Could a common heartburn drug be the key to slowing a deadly lung disease?

NCT ID NCT04965298

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether lansoprazole, a medicine that reduces stomach acid, can slow the progression of idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing problems. About 298 adults with IPF will take either lansoprazole or a placebo twice daily for 12 months. Researchers will measure changes in lung function, cough, and quality of life to see if the drug helps.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Barts Health NHS Trust

    RECRUITING

    London, E1 2ES, United Kingdom

  • Bedfordshire Hospitals NHS Foundation Trust

    COMPLETED

    Luton, LU4 0DZ, United Kingdom

  • Blackpool Teaching Hospitals NHS Foundation Trust

    NOT_YET_RECRUITING

    Blackpool, FY3 8NR, United Kingdom

  • Calderdale and Huddersfield NHS Foundation Trust

    COMPLETED

    Huddersfield, HD3 3EA, United Kingdom

  • Cardiff and Vale University Health Board

    COMPLETED

    Cardiff, CF14 4XW, United Kingdom

  • Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust

    RECRUITING

    Doncaster, DN2 5LT, United Kingdom

  • East Cheshire NHS Trust

    COMPLETED

    Macclesfield, SK10 3BL, United Kingdom

  • East Lancashire Hospitals NHS Trust

    COMPLETED

    Blackburn, BB2 3HH, United Kingdom

  • East and North Hertfordshire NHS Trust

    RECRUITING

    Stevenage, SG1 4AB, United Kingdom

  • Frimley Health NHS Foundation Trust

    COMPLETED

    Frimley, GU16 7UJ, United Kingdom

  • Hampshire Hospitals NHS Foundation Trust

    COMPLETED

    Basingstoke, RG24 9NA, United Kingdom

  • Hull University Teaching Hospitals NHS Trust

    RECRUITING

    Hull, HU3 2JZ, United Kingdom

  • Hywel Dda University Health Board

    RECRUITING

    Carmarthen, SA31 3BB, United Kingdom

  • Imperial College Healthcare NHS Trust

    RECRUITING

    London, W2 1NY, United Kingdom

  • Kingston and Richmond NHS Foundation Trust

    RECRUITING

    Teddington, TW11 8HU, United Kingdom

  • Lancashire Teaching Hospitals NHS Foundation Trust

    COMPLETED

    Preston, PR2 9HT, United Kingdom

  • Leeds Teaching Hospitals NHS Trust

    RECRUITING

    Leeds, LS9 7TF, United Kingdom

  • Lewisham and Greenwich NHS Trust

    RECRUITING

    London, SE13 6LH, United Kingdom

  • Liverpool University Hospitals NHS Foundation Trust

    RECRUITING

    Liverpool, L7 8XP, United Kingdom

  • Manchester University NHS Foundation Trust

    RECRUITING

    Manchester, M13 9WL, United Kingdom

  • Mid Cheshire Hospitals NHS Foundation Trust

    COMPLETED

    Crewe, CW1 4QJ, United Kingdom

  • NHS Grampian

    RECRUITING

    Aberdeen, AB15 6RE, United Kingdom

  • NHS Tayside

    RECRUITING

    Dundee, DD2 1UB, United Kingdom

  • Norfolk and Norwich University Hospitals NHS Foundation Trust

    RECRUITING

    Norwich, Norfolk, NR4 7UY, United Kingdom

  • North Bristol NHS Trust

    COMPLETED

    Bristol, BS10 5NB, United Kingdom

  • North Tees and Hartlepool NHS Foundation Trust

    RECRUITING

    Stockton-on-Tees, TS19 8PE, United Kingdom

  • Northern Health and Social Care Trust

    RECRUITING

    Antrim, BT41 2RL, United Kingdom

  • Northumbria Healthcare NHS Foundation Trust

    RECRUITING

    North Shields, NE29 8NH, United Kingdom

  • Nottingham University Hospitals NHS Trust

    COMPLETED

    Nottingham, NG5 1PB, United Kingdom

  • Oxford University Hospitals NHS Foundation Trust

    COMPLETED

    Oxford, OX3 9DU, United Kingdom

  • Portsmouth Hospitals NHS Trust

    COMPLETED

    Portsmouth, PO6 3LY, United Kingdom

  • Royal Brompton & Harefield NHS Foundation Trust

    RECRUITING

    London, SW3 6PY, United Kingdom

  • Royal Devon University Healthcare NHS Foundation Trust

    RECRUITING

    Exeter, EX2 5DW, United Kingdom

  • Royal Papworth Hospital NHS Foundation Trust

    RECRUITING

    Cambridge, CB2 0AY, United Kingdom

  • Royal United Hospitals Bath NHS Foundation Trust

    RECRUITING

    Bath, BA1 3NG, United Kingdom

  • Sheffield Teaching Hospitals NHS Foundation Trust

    COMPLETED

    Sheffield, S10 2JF, United Kingdom

  • Sherwood Forest Hospitals NHS Foundation Trust

    RECRUITING

    Sutton in Ashfield, NG17 4JL, United Kingdom

  • Shrewsbury and Telford Hospital NHS Trust

    RECRUITING

    Shrewsbury, SY3 8XQ, United Kingdom

  • Somerset NHS Foundation Trust

    RECRUITING

    Taunton, TA1 5DA, United Kingdom

  • South Tyneside And Sunderland NHS Foundation Trust

    RECRUITING

    Sunderland, SR4 7TP, United Kingdom

  • Southern Health & Social Care Trust

    COMPLETED

    Craigavon, BT63 5QQ, United Kingdom

  • The Newcastle upon Tyne Hospitals NHS Foundation Trust

    RECRUITING

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • The Princess Alexandra Hospital NHS Trust

    RECRUITING

    Harlow, CM20 1QX, United Kingdom

  • The Royal Wolverhampton NHS Trust

    RECRUITING

    Wolverhampton, WV10 0QP, United Kingdom

  • Torbay and South Devon NHS Foundation Trust

    RECRUITING

    Torquay, TQ2 7AA, United Kingdom

  • University College London Hospitals NHS Foundation Trust

    RECRUITING

    London, NW1 2PG, United Kingdom

  • University Hospital Southampton NHS Foundation Trust

    RECRUITING

    Southampton, SO16 6YD, United Kingdom

  • University Hospitals Birmingham NHS Foundation Trust

    RECRUITING

    Birmingham, B15 2GW, United Kingdom

  • University Hospitals Birmingham NHS Foundation Trust (QEHB)

    RECRUITING

    Birmingham, B15 2GW, United Kingdom

  • University Hospitals of Leicester NHS Trust

    RECRUITING

    Leicester, LE1 5WW, United Kingdom

  • University Hospitals of Morecambe Bay NHS Foundation Trust

    RECRUITING

    Kendal, LA9 7RG, United Kingdom

  • University Hospitals of North Midlands

    RECRUITING

    Stoke-on-Trent, ST4 6QG, United Kingdom

  • West Suffolk NHS Foundation Trust

    RECRUITING

    Bury St Edmunds, IP33 2QZ, United Kingdom

  • Western Health and Social Care Trust

    RECRUITING

    Londonderry, BT47 6SB, United Kingdom

  • Worcestershire Acute Hospitals NHS Trust

    RECRUITING

    Worcester, WR5 1DD, United Kingdom

  • Wrightington, Wigan and Leigh NHS Foundation Trust

    RECRUITING

    Wigan, WN1 2NN, United Kingdom

  • York and Scarborough Teaching Hospitals NHS Foundation Trust

    RECRUITING

    York, YO31 8HE, United Kingdom

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Other studies related to the condition(s) this trial covers.