COLORECTAL CANCER

This early-stage study tests a new vaccine called YMN-136 in 9 people with advanced colorectal cancer that has spread to the liver and no longer responds to standard treatments. The main goals are to check the vaccine's safety and find the best dose. Researchers will also watch f…

This early-phase study tests a new drug called QLS5316 in about 300 adults with advanced solid tumors (including colorectal, stomach, head and neck, and lung cancers) that have stopped responding to standard treatments. The main goals are to check the drug's safety, find the best…

This phase 3 trial tests whether fruquintinib plus chemotherapy works better than the standard bevacizumab plus chemotherapy for people with a specific type of advanced colorectal cancer (RAS-mutant). About 224 adults aged 18-75 will be randomly assigned to one of the two treatme…

This study tests the drug everolimus in people with advanced colorectal cancer that has a specific genetic marker (CDK12 deficiency) and has not responded to other treatments. The goal is to see if the drug can shrink tumors or slow the disease, and to find the safest dose. About…

This early-phase trial tests whether adding two drugs (pirfenidone and sintilimab) to standard chemotherapy can shrink tumors in 30 people with colorectal cancer that has spread to the lining of the belly. The study will first check if enough patients respond before expanding. Th…

This early-phase study tests a new treatment called TCR1188-ABC for people with certain advanced cancers (pancreatic, colorectal, lung, or bile duct) that have a specific genetic change called KRAS G12V. The treatment uses a patient's own immune cells, modified in a lab to better…

This early-phase study tests DCTY1102, a personalized cell therapy, in 18 adults with advanced colorectal, lung, or pancreatic cancers that have a specific KRAS/NRAS G12D mutation and HLA type. Participants receive a single infusion of their own genetically modified immune cells …

This study tests a new robotic surgery system that lets doctors operate remotely on patients with colorectal, esophageal, liver, or cervical cancer. About 98 adults aged 18 to 80 will have their surgeries assisted by this system. The main goal is to see how often the surgery can …

This study looks at 280 adults with advanced colorectal cancer on the right side of the colon whose tumors have a normal RAS gene. Researchers want to see if a biomarker test (EREG/AREG) can identify who benefits from adding a targeted drug (cetuximab) to standard chemotherapy. T…

This study tests a new combination of drugs (aipalolitovorelizumab, bevacizumab, and standard chemo) as a first treatment for people with advanced colorectal cancer that has a specific gene change called BRAF V600E. The goal is to see if this combo can shrink tumors and control t…

This study tests a new drug called AMT-676 combined with standard chemotherapy and targeted therapy for people with advanced colorectal cancer that cannot be removed by surgery. The goal is to see if the combination is safe and effective at shrinking tumors or slowing cancer grow…

This study tests whether a new drug combination (fruquintinib plus trifluridine/tipiracil) works better than a standard combination (bevacizumab plus trifluridine/tipiracil) for people with advanced colorectal cancer that has not responded to prior treatments. About 292 adults ag…

This study tests whether giving oral nutritional supplements along with a personalized diet before and after colorectal cancer surgery can lower the risk of complications and improve recovery. About 190 adults scheduled for minimally invasive colorectal cancer surgery will take p…

This trial tests a program called ONLOOP that reminds adult survivors of childhood cancer to get important screening tests. These tests can catch serious late effects like heart disease or second cancers early. About 900 survivors in Ontario will be randomly assigned to use ONLOO…

This early-phase study tests a new cell therapy called NK510 in 15 people with advanced stomach or colorectal cancer that has not responded to or returned after at least two prior treatments. The therapy is given through an IV or directly into the abdomen. The main goals are to c…

This early-phase study tests a combination of two drugs—aipalirovorelizumab (QL1706) and fruquintinib—in 18 adults with advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if the combination can shrink tumors or slow disease prog…

This study tests whether giving chemotherapy directly into the liver artery (HAI) after surgery can delay cancer recurrence in people with colorectal cancer that spread to the liver. About 272 high-risk patients will receive either standard IV chemo or IV chemo plus HAI for at le…

This early-phase study tests whether adding donor natural killer (NK) cells to standard maintenance therapy can safely help control advanced solid tumors, including non-small cell lung cancer and colorectal cancer. About 20 adults aged 18-75 will receive NK cell infusions alongsi…

This study tests whether taking a daily 2-gram histidine supplement is safe and can help boost the immune system's ability to fight colorectal cancer during standard treatment. Twenty adults with stage II or higher colorectal cancer will take the supplement and provide blood samp…

This early-phase trial tests the safety of a new drug, IM-1617, in about 175 adults with advanced solid tumors (colorectal, lung, breast, stomach, esophageal, or other cancers that have spread or can't be removed by surgery). The study first finds a safe dose, then checks how wel…

This study looks at whether lightly burning the edges of the spot where a large colon polyp was removed can stop it from growing back. About 752 adults with large, flat polyps will either get this extra treatment or not. Doctors will check for regrowth at 6 and 18 months after th…

This early-stage trial tests an experimental drug called RP-001 in 66 adults with advanced solid tumors, including colorectal and pancreatic cancers. The main goal is to check the drug's safety and find the best dose. Researchers will also look for signs that the drug shrinks tum…

This early-phase study tests a new treatment for people with advanced colorectal cancer that has spread to the liver and hasn't responded to at least two prior treatments. The treatment combines a modified virus (PIN) that kills cancer cells with an immunotherapy drug (sintilimab…

This early-stage trial tests a new drug called TB511, alone or with pembrolizumab, in people with advanced solid tumors (lung, prostate, colorectal, or liver cancer) that stopped responding to standard treatments. The study has two parts: first, finding the safest dose of TB511 a…

This early study tests a new drug called SHR-3821 combined with another drug, fruquintinib, in people with advanced colorectal cancer that has not responded to at least two standard treatments. The goal is to see if the combination is safe and can shrink tumors. Only 12 participa…

This study tests whether adding immunotherapy drugs (cemiplimab alone or with fianlimab or REGN7075) to standard chemotherapy (CAPOX) can eliminate or shrink rectal cancer before surgery. About 66 adults with a specific type of rectal cancer (MSS, locally advanced) who have not h…

This study tests a combination of chemotherapy drugs given directly into the liver (hepatic arterial infusion) plus standard chemo pills and IV drugs after surgery to remove colorectal cancer that spread to the liver. The goal is to see if this approach can prevent the cancer fro…

This study tests a new combination of drugs and short radiation therapy for people with advanced colorectal cancer that has spread to the liver and cannot be removed by surgery. The goal is to see if this combination is safer and works better than standard third-line treatments. …

This study tests a new drug, telisotuzumab adizutecan, combined with bevacizumab, against the standard treatment (LONSURF plus bevacizumab) for people with advanced colorectal cancer that no longer responds to other therapies. About 700 adults with a specific marker (c-Met) on th…

This early-stage study tests a new drug called SNA028 in 20 people with advanced colorectal cancer that has gotten worse after standard treatments. The drug uses a two-step process to deliver radiation directly to cancer cells that have a specific marker (GPA33). The main goals a…

This early-phase study tests a new drug called CT-202 in people with recurrent triple negative breast, colorectal, or urothelial cancers that have not responded to standard treatments. The drug is designed to help the immune system attack cancer cells. The main goals are to check…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests whether a special omega-3-enriched nutritional drink can help people with lung or colorectal cancer who are losing weight and at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The goal is …

This early study tests a new radioactive drug called NTH-2403 in about 16 people with advanced colorectal, head and neck, lung, or triple-negative breast cancers. The drug is designed to attach to a protein found on certain cancer cells and light them up on scans. The main goal i…

This study aims to improve early detection of bowel cancer by using multiple stool blood tests (FIT) instead of just one. Around 1,000 patients referred to hospital with bowel symptoms will provide extra stool samples to see if changes in blood levels over time can better identif…

This study aims to see if offering a blood test (Guardant Shield) along with standard reminders helps more people who are overdue for colon cancer screening actually get screened. About 500 adults aged 45-85 will be randomly assigned to receive either a standard reminder or a sta…

This study looks at whether a non-invasive stool test (qFIT) can accurately detect colorectal cancer and precancerous lesions in adults aged 40–75. Researchers will compare the test results with colonoscopy findings to see how well it works for different types and locations of gr…

This study tests whether an artificial intelligence system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assisted …

This study tests a new type of PET scan that uses a special probe to find cancers that have a protein called GPA33. The study will include 56 people with suspected or confirmed colorectal, stomach, or pancreatic cancer, as well as healthy volunteers. The goal is to see if this im…

This study aims to improve how we screen for colorectal cancer by using a new blood test. Researchers will look for special molecules called oncofetal chondroitin sulfate (ofCS) that appear in tumors. They will collect blood from 2000 people scheduled for a colonoscopy to see if …

This study tests whether sending text message reminders can increase colorectal cancer screening among homeless adults aged 45-75 who are not up to date on screening. About 588 participants from shelter clinics in New York City will be randomly assigned to receive SMS navigation …

This study looks at whether having general practitioners (GPs) give colorectal cancer screening kits directly to patients aged 50-74 during visits can increase screening rates compared to the usual method of sending invitation letters. About 26,260 people will take part. The goal…

This study tests whether taking S-adenosylmethionine (SAMe), a natural supplement, can prevent liver injury caused by the chemotherapy drug oxaliplatin in people with colorectal cancer that has spread to the liver. About 30 adults with resectable liver tumors will take SAMe pills…

This study looks at whether specially trained community health workers (called promotoras) can help Latinx people recently diagnosed with colorectal cancer feel better and manage their care. About 60 patients will either get this extra support or just a list of resources. The goa…

This study tests whether a supervised exercise program, started before chemotherapy and continued during treatment, helps adults aged 35-65 with breast, lung, or colon cancer tolerate chemo better. The goal is to see if exercise allows patients to receive more than 85% of the pla…

This study tests if a special exercise program, done before starting chemotherapy, can help prevent or reduce memory loss and brain fog (chemo brain) in older adults with colorectal cancer. The study will include 86 people aged 60-85 who are not currently active. Researchers will…

This study tests whether watching a virtual reality training video after colorectal surgery helps patients feel more confident in managing their recovery. About 66 adults will be split into two groups: one gets the video training, the other does not. Both groups will fill out a s…

This study tests whether a simple bowel rinsing technique (transanal irrigation) can help people who have bowel control problems after rectal cancer surgery. The study will include 60 adults who recently had surgery and still have a temporary colostomy bag. Researchers want to se…

This study looks at whether a special version of Baduanjin, a gentle exercise, is safe and helpful for people with colorectal cancer who have an ostomy (a bag on their belly for waste). About 258 adults will either do Baduanjin or walk five times a week for 12 weeks. Researchers …

This study tests whether a probiotic called Clostridium butyricum can reduce severe diarrhea and other side effects in people receiving chemotherapy after colorectal cancer surgery. About 238 adults who have had their tumor removed will take either the probiotic or a placebo duri…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers. About 98 adults will be randomly assigned to either the exercise program or standard follow-up. The main goals …

This study tests a 'Flipped Discharge' program for 200 colorectal cancer patients with a new stoma. Instead of standard hospital discharge, patients get a home visit or video follow-up from a specialist nurse three days after leaving the hospital. The goal is to reduce stoma comp…

This study tests a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) to see if it helps reduce anxiety and depression and improve quality of life in 300 Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. Participants will be randomly a…

This study looks at whether a simple blood test that detects tumor DNA can help doctors choose the right amount of chemotherapy for people with stage III colorectal cancer. About 2,450 participants will be split into groups based on their blood test results. Those with no detecta…

This study looks at whether offering colorectal cancer screening kits at local pharmacies can increase the number of people who get screened. About 1,500 patients and pharmacy staff in North Carolina and the Pacific Northwest will take part. The goal is to see if this approach is…

This study will examine tissue samples from 30 adults with colorectal cancer that has spread to the lining of the abdomen (peritoneum). Researchers want to see if the way the tumor grows into the peritoneum can help predict which patients will do well after surgery. The goal is t…

This study looks at whether a patient decision aid helps people with a cancerous colon or rectal polyp choose between surgery or careful monitoring. About 110 adults who had a polyp removed but may still have cancer cells will use the aid during their doctor visit. The goal is to…

This study looks at whether a new blood test can find tiny bits of cancer DNA left after surgery in people with stage III colorectal cancer. About 229 patients will give blood samples over time, and researchers will compare different ways to detect this leftover DNA. The goal is …

This study aims to see if text message reminders can encourage more adults aged 45-75 to complete at-home colorectal cancer screening. Researchers will work with community health centers to design and test different message versions. The goal is to increase screening rates and en…

This study is testing a new method called Personalized Functional Profiling (PFP) to see if it can predict which standard cancer drugs will work best for people with colorectal or pancreatic cancer. Researchers will take tumor samples from 188 patients, grow them in the lab, and …

This study looks at the safety of a drug called Bevacizumab BS (a biosimilar to Avastin) in 1000 colorectal cancer patients in Japan. Researchers will check how often serious side effects like bleeding, high blood pressure, and kidney problems happen. The goal is to understand re…

This study tests a new imaging tool that helps surgeons see blood flow in real time during colon surgery for colorectal cancer. About 150 adults will have both a standard dye method and a new laser-based imaging technique to check tissue health. The goal is to see if the new meth…

This study looks at why some people with colorectal cancer feel very tired. Researchers will use questionnaires and blood tests to find connections between fatigue, body chemistry, and Traditional Chinese Medicine body types. The goal is to better understand fatigue, not to test …

This study looks at how to safely test for allergic reactions to biotherapy drugs in cancer patients. Researchers will find the highest skin test dose that does not cause irritation in most people. The goal is to create clear guidelines for doctors to diagnose allergies to these …

This study looks at whether tumor DNA found in blood or belly fluid can predict if stomach, colon, or pancreatic cancer will spread to the lining of the abdomen (peritoneum). Researchers will follow 300 patients with early-stage cancers to see if those with positive tumor DNA hav…

This study looks at how histidine, a common amino acid, might help make immunotherapy more effective for colorectal cancer. Researchers will measure histidine levels and related proteins in 150 patients' blood and tumor samples. The goal is to find new ways to overcome treatment …

This study aims to see if a new, simpler scoring tool (CRIS) can help doctors accurately predict which large colon polyps contain cancer. About 764 patients and many endoscopists will take part in image reviews and live procedures. The goal is to improve treatment choices and red…