New pill for scarred lungs enters human testing

NCT ID NCT05975983

Recruiting now Disease control Sponsor: InSilico Medicine Hong Kong Limited Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental oral drug called INS018_055 in 40 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. The main goal is to check the drug's safety over 12 weeks. Participants will be randomly assigned to receive either the drug or a placebo, and researchers will also measure how the drug moves through the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: INS018_055 (an oral tablet)
What this could lead to: If successful, this could point toward a new oral treatment option for idiopathic pulmonary fibrosis, a serious lung disease with limited therapies.
What could go wrong: This is an early Phase IIa trial with only 40 participants, focused mainly on safety. It is too small and short (12 weeks) to prove the drug works, and many promising drugs fail in later stages.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fibrosis idiopathic pulmonary fibrosis interstitial lung disease lung disorder Pathologic Processes pulmonary fibrosis respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS (IPF)

Contacts and locations

Locations

Bogan Sleep Consultants, LLC
RECRUITING

Columbia, South Carolina, 29201-2953, United States
Central Florida Pulmonary Group, P.A. (CFPG) - Downtown Orlando
RECRUITING

Orlando, Florida, 32803-5727, United States
Florida Lung Asthma and Sleep Specialist
RECRUITING

Celebration, Florida, 34747-1818, United States
HonorHealth Research Institute
RECRUITING

Scottsdale, Arizona, 85258, United States
Keck School of Medicine of USC
RECRUITING

Los Angeles, California, 90033, United States
Metroplex Pulmonary and Sleep Center
RECRUITING

McKinney, Texas, 75069-1898, United States
Research Centers of America
RECRUITING

McKinney, Texas, 75071, United States
Southeastern Research Center
RECRUITING

Winston-Salem, North Carolina, 27103-4007, United States
Temple University Hospital-Temple Lung Center
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of Oklahoma Health Sciences Center (OUHSC)
RECRUITING

Oklahoma City, Oklahoma, 73104-5417, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75235-6243, United States

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