Hypersensitivity pneumonitis

This study tests a drug called H01 (hymecromone) in adults with interstitial lung disease, a condition that causes lung scarring and makes breathing hard. The goal is to see if H01 can lower a marker of lung damage and improve lung function. Participants take the drug as a tablet…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This study tests whether quercetin, a natural compound found in many fruits and vegetables, can slow lung scarring and improve breathing in people with pulmonary fibrosis. Half of the 100 participants will take quercetin pills daily for 24 weeks, while the other half receive stan…

This early-stage trial tests a single dose of an inhaled drug called RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to see how much drug reaches the lungs and blood, and whether it is safe. Researchers hope that inhaling the drug wi…

This study aims to find better, non-invasive tests to diagnose and predict the course of interstitial lung disease (ILD). Researchers will test blood and breath samples from 750 people, including pigeon fanciers at high risk for ILD and patients already diagnosed. The goal is to …

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study tests a special PET scan that uses a radioactive tracer to find collagen buildup in the lungs, a sign of early scarring. Researchers will scan 30 people, including relatives of patients with pulmonary fibrosis and those with early lung abnormalities. The goal is to see…

This study tests whether using a robotic arm during a lung biopsy helps doctors get better tissue samples to diagnose interstitial lung disease. About 30 adults with unclear CT scans will be randomly assigned to either standard or robotic-assisted bronchoscopy. The goal is to see…

This study tests whether a simple, non-invasive nail microscope exam (capillaroscopy) can help doctors find connective tissue disease faster in people newly diagnosed with interstitial lung disease. 48 adults will get the exam alongside standard care. The goal is to see if this e…

This study tests whether a special PET scan (FAPI PET) can better detect active scarring in the lungs of people with fibrotic lung disease. About 50 adults with idiopathic pulmonary fibrosis or fibrotic hypersensitivity pneumonitis will get up to 4 PET/MRI scans. The goal is to i…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This study looks at whether automated software can consistently measure the amount of lung scarring (interstitial lung disease) on chest CT scans. Researchers will scan 150 adults with known lung scarring twice in a row to see if the measurements match. The goal is to improve the…

This study tests a 10-week program called RISE-HP for people with hypersensitivity pneumonitis (HP), a lung condition that can cause anxiety, depression, and poor quality of life. Participants work one-on-one with a trained peer coach (someone who also has HP) to learn coping ski…

This study looks at whether drinking beetroot juice, which is high in nitrate, can help people with fibrotic interstitial lung disease exercise longer. Participants will drink either nitrate-rich or nitrate-free beetroot juice and then do a cycling test. The goal is to see if the…

This study looks at the safety of a nasal spray called neffy compared to a standard epinephrine shot for treating allergic reactions. It involves 600 people aged 4 and older who have an allergic reaction during a food challenge or allergy shot session. The goal is to see if the s…

This study aims to see if bundling all routine tests and doctor visits into one coordinated hospital trip can save time for people with interstitial lung disease. About 152 adults with the condition will either receive standard care or the new streamlined approach. The goal is to…

This study tests whether a 12-week home-based pulmonary rehabilitation program, combined with health coaching, can improve quality of life and physical activity in people with fibrotic interstitial lung disease. Participants will do daily breathing exercises, balance walks, and m…

This study tests whether analyzing a patient's phlegm can help doctors choose better treatments for chronic cough in interstitial lung disease (ILD). About 120 adults with ILD and daily cough for at least 8 weeks will be randomly assigned to either phlegm-guided treatment or stan…

This study tests whether bundling key tests like scans and lung function tests into a single, fast-tracked appointment can help people with suspected interstitial lung disease get a diagnosis sooner. About 92 adults will be randomly assigned to either the usual step-by-step testi…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study looks at whether an artificial intelligence (AI) tool can predict if lung scarring (pulmonary fibrosis) will get worse over time. Researchers will analyze CT scans from 200 people with either idiopathic pulmonary fibrosis (IPF) or other types of interstitial lung disea…

This study is a registry that will follow about 900 adults with both interstitial lung disease and pulmonary hypertension. Researchers will collect information on patients' medical history and track changes in their condition over time. The goal is to better understand these dise…

This study follows 4,000 people with interstitial lung disease (including conditions like pulmonary fibrosis and sarcoidosis) to understand how the disease naturally changes over time. Researchers will collect medical data and blood samples, and compare them to a healthy control …

This study is analyzing the exhaled breath of 5,000 people with lung or airway diseases to find unique molecular patterns. The goal is to better identify and distinguish different respiratory conditions and improve disease management. Participants simply provide breath samples, a…

This study looks at why people with interstitial lung disease (ILD) often feel breathless and have trouble exercising. Researchers think leg muscle problems might be a cause. They will measure leg muscle strength and structure in 40 ILD patients and test how extra oxygen affects …

This observational study aims to find early biomarkers that can predict if a person's lung scarring (pulmonary fibrosis) will get worse quickly. Researchers will follow 450 adults with various types of interstitial lung disease, including IPF and other fibrotic conditions. Partic…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at how immunosuppression treatment changes lung scarring in people with certain types of interstitial lung disease (not IPF). Using advanced PET and MRI scans, researchers will measure collagen buildup and tissue damage. The goal is to better understand the effec…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This registry is following 3,000 adults with idiopathic pulmonary fibrosis (IPF) or other chronic fibrosing interstitial lung diseases (ILDs) to understand how these conditions progress over time. Researchers collect information on symptoms, treatments, quality of life, and store…

This study tests whether special PET and MRI scans can predict how fast lung scarring (pulmonary fibrosis) will get worse in 60 adults aged 18-80 with certain types of this disease. Participants will have scans and breathing tests over 2 years. The goal is to see if these imaging…

This study will follow 1000 adults for up to 10 years, using a special type of CT scan (photon-counting) to look for lung nodules, tumors, and other lung conditions. Researchers will also use artificial intelligence to create a virtual copy of each person's lungs, called a 'digit…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This pilot study compares two ways to perform a lung biopsy for people with undetermined interstitial lung disease. One method uses a breathing tube and deep anesthesia (standard), while the other uses only mild sedation and numbing medicine. The goal is to see if the gentler met…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

Stanford University is recruiting 2,500 people with possible allergies to improve how allergies are diagnosed. Researchers will study skin test responses and look at genetic and immune system factors. This study does not test any new treatment, but aims to deepen knowledge of all…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study is testing a new method to measure allergy-related substances (IgE) in blood and urine. Researchers want to see if this new technique works as well as current tests. About 1,376 children and adults with allergies will provide blood and urine samples during routine visi…

This study looks at whether a new digital education and self-management program is practical and helpful for people with fibrotic interstitial lung disease. About 80 participants will use the program on their phone or computer during rehab or clinic visits. Researchers will measu…

This study looks at 100 adults with fibrosing interstitial lung diseases (a type of lung scarring) to see if things like mold, dust, air pollution, and other home factors make the disease progress faster. Researchers will compare patients whose disease is getting worse to those w…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study is gathering detailed information from 470 adults with chronic inflammatory lung diseases like asthma, COPD, and cystic fibrosis, as well as healthy volunteers. Researchers will analyze clinical, biological, and lifestyle factors to identify distinct disease subtypes. …

This study looks at small molecules (metabolites) in the blood and urine of people with pulmonary hypertension caused by lung fibrosis. Researchers want to see how these metabolites change with treatment and whether they can tell who will respond well. The goal is to better under…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to understand how these images change after treatments like blood transfusions or oxygen therapy. The study involves 125 adul…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This study will use advanced CT scans to look at both the lungs and heart in people with interstitial lung disease (ILD). The goal is to find early signs of heart problems, which are common but often missed until serious. Researchers hope to create better ways to predict and mana…

This study is testing a special MRI technique that uses a harmless xenon gas to create detailed images of lung function. Researchers will compare healthy volunteers and people with interstitial lung disease to see if the method can detect problems with air flow, lung structure, a…

This study explores whether functional MRI can help doctors tell different types of interstitial lung disease apart and track how they change over time. About 200 adults with certain lung conditions will get MRI scans alongside standard CT scans. The goal is to see if MRI can pro…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This study is looking for better ways to predict if a lung transplant will be rejected. Researchers will collect blood samples from 244 lung transplant recipients over time and analyze them using advanced techniques. The goal is to create a model that can identify early signs of …

This study is creating a registry of medical information from people with interstitial lung disease (ILD). Researchers will collect past, current, and future health records from up to 5,000 adults treated at the UPMC Simmons Center. The goal is to build a database that can be use…

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis, idiopathic pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to su…

This study follows 500 adults with progressive pulmonary fibrosis (a type of lung scarring) for 24 months. Researchers will collect medical images, lung function tests, and blood samples to better classify the disease and predict its course. The goal is to improve how doctors ide…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…