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New cancer pill shows promise in early trial, but study halted

NCT ID NCT06270082

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 25 times

Summary

This early-phase study tested an experimental oral drug called IK-595 in 75 adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have specific RAS or RAF gene mutations and no standard treatment options left. The goal was to check the drug's safety, how the body processes it, and any signs of tumor shrinkage. However, the study was terminated early, so results are limited.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • INOVA Schar Cancer Institute

    Fairfax, Virginia, 22031, United States

  • Johns Hopkins University of Medicine Sidney Kimmel Comprehensive Care Center

    Washington D.C., District of Columbia, 20016, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Next Oncology

    Austin, Texas, 78758, United States

  • Next Oncology- San Antonio

    San Antonio, Texas, 78229, United States

  • START Midwest

    Grand Rapids, Michigan, 49546, United States

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Sarah Cannon Research Institute at HealthOne

    Denver, Colorado, 80218, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107, United States

  • University of California Irvine

    Orange, California, 92868, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of Pittsburgh Medical Center- Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.