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Why are more young people getting colon cancer? new study seeks answers

NCT ID NCT05732623

Knowledge-focused Sponsor: San Raffaele University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This international study aims to understand why colorectal cancer is becoming more common in people under 50. Researchers will compare the diet, lifestyle, and medical history of 2,300 participants—half with early-onset colorectal cancer and half healthy volunteers. The goal is to identify risk factors like smoking, diet, and physical activity that may contribute to this trend.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify key lifestyle and dietary risk factors for early-onset colorectal cancer, leading to better prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Jan 2035

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

at least 300 patients in total (100 at IRCCS San Raffaele Scientific Institute) with a recent diagnosis of eoCRC (diagnosis made within 2 years prior to enrollment), aged 18-49 years, will be prospectively recruited at least 600 Healthy controls (HCs) totally (200 at IRCCS San Raffaele Scientific Institute), matched by age (matching range ± 5 years) and sex with eoCRCs will be prospectively enrolled. Healthy volunteers will be mainly enrolled among workers within the participating hospital center, followed regularly by preventive medicine. This enrollment will be carried out by e-mail invitation disseminated through the hospital's official mailing list

Ages

18 to 49 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All sexes eligible * (for Cases) eoCRC diagnosed between 18 and 49 years and confirmed by histology (biopsy or surgical specimen in case of surgery) * (for Controls) negative past and present history of cancer; negative fecal occult blood test (FOBT), or negative colonoscopy. Exclusion Criteria: * CRC diagnosed at ≥ 50 years * Diseases that can modify the dietary regimen (celiac disease, diabetes) * Diseases that are known to predispose to eoCRC (personal past or recent history of inflammatory bowel disease, past history of pelvic irradiation) * Unable to give written consents and to fill in the electronic questionnaire

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer colorectal neoplasm Feeding Behavior rectal neoplasm Risk Reduction Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colorectal cancer Diet habit Early onset colorectal cancer Risk reduction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites in 6 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Gastroenterology, Hospital Clínic de Barcelona, University of Barcelona

    RECRUITING

    Barcelona, Spain

  • Department of Gastrointestinal Surgery, Helsinki University Hospital

    RECRUITING

    Helsinki, Finland

  • Department of General, Visceral and Transplant Surgery, Hospital of the University of Munich (LMU)

    RECRUITING

    Munich, Germany

  • Department of Medicine-Gastroenterology, Denver Veterans Affairs Medical Center, University of Colorado Hospital

    RECRUITING

    Denver, Colorado, 80045, United States

  • Division of Cancer Medicine, Oslo University Hospital (OUS), Institute for Cancer Genetics and Informatics Norwegian Radium Hospital

    RECRUITING

    Oslo, Norway

  • Gabriela Moslein

    RECRUITING

    Wuppertal, Germany

  • Prof Giulia Martina Cavestro, MD PhD

    RECRUITING

    Milan, Lombardy, 20132, Italy

  • Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine University of Chicago Medicine

    RECRUITING

    Chicago, Illinois, 60637, United States

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