to standard targeted therapy can help people with a specific type of advanced colon cancer (BRAF V600E mutation) that has stopped responding to other treatments. About 43 adults will receive the combinat…

This early-phase study tests a combination of a vaccine targeting mutant KRAS proteins and two immunotherapy drugs (balstilimab and botensilimab) in adults with advanced colorectal or pancreatic cancer that has not responded to first-line chemotherapy. The goal is to see if the t…

This study tests whether the antibiotic metronidazole can lower the amount of a specific bacteria (Fusobacterium nucleatum) in colorectal cancer tumors. About 40 adults with untreated colorectal cancer will take metronidazole before surgery. Researchers will compare bacteria leve…

This study tests a personalized cancer vaccine made from patients' own tumor cells. The goal is to train the immune system to fight metastatic cancers like melanoma, breast, lung, and colorectal cancer. Participants receive eight injections over 16 weeks. The study is for adults …

This study is testing a new drug called Dato-DXd, either alone or with other cancer drugs, in people with advanced solid tumors that have spread. The goal is to see if the drug can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gastric, prost…

This early-stage study tests a new drug called CT3001 in people with advanced solid tumors (like colorectal or pancreatic cancer) that haven't responded to standard treatments. The study has two parts: first, finding a safe dose of CT3001 alone, then testing it combined with chem…

This study tests if a new combination of drugs (DSP107 and atezolizumab) works better than an existing drug (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable. About 90 adults who have already tried other treatments will be randomly assigned t…

This study tests a combination of four drugs (sintilimab, ipilimumab, cetuximab, and dabrafenib) in people with a specific, hard-to-treat type of colorectal cancer that has spread. The cancer must have a BRAF V600E mutation and be microsatellite stable (MSS). The goal is to see i…

This study tests a new oral drug, IPN01194, in adults with advanced solid tumors (melanoma, colorectal, pancreatic, or head and neck cancers) that have not responded to standard treatments. The goal is to find the right dose and check if the drug is safe and can shrink tumors. Ab…

This study tests whether adding two drugs (serplulimab and bevacizumab) to standard chemotherapy before surgery can improve outcomes for people with colorectal cancer that has spread to the liver. The trial involves 156 adults whose tumors have specific genetic features (RAS/BRAF…

This study tests a personalized vaccine made from a patient's own immune cells, combined with an immunotherapy drug (nivolumab), after surgery to remove liver cancer or colorectal cancer that spread to the liver. The goal is to see if this treatment can prevent the cancer from re…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to activate the immune system, followed by an infusion…

This early-stage study tests a new drug (177Lu-DFC413) that delivers radiation directly to cancer cells in adults with advanced solid tumors, including pancreatic, lung, breast, colorectal, and soft tissue cancers. The main goals are to check safety, find the right dose, and see …

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…

This study tests lower doses of chemotherapy for people with digestive cancers who have a DPD deficiency, which puts them at high risk for severe side effects. Researchers will monitor 400 participants to find the safest dose that still fights the cancer. The goal is to reduce da…

This study tests a new drug, ASP5834, for people with advanced solid tumors that have certain changes in the KRAS gene. The drug is given alone or with another drug (panitumumab) for colorectal cancer. The main goals are to find a safe dose and check for side effects. About 364 a…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to shrink or control advanced solid tumors like lung, pancreas, and colorectal cancer. About 54 adults whose cancers hav…

This study tests an experimental drug called FMC-376 in people with advanced solid tumors that have a specific genetic change (KRAS G12C). The goal is to find a safe dose and see if the drug can shrink tumors. About 400 adults whose cancer has worsened after standard treatments w…

This study is for people with advanced colorectal cancer that has a certain genetic makeup (RAS/BRAF wild type) in the tumor but shows a different genetic change (RAS mutation) in a blood test. The goal is to see if a combination of chemotherapy (FOLFIRI) plus a drug called bevac…

This phase 3 trial compares two chemotherapy combinations (mFOLFOXIRI vs mFOLFOX-6), both given with bevacizumab, as first treatment for people with metastatic colorectal cancer that cannot be removed by surgery. The study includes 528 adults in China and measures how long the ca…

This study tests a new combination of chemotherapy, an immunotherapy drug, and a diabetes medicine (sitagliptin) in people with a specific type of advanced colorectal cancer. The goal is to shrink tumors before surgery and improve outcomes. About 138 adults aged 18-75 with locall…

This study is for adults who have finished chemotherapy for gastrointestinal cancer and are in remission, but still have dangerously low platelet counts. Researchers want to see if adding a second drug (ATRA) to the standard platelet-boosting drug (romiplostim N01) works better t…

This study is testing a new treatment that uses a radioactive substance to target and destroy cancer cells in people with advanced solid tumors (like pancreatic, stomach, or ovarian cancer) that have not responded to standard treatments. The therapy works by attaching to a protei…

This study is for people who had surgery for stage II or III colon cancer with a PI3K mutation. It tests whether taking a low-dose aspirin daily can lower the chance of the cancer returning or a new cancer developing. Half the participants will get aspirin, the other half a place…

This study tests a new oral drug, VS-7375, in people with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a specific KRAS G12D mutation. The trial will first find the safest dose, then check if the drug shrinks tumors when used alone or with other ca…

This study tests whether two immunotherapy drugs, botensilimab and balstilimab, help people with advanced colorectal cancer that cannot be removed by surgery and has stopped responding to standard treatments live longer. About 834 participants will receive either the drug combina…

This study tests two different radiation schedules (long or short course) combined with chemotherapy (CAPOX), an immunotherapy drug (PD-1 inhibitor), and a COX-2 inhibitor in people with a specific type of locally advanced rectal cancer (MSS). The goal is to see which approach le…

This study tests a drug called AMB-05X in 15 people with colorectal cancer who have no visible tumors but still have cancer DNA in their blood (ctDNA positive). The goal is to see if the drug can eliminate these hidden cancer cells and prevent the cancer from coming back. Partici…

This study tests a new treatment called CHM-2101 for people with advanced gastrointestinal cancers (stomach, colon, or neuroendocrine tumors) that have stopped responding to standard therapies. The treatment uses a patient's own immune cells, modified to recognize and attack canc…

This early-phase trial tests a new drug called ZM008, alone and with another drug (toripalimab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. About 100 adults with canc…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study tests a new drug called IDE196 in people with certain cancers that have specific gene mutations (GNAQ/11 or PRKC fusions), including metastatic uveal melanoma and colorectal cancer. The trial has two phases: first to find safe doses, then to see if the drug shrinks tum…

This early-phase trial tests a new treatment for colorectal cancer that has spread to the lining of the abdomen. The therapy uses specially engineered natural killer (NK) cells designed to recognize and attack cancer cells, given both through a vein and directly into the abdomen.…

This study is for people with a specific type of colorectal cancer (dMMR/MSI-H) that hasn't spread far. It tests giving an immunotherapy drug (toripalimab) with or without an anti-inflammatory drug (celecoxib) before surgery. The goal is to see if this approach can shrink or elim…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This early-stage study tests a new cancer treatment called FT836, a ready-made immune cell therapy, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers. The treatment is given alone or with chemotherapy and/or antibod…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study tests a new device that uses magnets to reconnect parts of the colon after surgery for colorectal cancer or diverticular disease. About 20 adults will receive the device during their operation. The goal is to see if the magnet connection works well and reduces the need…

This study is testing whether a simple rectal mucus sample can detect DNA changes linked to lung, pancreatic, bladder, and colorectal cancers. Researchers will collect samples from 450 adults using a special device and compare them to known tumor DNA. The goal is to see if this n…

This study tests a new PET/CT scan using an investigational agent (GEH300079) to detect peritoneal carcinomatosis—cancer spread in the lining of the abdomen—in people with colorectal, gastric, ovarian, or pancreatic cancers. About 175 adults with known or suspected spread will re…

This study compares a new type of CT scanner (photon-counting CT) to MRI for finding liver tumors that have spread from colorectal cancer. About 100 adults with colorectal cancer will get both scans, and researchers will check if the new CT is as good as MRI at spotting these tum…

This study tests a new microwave-based device, called MiWEndo, during colonoscopy in 50 patients who already have a polyp in their rectum. The goal is to see if the device can find more polyps safely without changing the usual procedure. The device has been tested in earlier lab …

This study is testing whether a camera capsule you swallow can be used as a first step to check for colorectal cancer, instead of a traditional colonoscopy. About 800 adults with symptoms will either get the capsule or a standard colonoscopy. The goal is to see if this approach i…

This study is testing a new blood test to quickly identify people who may have colorectal cancer. The goal is to help doctors decide who needs urgent care, especially when colonoscopy appointments are delayed. About 400 adults with suspected or confirmed colorectal cancer will ta…

This study aims to improve a blood test that looks for DNA fragments to detect colorectal cancer and pre-cancerous growths. Researchers will collect blood samples from 6,500 people, including those newly diagnosed with colorectal cancer and those at average risk getting routine c…

This study tests a special dye and imaging system that makes cancer cells glow, helping surgeons see and remove tumors more completely during surgery for colorectal, pancreatic, esophageal, and gastric cancers. About 66 adults scheduled for surgery will receive the dye beforehand…

This study aims to create a new, non-invasive stool test that looks at gut bacteria to detect colorectal cancer and advanced polyps. Researchers will collect stool samples from 1,006 people aged 50-74 who are part of a national screening program and have had a positive initial st…

This study is testing a blood test (called a liquid biopsy) to see if it can find colorectal cancer, precancerous polyps, and Lynch syndrome-related cancers early. Researchers will collect blood from 1,200 people who have already had a colonoscopy and see how accurate the test is…

This study is testing a new type of PET scan that uses a special tracer to find cancers like pancreatic, breast, lung, and others. The goal is to see if this scan can better detect and stage tumors compared to standard scans. About 26 adults with suspected or confirmed cancer, pl…

This study checks if a new blood test, developed using artificial intelligence, can accurately rule out colorectal cancer in people who have other cancers or gut diseases. Researchers will collect blood samples from 250 adults and measure how often the test gives a false positive…

This study tests a new imaging agent called [18F]FPyQCP for PET scans to better detect several cancers, including colorectal, ovarian, gastric, breast, and pancreatic. About 71 adults with these cancers will receive the agent and undergo PET/CT imaging. The goal is to see if it i…

This study looks at whether a non-invasive stool test (FIT) can accurately detect colorectal cancer in people with Lynch Syndrome, a genetic condition that raises cancer risk. Researchers will compare FIT results to standard colonoscopy findings in 400 participants. If accurate, …

This study tests a new, dye-free way to check blood flow during gastrointestinal surgery. About 200 adults having planned gut surgery will be randomly assigned to either the new light-based method (iPPG) or the standard dye method (ICG). The goal is to see if the new method works…

This study is developing a blood test to detect colorectal cancer in people under 50, a group where cases are rising. The test looks at tiny particles called exosomes and uses machine learning to find cancer signals. Researchers will test blood samples from 400 participants, incl…

This study is testing a new blood test called Signal-C that looks for DNA fragments in the blood to find colorectal cancer and advanced precancerous growths. About 12,000 people aged 45 to 84 who are at average risk and scheduled for a routine colonoscopy will give a blood sample…

This study is testing a new endorectal imaging device that combines ultrasound and photoacoustic imaging to better assess rectal cancer after treatment. About 90 adults with rectal cancer who are scheduled for surgery will be scanned with the device. The goal is to see if the dev…

This study is creating new, easy-to-use tests to find colorectal cancer early in people at high risk. Researchers will collect blood, breath, stool, and cheek swab samples from 4,100 adults across Europe. The goal is to replace uncomfortable colonoscopies with simple, low-cost sc…

This early study is testing a new imaging agent called FL-261 to see if it can safely and accurately detect and stage several types of cancer, including lung, colorectal, and head & neck cancers. The agent targets a protein (c-MET) found on many cancer cells but not on most healt…

This study is testing a new blood test that looks for circular RNA to find colorectal cancer early. Researchers will collect blood samples from 600 adults with stage I-III colorectal cancer to see how accurate the test is. If successful, this could offer a non-invasive way to det…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study is testing a new type of PET/CT scan that uses a special tracer called 18F-T2 to find cancers that have high levels of a protein called CAIX. About 200 adults with cancers like kidney, bladder, lung, or breast cancer will get this scan to see if it works better than th…

This study tests whether giving personalized diet and lifestyle advice to people at high risk for colorectal cancer helps them adopt healthier habits. About 800 participants will be followed for a year to see if they improve their diet, exercise, and other behaviors linked to can…

This study tests whether community health workers can help people aged 45 and older who are not up-to-date on colorectal cancer screening get tested and adopt healthier lifestyles. Participants will be recruited through churches and receive either a referral as usual or a program…

This study will enroll 60,300 people aged 45-74 who are at average risk for colorectal cancer. Participants will be randomly assigned to one of three screening methods: colonoscopy, a stool test (FIT), or a stool test plus a blood test that looks for cancer DNA. The goal is to se…

This study tests whether naproxen or aspirin can increase immune cells in the colon to prevent cancer in people with Lynch syndrome, a genetic condition that raises colon cancer risk. About 40 participants will take either naproxen, aspirin, or a placebo for a short time. Researc…

This study aims to increase colorectal cancer screening among African Americans, who face higher rates of this cancer. Researchers will provide 1,200 participants aged 45-75 with free take-home test kits and educational materials. Some participants will also see social media ads …

This study tests whether eating a high-fiber, low-fat diet for three weeks before colorectal cancer surgery can change gut bacteria to help prevent the cancer from coming back or spreading. About 80 adults with colorectal cancer will follow this diet and provide blood, stool, and…

This study tests whether telehealth tools can help more people aged 45-64 complete colorectal cancer screening. Researchers will compare screening rates before and after the intervention in 6,000 participants. The goal is to counter misinformation and make screening easier, espec…

This study tests whether taking polyunsaturated fatty acids (like omega-3s) can prevent nerve damage in the hands and feet of people with colorectal cancer who receive oxaliplatin chemotherapy after surgery. About 120 participants will be followed for 8 months to see if the suppl…

This study tests a new approach to prevent a serious complication called anastomotic leakage after colorectal cancer surgery. About 110 adults having surgery for colorectal cancer will either get a temporary tube placed inside the bowel (endoscopic vacuum therapy) right after sur…

This study looks at whether a team of geriatric specialists can help patients aged 70 and older recover their daily living skills better after colorectal cancer surgery, compared to standard care. About 90 participants will be randomly assigned to either the special geriatric uni…

This study tests whether increasing fiber intake before colorectal cancer surgery is practical and helpful. 54 adults scheduled for surgery will either get personalized diet advice, a dried vegetable product, or follow their usual diet. The goal is to see if fiber can be safely i…

This study tests an experimental drug called NGM120 in 136 people with colorectal cancer who are experiencing cancer-related weight loss (cachexia). The goal is to see if the drug helps patients gain or maintain weight and is safe to use. Participants will receive either NGM120 o…

This study tests a new care plan that uses technology to help doctors better manage the health of older adults (70+) who have cancer and other medical conditions. The goal is to see if this approach improves their quality of life over six months. About 720 people with breast, lun…

This study tests a telehealth program that teaches cancer survivors with an ostomy how to manage their care before and after surgery. The program includes seven group sessions online. Researchers want to see if it helps patients feel more confident and improves their quality of l…

This study looks at whether giving lidocaine (a numbing medicine) or high-dose dexamethasone (a strong anti-inflammatory) during colon cancer surgery can help the immune system recover better afterward. About 100 adults having colon cancer surgery will be randomly assigned to rec…

This study looks at whether giving breast, prostate, and colorectal cancer survivors a personal referral to a tailored nutrition and exercise program helps them eat better and move more. About 306 survivors and healthcare providers will take part. The goal is to see if survivors …

This study tests a new digital follow-up program for people who have had early-stage colorectal cancer. The program uses a smartphone app to monitor symptoms, fear of cancer returning, and quality of life, and provides personalized care. About 400 participants will be split into …

This study tests whether an AI tool can help doctors better manage chemotherapy side effects in people with breast or colorectal cancer. About 174 adults will be split into two groups: one where doctors use AI suggestions for side effect care, and one with standard care. The goal…

This study compares a new AI-enabled robotic stapler to a conventional stapler in colorectal cancer surgery. The goal is to see if the smart stapler reduces serious complications like anastomotic leaks. About 200 adults aged 18-90 undergoing planned robotic or laparoscopic surger…

This study tests whether adding acupuncture to standard anti-nausea medicine works better than medicine alone for people with nausea caused by chemotherapy. About 90 adults with breast, prostate, lung, gynecologic, colorectal, or metastatic pancreatic cancer will be split into tw…

This study tests a smartphone app called ASSIST that uses artificial intelligence to help people with breast, colorectal, or lymphoma cancer manage symptoms while receiving chemotherapy or other systemic therapy. About 60 adults will be split into two groups: one uses the app for…

This study tests whether offering free legal services to people caring for a loved one with advanced colorectal cancer can reduce their stress and improve their finances. About 20 patient-caregiver pairs will receive personalized legal help from a nonprofit. The goal is to see if…

This study tests whether a telerehabilitation program (exercise and breathing exercises done at home with remote guidance) can improve physical function and quality of life for 54 adults recovering from colorectal cancer surgery. Participants will be randomly assigned to either t…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage symptoms like pain, fatigue, and emotional distress, and encourages engagement with recommended follow-up care. Researchers will enroll 260 people …

This study compares standard pain relief (IV drugs plus wound numbing) to a combination of two nerve blocks (BAP and TAP) in 140 adults having minimally invasive left-sided colorectal surgery. The goal is to see if the nerve blocks lower pain intensity and reduce the need for opi…

This study compares three standard pain management methods used during minimally invasive cancer surgery. 48 adults having surgery for cancers of the liver, stomach, pancreas, or other organs will be randomly assigned to one of three groups. The goal is to see which method provid…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study looks at whether mandala art therapy can improve psychological resilience and coping skills in people recovering from colorectal cancer surgery. About 70 adults will be randomly assigned to either receive the art therapy or standard care. The goal is to see if this sim…

This study tests a mobile health program that combines exercise and nutrition advice to help older adults (60+) with colorectal cancer reduce frailty and improve physical fitness. About 140 participants will use the program on their smartphones and be compared to those receiving …

This study tests if limiting when you eat (time-restricted eating) can reduce side effects from cancer treatment, improve mood, and even affect tumor biology. Researchers will enroll 175 adults with rectal or breast cancer who are receiving treatment. Participants will follow a s…

This study tests whether a virtual hub offering personalized education, exercise, nutrition, and peer support before and after surgery can reduce complications within 30 days. About 564 adults in Australia having colorectal cancer surgery will be randomly assigned to the hub plus…

This study looks at whether patients with locally advanced colorectal cancer that improved to stage II after pre-surgery chemotherapy or chemoradiotherapy still need additional chemotherapy. Researchers will follow 650 participants to compare disease-free survival and side effect…

This study aims to understand how a patient's physical function and breathing capacity before surgery influence their recovery after colorectal cancer surgery. Researchers will assess 42 participants using simple physical tests. The goal is to identify patients at higher risk for…

This study looks at genetic changes in people with colorectal cancer that has spread only to the liver and cannot be removed by surgery. Researchers want to understand why this happens and how liver transplants might help. They will follow 35 patients for up to 5 years to see how…

This study looks at whether adding a simple blood test that tracks tumor DNA (ctDNA) to regular scans can help doctors choose better treatments and improve survival. About 332 adults with advanced colorectal or non-small cell lung cancer will be randomly assigned to either standa…

This study is for people with colorectal cancer that has spread only to the liver. Researchers want to see if using MRI scans can help doctors better decide who should have surgery to remove liver tumors. About 100 adults will take part, and the study will track how often surgery…

This study looks at whether older adults (75+) who had precancerous polyps removed in the past still benefit from repeat colonoscopy. Researchers will analyze data from 130,000 Veterans to compare cancer risks and gather opinions from patients and doctors. The goal is to create c…

This study is developing a blood test that uses artificial intelligence to spot cancer early and see how well treatments are working. Researchers will analyze blood samples from 6000 adults with or without cancer to find unique signals in platelets and immune cells. The goal is a…

This study looks at how different types of anesthesia affect cancer cells and recovery in 90 adults having colorectal cancer surgery. Participants are randomly assigned to receive opioid-free, opioid-sparing, or standard opioid-based anesthesia. Researchers will measure blood mar…

This study looks at how well doctors can spot leftover polyp tissue at the scar site after a colonoscopy removal. About 141 doctors of all experience levels will view 15 images before and after a short video training. The goal is to see if the training improves their ability to d…

This study looks at the best times to send messages encouraging physical activity to older cancer survivors (age 65+) who have chronic pain. Researchers will track activity levels and pain ratings to see how messages affect movement and pain episodes. The goal is to learn how to …

This study is observing 50 adults with advanced cancers (lung, breast, colorectal, liver, stomach) who are starting immunotherapy. Researchers will track ctDNA levels in the blood to see if changes can predict early whether the treatment is working. They will also look at other m…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial resources. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it helps them feel more …

This study is developing a computer model that uses genetic information from tumors to predict which colorectal cancer patients will benefit from chemotherapy after surgery. Researchers will analyze tumor samples from 200 patients to find patterns linked to treatment success or c…

This study tests whether checking for leaks in the newly connected bowel during colorectal cancer surgery can lower the risk of serious complications, especially leakage. About 264 adults having surgery will be randomly assigned to receive leak testing or not. The goal is to see …

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. Researchers will measure changes in food security, di…

This study is for older adults with advanced colorectal cancer who are about to start chemotherapy. It aims to find out if having low muscle mass at the start of treatment leads to more severe side effects. Researchers will track side effects and survival over at least one year. …

This study collects tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could lead to better scree…

This study aims to understand why some cancers come back after surgery by detecting tumor cells and DNA in blood, urine, and bone marrow. Researchers will collect samples from 620 adults with various solid cancers (like lung, colon, or pancreatic cancer) and track their health ov…

This study is for adults with cancers that have spread to the lining of the abdomen. Doctors will remove most tumors during surgery, then give heated chemotherapy directly into the abdomen. They will also test the same chemo on tumor samples in the lab to see if lab results match…

This study aims to understand why muscle wasting (cachexia) happens in some colorectal cancer patients. Researchers will take small muscle samples and compare them between patients with and without cachexia, as well as healthy volunteers. The goal is to learn more about the muscl…

This study collects tumor samples from 2,000 people with various cancers to learn how to predict who will respond to immunotherapy. Participants donate tissue during a routine biopsy. The goal is to understand tumor biology and improve future treatment decisions, not to test a ne…

This study collects blood, tissue, and stool samples along with health information from 160 people aged 18-49, both with and without young onset colorectal cancer. Researchers will analyze the samples to better understand what causes this cancer in younger adults. The goal is to …

This study looks at medical records from large national databases to compare colorectal cancer in patients younger than 35 with those older than 35. The goal is to understand how the disease and its treatment differ in younger people. About 100 participants will be included, and …

This study follows 368 colorectal cancer survivors aged 25 to 65 to see how their quality of life changes 6, 12, and 24 months after finishing treatment. Researchers will use questionnaires to measure physical, mental, and social well-being, as well as any long-term side effects.…

This study looks at how much protein people with colorectal or breast cancer need to keep their muscles strong during treatment. Muscle loss is common in cancer patients and can lead to worse health outcomes. Researchers will use a simple, non-invasive test to measure protein nee…

This study is creating a new computer framework to analyze complex biological data from 15 colorectal cancer patients. Researchers will collect blood, stool, and tissue samples before and after surgery to study changes in gut bacteria, metabolites, and gene expression. The goal i…

This study looks at how eating different amounts of cysteine, a protein building block, affects gut bacteria and inflammation in people at higher risk for colon cancer. Researchers will compare Black and White adults aged 45-75 who have had colon polyps. Participants will follow …

This study is for people with advanced liver or colorectal cancer that has stopped responding to standard treatments. Researchers will take a small sample of the tumor, grow it in the lab as a 3D 'organoid,' and test different drugs on it to find which one works best. The goal is…

This study is a registry that collects information and tissue samples from 2,100 adults having surgery for colorectal cancer. Researchers will track survival and disease recurrence, and analyze genetic mutations and biomarkers. The goal is to better understand the disease, not to…

This study is observing 430 adults who have colorectal surgery to understand why some develop a serious complication called an anastomotic leak (a leak where the bowel is reconnected). Researchers will track factors before, during, and after surgery to build a risk prediction mod…

This study aims to describe the immune cells and bacteria in colorectal tissue from people with benign or early-stage malignant growths. Researchers will analyze tissue samples from 400 patients undergoing surgery. The goal is to better understand how the local environment change…

This study tracks side effects and safety of the drug fruquintinib (Fruzaqla) in 600 adults with colorectal cancer in South Korea. Participants take the drug as prescribed by their doctor. The goal is to see how often side effects occur in everyday use, not to test a new treatmen…

This study looks at muscle wasting, weight loss, and tiredness in people with stomach, pancreas, or bowel cancer who are having surgery. Researchers will track changes in body composition, physical activity, and quality of life over a year. The goal is to better understand cachex…

This study tests whether a large language model (a type of AI) can help junior doctors write more accurate and efficient cancer treatment reports. 40 junior doctors will be split into two groups: one uses AI assistance, the other uses traditional methods. Their reports will be sc…

This study looks at whether a simple blood test after surgery for colorectal cancer can better predict if the cancer will come back. About 1,600 patients will give blood samples to check for leftover tumor DNA. If successful, this test could help doctors decide who really needs c…

This study aims to help Black individuals and their families in Houston learn about their risk for hereditary cancers like breast and colorectal cancer. Researchers will use a simple screening tool and offer genetic counseling and testing through trusted community organizations. …

This study looks at how a person's ability to perform daily activities and their lung function may influence long-term health in colorectal cancer patients. Researchers will measure walking distance and breathing capacity in 52 adults aged 18-80. The goal is to understand if thes…

This study looks at whether a program of exercise and nutrition before surgery is practical for people with stage II or III rectal cancer. About 40 participants will either join the program or receive usual care. The main goal is to see if enough people sign up and stick with the…

This study is gathering tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to learn how often certain genetic changes occur and to store participants' own immune cells for possible future use in making …

This study tracks 120 young adults (women under 40, men under 50) with early-onset colorectal cancer to see how chemotherapy and radiation affect their hormone levels, sexual health, and ability to have children. Researchers will measure changes in key hormones over time. The goa…

This study is collecting stool and saliva samples from 2,500 people with colorectal cancer to look for genetic markers (microRNA) and bacterial patterns (microbiome) that could help doctors diagnose and predict the course of the disease. The goal is to create a detailed map of th…

This study is testing a new way to reconnect the colon after surgery for cancer or diverticular disease. The goal is to see if a single-stapled technique causes fewer leaks than the standard double-stapled method. About 500 adults having planned left-sided colon surgery will be o…

This study is for people with advanced cancers who are taking targeted treatments for months or years. Researchers will interview 75 participants to understand their experiences and needs. The goal is to find better ways to support patients living with chronic cancer treatments.

This study looks at why some people under 50 develop colorectal cancer. Researchers will compare 2,300 participants—those recently diagnosed with early-onset colorectal cancer and healthy volunteers—to see how diet, smoking, exercise, weight, and genetics affect risk. The goal is…

This study compares two ways to check for colon cancer in adults aged 65-82 who have had polyps before. About 9,000 participants will either get a yearly stool test (FIT) or a colonoscopy. Researchers will track which group finds more advanced polyps or cancer over up to 11 years…

This study is collecting blood and tumor tissue from 1,200 people undergoing surgery for colorectal cancer that has spread to the liver. The goal is to look for biomarkers that might help predict how the disease will progress. Participants are followed over time to track cancer r…

This study screens up to 7,000 adults with cancers like melanoma, lung, or colorectal cancer to see if they qualify for experimental treatments developed by the National Cancer Institute's Surgery Branch. These treatments involve taking a patient's own immune cells, growing them …

This study aims to see if watching a video before genetic testing helps people with certain cancers better understand their hereditary cancer risk. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Resear…

This study looks at whether the way a stapler is placed during colorectal surgery affects bleeding where the bowel is reconnected. About 102 adults having surgery for colon cancer or diverticulitis will take part. Doctors will check for bleeding during and after surgery to see if…

This study aims to create and improve educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 participants from diverse cultural and language backgrounds to get their feedback on the m…

This study takes tumor samples from people with breast, colorectal, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to find personalized treatment options and lear…

This study collects blood, urine, and bone marrow samples from 320 people with solid cancers (like lung, colon, or pancreatic cancer) and from those undergoing lung cancer screening. The goal is to detect tiny bits of tumor cells and DNA in these fluids to learn how cancer spread…

This study looks at a protein called PRDX1 found in blood taken from the surgical specimen of colorectal cancer patients. Researchers want to see if higher levels of this protein can predict if the cancer will spread to the liver after surgery. About 252 patients who had their co…

This study looks at which intravenous fluid—albumin or Ringer's solution—is better at increasing blood volume during laparoscopic surgery. About 60 adults having abdominal surgery will receive one of three fluid doses. The goal is to see which fluid keeps the heart and blood vess…

This study looks at how cancer impacts the health and well-being of both patients and their family caregivers. Researchers will survey 240 Danish adults with breast, prostate, colorectal cancer, or lymphoma, along with their chosen caregivers. The goal is to identify families who…

This study aims to collect tissue samples, medical data, and family histories from 1120 adults undergoing routine screening for colorectal or endometrial cancer. Researchers will use this information to discover new genes and mechanisms that increase cancer risk, and to learn how…

This study collects information and videos from colonoscopies to see how well different removal techniques work in real life. About 1,800 people having a colonoscopy will take part. The goal is to improve doctor training, help researchers, and make sure patients get the best care…

This study tests whether a personalized self-management program helps gastrointestinal cancer patients adopt healthier habits better than a standard program. 120 adults with past or current GI cancer will take part in a 6-week training led by occupational therapists. The goal is …

This study looks at 60 people with a specific type of advanced colorectal cancer (dMMR/MSI-H) who are receiving immunotherapy. Researchers want to see if changes in a blood test called ctDNA can tell if the cancer is truly gone, even when scans don't show it. The goal is to find …

This study looks at how radiation from a procedure called Y90 radioembolization damages liver tumors that have spread from colorectal cancer. Researchers will take small tissue samples (biopsies) from the tumors after treatment to see how much cell death and injury occurs. The go…

This study watches 40 adults with colorectal cancer who have no visible tumors but have minimal residual disease (MRD) detected by a blood test. Participants receive standard biomarker-directed therapy chosen by their own doctor. The goal is to see how this therapy affects cancer…

This study creates a database of information from people diagnosed with colorectal cancer before age 50. Researchers will use this data to compare young-onset and later-onset colorectal cancer, and to guide future research. About 1,366 participants will provide medical informatio…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers by offering genetic screening and counseling at mobile mammography units. About 1,000 underserved women in Texas will be invited to participate when they come for their routine mammog…

This study tests a new tool that lets cancer patients report any issues that might delay their treatment. Researchers want to see if this tool can help identify and address problems sooner, especially for racial groups that often face longer delays. The study will enroll 240 adul…

This study examines whether receiving radiation therapy before colorectal cancer surgery leads to more complications during or after the operation. Researchers will compare 80 patients who had radiation with those who did not, looking at issues like infections, wound problems, an…