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Which painkiller combo works best for cancer surgery? new trial aims to find out

NCT ID NCT06731998

Symptom relief Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study compares three routine pain control methods used during minimally invasive cancer surgery: a nerve block plus local anesthetic, nerve block alone, or local anesthetic alone. About 48 adults having surgery for various cancers will be randomly assigned to one of the three groups. Researchers will track pain scores, opioid use, and side effects for the first 24 hours after surgery to see which method works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ropivacaine (local anesthetic)
What this could lead to
If successful, this could identify the best pain management approach for cancer surgery, potentially reducing opioid use and improving recovery.
What could go wrong
This is a small, early-stage trial with only 48 participants, so results may not apply to all patients. The differences between groups might be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 89 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male and female patients age ≥ 18 - 89 2. Patients scheduled for elective (clinically indicated) hepatic, gastric, biliary, pancreatic, gynecologic, colorectal, other GI Minimally invasive oncologic surgery. 3. Patients who have provided informed consent to participate in the study. 4. Patients with an American Society of Anesthesiologists (ASA) physical status classification of I, II, or III. 5. Patients undergoing procedures anticipated to last more than 1 hour but less than 8 hours. 6. Patients able to understand and self-report pain using the designated pain Visual Analog Scale Exclusion Criteria: 1. Patients age less than 18 or ≥ 90 2. Pre-existing hepatic dysfunction, cirrhosis 3. Patients with an ASA classification of IV or higher. 4. Patients with chronic pain disorders or on long-term opioid or analgesic therapy. 5. Patients with known contraindications to the study drugs or procedures (e.g., allergy to LA or contraindications to LapTAP). 6. Patients with cognitive impairments or psychiatric conditions that could interfere with pain assessment or understanding of informed consent. 7. Patients unable to understand the language in which consent and study-related information are provided (The study and the study-related information will be in the English Language).. 8. Patients who have undergone major surgery within the last 6 months. 9. Female patients who are pregnant. 10. Patients currently enrolled in another clinical trial that might interfere with the outcome measures of this study.

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Conditions

The condition(s) this trial relates to.

agnosia biliary tract cancer Biliary Tract Neoplasms cancer carcinoma of liver and intrahepatic biliary tract colorectal cancer colorectal neoplasm digestive system cancer digestive system neoplasm female reproductive organ cancer gastric cancer liver cancer Liver Neoplasms malignant pancreatic neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biliary tract cancer Cancer Cancer surgery Colorectal cancer Gastric (cardia, body) cancer Gastrointestinal cancers Gynecologic cancers Hepatic cancer Minimally invasive surgical procedures Oncologic surgery Pancreatic cancer resectable

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AHN West Penn Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

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