Could a common heartburn drug be the key to slowing a deadly lung disease?
NCT ID NCT04965298
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether lansoprazole, a medicine that reduces stomach acid, can slow the progression of idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. About 298 adults with IPF will take either lansoprazole or a placebo twice daily for 12 months. Researchers will measure changes in lung function, cough, and quality of life to see if the drug helps.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Barts Health NHS Trust
RECRUITINGLondon, E1 2ES, United Kingdom
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Bedfordshire Hospitals NHS Foundation Trust
COMPLETEDLuton, LU4 0DZ, United Kingdom
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Blackpool Teaching Hospitals NHS Foundation Trust
NOT_YET_RECRUITINGBlackpool, FY3 8NR, United Kingdom
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Calderdale and Huddersfield NHS Foundation Trust
COMPLETEDHuddersfield, HD3 3EA, United Kingdom
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Cardiff and Vale University Health Board
COMPLETEDCardiff, CF14 4XW, United Kingdom
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Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
RECRUITINGDoncaster, DN2 5LT, United Kingdom
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East Cheshire NHS Trust
COMPLETEDMacclesfield, SK10 3BL, United Kingdom
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East Lancashire Hospitals NHS Trust
COMPLETEDBlackburn, BB2 3HH, United Kingdom
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East and North Hertfordshire NHS Trust
RECRUITINGStevenage, SG1 4AB, United Kingdom
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Frimley Health NHS Foundation Trust
COMPLETEDFrimley, GU16 7UJ, United Kingdom
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Hampshire Hospitals NHS Foundation Trust
COMPLETEDBasingstoke, RG24 9NA, United Kingdom
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Hull University Teaching Hospitals NHS Trust
RECRUITINGHull, HU3 2JZ, United Kingdom
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Hywel Dda University Health Board
RECRUITINGCarmarthen, SA31 3BB, United Kingdom
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Imperial College Healthcare NHS Trust
RECRUITINGLondon, W2 1NY, United Kingdom
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Kingston and Richmond NHS Foundation Trust
RECRUITINGTeddington, TW11 8HU, United Kingdom
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Lancashire Teaching Hospitals NHS Foundation Trust
COMPLETEDPreston, PR2 9HT, United Kingdom
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Leeds Teaching Hospitals NHS Trust
RECRUITINGLeeds, LS9 7TF, United Kingdom
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Lewisham and Greenwich NHS Trust
RECRUITINGLondon, SE13 6LH, United Kingdom
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Liverpool University Hospitals NHS Foundation Trust
RECRUITINGLiverpool, L7 8XP, United Kingdom
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Manchester University NHS Foundation Trust
RECRUITINGManchester, M13 9WL, United Kingdom
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Mid Cheshire Hospitals NHS Foundation Trust
COMPLETEDCrewe, CW1 4QJ, United Kingdom
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NHS Grampian
RECRUITINGAberdeen, AB15 6RE, United Kingdom
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NHS Tayside
RECRUITINGDundee, DD2 1UB, United Kingdom
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Norfolk and Norwich University Hospitals NHS Foundation Trust
RECRUITINGNorwich, Norfolk, NR4 7UY, United Kingdom
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North Bristol NHS Trust
COMPLETEDBristol, BS10 5NB, United Kingdom
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North Tees and Hartlepool NHS Foundation Trust
RECRUITINGStockton-on-Tees, TS19 8PE, United Kingdom
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Northern Health and Social Care Trust
RECRUITINGAntrim, BT41 2RL, United Kingdom
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Northumbria Healthcare NHS Foundation Trust
RECRUITINGNorth Shields, NE29 8NH, United Kingdom
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Nottingham University Hospitals NHS Trust
COMPLETEDNottingham, NG5 1PB, United Kingdom
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Oxford University Hospitals NHS Foundation Trust
COMPLETEDOxford, OX3 9DU, United Kingdom
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Portsmouth Hospitals NHS Trust
COMPLETEDPortsmouth, PO6 3LY, United Kingdom
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Royal Brompton & Harefield NHS Foundation Trust
RECRUITINGLondon, SW3 6PY, United Kingdom
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Royal Devon University Healthcare NHS Foundation Trust
RECRUITINGExeter, EX2 5DW, United Kingdom
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Royal Papworth Hospital NHS Foundation Trust
RECRUITINGCambridge, CB2 0AY, United Kingdom
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Royal United Hospitals Bath NHS Foundation Trust
RECRUITINGBath, BA1 3NG, United Kingdom
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Sheffield Teaching Hospitals NHS Foundation Trust
COMPLETEDSheffield, S10 2JF, United Kingdom
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Sherwood Forest Hospitals NHS Foundation Trust
RECRUITINGSutton in Ashfield, NG17 4JL, United Kingdom
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Shrewsbury and Telford Hospital NHS Trust
RECRUITINGShrewsbury, SY3 8XQ, United Kingdom
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Somerset NHS Foundation Trust
RECRUITINGTaunton, TA1 5DA, United Kingdom
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South Tyneside And Sunderland NHS Foundation Trust
RECRUITINGSunderland, SR4 7TP, United Kingdom
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Southern Health & Social Care Trust
COMPLETEDCraigavon, BT63 5QQ, United Kingdom
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The Newcastle upon Tyne Hospitals NHS Foundation Trust
RECRUITINGNewcastle upon Tyne, NE7 7DN, United Kingdom
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The Princess Alexandra Hospital NHS Trust
RECRUITINGHarlow, CM20 1QX, United Kingdom
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The Royal Wolverhampton NHS Trust
RECRUITINGWolverhampton, WV10 0QP, United Kingdom
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Torbay and South Devon NHS Foundation Trust
RECRUITINGTorquay, TQ2 7AA, United Kingdom
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University College London Hospitals NHS Foundation Trust
RECRUITINGLondon, NW1 2PG, United Kingdom
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University Hospital Southampton NHS Foundation Trust
RECRUITINGSouthampton, SO16 6YD, United Kingdom
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University Hospitals Birmingham NHS Foundation Trust
RECRUITINGBirmingham, B15 2GW, United Kingdom
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University Hospitals Birmingham NHS Foundation Trust (QEHB)
RECRUITINGBirmingham, B15 2GW, United Kingdom
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University Hospitals of Leicester NHS Trust
RECRUITINGLeicester, LE1 5WW, United Kingdom
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University Hospitals of Morecambe Bay NHS Foundation Trust
RECRUITINGKendal, LA9 7RG, United Kingdom
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University Hospitals of North Midlands
RECRUITINGStoke-on-Trent, ST4 6QG, United Kingdom
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West Suffolk NHS Foundation Trust
RECRUITINGBury St Edmunds, IP33 2QZ, United Kingdom
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Western Health and Social Care Trust
RECRUITINGLondonderry, BT47 6SB, United Kingdom
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Worcestershire Acute Hospitals NHS Trust
RECRUITINGWorcester, WR5 1DD, United Kingdom
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Wrightington, Wigan and Leigh NHS Foundation Trust
RECRUITINGWigan, WN1 2NN, United Kingdom
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York and Scarborough Teaching Hospitals NHS Foundation Trust
RECRUITINGYork, YO31 8HE, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new pill slow lung scarring in IPF?
- Beyond the lungs: the hidden emotional toll of IPF medications
- Can umbilical cord stem cells ease a scarring lung disease?
- Spotting hidden blood clots in scarred lungs: a study hunts for clues
- What makes someone stop a lung fibrosis drug? a study asks patients directly
- A smarter way to track lung disease? new platform aims to personalize COPD and IPF care