Pneumonitis

This study is testing how well a 20-valent pneumococcal vaccine works against pneumonia in adults aged 65 and older. Researchers will compare vaccinated and unvaccinated hospitalized patients with pneumonia to see if the vaccine reduces infections from seven specific bacterial st…

This study tests whether a two-shot pneumonia vaccine series (PCV20 and PPSV23) can help people with chronic lymphocytic leukemia (CLL) build a stronger immune defense against pneumococcal infections. About 61 adults with CLL who have not yet had treatment, or who are on a specif…

This Phase 2 trial tests an experimental inhaled medication called LTI-03 in about 120 people with idiopathic pulmonary fibrosis (IPF), a progressive lung disease that causes scarring and breathing difficulty. Participants will inhale LTI-03 or a placebo twice daily for 24 weeks.…

This study looks at the long-term safety of an inhaled drug (AP01) for people with progressive lung scarring (pulmonary fibrosis). It is for those who already completed an earlier Avalyn Pharma study. About 340 participants will receive the drug and be monitored for side effects …

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are also receiving a beta-lactam antibiotic. The goal is to see which combination helps patients leave the hospital sooner and reduces the need f…

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesiv…

This phase 2 trial tests an oral drug called PIPE-791 in 324 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either a low or high dose of PIPE-791 or a placebo daily for several months. The main goal is t…

This study tests a drug called H01 (hymecromone) in adults with interstitial lung disease, a condition that causes lung scarring and makes breathing hard. The goal is to see if H01 can lower a marker of lung damage and improve lung function. Participants take the drug as a tablet…

This study tests an oral medication called ibuzatrelvir in adults and teens with COVID-19 who are not hospitalized but have a high risk of becoming severely ill. Participants will receive either the drug or a placebo for 5 days, and researchers will track whether it reduces emerg…

This study tests whether a single dose of an experimental immune cell therapy called agenT-797, given alongside standard care, can lower the risk of death in adults with severe pneumonia and breathing failure. About 90 people in intensive care will receive either agenT-797 or a p…

This study tests the long-term safety of the drug nerandomilast in people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). All 1,700 participants have already taken the drug in a previous study. They will take nerandomilast tablets for up to 1 yea…

This phase IIb study tests three doses of AZD8965 against a placebo in 359 adults with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. The main goal is to see if AZD8965 can slow the decline in lung function over 24 weeks. Participants may also be taking standard IP…

This study tests a new medicine called BI 765423 in 71 adults with idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. Participants receive either the drug or a placebo by infusion every four weeks for about 3 months. The main goal is …

This study tests whether taking pentoxifylline and vitamin E during chemoradiation can prevent lung injury (pneumonitis) in stage III non-small cell lung cancer patients. 150 participants will receive either the drug combo or a placebo for 6 months. The goal is to see if this red…

This study compares two treatments after surgery for stage III-IVA head and neck cancer: radiation alone versus radiation plus the chemotherapy drug cisplatin. The goal is to see which approach better prevents the cancer from returning, especially in patients with certain TP53 ge…

This phase 2 trial tests whether MTX-463, an antibody that blocks a protein linked to scarring, can slow lung function decline in people with idiopathic pulmonary fibrosis (IPF). About 164 adults with IPF will receive either the drug or a placebo for 24 weeks. The main goal is to…

This early-stage trial tests a new drug called PRS CK STORM, made from a mix of immune and fat cells, to see if it can safely calm the 'cytokine storm'—a dangerous overreaction of the immune system—in people with severe lung infections from COVID-19, flu, or RSV. The study will e…

This study compares two pneumococcal vaccination strategies in 160 adults with lymphoma who have had chemotherapy. One group gets two vaccines (Prevenar 13 followed by Pneumovax 23), while the other gets a single newer vaccine (Prevenar 20). Researchers will measure immune respon…

This early-stage trial tests whether high doses of inhaled nitric oxide gas are safe and potentially helpful for critically ill pneumonia patients on breathing machines. About 34 adults will receive either the gas or a sham treatment for 5 days. Researchers will monitor blood oxy…

This study tests whether adding the antibiotic azithromycin to standard treatment helps people with idiopathic pulmonary fibrosis (IPF) recover faster from sudden, severe flare-ups. Researchers will compare hospital stay length and other outcomes between those who get azithromyci…

This Phase II study tests a drug called BC006 in 96 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. The trial first checks safety in a small group, then randomly assigns patients to receive BC006 or a placebo every tw…

This study tests whether a drug called icosapent ethyl (Vascepa) can reduce inflammation in the arteries of people hospitalized with pneumonia. Pneumonia can trigger body-wide inflammation that may harm blood vessels. Researchers will give 168 adults either Vascepa or a placebo t…

This study tests whether the drug senicapoc can prevent lung scarring from getting worse in people with progressive fibrotic interstitial lung disease (ILD) or idiopathic pulmonary fibrosis (IPF). About 140 adults will take either senicapoc or a placebo daily for 26 weeks, and do…

This study tests whether awake patients with acute breathing failure who lie face down (prone positioning) for at least 10 hours a day for 3 days are less likely to need a breathing tube or die within 28 days, compared to standard care. The trial will include 342 intensive care u…

This early-stage trial is testing an inhaled form of nintedanib (called MNKD-201) in 24 people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs. The study aims to see if the drug is safe and tolerable when breathed in, and how the body processes it. Partic…

This study looks at whether a new approach can safely reduce antibiotic use in children aged 6 months to 18 years who have mild pneumonia and are sent home from the emergency room. About 700 children will take part. The goal is to give antibiotics only when truly needed, while st…

This study tests whether adding low-intensity laser therapy and breathing exercises to standard medical care can improve immune function in 40 children with Down syndrome who have pneumonia. One group gets laser therapy plus breathing training, while the other gets only breathing…

This Phase 3 trial tests a new drug called HEC585, taken once daily, to see if it can slow lung function decline in people with idiopathic pulmonary fibrosis (IPF), a serious lung-scarring disease. About 472 adults aged 40 to 80 will be randomly assigned to receive HEC585, a plac…

This large Phase 3 trial is testing many different treatments, including antiviral drugs and steroids, in 70,000 hospitalized patients with pneumonia (including COVID-19). The goal is to see which treatments reduce deaths and speed up recovery. Researchers compare each treatment …

This study tests if the drug pirfenidone can help people with lung damage caused by radiation therapy (with or without immunotherapy). About 298 adults with certain cancers who received chest radiation will take pirfenidone or a placebo for 24 weeks. The goal is to see if the dru…

This study tests whether a blood thinner (heparin) can help hospitalized adults with pneumonia avoid serious complications like needing a breathing machine or intensive care. About 4000 participants will receive either heparin or standard care. The goal is to see if heparin reduc…

This study tests whether taking inhaled budesonide (a steroid) twice daily during radiation therapy can reduce the severity of radiation pneumonitis—a common and serious lung inflammation—in people with non-small cell lung cancer. About 72 patients will be randomly assigned to re…

This phase 3 trial compares amoxicillin alone to amoxicillin/clavulanate for treating community-acquired pneumonia in adults aged 65 and older who are hospitalized but not in intensive care. The goal is to see if the narrower antibiotic works just as well, which could reduce side…

This study tests an experimental drug called ABBV-142 in people with idiopathic pulmonary fibrosis (IPF), a rare lung disease that causes scarring and breathing problems. About 165 adults will receive either ABBV-142 or a placebo for 52 weeks to see if the drug is safe and can he…

This study tests an inhaled version of the drug nintedanib (called AP02) in people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. About 160 adults aged 40 and older who are not currently on IPF treatment will take either a low o…

This phase 3 trial tests whether adding trimodulin (a protein mixture from donated blood) to standard care can lower death rates in adults with severe community-acquired pneumonia who need a breathing machine. About 590 hospitalized patients will receive either trimodulin or a pl…

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This study tests whether using inhaled budesonide (a steroid commonly used for asthma) for one year can stop lung inflammation from coming back in cancer patients who had a serious immune reaction to immunotherapy. About 94 adults with solid tumors who recently had lung inflammat…

This study compares two common steroids, hydrocortisone and prednisolone, in 1,600 adults hospitalized with severe community-acquired pneumonia. The goal is to see which one reduces deaths within 30 days. Participants are randomly assigned to one of the two treatments.

This study tests whether adding intravenous immunoglobulin (IVIG) to standard care helps people hospitalized with a sudden, severe worsening of idiopathic pulmonary fibrosis (IPF). About 196 adults with IPF who are having an acute exacerbation will receive either usual treatment …

This study is testing whether a dietary supplement called IDP (Immune Defense Protein) can reduce the length and severity of cold and flu symptoms in people aged 60 and older. About 300 participants will take either a low or high dose of IDP or a placebo daily during cold and flu…

This study tests whether quercetin, a natural compound found in many fruits and vegetables, can slow lung scarring and improve breathing in people with pulmonary fibrosis. Half of the 100 participants will take quercetin pills daily for 24 weeks, while the other half receive stan…

This study tests a new drug called TDI01 for people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. About 508 adults in China will receive either TDI01 or a placebo to see if the drug helps slow lung function decline over 24 to 5…

This early-phase study tests a new drug called SV001 in 53 healthy Chinese adults to see if it is safe and how the body processes it. Participants receive a single dose of SV001 or a placebo. The goal is to check for side effects and measure drug levels in the blood. This is a fi…

This Phase 2 trial tests whether an oral drug called ifetroban can slow the decline in lung function for people with idiopathic pulmonary fibrosis (IPF), a progressive lung-scarring disease. About 128 adults aged 40 and older with IPF will receive either ifetroban or a placebo da…

This phase II trial tests whether a drug called BIO 300, made from a soy compound, can prevent severe lung inflammation (pneumonitis) in people with early-stage non-small cell lung cancer who also have interstitial lung disease. About 25 participants will receive BIO 300 along wi…

This Phase 3 trial tests whether high-dose steroids (methylprednisolone and prednisone) can reduce deaths within 30 days for people hospitalized with a sudden worsening of idiopathic pulmonary fibrosis (IPF). About 110 adults with IPF and an acute exacerbation will receive either…

This study tests a new drug called AV-001 in 120 hospitalized adults with pneumonia who need extra oxygen. The drug is given daily for up to 28 days alongside standard care. The goal is to see if it is safe and helps patients recover faster from pneumonia caused by COVID-19 or ot…

This study tests whether using a SPECT scan to map healthy, working lung tissue can help doctors aim radiation away from those areas during treatment for advanced lung cancer. The goal is to reduce lung damage and side effects like breathing problems. About 90 people with lung ca…

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This study is for people with a weakened immune system who have a serious lung infection called PCP. The standard treatment often causes bad side effects. Researchers want to see if a lower dose of the antibiotic TMP-SMX works just as well but with fewer side effects. About 416 a…

This study looks at whether giving vitamin C alongside standard hospital care can help children under five with severe pneumonia recover faster. Ninety children will be split into two groups: one gets standard treatment alone, the other gets standard treatment plus a daily dose o…

This trial tests two ways of using a breathing machine during surgery in 200 adults at high risk for lung complications. One method uses standard protective settings, while the other adjusts the machine based on each patient's lung stiffness. Researchers will track lung problems,…

This study tests a new drug, SV001, in 48 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing hard. The main goal is to check if SV001 is safe and how the body processes it. Participants will receive either SV001 or a placebo, …

This early-stage trial tests a single dose of an inhaled drug called RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to see how much drug reaches the lungs and blood, and whether it is safe. Researchers hope that inhaling the drug wi…

This study compares two ways of giving antibiotics to children with mild pneumonia: giving them right away versus waiting 72 hours to see if symptoms improve. The goal is to see if the 'watch and wait' approach can safely reduce unnecessary antibiotic use. About 2,000 children wi…

This study is testing a new approach for people with severe lung disease (like pulmonary fibrosis or COPD) who also have bone marrow failure. First, participants receive a lung transplant to restore breathing. Then, about 8 weeks later, they get a bone marrow transplant using the…

This early-stage trial tests whether artesunate, a drug used for malaria, is safe for people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Fifteen adults with IPF will receive either artesunate capsules or a placebo for 12 week…

This study looks at whether using higher pressure during noninvasive breathing support (a mask that helps you breathe) can help people with pneumonia or ARDS avoid needing a breathing tube. About 700 adults will be randomly assigned to receive either high or low pressure. The mai…

This study tests an inhaled medicine called SNG001 in patients with severe viral pneumonia who need a breathing machine. The goal is to see if it safely helps clear the virus faster and lowers the risk of death. About 550 adults, mostly over 50 or with weakened immune systems, wi…

This study tests a new drug called HRS-9813 in 270 adults with pulmonary fibrosis (IPF or PPF), a condition where lung tissue becomes scarred and breathing gets harder. The trial compares the drug to a placebo to see if it improves lung function and is safe. Participants take the…

This study tests whether lansoprazole, a medicine that reduces stomach acid, can slow the progression of idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. About 298 adults with IPF will take either lansoprazole or a placebo twice dai…

This study looks at how long kidney transplant patients should take a common antibiotic (TMP-SMX) to prevent a serious lung infection called PJP. About 450 participants will be randomly assigned to different treatment durations. The goal is to find the safest and most effective l…

This study tests whether giving the antibiotic clarithromycin early, guided by a blood test (suPAR), can prevent pneumonia from worsening into sepsis. About 330 adults with community-acquired pneumonia will receive either clarithromycin or a placebo. The goal is to see if this ap…

This study tests whether the steroid hydrocortisone, added to usual care, can help ICU patients with severe hospital-acquired pneumonia. Researchers will compare hydrocortisone against a placebo in 180 adults. The goal is to see if the drug reduces early death or worsening of bre…

This study tests whether the antiviral drug acyclovir helps people on breathing machines who have pneumonia and also have herpes simplex virus (HSV) in their lungs. About 616 adults in intensive care will be randomly assigned to receive acyclovir or no antiviral treatment. The go…

This large Phase 3 trial is testing an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. Participants receive either a single dose of tozorakimab or a placebo, added to standard care. The main goal is to see…

This study compares two antibiotics, clarithromycin and azithromycin, for treating MAC lung infections, a serious bacterial lung disease. About 424 adults with MAC infection will receive one of the two drugs alongside standard treatments. The goal is to see if azithromycin works …

This study tests an experimental drug called SB17170 in 30 adults with moderate to severe idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either the drug or a placebo daily for 12 weeks. The main goal is to see if th…

This study tests an experimental oral drug called INS018_055 in 40 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. The main goal is to check the drug's safety over 12 weeks. Participants will be randomly assigned to r…

This study looks at whether children with medical complexity who have pneumonia can safely stop antibiotics sooner if they are clinically stable. Researchers will track how many families agree to the approach and monitor for worsening symptoms or return to the hospital. The goal …

This study looks at whether adding a non-invasive brain stimulation technique (rTMS) to standard swallowing therapy can reduce pneumonia in stroke patients who have trouble swallowing. About 70 adults aged 49-65 with moderate to severe swallowing problems after a stroke will be e…

This study tests whether a special filter (oXiris) is better than a standard filter (M100) for cleaning the blood in pneumonia patients whose kidneys have suddenly failed. About 60 adults will be enrolled to measure changes in inflammation levels, kidney function, and survival at…

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study tests whether an AI-powered digital stethoscope can help doctors in rural Bangladesh safely reduce antibiotic use in children with respiratory infections. About 2,500 children will be randomly assigned to standard care or care guided by the AI stethoscope. The goal is …

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This early-phase study tests a radioactive tracer called Cu-DOTA-ECL1i that binds to certain inflammatory cells in the lungs. Researchers will use PET scans to see how the tracer spreads in people with fibrotic lung disease, comparing it to CT scans and clinical status. The goal …

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study is testing whether a mouthwash or a nasal swab can accurately detect pneumocystis pneumonia (PcP) in immunocompromised patients. Currently, diagnosis often requires a bronchoscopy, which is invasive and uncomfortable. Researchers will compare the new non-invasive metho…

This study tests a wearable device called the C-mo System that automatically detects and describes coughs. Researchers want to see if it can accurately count coughs, measure their intensity, and identify wheezing. 300 people aged 2 and older with cough-related conditions will wea…

This study tests whether a special PET scan (FAPI PET) can better detect active scarring in the lungs of people with fibrotic lung disease. About 50 adults with idiopathic pulmonary fibrosis or fibrotic hypersensitivity pneumonitis will get up to 4 PET/MRI scans. The goal is to i…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study aims to create a better way to diagnose pneumonia in older adults (65+) who come to the emergency department with suspected pneumonia. Researchers will observe 250 participants and test whether new biomarkers can improve diagnostic accuracy. The goal is to help doctors…

This study tests a non-invasive imaging method called electrical impedance tomography (EIT) to monitor lung function in 400 adults with lung diseases like COPD, asthma, or pneumonia. Unlike standard spirometry, which requires active blowing, EIT works even in patients who cannot …

This study looks at whether automated software can consistently measure the amount of lung scarring (interstitial lung disease) on chest CT scans. Researchers will scan 150 adults with known lung scarring twice in a row to see if the measurements match. The goal is to improve the…

This study aims to see if a new PCR-based test can diagnose malaria, leishmania, and pneumocystis infections faster and more accurately than current methods. Researchers will analyze about 200 stored samples from patients. The goal is to improve diagnosis and species identificati…

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study checks how well standard devices measure blood flow in patients on ECMO, a machine that adds oxygen to blood outside the body. About 30 adults on ECMO will have their blood flow measured using different methods, including ultrasound and a leg-raising test. The goal is …

This study checks how well standard devices measure blood flow in 30 adults on ECMO, a machine that pumps and oxygenates blood outside the body. The goal is to see if these monitors give accurate readings during this special situation. Results could help doctors better manage flu…

This study tests whether intensive oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with small to medium bleeds will be randomly assigned to receive either standard care or enhanced mouth care plus antibiotic…

This study tests whether Buccalin tablets can reduce the number of lower respiratory tract infections in adults who get them often. 240 participants will receive either Buccalin or a placebo for 12 months. The goal is to see if the treatment lowers infection episodes compared to …

This study tests whether training NICU teams on a bundle of best practices (like mouth care and proper suctioning) can reduce ventilator-associated pneumonia in newborns. About 1500 babies on breathing machines will be tracked before and after the training. The goal is to standar…

This study tests whether using a positive expiratory pressure (PEP) device before and after hip fracture surgery can prevent hospital-acquired pneumonia. About 566 patients will either receive the PEP therapy plus standard care or standard care alone. The goal is to see if this s…

This study investigates whether drinking nitrate-rich beetroot juice twice a day for three days can improve exercise capacity in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease that limits activity. Researchers will compare the juice to a placebo in a sma…

This study tests whether using a portable oxygen concentrator (a lightweight, battery-powered device) during walking or exercise helps people with interstitial lung disease (ILD) or COPD feel less breathless and be more active in their daily lives. Twenty-four participants will t…

This study compares two sedation methods for elderly ICU patients (65+) who need a breathing tube. One group gets a mix of propofol and ketamine, the other gets propofol alone. The goal is to see which causes fewer dangerous drops in blood pressure. The trial involves 41 particip…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study tests a 10-week program called RISE-HP for people with hypersensitivity pneumonitis (HP), a lung condition that can cause anxiety, depression, and poor quality of life. Participants work one-on-one with a trained peer coach (someone who also has HP) to learn coping ski…

This study tests whether adding a special breathing treatment called intrapulmonary percussive ventilation (IPV) to standard care helps patients with pneumonia who are on a breathing machine. About 96 adults will be randomly assigned to receive either standard therapy alone or st…

This study tests a new way to plan radiation therapy for people with stage 3 lung cancer. The method uses CT ventilation imaging to identify and avoid the healthiest parts of the lungs during treatment. Researchers want to see if this approach helps patients maintain a better qua…

This study looks at whether drinking beetroot juice, which is high in nitrate, can help people with fibrotic interstitial lung disease exercise longer. Participants will drink either nitrate-rich or nitrate-free beetroot juice and then do a cycling test. The goal is to see if the…

This study tests two simple breathing exercises—balloon blowing and bubble PEP—in 40 children aged 6 to 12 with pneumonia. The goal is to see which one improves oxygen levels and reduces shortness of breath better, and which kids enjoy more. Both are non-drug therapies done daily…

This study looks at whether children with pneumonia caused by Mycoplasma bacteria need antibiotics to get better. About 376 children aged 3-17 will receive either a placebo (inactive pill) or a common antibiotic. Researchers will track how long symptoms like fever and fast breath…

This study tests whether awake patients with severe pneumonia can avoid being put on a breathing machine by lying face down (prone position) for up to 16 hours a day. Researchers will track 1078 adults in intensive care to see if this simple position change reduces the need for i…

This study tests whether a newer breathing machine (HVNI) works better than standard noninvasive ventilation (NIV) for adults with pneumonia who are having trouble breathing. About 100 participants will be randomly assigned to one of the two machines. The main goal is to see whic…

This study compares two ways to help pneumonia patients who have trouble breathing: alternating between a mask that helps push air in (non-invasive ventilation) and high-flow oxygen through the nose, versus using high-flow oxygen alone. The goal is to see which approach improves …

This study tests whether using an incentive spirometer—a device that encourages deep breathing—can lower the risk of lung inflammation (pneumonitis) in people with advanced lung cancer receiving chemotherapy and radiation. About 100 participants will use the device 10 times every…

This early-stage study is testing an extended-release tablet called nalbuphine ER in 10 people with idiopathic pulmonary fibrosis (IPF). The main goal is to see if the drug is safe and whether it affects breathing function. Researchers will monitor oxygen levels, breathing rate, …

This study aims to see if bundling all routine tests and doctor visits into one coordinated hospital trip can save time for people with interstitial lung disease. About 152 adults with the condition will either receive standard care or the new streamlined approach. The goal is to…

This study tests whether a special light therapy called photobiomodulation (PBM) can reduce swelling and tissue hardening caused by radiation treatment in head and neck cancer survivors. Sixty participants who completed radiation at least 3 months ago will be randomly assigned to…

This study tests whether N-acetyl cysteine (NAC) and a short course of steroids can reduce severe shortness of breath after lung radiation in people with both lung cancer and interstitial lung disease. About 98 participants will receive either NAC or placebo, plus either steroids…

This study compares a 5-day antibiotic course to the usual 7-14 day course for hospitalized children aged 3 months to 18 years with uncomplicated pneumonia. The goal is to see if the shorter treatment is just as effective and causes fewer side effects. Participants are randomly a…

This study tests whether exposure to bright blue light can reduce inflammation and organ damage in people hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. Participants will be randomly assigned to receive either blue-enriched light or…

This study tests whether a special imaging method (4DCT) can help doctors avoid giving too much radiation to healthy, working parts of the lung during radiotherapy for lung cancer. About 100 adults with lung cancer will receive standard radiation, but their treatment plan will be…

This study tests a special vest that vibrates to help loosen mucus in the lungs for people who have trouble coughing it up. About 45 hospitalized adults will use the vest and report how their breathing, cough, and mucus symptoms change. The goal is to see if this device is safe a…

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

This study tests two types of home exercise programs for people with idiopathic pulmonary fibrosis (IPF), a lung disease that makes breathing hard. Participants will be split into two groups: one does live online exercise sessions, the other follows video workouts. The goal is to…

This study tests whether a combination of zinc and nicotinamide riboside can help people with idiopathic pulmonary fibrosis (IPF) feel better and breathe easier. Sixty participants will take the supplements or a placebo twice a day for 24 weeks, all from home with remote check-in…

This study tests whether analyzing a patient's phlegm can help doctors choose better treatments for chronic cough in interstitial lung disease (ILD). About 120 adults with ILD and daily cough for at least 8 weeks will be randomly assigned to either phlegm-guided treatment or stan…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes skin and lung infections. Researchers will follow 600 patients and their relatives over time, examining their health and genetics. The goal is to better understand the disease and improve c…

This study tests whether bundling key tests like scans and lung function tests into a single, fast-tracked appointment can help people with suspected interstitial lung disease get a diagnosis sooner. About 92 adults will be randomly assigned to either the usual step-by-step testi…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical data, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better understan…

This study looks at proteins in lung fluid from 750 people with pneumonia to find biomarkers that could reveal what's causing the lung inflammation. Participants undergo a standard bronchoscopy with lung washings, plus a blood draw. The goal is to better understand different type…

This study looks at whether an artificial intelligence (AI) tool can predict if lung scarring (pulmonary fibrosis) will get worse over time. Researchers will analyze CT scans from 200 people with either idiopathic pulmonary fibrosis (IPF) or other types of interstitial lung disea…

This study looks at 790 adults with S. maltophilia infections, a hard-to-treat bacteria. Researchers will compare patients who got one antibiotic versus those who got a combination, to see which group has fewer deaths within 30 days. The goal is to find the best treatment approac…

This study follows 650 adults who had pneumonia (including COVID-19) to see how the infection might lead to heart disease later. Researchers will collect blood samples, run heart and lung tests, and track heart attacks, strokes, and other events over three years. No new treatment…

This study follows 4,000 people with interstitial lung disease (including conditions like pulmonary fibrosis and sarcoidosis) to understand how the disease naturally changes over time. Researchers will collect medical data and blood samples, and compare them to a healthy control …

This study tests whether two types of PET/CT scans can show inflammation and scarring in the lungs of people with idiopathic pulmonary fibrosis (IPF). Ten adults aged 40-85 with IPF will receive the scans. The goal is to help doctors better understand the disease and guide future…

This study is analyzing the exhaled breath of 5,000 people with lung or airway diseases to find unique molecular patterns. The goal is to better identify and distinguish different respiratory conditions and improve disease management. Participants simply provide breath samples, a…

This study is observing 200 hospitalized adults with carbapenem-resistant Acinetobacter baumannii (CRAB) infections—a type of superbug—who are treated with the antibiotic sulbactam-durlobactam. Researchers will compare their outcomes to patients receiving other treatments to see …

This study looks at 60 adult male smokers under 65 who have both heart disease (acute coronary syndrome) and pneumonia along with COPD. Researchers want to see if certain blood markers (GDF-15, MR proADM, and Presepsin) change after getting a flu shot. The goal is to understand h…

This study will enroll 25 adults with interstitial lung disease or COPD to investigate the physical origins of ultrasound artifacts seen in lung scans. Researchers will compare ultrasound findings with CT scans and wearable sensor data to understand what these artifacts really me…

This early-stage study tests how a new drug called ENV-101 (taladegib) interacts with two standard medicines for idiopathic pulmonary fibrosis (IPF): nintedanib and pirfenidone. About 57 healthy adults will take ENV-101 alone and with these drugs to measure how the body absorbs a…

This study looks at why people with interstitial lung disease (ILD) often feel breathless and have trouble exercising. Researchers think leg muscle problems might be a cause. They will measure leg muscle strength and structure in 40 ILD patients and test how extra oxygen affects …

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This observational study aims to find early biomarkers that can predict if a person's lung scarring (pulmonary fibrosis) will get worse quickly. Researchers will follow 450 adults with various types of interstitial lung disease, including IPF and other fibrotic conditions. Partic…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at how immunosuppression treatment changes lung scarring in people with certain types of interstitial lung disease (not IPF). Using advanced PET and MRI scans, researchers will measure collagen buildup and tissue damage. The goal is to better understand the effec…

This study is testing a new type of MRI that uses xenon gas to see how well the lungs are working in people who have had a bone marrow transplant. Researchers will scan 25 transplant patients with or without lung problems, plus 10 healthy volunteers. The goal is to see if this MR…

This study is collecting information from 20,000 adults with community-acquired pneumonia to understand how common it is, what puts people at risk, and how it interacts with other health conditions. Researchers will ask about symptoms, treatments, and hospital stays. No new treat…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This registry is following 3,000 adults with idiopathic pulmonary fibrosis (IPF) or other chronic fibrosing interstitial lung diseases (ILDs) to understand how these conditions progress over time. Researchers collect information on symptoms, treatments, quality of life, and store…

This study looks at 750 people with rheumatoid arthritis (RA) who are 45 or older to find early signs of interstitial lung disease (ILD), a serious lung complication. Researchers will use CT scans and track changes over 3-5 years to identify risk factors. The goal is to better un…

This study looks at how pirfenidone changes the amount of a new medicine (BI 1015550) in the blood of adults with idiopathic pulmonary fibrosis (IPF). Twenty participants aged 40 and older will take both drugs over about a month. Researchers will measure blood levels to understan…

This study is creating a repository of blood samples from 635 people with interstitial lung diseases (ILD), pneumonia, and healthy volunteers. Researchers hope these samples will help identify biomarkers to improve diagnosis and treatment. No experimental treatments are given; pa…

This study looks at whether people with a narrow upper jaw have different muscle pressures in their tongue, lips, and cheeks compared to those with normal jaw width. Researchers will measure these pressures using a special device in 40 participants aged 12 to 25. The goal is to u…

This pilot study tests whether sodium bicarbonate (baking soda) can be used safely as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on breathing machines. Researchers will compare it to standard hypertonic saline in 41 ICU patients.…

This study looks at the types of germs and their resistance genes in 800 people with pneumonia. Researchers will compare severe and mild cases to understand which microbes and resistance patterns are most common. The goal is to improve how doctors diagnose and treat pneumonia, es…

This study tests whether special PET and MRI scans can predict how fast lung scarring (pulmonary fibrosis) will get worse in 60 adults aged 18-80 with certain types of this disease. Participants will have scans and breathing tests over 2 years. The goal is to see if these imaging…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study will follow 1000 adults for up to 10 years, using a special type of CT scan (photon-counting) to look for lung nodules, tumors, and other lung conditions. Researchers will also use artificial intelligence to create a virtual copy of each person's lungs, called a 'digit…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study looks at whether using lung ultrasound can help doctors avoid giving antibiotics to children who don't need them. About 659 children aged 3 to 10 with suspected pneumonia will be randomly assigned to get either standard care or care guided by lung ultrasound. The goal …

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study will use advanced MRI techniques to measure oxygen levels in the lungs of 50 people with early-stage idiopathic pulmonary fibrosis (IPF). The goal is to see if MRI can identify areas of low oxygen, which may be linked to disease progression. This is an observational st…

This study follows 80 adults who had coronary bypass surgery to see how developing pneumonia in the hospital affects their heart and lung health over the next year. Researchers will compare patients who get pneumonia with those who don't, using blood tests, heart and lung functio…

This study follows 800 adults admitted to the respiratory ICU with severe pneumonia. Researchers will collect data on symptoms, breathing support, and death rates to better understand the disease. No new treatments are tested; the goal is to gather information to guide future car…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study will gather health information from 5,000 children in China who have severe infections like pneumonia or sepsis. The goal is to learn how common these infections are, how well different treatments work, and to create tools that can predict which children are at highest…

This study looks at 100 adults with fibrosing interstitial lung diseases (a type of lung scarring) to see if things like mold, dust, air pollution, and other home factors make the disease progress faster. Researchers will compare patients whose disease is getting worse to those w…

This study compares two strong antibiotics, polymyxin B and colistin, in treating serious infections caused by bacteria that are resistant to many common drugs. Researchers will look at medical records of 480 adults with pneumonia or bloodstream infections to see which antibiotic…

This study is an early safety check for a new drug called HW241045, which may one day help treat a lung disease called IPF. Researchers are giving a single dose to 56 healthy adults to see if it is safe and how the body processes it. No treatment benefit is expected for participa…

This study looks at whether a simple frailty assessment can better predict serious outcomes like death in older adults with pneumonia. Researchers will follow 150 patients aged 65 and older in the emergency department, comparing the frailty scale to standard severity scores. The …

This study is looking at whether a blood test called D-dimer can help doctors understand how serious pneumonia is and how well patients might recover. Researchers will measure D-dimer levels in 50 adults admitted to the hospital with community-acquired pneumonia and compare them …

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI results with lung tissue from 30 patients awaiting lung transplant. The goal is …

This study is enrolling 4,000 adults in intensive care with ARDS, sepsis, or pneumonia. Researchers will collect blood, urine, and swab samples, plus track recovery for up to a year. The goal is to identify different patient subtypes and find clues that could lead to better treat…

This study is for children and adults with interstitial lung disease, a group of conditions that scar the lungs and make breathing hard. Researchers will follow 3000 patients and their relatives for up to 10 years, collecting medical data and genetic information. The goal is to l…

This Phase 1 trial tests the safety and tolerability of an investigational drug called SRN001 in 30 healthy Korean and Caucasian men. Participants receive either SRN001 or a placebo to see how the drug moves through the body and whether it causes side effects. The goal is to gath…

This study looks at whether a special breathing therapy called OLE (Oscillatory Lung Expansion) helps ICU patients with pneumonia clear mucus from their lungs. Researchers will use a lung imaging tool (EIT) to see how well the therapy works. About 62 adults in the ICU will take p…

This study looks at whether the effort it takes to breathe can cause further lung damage in people with idiopathic pulmonary fibrosis (IPF). Researchers will measure breathing effort using a simple nose pressure test before and after exercise. The goal is to find patients whose b…

This study looks at how medical oxygen programs work in six countries across Africa and Asia. Researchers will interview policymakers, health workers, and others to find out what helps or hinders oxygen access. The goal is to improve national and global policies, not to test a ne…

This study aims to understand how a gene called HOXB7 and related molecules behave in the lungs and blood of people with pulmonary fibrosis, a condition that causes lung scarring. Researchers will collect lung tissue and blood samples from 80 adults to look for biomarkers that mi…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to understand how these images change after treatments like blood transfusions or oxygen therapy. The study involves 125 adul…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study tests whether monitoring changes in airway resistance can help doctors decide the best time to suction mucus from the lungs of patients on ventilators. Researchers will use machine learning to analyze data from 258 patients with conditions like ARDS or severe pneumonia…

This study looks at whether people newly diagnosed with idiopathic pulmonary fibrosis (IPF) have problems in their small airways, which are tiny air passages in the lungs. Researchers will use a simple breath test called nitrogen washout to check for these issues before starting …

This study looks at children with Down Syndrome who have pneumonia to see if there is a link between their immune system and how well they breathe. Researchers will measure immune markers in the blood and breathing rate and oxygen levels. The goal is to better understand these re…

This study tests whether computer-based decision support tools can help doctors reduce unnecessary antibiotic use in children with lower respiratory tract infections like pneumonia, bronchiolitis, and asthma flare-ups. Most of these infections are caused by viruses, not bacteria,…

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This pilot study looks at how anti-fibrotic medications affect body composition in people with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF). Researchers will use bioelectrical impedance analysis (BIA) and muscle ultrasound to track changes in muscle…

This study aims to develop a simple, non-invasive way to detect lung diseases like cancer, asthma, and COPD by analyzing DNA and proteins from cough samples. Researchers will collect cough specimens from 2000 adults, including smokers and non-smokers, and compare them to samples …

This study looks at lung inflammation caused by radiation therapy for cancer, called radiation pneumonitis. Researchers will take cell samples from the lungs of 5 patients during a routine bronchoscopy and use a technique called single-cell sequencing to see which cells are activ…

This study follows 750 healthy family members of people with familial pulmonary fibrosis, a lung scarring disease that runs in families. Researchers will track participants with yearly questionnaires and in-person visits every two years to see who develops the disease and why. Th…

This study explores whether functional MRI can help doctors tell different types of interstitial lung disease apart and track how they change over time. About 200 adults with certain lung conditions will get MRI scans alongside standard CT scans. The goal is to see if MRI can pro…

This study reviews medical records of 350 adults who had surgery for esophageal cancer in France between 2017 and 2024. Researchers want to understand how often infections happen after surgery, what causes them, and how they affect recovery. The goal is to find ways to prevent th…

This study will follow 1,000 adults who come to fever clinics with a respiratory infection. Researchers will collect data on symptoms, lab tests, and chest scans at the start, then check in over time to see who develops pneumonia or other complications. The goal is to better unde…

This study looks at 100 ICU patients in France who were on breathing machines and had a lung infection (ventilator-associated pneumonia). Researchers want to see if the way doctors diagnosed these infections matches official 2017 guidelines. The goal is to understand how often th…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This study aims to uncover the genetic causes of familial pulmonary fibrosis, a progressive lung disease that runs in families. Researchers will analyze DNA from 126 adults with a family history of the condition, looking for gene changes linked to lung scarring. The goal is to im…

This study is looking for better ways to predict if a lung transplant will be rejected. Researchers will collect blood samples from 244 lung transplant recipients over time and analyze them using advanced techniques. The goal is to create a model that can identify early signs of …

This study examines how the community of bacteria in the lungs (the microbiome) affects how well pneumonia patients respond to antibiotics. Researchers will follow 300 adults with pneumonia, taking samples from the mouth, rectum, and lungs over 90 days. The goal is to see if the …

This early-stage study tests a new medicine called GNS-3545 in 72 healthy adults to see if it is safe and how the body processes it. The drug is being developed for idiopathic pulmonary fibrosis, a disease that causes lung scarring. Participants will receive either the drug or a …

This study is trying to understand why some people with severe flu in the ICU develop a dangerous fungal lung infection called aspergillosis. Researchers will compare the immune systems of 45 flu patients and non-flu pneumonia patients in the ICU. They hope to find differences in…

This study is observing about 1,300 hospitalized adults with weakened immune systems who have pneumonia. Researchers will track their health for one year, looking at causes, treatments, and outcomes. The goal is to gather information to improve care for this high-risk group.

This study collects blood, airway, and urine samples from 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare samples to establish normal ranges and learn how genes change in lung disease. The goal is to better underst…

This study collects blood samples from 2,000 adults with pulmonary fibrosis to find genetic traits that may explain why they developed the disease and why scarring patterns differ. Participants must be 18 or older and have a confirmed diagnosis. The goal is to better understand t…

This study is collecting blood and tissue samples from 500 people with idiopathic pulmonary fibrosis to find genetic and protein markers that might predict rapid lung function decline. Researchers will compare these markers with changes in symptoms over time. The goal is to bette…

This study looks at whether patients in the ICU who need a tracheostomy can keep getting nutrition through a tube right up until surgery, instead of stopping 6 hours before. The goal is to see if this helps them get more food without increasing the risk of food getting into the l…

This study collects pleural fluid (fluid around the lungs) and medical information from patients with known or suspected lung cancer or lung infections. The goal is to build a registry of samples that researchers can use to develop better tests and treatments in the future. Parti…

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis, idiopathic pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to su…

This study follows 500 adults with progressive pulmonary fibrosis (a type of lung scarring) for 24 months. Researchers will collect medical images, lung function tests, and blood samples to better classify the disease and predict its course. The goal is to improve how doctors ide…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…

This study will examine chest CT scans from 500 adults with rheumatoid arthritis, connective tissue diseases, or idiopathic pulmonary fibrosis to better understand lung disease patterns. Researchers want to see which scan features are most common in rheumatoid arthritis-related i…