Mouth mucosa disorder

This trial tests whether adding a sticky bone graft to a standard gum flap procedure helps cover exposed tooth roots better than the flap alone. It includes 30 adults with mild-to-moderate gum recession. The study measures how much the gum covers the root and how thick the gum ti…

This study compares a new probiotic gel to a standard steroid gel for treating minor recurrent canker sores—painful mouth ulcers that make eating and talking difficult. Adults with these sores will apply either the probiotic or steroid gel four times daily for up to two weeks. Re…

This study looked at 40 adults aged 35–55 with a history of periodontitis (gum disease) who needed a dental implant. Each received one of two implant surface types: sandblasted acid-etched or plasma-sprayed. Researchers measured bone loss around the implant and gum health over on…

This study tested whether a stannous fluoride toothpaste can reduce gum inflammation, bleeding, and plaque better than a standard fluoride toothpaste. Over 12 weeks, 133 adults brushed with one of the two toothpastes and had their gums checked at several visits. The goal was to s…

This study tested whether a hands-on teaching method called Touch-to-Teach helps people with dental crowns clean between their teeth better than standard advice. 36 adults with at least one crown took part and were split into two groups: one got personalized brush training, the o…

This completed study tested a surgical technique called the combined bilaminar tunnel method for treating gum recession in patients with challenging tooth anatomy. Twelve participants received the procedure and were followed for six months. The goal was to see how much of the exp…

This study tested a new surgical technique called the NORD flap for treating receding gums, comparing it to the standard method that uses a tissue graft from the roof of the mouth. The goal was to see if the new technique could cover exposed tooth roots just as well, with less pa…

This study tested whether using a stannous fluoride toothpaste, a cetylpyridinium chloride mouthwash, and a battery-powered toothbrush together can reduce dental plaque and gingivitis (gum inflammation). 134 adults with at least 20 teeth and signs of gum disease used the regimen …

This study tested a surgical technique for treating multiple receding gums. Twenty-one adults with gum recession on both sides of the mouth received a modified tunnel procedure with a connective tissue graft. The researchers compared two ways of placing the graft to see which gav…

This study tested two ways to treat receding gums: a new material made from the patient's own blood (T-PRF) and a standard connective tissue graft. Twenty healthy adults with gum recession on both sides of the mouth received both treatments, one on each side. The researchers meas…

This study tested a chlorhexidine varnish applied to teeth in people with braces. Each person's mouth was split: one side got the active varnish, the other a placebo. Over 3 months, researchers measured gum overgrowth, plaque buildup, and early tooth decay (white spots). The goal…

This study tested whether adding microneedling before standard gum surgery (coronally advanced flap) improves root coverage for people with thin gums and receding gums. Thirty-six adults with isolated gum recession on upper front teeth were randomly assigned to receive either mic…

This study tested whether a custom digital surgical guide helps dentists perform crown lengthening more accurately than the usual method. Twenty-four adults with gummy smiles due to a condition called altered passive eruption took part. The digital guide uses 3D scans and imaging…

This study tested whether a mouthrinse with benzydamine hydrochloride could reduce plaque buildup when people stopped brushing for three days. Fifty healthy women with no gum disease used either the active mouthrinse or a placebo. The results showed no significant difference in p…

This study tested whether toothpaste containing hops extract can reduce gum inflammation (gingivitis) better than standard fluoride toothpaste. 120 adults brushed twice daily for 3 months with one of four toothpastes. Researchers measured bleeding and gum health to see if the hop…

This study tested whether a new mouthwash called MicroRepair ABX works as well as the standard chlorhexidine mouthwash for treating plaque-induced gingivitis (gum inflammation). Forty adults with gum disease used one of the two mouthwashes twice daily for 14 days after a professi…

This study tested four different mouthwashes—hydrogen peroxide with hyaluronic acid, hyaluronic acid alone, chlorhexidine, and a placebo—in 80 healthy adults aged 18 to 35 with mild gum inflammation. Participants used their assigned rinse twice daily for three weeks. The goal was…

This study tested whether injectable platelet-rich fibrin (i-PRF), titanium platelet-rich fibrin (t-PRF), or hyaluronic acid gel can improve wound healing after gum surgery for overgrown gums. Sixty healthy adults were randomly assigned to one of four groups. Researchers measured…

This study tested a porcine collagen matrix (Mucoderm) against the standard connective tissue graft for covering exposed tooth roots due to gum recession. Eighteen adults with gum recession on both sides of the mouth received one treatment on each side. The goal was to see if the…

This study tested two daily-use mouth rinses containing chlorhexidine (CHX) plus either hydrogen peroxide or cetylpyridinium chloride against a placebo rinse. Over 3 months, 81 adults used the rinse twice daily alongside normal brushing. Researchers measured plaque buildup, gum i…

This study tested a new material called Mucoderm, made from donated animal tissue, to treat receding gums. It compared it to the standard treatment, which uses a small piece of tissue from the patient's own palate. The goal was to see if Mucoderm could cover exposed tooth roots j…

This study tested whether a probiotic called Lactobacillus rhamnosus Lcr35® can reduce the number of painful canker sores in people who get them often. Twenty adults with frequent outbreaks took either the probiotic or a placebo daily for 3 months, then were monitored for another…

This study tested whether a new Colgate toothpaste with dual zinc can better control plaque and gingivitis (gum inflammation) compared to a standard cavity protection toothpaste. 86 adults with mild to moderate plaque and gum issues used one of the two toothpastes for three month…

This study compared a stannous fluoride toothpaste paired with a newly designed toothbrush to a standard toothpaste and brush for reducing plaque and gingivitis (gum inflammation). 95 adults with mild to moderate gum issues used their assigned products for 3 months. Researchers m…

This study tested whether a special dental care routine (PerioGard) works better than standard products for reducing plaque and gum inflammation. Eighty adults with mild to moderate gingivitis used either the PerioGard regimen or a regular fluoride toothpaste and mouthwash for th…

This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash and a manual toothbrush reduces dental plaque and gingivitis better than using regular fluoride toothpaste with a standard toothbrush. Eighty-two adults with mild gum di…

This completed Phase 2 study enrolled 84 adults with mild to moderate plaque and gingivitis. Participants were randomly assigned to use one of two manual toothbrush and toothpaste regimens at home for 6 weeks. Dentists measured plaque and gum inflammation at 1, 3, and 6 weeks to …

This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash can improve gum health and reduce plaque buildup better than using regular fluoride toothpaste alone. About 199 adults with mild gum disease (gingivitis) took part. Rese…

This study tested a new, less invasive surgery for receding gums. 24 adults with gum recession received a procedure using a donated tissue graft placed through a small tunnel under the gum. The goal was to cover exposed tooth roots and improve gum health. Results showed the treat…

This study tested two different places to take gum tissue for grafting—the back of the mouth (tuberosity) or the roof of the mouth (palate)—to fix receding gums on a single tooth. Thirty healthy adults with gum recession received one of the two grafts along with a gum-lifting pro…

This study looked at whether a toothpaste made from black seed (Nigella sativa) can lower signs of gum inflammation in 100 Indonesian soldiers with gingivitis. Researchers measured certain proteins in saliva that are linked to gum disease. The goal was to see if this toothpaste c…

This study tested whether adding a hyaluronic acid gel to standard gum surgery (coronally advanced flap) helps treat type 1 gum recession. Twenty adults with gum recession on both sides of the mouth took part. The gel aims to improve gum coverage and reduce discomfort. Results we…

This study tested whether a mouthwash made from Triphala, an Ayurvedic herbal formula, works as well as the standard chlorhexidine mouthwash for reducing plaque and gum inflammation. 220 adults with mild to moderate gingivitis used one of the two mouthwashes twice daily for 30 da…

This study compared two surgical techniques to treat receding gums: the pinhole technique and the tunnel technique. 21 adults with gum recession received both procedures on different teeth. The goal was to see which method better covered exposed roots and increased gum thickness …

This study tested whether a mouthwash made from guava leaf extract can reduce plaque and gum inflammation as well as a standard chlorhexidine mouthwash. 160 adults with chronic gingivitis rinsed twice daily for up to 90 days. Researchers measured plaque buildup and gum health to …

This study involved 24 adults with receding gums to see if adding an enamel protein to a standard gum graft procedure improves results. The standard method uses a tissue graft placed under the gum with a small tunnel. Half the participants also got the enamel protein. Researchers…

This study tested whether using a special toothpaste and mouthwash together with a manual toothbrush works better than regular fluoride toothpaste alone for reducing plaque and improving gum health. 90 adults with mild to moderate gum problems brushed twice daily for 12 weeks. Re…

This completed Phase 3 study tested whether a battery toothbrush paired with a stannous fluoride toothpaste is more effective at reducing plaque and gingivitis than a regular fluoride toothpaste with a manual toothbrush. 130 adults with mild gum disease brushed twice daily for 12…

This study tested whether adding hyaluronic acid to a standard chlorhexidine mouthwash helps treat gingivitis (gum inflammation). Sixteen adults with gingivitis used two different mouthwashes after a professional teeth cleaning. Researchers measured bleeding and plaque levels to …

This study tested whether a special light device used at home can improve oral health in teenagers with braces. Forty teens used the device daily for two months, while others received standard brushing instructions. The goal was to see if the device reduces plaque and gum bleedin…

This study tested whether an experimental toothpaste with stannous fluoride, zinc chloride, and alumina can improve gum health better than a regular fluoride toothpaste. 175 adults with mild to moderate gingivitis used the toothpaste for 4 weeks. Researchers measured gum bleeding…

This study tested whether a medical glue (butyl-cyanoacrylate) works as well as traditional stitches for holding gum grafts in place. Twenty-four adults with thin gums received either glue or stitches after graft surgery. Researchers tracked healing, graft size, patient comfort, …

This study tested whether a toothpaste with stannous fluoride can improve gum health better than a regular fluoride toothpaste. 154 adults with mild gum inflammation (gingivitis) used one of the two toothpastes for 12 weeks. Researchers measured gum bleeding and plaque to see whi…

This study tested three treatments for multiple receding gums in 60 healthy adults. It compared a collagen matrix, platelet-rich fibrin, and a connective tissue graft to see which covers exposed tooth roots best. The goal was to improve gum health and appearance.

This study looked at whether giving radiation therapy after surgery can prevent early-stage oral cancer from coming back. It included 392 patients with tumors at least 5mm thick. Half received radiation, half were just watched. The main goal was to see if radiation reduced local …

This completed trial tested two surgical procedures to reduce a gummy smile (excessive gum display when smiling). Sixteen women aged 18 to 30 received either a modified lip repositioning surgery or a Z-plasty frenectomy. Researchers measured how much the gum show decreased, pain …

This study tested a cream containing acyclovir and penciclovir against an over-the-counter cream (Abreva) for preventing cold sores caused by UV light. Forty adults with a history of cold sores were exposed to UV light to trigger an outbreak, then treated with one of the creams. …

This study tested two surgical techniques for fixing receding gums in 50 adults aged 18-35. Both methods used a coronally advanced flap, but one added a platelet-rich fibrin membrane and the other a chorion membrane. The goal was to see which better reduces gum recession and impr…

This study tested whether adding two special gels to standard cleaning helps treat gum inflammation around dental implants. 92 adults with at least one inflamed implant received either standard cleaning alone or cleaning plus the gels. The gels aim to reduce bleeding and plaque. …

This completed study tested whether a new herbal mouthwash and gel (StellaLife) works as well as the standard chlorhexidine mouthwash for treating gingivitis (early gum disease). 34 healthy adults without gum disease took part. The goal was to see if StellaLife can control plaque…

This study tested a new mouthwash containing CPC, hyaluronic acid, and zinc lactate against a standard fluoride mouthwash. The goal was to see if it reduces plaque and prevents gum problems in adults with at least two dental implants. Eighty participants used the mouthwash for si…

This study tested two mouthwashes—one with 0.12% chlorhexidine and another with a lower dose of chlorhexidine plus cetylpyridinium chloride—to see which better controls gum inflammation and bacteria in people with gum disease. 72 adults used one of the rinses for a month after a …

This study tested how well floss and three different mouthwashes (one with essential oils and alcohol, one with essential oils but no alcohol, and one with CPC+Zn and no alcohol) reduce plaque and gum inflammation. 228 adults with mild to moderate gum disease took part. The goal …

This study tested whether EDTA eye drops can shorten cold sore outbreaks compared to the over-the-counter cream Abreva. Ten adults with a history of sun-triggered cold sores were randomly assigned to one of the two treatments. Researchers tracked how many days it took for each co…

This study tested whether taking a daily probiotic (Bifidobacterium Lactis HN019) can reduce plaque buildup and gum bleeding in people undergoing orthodontic treatment with braces or clear aligners. Sixty participants, aged 10 to 30, took the probiotic or a placebo for a period w…

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo…

This study tested whether lozenges made from propolis (a substance bees produce) can improve gum health in 100 young adults with mild to moderate gingivitis. Participants chewed the lozenges twice daily for a week while keeping their normal brushing routine. Researchers measured …

This study tested whether using a mouthwash with cetylpyridinium chloride (CPC) along with regular brushing improves gum health and reduces plaque more than brushing alone. 136 adults with mild to moderate gingivitis used either the CPC mouthwash or just brushed with fluoride too…

This study compared interdental brushes and rubber bristle cleaners in 40 adults with gingivitis (early gum disease). Participants used one of the two tools for four weeks. Researchers measured plaque removal and gum bleeding, and also asked about satisfaction. The goal was to se…

This study looked at whether smokers who switch to combustion-free nicotine products (like e-cigarettes or heated tobacco) see improvements in their gum health and tooth appearance. 460 smokers with mild gum disease were randomly assigned to keep smoking, switch to these products…

This study tested whether a gentler, magnified cleaning method (MINST) works better than standard deep cleaning for treating early gum recession. Fifty-four adults with shallow gum recession (3 mm or less) took part. The goal was to see if MINST could reduce recession depth and w…

This study tested a special dental floss coated with a probiotic (good bacteria) to see if it could reduce harmful mouth germs and improve gum health. Thirty-three healthy men used the probiotic floss and a placebo floss for two weeks each, with a break in between. Researchers me…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

This study tested a non-invasive optical device that uses different types of light to detect and diagnose various mouth conditions, including oral cancer, gum disease, and dry mouth. Over 1,000 participants with and without oral lesions were imaged, and the results were compared …

This study tested a custom device that measures electrical impedance (how tissues resist electric current) in mouth lesions. Researchers enrolled 114 people with suspected oral cancer to see if the device could tell the difference between normal, benign, precancerous, and cancero…

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This study tested a procedure called Periodontally Accelerated Osteogenic Orthodontics (PAOO) in 20 adults getting braces. The goal was to see if it could prevent bone loss and gum recession on the front of the lower teeth. The procedure combines a small cut in the gum with a bon…

This study tested whether adding thalidomide to glutamine can delay the onset of severe mouth sores caused by radiation therapy. 138 oral cancer patients were randomly assigned to receive either the combination or glutamine alone during their radiation treatment. The main goal wa…

This study looked back at medical records of 58 adult cancer patients who developed painful mouth sores from chemotherapy or radiation. They had been treated with a combination of ozone applied in the dentist's chair and ozone-based gels, toothpaste, and mouthwash at home. The go…

This study tested two methods to help gums heal after a gingivectomy (removing excess gum tissue). Sixty-four healthy adults received either a hyaluronic acid spray (applied twice daily for 7 days) or low-level laser therapy (applied 4 times over 7 days). Researchers measured wou…

This study tested whether a new mouthwash can reduce dental plaque and help prevent gum problems better than a control mouthwash. 80 adults with mild to moderate gum inflammation and plaque used the product for three months. Researchers measured gum health and plaque levels at 2 …

This study tested whether ozonized gel or a special laser helps gums heal faster and with less pain after a gingivectomy (gum removal surgery). 48 adults received one of the two treatments or standard care. Researchers checked healing, pain, and tissue regrowth over 28 days. The …

This study tested whether a propolis mouth rinse could delay or prevent severe oral mucositis (painful mouth sores) in 140 head and neck cancer patients undergoing radiation. Participants used either a 15% propolis solution or a placebo four times daily alongside standard oral ca…

This study tested whether a mouth rinse made from sumac, a common spice, can help heal painful canker sores and reduce pain. Thirty-eight healthy adults with minor mouth ulcers used the rinse and were monitored for healing and pain levels. Researchers also measured inflammation m…

This phase 3 trial tested whether ulinastatin, a drug that blocks certain enzymes, can reduce severe mouth sores caused by chemoradiotherapy in 179 patients with advanced nasopharyngeal cancer. Patients received either standard care or ulinastatin alongside their cancer treatment…

This study tested if zinc oxide ointment can help heal painful canker sores. One hundred people with canker sores used either the zinc ointment or a placebo three times a day for six days. Researchers measured pain and how the sores affected daily life to see if the ointment made…

This study tested whether taking a specific probiotic (Limosilactobacillus reuteri) can improve gum health in adults with braces who also have gingivitis (gum inflammation). One hundred participants either received the probiotic or no supplement. Researchers measured gum bleeding…

This study tested two mouthwashes—a standard antiseptic (chlorhexidine) and a new one (MicroRepair ABX)—in 40 adults with gingivitis (gum inflammation). After a professional cleaning, participants used their assigned mouthwash twice daily for 14 days. Researchers measured gum ble…

This study looked at whether applying ozone gas to surgical wounds in the mouth can help gums heal faster after gum surgery. Twenty-four people with enlarged gums due to chronic inflammation took part. Each person had two similar areas treated: one with standard surgery alone, an…

This study tested a custom 3D-printed PEEK shell placed under the gum in the upper jaw to reduce excessive gum display (gummy smile) in 10 patients. The shell was inserted through small incisions using a tunnel technique. The goal was to see if it could decrease the amount of gum…

This study tested a new device called Mucopad HA in 50 adults who had painful mouth sores (oral mucositis) after radiation therapy. The goal was to see if the pad is safe and helps the sores heal. Researchers measured healing time, pain levels, and dry mouth.

This study tested whether placing orange blossom essential oil inside a stoma bag can reduce odor, lessen social isolation, and help people adapt to life with a stoma. Sixty adults with a stoma took part. Researchers measured changes using a stoma adaptation scale and a social is…

This study tested two ways to teach people with gingivitis (early gum disease) how to clean their teeth better. One group watched a video, the other practiced on a dental model. After one month, both groups showed improved gum health and awareness, with no major difference betwee…

This study tested whether a benzydamine hydrochloride (Difflam) oral spray can reduce the severity of mouth sores caused by high-dose radiation in head and neck cancer patients. Thirty-five adults receiving radiation without chemotherapy were randomly assigned to standard mouth c…

This study tested whether vitamin B12 tablets can ease painful mouth ulcers caused by braces, comparing them to a standard steroid gel (Kenalog). 82 adults with traumatic ulcers were split into two groups. Researchers measured pain and ulcer size after 4 and 8 days to see which t…

This study tested whether adding a propolis mouth rinse to standard oral care could prevent or reduce mouth sores in 60 COPD patients in the intensive care unit. Half the patients received propolis care for 15 days, while the other half got standard care only. Researchers checked…

This study tested whether mouth rinses containing the amino acids arginine or glutamine could reduce the severity of painful mouth sores caused by radiation therapy in head and neck cancer patients. 69 participants swished and swallowed these supplements three times daily during …

This study tested whether ozone therapy can help treat oral mucositis—painful mouth sores—in 38 patients receiving radiation and chemotherapy for head and neck cancer. Patients received in-office ozone gas treatment plus at-home ozonated oil products. The researchers measured cha…

This study tested two ways to protect gums during in-office teeth whitening: relative isolation (using a tray) and absolute isolation (covering gums completely). Thirty healthy adults with no cavities or gum disease took part. Researchers checked for gum irritation, tooth sensiti…

This study looked at 30 adults with braces and gum inflammation (gingivitis). Each person received two different cleanings—one side of the mouth got a newer method called Guided Biofilm Therapy (using air and powder), and the other side got the standard ultrasonic cleaning and po…

This study tested two treatments—ozonated gel and titanium platelet-rich fibrin (T-PRF)—on 39 people to see which helps palatal wounds heal better after gum graft surgery. Participants were followed for 14 days to measure pain and wound size. The goal is to find a simple way to r…

This pilot study tested a new treatment called non-thermal plasma (NTP) for painful mouth ulcers in 50 adults. The goal was to see if NTP could speed up healing and reduce pain better than standard laser therapy or a placebo. Participants were randomly assigned to one of three gr…

This study tested whether placing stitches (pre-sutures) in the roof of the mouth before taking a gum graft can reduce bleeding and pain. 32 adults with gum recession took part. Researchers measured blood loss, pain, and healing after surgery. The goal was to see if this simple s…

This study aimed to create a better nursing plan for mouth sores caused by cancer treatments like chemo and radiation. Researchers worked with 54 cancer patients to test a new care routine based on the best available evidence. The goal was to reduce mouth soreness and improve dai…

This study tested whether adding injectable platelet-rich fibrin (i-PRF) and low-level laser therapy to standard gum graft surgery could reduce the amount the graft shrinks during healing. Gum grafts are used to cover exposed tooth roots, but they often shrink over time. The stud…

This study tested a full-mouth electronic toothbrush (FMET) to see if it reduces gum inflammation and plaque better than a regular electronic toothbrush. 94 adults with mild to moderate gingivitis used either the FMET, a conventional electronic toothbrush, or the FMET with a spec…

This study tested two surgical methods to reduce a gummy smile in 20 adults aged 18-38. One method was the standard lip repositioning, the other a modified technique that also controls a specific lip muscle. The goal was to see which approach reduces gum show more effectively and…

This study tested whether low level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health in people getting braces. 108 Pakistani patients aged 18-30 received either standard braces or braces plus laser treatment on their front teeth every three we…

This study tested whether a water flosser is better than an interdental brush at removing plaque and reducing gum inflammation in people with braces. 75 adults with braces used both tools on different sides of their mouth for 3 months. The goal was to see which tool cleans better…

This study tested whether a low-level laser can be used to treat painful mouth sores caused by chemotherapy or radiation in children with cancer. The laser was applied to the inside of the mouth every two days while sores were present. The main goal was to see if the treatment co…

This study tested two ways to remove extra gum tissue (gingival hyperplasia) in people with braces: using a surgical scalpel or a diode laser. Thirteen adults with fixed braces and gum overgrowth took part. The goal was to see which method led to better healing, less pain, and im…

This study tested ozone therapy to treat painful mouth sores caused by radiation and chemotherapy in 58 head and neck cancer patients. Patients received professional ozone treatments at the dental clinic plus ozone-based toothpaste, mouthrinse, and gel to use at home for 15 days.…

This study tested two treatments—laser therapy and ozone gas—to relieve painful mouth sores caused by cancer treatment. Forty adults with head and neck or blood cancers took part. Each received one treatment daily for five days. The goal was to see which therapy better reduced so…

This study tested whether gargling with hawthorn vinegar, black mulberry syrup, or green tea could improve oral health and quality of life in 120 adults with diabetes who had mouth sores (mucositis). Participants used one of the three gargles three times a day for 14 days alongsi…

This study looked at how satisfied people were with at-home tooth bleaching using two different types of orthodontic retainers. Forty adults who had finished Invisalign treatment used both retainer designs and rated their experience. The goal was to see if one design caused less …

This study tested whether a specific routine—using a power toothbrush and mouth rinse twice daily—reduces gum bleeding and inflammation better than a manual toothbrush alone. 69 adults with gingivitis participated for 6 weeks. Researchers measured gum health at the start and afte…

This study tested how satisfied people are with at-home teeth whitening using two different types of trays: Vivera and Essix. Forty adults with healthy teeth used a 10% carbamide peroxide gel for 2 hours a day, 3 days a week, for 4 weeks with each tray. Researchers measured satis…

This study tested two treatments for painful mouth sores caused by radiation therapy: MEBO ointment and Tantum Verde mouthwash. 36 adults with moderate to severe sores were randomly assigned to one treatment for two weeks. Researchers measured soreness and healing at the start, a…

This study looked at a modified lip repositioning surgery for people with a gummy smile (too much gum showing when smiling). The surgery was done without removing gum tissue or cutting a lip muscle. Researchers reviewed records and photos of 32 patients who had the procedure. The…

This study tested whether a toothpaste and mouthwash made with biomimetic hydroxyapatite could reduce tooth sensitivity in 100 adults with receding gums. Participants had one 30-second application of either the toothpaste or mouthwash in a clinic. Sensitivity was measured before …

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This completed study looked at how oral health problems like cavities and gum issues affect the daily lives of 454 preschool children in Portugal. Researchers asked parents about their child's oral health and its impact on the child and family. The goal was to understand which so…

This study examined 180 adults to see if the shape of their gums and their oral habits (like brushing force or teeth grinding) are linked to non-carious cervical lesions — wear on teeth not caused by cavities. Participants filled out a questionnaire and had a dental exam. The goa…

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This study looked at immune cells in a non-cancerous gum growth called peripheral giant cell granuloma (PGCG) and compared them to healthy gum tissue from the same 28 patients. Researchers used special staining to count different types of immune cells. The goal was to better unde…

This study looked at how gum tissue heals when taken from two different areas of the palate (roof of the mouth) to treat receding gums. Forty healthy adults aged 20-40 had a gum graft taken either from the front or back of the palate. Using 3D scans, researchers measured volume c…

This study tested whether custom-made orthodontic molar bands, created using digital scans and 3D printing, lead to better gum health than standard pre-made metal bands. 180 teenagers getting braces were randomly assigned to one type of band. Researchers checked plaque buildup, g…

This study measured levels of a protein called IL-36α in saliva and gum fluid from 80 people with gum disease, gingivitis, or healthy gums. The goal was to see if this protein is linked to gum inflammation and damage. No treatment was given; it was purely an observational study t…

This study examined how standard non-surgical gum disease treatment changes the jaw bone structure in 69 people with gingivitis or periodontitis. Researchers used fractal analysis of dental X-rays taken before and 6 months after treatment to detect subtle bone changes. The goal i…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study measured two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 people with healthy gums, gingivitis, or periodontitis. Researchers collected samples before and after non-surgical periodontal treatment (deep cleaning) to see if these proteins change with treatment. The …

This completed study from Saudi Arabia surveyed 100 adult denture wearers about their knowledge of denture care and oral probiotics. Participants also had a dental exam and provided plaque samples to check for bacteria and fungi. The goal was to see how awareness and practices re…

This study looked at how a toothpaste with sodium bicarbonate (baking soda) affects the bacteria living in the mouth over 12 weeks. Seventy-four adults with mild gum inflammation (gingivitis) used either the baking soda toothpaste or a regular fluoride toothpaste. Researchers che…

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study looked at whether gum inflammation affects the genes that control the body's daily (circadian) clock. Researchers collected gum tissue from 60 healthy adults with similar sleep habits, comparing those with healthy gums, gingivitis, or advanced gum disease. They measure…

This study looked at saliva from 21 people: some with oral lichen planus, some with oral leukoplakia, and some healthy. The goal was to see if proteins in saliva are different between these groups. Researchers hope these protein differences could one day help doctors tell these t…

This study looked at the oral health of 61 obese adults, comparing those who had bariatric surgery to those who did not. Researchers measured tooth wear, cavities, and gum disease to understand how surgery might affect the mouth. The goal was to gather information, not to test a …

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This study measured the amount and type of dark coloring (pigmentation) on the gums of 70 healthy Egyptian adults. Researchers used standard dental scales to record how widespread and how dark the pigmentation was. The goal was simply to describe normal gum color patterns in this…

This completed study checked the gum health of 226 adults with hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. Researchers measured gum pockets, bleeding, and plaque, and compared them to healthy people. The goal was to see if HS inflammation might …

This study examined whether certain gene variations (FCGR2A and FCGR3A) influence how well the drug cetuximab works in people with advanced upper aerodigestive tract cancers that have spread or come back. Researchers analyzed blood samples from 121 participants to look for these …

This study looked at levels of two immune-related substances, fractalkine and CX3CR1, in the gum fluid of people with gingivitis or periodontitis. Researchers measured these before and after standard non-surgical gum treatment, like deep cleaning and oral hygiene advice. The goal…

This completed study looked at how smoking affects gum health in 484 adults. Researchers compared current smokers to non-smokers by measuring plaque, gum bleeding, pocket depth, and gum recession. The goal was to better understand the link between smoking and periodontal disease.

This study looked at stem cells taken from two different areas of the gums (the front and back of the palate) to see which ones are better at forming bone and other dental tissues. Researchers collected gum tissue from 7 people and grew the cells in the lab to test their ability …

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study looked at 36 adults who needed gum graft surgery to see how their anxiety before the procedure affected their quality of life and pain during the first month after surgery. Researchers measured anxiety levels and asked patients daily about their oral health and comfort…

This study looked at three proteins in saliva—IL-6, IL-8, and LIGHT—to see if they can tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers measured these proteins in 60 non-smoking, healthy adults (20 …

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study looked at the free amino acids in saliva from 120 people with healthy gums, gingivitis, periodontitis, healthy implants, implant mucositis, or implantitis. Researchers wanted to see if different amino acid patterns could help tell these conditions apart. The goal is to…