Mouth mucosa disorder

This study tests whether a hyaluronic acid mouthwash is more acceptable to children than a standard chlorhexidine mouthwash, while still controlling plaque-induced gingivitis. Thirty-two children aged 8 to 12 with signs of gingivitis will use one of the two mouthwashes. Researche…

This early-phase trial tests whether specially engineered immune cells (NK cells) can safely treat high-risk precancerous spots in the mouth. The cells are injected directly into the lesions and are designed to target a protein called TROP2, while also resisting signals that norm…

This study tests a surgical procedure to cover exposed tooth roots on the tongue side of lower teeth. Twenty adults with gum recession will receive the surgery and be followed for up to 24 months. The main goal is to see how much root coverage is achieved at 6 months, along with …

This study tests whether a special collagen matrix can replace tissue taken from the roof of the mouth to fix receding gums. Forty adults with at least two areas of gum recession will receive either the collagen matrix or a standard palate graft. The main goal is to see how much …

This study tests whether a new experimental effervescent tablet can clean removable partial dentures better than a commercial cleanser or water. Fifteen adults with denture stomatitis will wear dentures with small material discs to collect plaque, then soak them daily in one of t…

This study tests whether a cream made from phenytoin, a seizure drug known to cause gum overgrowth, can help receding gums grow back. Thirty adults who want to avoid surgery will apply either the phenytoin cream or a placebo paste. Researchers will measure changes in gum attachme…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

Gum recession exposes tooth roots, causing sensitivity and cosmetic concerns. Standard surgery (CAF + SCTG) covers the root, but healing can be slow. This trial tests whether adding a hyaluronic acid gel (hyaDENT BG®) to the surgery improves root coverage and recovery. Thirty-fou…

This study tests whether adding cross-linked hyaluronic acid through microneedling after gum surgery can improve gum thickness and cover exposed tooth roots better than microneedling alone. It involves 22 adults with a single gum recession and thin gums. Participants will receive…

This Phase 3 trial will test whether a toothpaste containing chitosan, a natural substance, can reduce plaque, gingivitis, and gum bleeding better than a standard fluoride toothpaste. About 90 adults aged 18-70 with good general health will brush with either the chitosan toothpas…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This study tests whether a probiotic lozenge containing a special strain of Streptococcus salivarius (SALI-10) can reduce gum inflammation and bad breath. Sixty adults with gingivitis will take the lozenge or a placebo twice daily for four weeks. The goal is to see if the probiot…

This study tests whether thalidomide can reduce or stop fever episodes in children with PFAPA syndrome, a condition causing repeated fevers and sore throats. About 106 children aged 3 to 18 will take either thalidomide or colchicine daily for 6 months. Researchers will track how …

This study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial …

This study is testing a mouth rinse made from stingless bee honey as a gentler alternative to standard chemical mouthwashes for gingivitis (gum inflammation). Researchers will develop the rinse, check its safety and germ-fighting power in the lab, then test it in 20 volunteers to…

This study will test if a toothpaste with stannous fluoride can reduce bacteria on teeth, tongue, cheeks, and gums better than a regular toothpaste. About 100 adults with plaque and gingivitis will brush with one of the two toothpastes. The goal is to see which one controls bacte…

This study tests two non-surgical treatments for oral leukoplakia, a white patch in the mouth that can turn into cancer. One treatment uses a light-activated dye (photodynamic therapy) and the other uses a vitamin D-based cream (calcipotriol). The goal is to see which works bette…

This study compares toothpaste tablets to a standard toothpaste (Colgate Cavity Protection) for cleaning teeth and gums. Fifty adults will use one of the two products for six weeks. Researchers will measure plaque, gum inflammation, and cavities before and after the trial to see …

This study tests whether a mouthwash made from moringa leaves can reduce dental plaque, bacteria, and early cavities as well as the standard chlorhexidine rinse. Researchers will enroll 90 adults with mild gum inflammation and moderate-to-high cavity risk. Participants will use e…

This 6-week study tests whether an AI-based toothbrush (Xiaomi T501) with pressure sensing and coaching removes more plaque and reduces gum bleeding than a standard electric or manual toothbrush. Thirty-three adults with plaque-induced gingivitis will be randomly assigned to one …

This study compares two surgical techniques to treat single gum recession defects, where the gum has pulled away from the tooth. One method uses a tunnel without cuts, the other adds a small cut. The goal is to see which covers the exposed root better and is less invasive. The tr…

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study will test whether artificial intelligence can help diagnose oral lesions that might turn into cancer. Researchers will use photos of the lesions and cell samples from the mouth, along with a special blue stain, to train an AI model. The goal is to see if the AI can mat…

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

This study tests whether a 3D intraoral scanner can accurately measure dental plaque compared to the traditional method of applying a dye and visually scoring. Twenty adults with at least 20 natural teeth and visible plaque will be scanned before and after plaque disclosure and a…

This study tests whether light therapy (photobiomodulation) can prevent mouth sores in children receiving chemotherapy. Fifty children aged 0-30 will receive daily light treatments during hospital stays and at home. Researchers will check if the therapy is easy to use and accepta…

This pilot study tests two light therapy devices—one placed inside the mouth and one outside—to prevent and treat painful mouth sores caused by radiation therapy. Sixty adults with oral cavity or oropharynx cancer will receive light sessions twice a week for prevention, then thre…

This study tests whether a simple, low-cost oral health program for pregnant women in rural Nepal can reduce the number of babies born too early, too small, or underweight. About 2,280 women will either receive daily antiseptic mouthwash and intensive oral hygiene education, or j…

This study tests whether a modified herbal mouthwash can prevent painful mouth sores caused by radiation therapy in people with head and neck cancer. About 156 participants will use either the herbal mouthwash or a placebo during their radiation treatment. The goal is to see if t…

This study tests if a spray called Kangfu Spray can prevent severe mouth sores in people with oral cancer who are getting radiation therapy. About 140 participants will either get the spray plus standard mouth care, or standard care alone. The goal is to see if the spray reduces …

This study tests if a special light (photobiomodulation) can prevent and treat painful mouth sores caused by chemotherapy in children aged 4-17 with cancer. Half of the 49 participants will get light therapy, and the other half will get a standard gel. The goal is to see if the l…

This study tests an oral spray made from stem cell exosomes to prevent severe mouth sores in head and neck cancer patients undergoing radiation. 200 participants will use the spray three times daily, starting a week before radiation and continuing for two weeks after. The goal is…

This study tests two simple, low-cost methods—cold application (like ice chips) and artificial saliva—to prevent painful mouth sores caused by chemotherapy. About 60 cancer patients starting chemo will be randomly assigned to one of the two treatments or standard care. The goal i…

This phase 3 trial tests whether a lozenge called BupiZenge, which contains the long-acting painkiller bupivacaine, can relieve mouth pain from radiation therapy better than the standard lidocaine rinse. About 150 adults with head and neck cancer will be randomly assigned to one …

This study tests whether sucking on ice chips during chemotherapy can prevent or reduce the severity of painful mouth sores (oral mucositis) in cancer patients. 102 adults receiving 5-fluorouracil or methotrexate will be randomly assigned to either get ice chips during infusion p…

This pilot study will test whether a dental gel called theranovis can improve gum health in people with gingivitis (mild gum disease). Twenty adults with gingivitis will use either the gel or a placebo twice daily for a period. Researchers will measure changes in gum bleeding and…

This study tests a painless light treatment called photobiomodulation for children aged 3 to 14 who get severe mouth sores from chemotherapy. The treatment uses a handheld red light device for about 5-10 minutes daily for four days, alongside standard care. Researchers want to se…

This study will compare two types of tooth separators—elastomeric and nickel-titanium—used before placing orthodontic bands for braces. Thirty patients with crowded teeth will have one separator type on each side of their mouth. Researchers will measure how well they create space…

This phase 2 trial tests whether taking taurine (a common amino acid) can prevent or reduce severe mouth sores caused by radiation therapy in people with nasopharyngeal cancer. 130 patients will take taurine pills or receive standard care starting 3 days before radiation until 1 …

This study tests whether a special mouthwash can reduce gum inflammation (gingivitis) in adults. Thirty healthy volunteers with moderate gum redness and swelling will rinse daily for 4 weeks. Dentists will check their gums at the start and end to see if the product helps ease sym…

This study tests whether daily red light therapy can prevent or reduce skin and mouth side effects in children aged 0-16 receiving radiation for cancer. About 248 kids will get a daily LED light treatment on the radiated area. Researchers will compare their side effects to those …

This study compares two ways of teaching oral hygiene to adults with braces who have gum inflammation (gingivitis). One group gets personalized training called iTOP, while the other gets standard video and model instruction. Researchers will measure plaque and gum health after th…

This study compares a homemade herbal mouthwash to chlorhexidine, the standard mouthwash for gingivitis. Gingivitis is a common gum disease caused by plaque buildup. The herbal option may have fewer side effects. The trial will include 12 adults with plaque-induced gingivitis and…

This study tests if a steroid mouthwash can prevent or reduce mouth sores caused by the cancer drug datopotamab deruxtecan (Dato-DXd). About 100 adults with advanced breast or lung cancer will use the mouthwash and be monitored for 12 weeks. The goal is to see if this simple step…

This study tests whether a mobile education app based on Kolcaba's Comfort Theory can improve comfort and well-being for people living with a stoma. About 68 adults scheduled for stoma surgery will be randomly assigned to use the app plus standard care, or standard care alone. Th…

This study will test whether rinsing with cold water (15-20°C) reduces mouth soreness and improves comfort compared to room-temperature water in 200 head and neck cancer patients undergoing radiotherapy. Participants will rinse four times daily for six weeks. The goal is to see i…

This study tests whether a water flosser can improve oral health in adults with plaque-induced gingivitis. Sixty-four healthy adults will use the device twice daily after brushing. Researchers will measure changes in plaque and gum inflammation over time.

This study tests whether applying injectable platelet-rich fibrin (I-PRF) to the wound after gum surgery (gingivectomy or gingivoplasty) can improve healing. Twenty adults with chronic inflammatory gum overgrowth will be split into two groups: one gets standard surgery alone, the…

This study looks at whether music therapy can reduce painful mouth sores (oral mucositis) in children with cancer. Researchers will interview 50 families online to learn about their experiences with music therapy. The goal is to find patterns that could lead to better, drug-free …

This study looks at how gum inflammation and the bacteria in your mouth interact with your body's immune system. Twenty healthy adults will use a special toothpaste and then stop brushing for a period to see how inflammation and bacteria change. The goal is to better understand t…

This study looks at how the width of healthy gum tissue affects the success of covering exposed tooth roots in 30 adults with gum recession. Participants will receive a minimally invasive gum graft surgery. The goal is to see if wider gum tissue leads to better root coverage and …

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study looks at how well the mouth heals after gum surgery in people with diabetes compared to those without. Researchers will track healing, measure gum recession, and check factors like bacteria and inflammation. The goal is to understand what affects recovery in diabetic p…

This study looks at how the mouth heals after gum surgery in people with and without diabetes. Researchers will measure wound size and track healing over 12 weeks. They will also check bacteria and inflammation levels to see what affects recovery. The goal is to learn why healing…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This study tests a new approach called 'Flipped Discharge' for people with colorectal cancer who have a stoma after surgery. Instead of focusing care in the hospital, it shifts support to the home, with a nurse visit or video follow-up three days after discharge. The goal is to s…

This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is …

This study looks at how two types of dental cement used to attach stainless steel crowns affect gum health in 45 children aged 6-10. Researchers measured gum inflammation and certain immune markers before and one week after placing the crowns. The goal is to see if one cement cau…

This study looks at whether playing an escape room game helps nursing students learn more about stoma care and feel more confident. About 60 students will be split into two groups: one will get a lecture plus the escape room game, and the other will get only a traditional lecture…

This study will test three ways to clean clear aligners: brushing with fluoride toothpaste, using chlorhexidine mouthwash, or using an oxygen-based cleanser. Twenty-one adults will try each method for one month to see how it affects bacteria and gum health. The goal is to find wh…

This study explores whether a health app and follow-up digital meetings can motivate teenagers to improve their oral hygiene. Researchers will interview 25 adolescents aged 16-17 who have gum disease (gingivitis) to see if the app helps them build better brushing habits. The goal…

This study aims to understand how certain immune proteins, called NOD1 and NOD2, relate to gum disease. Researchers will collect saliva and blood samples from 75 people with healthy gums, gingivitis, or periodontitis. They will measure levels of these proteins and other markers t…