Can steroids save lives during IPF Flare-Ups? new trial aims to find out

NCT ID NCT05674994

Recruiting now Disease control Sponsor: Fondation Hôpital Saint-Joseph Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether high-dose steroids (methylprednisolone and prednisone) can reduce deaths within 30 days for people hospitalized with a sudden worsening of idiopathic pulmonary fibrosis (IPF). About 110 adults with IPF and an acute exacerbation will receive either steroids or a placebo. Currently, no proven treatment exists for these dangerous episodes, which have a high short-term death rate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Methylprednisolone and Prednisone (corticosteroids)

What this could lead to

If successful, this could confirm that steroids improve survival during sudden worsening of IPF, offering a standard treatment for these dangerous flare-ups.

What could go wrong

This is a relatively small Phase 3 trial (110 people). Steroids may not improve survival and could have harmful side effects, as seen with other immunosuppressants in stable IPF.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE EXACERBATION OF IDIOPATHIC PULMONARY FIBROSIS

Contacts and locations

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CHIC
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Lille, France

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Angers, France

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CHU de Nantes
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Hospices Civils de Lyon
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Lyon, France

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Hôpital Avicenne
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Bobigny, France

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Hôpital Nord
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Marseille, France

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Paris, 75014, France

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