COLORECTAL CANCER

This study tested a new vaccine (EO2040) made from gut bacteria, combined with the immunotherapy drug nivolumab, in people with colorectal cancer who had tiny amounts of cancer DNA left in their blood after standard treatment. The goal was to see if the combination could clear th…

This study tested a personalized treatment where a patient's own immune cells were modified in a lab to recognize and attack unique mutations in their cancer. It was designed for people with advanced solid tumors like lung, pancreatic, or ovarian cancer who had not responded to s…

This study tested a new drug (SOT101) combined with pembrolizumab in 166 people with advanced solid tumors like lung, colon, and ovarian cancer. The goal was to see if the combo could shrink tumors. The trial was stopped early, and it is not a cure—patients still need ongoing tre…

This early-stage study tested a new drug called BDC-3042, alone or with another drug (cemiplimab), in people with advanced solid tumors like breast, kidney, ovarian, head and neck, colorectal, lung cancer, or melanoma. The goal was to check safety and see if tumors shrank. The st…

This study tested a new drug combination (NUFIRI-bev) against the standard treatment (FOLFIRI-bev) in 171 people with advanced colorectal cancer that had already been treated. The goal was to see if the new combination could better control tumor growth. The trial was stopped earl…

This study tested a new drug called TAK-186 in adults with advanced head and neck, lung, or colorectal cancer that could not be removed by surgery. The main goal was to check for side effects and find the best dose. The trial was stopped early, and 95 people took part.

This study tested whether adding the experimental drug ompenaclid to standard chemotherapy could shrink tumors in people with advanced colorectal cancer that has a RAS mutation. About 76 participants were randomly assigned to receive either ompenaclid or a placebo, along with the…

This early-phase study tested an experimental oral drug called IK-595 in 75 adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have specific RAS or RAF gene mutations and no standard treatment options left. The goal was to check the drug's safety…

This study tested a drug called tovorafenib in people aged 12 and older with advanced solid tumors that have specific genetic changes (MAPK pathway). The goal was to see if the drug could shrink tumors. The study was stopped early, but the results may help guide future treatments…

This study tested a combination of two drugs (atezolizumab and bevacizumab) in 46 people with advanced colorectal cancer that had stopped responding to chemotherapy and had a specific genetic marker called MSI-like. The goal was to see if the combination could shrink tumors. The …

This study looked at whether giving colorectal cancer patients a drink with branched-chain amino acids before surgery could prevent high blood sugar and insulin resistance after the operation. Insulin resistance after surgery can lead to complications. The trial planned to enroll…

This early-phase study tested a new medicine called PF-07921585, given alone or with another drug (sasanlimab), in adults with advanced solid tumors like lung, bladder, kidney, skin, head and neck, or colorectal cancer. The goal was to check safety and how the body handles the dr…

This study tested three different doses of an experimental drug called AUR 109 in 29 adults with advanced colorectal, ovarian, or kidney cancer who had already tried at least two other treatments. The goal was to see if the drug could shrink tumors and to check its safety. Howeve…

This early-stage trial tested a new drug (TNO155) combined with either spartalizumab or ribociclib in adults with advanced solid tumors like lung, head and neck, and colorectal cancers. The main goal was to check safety and find the right dose. The study was terminated, so result…

This study looked at whether people at high risk for colorectal cancer would prefer a CT scan (CT colonography) over a standard colonoscopy to find advanced polyps. The goal was to see which test was more acceptable and how well each detected serious growths. The study was stoppe…

This early-stage study tested a fluorescent dye called VGT-309 to see if it can make colorectal tumors glow during a colonoscopy, helping doctors find them more easily. Nine adults with colorectal cancer received the dye before their procedure. The study was stopped early, but re…

This study aimed to see if a shorter, less expensive liver MRI scan could find cancer that has spread from the colon or rectum to the liver as well as the standard longer scan. The researchers planned to compare the two methods in 10 adults with colorectal cancer and suspected li…

This study tested a technique that helps people with advanced cancer and their partners organize traumatic memories and practice slow breathing to reduce PTSD symptoms. The approach aimed to shift how the brain processes trauma, moving from emotional reactions to more controlled …

This research registry looks at the health, well-being, and needs of people who survived cancer as young adults (diagnosed between ages 18 and 39). It tracks levels of anxiety, depression, social support, and financial distress by having participants fill out online surveys every…

This study aimed to see if a short video explaining different colorectal cancer screening options (like colonoscopy and at-home tests) could help more people get screened. It included 1,823 adults aged 45-70 who had never been screened. The study was stopped early, so the main qu…

This study looked at whether tiny particles called exosomes, released by tumor cells into the blood, can serve as early warning signs for colorectal cancer progression. Researchers analyzed blood samples from 172 patients to see if the number, size, and contents of these particle…

This study looked at 289 people with early-onset breast, ovarian, colorectal, or pediatric cancers, plus those with multiple tumors. Researchers used a special test to check 200 genes for inherited mutations that standard tests might miss. The goal was to better understand why th…

This study aimed to see if using an electronic system to track symptoms could improve quality of life for people with early-stage breast or colorectal cancer receiving chemotherapy. Only 8 participants were enrolled before the trial was stopped early. The main goal was to measure…