Hypertensive disorder

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

This phase 3 study is testing an injectable drug called zilebesiran in about 11,000 adults whose high blood pressure is not well controlled despite taking at least two standard medications. Participants also have heart disease or are at high risk for it. The goal is to see if add…

This study tests whether coaching and support from community health workers, delivered by phone or video, can help people with dangerously high blood pressure avoid serious heart problems. Over 3,600 adults who came to the emergency room with very high blood pressure will be rand…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This trial tests whether a single daily pill that combines treatments for high blood pressure, high cholesterol, and type 2 diabetes can lower the risk of heart disease and dementia. The study involves over 8,000 adults aged 50 to 75 in China who have all three conditions. Partic…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests whether a dietary supplement made from omega-3 fatty acids (called SPM) can reduce blood vessel damage caused by inflammation in people with obesity and high blood pressure. Researchers will give 60 participants either the supplement or a placebo for 12 weeks and…

This study tests a single dose of an experimental drug called ALN-AGT01 in adults with mild to moderate high blood pressure who have already been treated with another drug, zilebesiran. The goal is to see if it safely helps control blood pressure by measuring changes in blood pre…

This trial tests whether losartan, a common blood pressure medication, can reduce scarring in the heart's main pumping chamber and improve exercise capacity in adults who had surgery to repair coarctation of the aorta. Participants will take losartan, amlodipine, or a placebo dai…

Researchers are following 500 people with resistant hypertension who have received the Barostim Neo device, an implant that stimulates blood pressure sensors in the neck. The registry tracks blood pressure readings, changes in blood pressure medications, and health care visits ov…

This study tests whether doing wall squat exercises for 14 minutes, three times a week, can lower blood pressure and slow the buildup of plaque in arteries. Researchers will compare 100 people doing the squats with 100 people doing gentle stretching, all with high blood pressure.…

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This study tests a new drug called RTN-001 in adults whose high blood pressure is not controlled by at least two other medications. About 280 participants will take either RTN-001 or a placebo daily for 12 weeks. The main goal is to see if RTN-001 lowers blood pressure more than …

This study tests whether shining a specific red laser light on the wrist (over the radial artery) can improve blood pressure and blood vessel function in people with hypertension who are already taking the medication losartan. Eighty adults will be randomly assigned to receive ei…

This pilot study will test whether training hair stylists to check blood pressure, combined with home monitoring, health coaching, and pharmacist support, can help Black and Hispanic women lower their blood pressure. About 144 women who visit participating salons will be randomly…

This study tests whether extra support from a navigator can help pregnant people with high blood pressure use a home monitoring program (Connected MOM) and follow up after giving birth. The trial includes about 2,000 participants who have a smartphone and speak English or Spanish…

This study compares two telehealth programs designed to help new mothers get faster care after childbirth, especially those with low income. About 3,500 women will receive either virtual education with reminders or a more interactive telehealth model. The goal is to see which app…

This study tests a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. About 261 adults with hypertension will either get the real procedure or a sham (fake) one. The goal is to see if this approach safely lowers blood pressu…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This trial tests whether trained community health workers can help adults with high blood pressure, diabetes, or high cholesterol address social needs like transportation, healthy food, housing, and job opportunities. Participants from clinics will be connected to a health worker…

This study tests a drug called tonlamarsen in adults who were recently hospitalized for dangerously high blood pressure. Participants receive either the drug or a placebo as a shot under the skin every 4 weeks. The goal is to see if tonlamarsen can lower blood pressure and reduce…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study tests whether group care—where patients meet together with health workers for education and check-ups—can improve control of high blood pressure and diabetes in Nepal. Over 1,100 adults from 37 health facilities will be assigned to standard care, low-intensity group ca…

This study tests whether a mobile health program that helps children sleep longer can lower their blood pressure. Ten children recently diagnosed with essential hypertension who sleep 7.5 hours or less on school nights will use a sleep tracker and receive guidance to extend their…

This trial tests whether taking 150 mg of grape seed extract (MegaNatural BP) daily for 6 weeks can lower blood pressure and improve heart health in adults aged 40 to 60 with elevated blood pressure and prediabetes. Researchers will measure changes in blood pressure, blood vessel…

This study is testing whether a year-long program of daily blueberries, protein powder, and three weekly exercise sessions can reduce frailty and lower the risk of heart disease in older adults. Researchers will enroll 240 people aged 65 and older in Nova Scotia. The goal is to s…

This trial tests whether cognitive-behavioural therapy for insomnia (CBT-I) can improve arterial function and mental well-being in adults with high blood pressure and poor sleep. Participants aged 18 to 70 with controlled hypertension and poor sleep quality are randomly assigned …

This study tests a special pacemaker setting designed to lower blood pressure in people with hypertension. About 500 adults who already have or need a pacemaker will take part. The goal is to see if this new setting safely reduces average blood pressure over 24 hours, compared to…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better protect the kidneys and heart in 5000 adults with chronic kidney disease and high blood pressure. Participants will receive either the combination or dapagliflozin alone. The stu…

This study tests whether a care model led by rural doctors and supported by telemedicine can reduce strokes, heart failure, and heart-related deaths in adults aged 65 and older who are at high risk of stroke in rural China. About 2,500 participants from 39 village clinics will be…

This study looks at how well a single tablet combining three blood pressure medicines—amlodipine, losartan, and chlorthalidone—works in Korean adults with hypertension. Researchers will track changes in blood pressure over six months and note any side effects. The goal is to see …

This phase 2 trial tests a radioactive drug called Lu-177-DOTATATE in 130 adults with rare adrenal or neck tumors that cannot be surgically removed. The drug is given four times over about 8 months, and researchers track how long the cancer stays under control. The goal is to see…

This trial investigates whether maintaining a higher blood pressure (85 mmHg or above) during surgery can reduce the risk of postoperative delirium—a sudden confusion that can occur after surgery—in older adults (65+) with high blood pressure. About 3,400 participants having non-…

This trial tests whether transcutaneous spinal cord stimulation (TSCS) can help stabilize blood pressure in people recently hospitalized with a spinal cord injury. After such injuries, blood pressure often swings between dangerously low and high levels, which can interfere with r…

This study will test whether a low-sodium salt substitute, which contains potassium chloride, is safe for adults with high blood pressure who are on medication. About 607 participants in Bangladesh will replace regular salt with the substitute for a period. Researchers will monit…

This study tests a 6-month digital care program for adults aged 50+ with type 2 diabetes and at least one other chronic condition like high blood pressure or kidney disease. The program combines online education, phone support, a mobile health app, home visits, and personalized c…

This trial tests whether using portable HEPA air cleaners at home can reduce exposure to fine air pollution particles and, in turn, lower systolic blood pressure in people with metabolic syndrome. Participants in Qatar will use either a real HEPA filter or a sham filter for four …

This trial tests whether starting a comprehensive, guideline-based treatment plan immediately after a heart attack can reduce the chance of another heart attack, stroke, or death. The plan targets key risk factors like high cholesterol, high blood pressure, and diabetes using a c…

Most older Americans eat too much salt, which can raise blood pressure and harm the kidneys. This study tests whether a ketone supplement (a substance the body makes during fasting or exercise) can block those harmful effects. Thirty-five adults aged 60-85 will follow a high-salt…

This study tests whether taking a ketone supplement can prevent the negative effects of eating too much salt, like high blood pressure and kidney strain. Researchers will give 35 healthy young adults either a high-salt diet with a ketone supplement or a placebo, then measure chan…

This study tests whether delivering healthy DASH-diet groceries and dietitian support to people with high blood pressure in Florida, Georgia, and Tennessee can lower their blood pressure. About 150 adults with elevated blood pressure will receive all their groceries for 4 weeks. …

This trial tests whether losartan, a common blood pressure medication, can improve heart and blood vessel function in adults who were exposed to secondhand tobacco smoke for many years, such as former flight attendants or casino workers. Participants will receive either losartan …

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs (pulmonary hypertension) in people with heart failure. The goal is to see if it can reduce serious heart events like hospitalizations or death. About 750 adults with stable heart f…

This study looks at whether taking melatonin for 12 weeks can help lower blood pressure in women going through menopause who already have high blood pressure. Researchers will measure nighttime blood pressure and check for changes in stress markers. The goal is to find a simple, …

This trial tests whether nurse-led motivational interviewing—a counseling style that helps people find their own motivation to change—can improve blood pressure control in adults with hypertension. Participants are randomly assigned to usual care, individual counseling, or counse…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study compares different ways to give blood pressure cuffs and training to adults with uncontrolled high blood pressure during routine primary care visits. Participants receive a cuff either in the clinic or by mail, and training either hands-on or through written instructio…

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study is tracking 1,000 patients with high blood pressure who receive the Paradise Ultrasound Renal Denervation treatment. The procedure uses ultrasound energy to calm overactive nerves near the kidneys, which can help lower blood pressure. Researchers are monitoring blood p…

This study looks at whether spinal cord stimulation, a device already used for chronic pain, can also reduce blood pressure in people with hypertension and low back pain. Researchers will measure blood pressure changes and pain levels, and explore how different stimulation patter…

This trial tests an experimental therapy called CTX340, which uses CRISPR gene editing to disable a gene in the liver that regulates blood pressure. It is designed for adults with uncontrolled hypertension despite taking multiple blood pressure medications. The study will first a…

This study tests whether doing strength exercises one limb at a time (unilateral) or both limbs together (bilateral) makes a bigger difference in heart rate variability, muscle strength, and daily function for adults with high blood pressure. Adults aged 40-75 with hypertension w…

This trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This study looks at whether giving enalapril, a standard blood pressure medicine, to women who had preeclampsia during pregnancy can help control their blood pressure after childbirth. Researchers will enroll 60 postpartum women and randomly assign them to enalapril or usual care…

This study tests whether a combination of nifedipine and enalapril controls high blood pressure after childbirth better than nifedipine and labetalol. It involves 200 postpartum women with persistent hypertension. The goal is to reduce hospital stays, readmissions, and severe blo…

This phase 3 trial is testing whether a blood pressure treatment plan that focuses on diuretics (water pills) works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. The study will include 720 participants and t…

This study tests whether doing wall squats at home, along with lifestyle advice, is a practical and acceptable way for people with high blood pressure to manage their condition. Seventy adults with hypertension will do supervised wall squat exercises three times a week for 12 wee…

This study tests whether a mobile app (MOM-HD) can help pregnant women with high blood pressure or diabetes monitor their blood pressure and blood sugar at home. About 864 women in Nepal will either use the app plus standard care or standard care alone. The goal is to see if home…

This Phase 2 trial tests a new drug called HDY015, which combines two medicines (QCZ484 and inclisiran) into a single injection. The goal is to see if it can safely lower both blood pressure and cholesterol in people who have both conditions. About 120 adults aged 18-75 with hype…

This study looks at the long-term safety and effectiveness of the drug QCZ484 in people with high blood pressure. It is for patients who already completed a previous study with the same drug. Researchers will monitor side effects and track blood pressure changes over time.

This trial tests whether a community health worker-led education program, called Heart Health and Nutrition for Life (HHNL), can help people with high blood pressure lower their numbers. The program covers healthy eating, physical activity, medication adherence, stress reduction,…

This study tests whether a mobile health program—combining home blood pressure monitoring with virtual coaching—can help midlife women control high blood pressure after having had a hypertensive disorder of pregnancy (like preeclampsia). About 50 women who had such a pregnancy 10…

This study tests whether using portable air cleaners with HEPA filters at home can lower blood pressure in adults with hypertension living in New York City public housing. Fine particle air pollution is linked to high blood pressure, and these devices aim to reduce indoor exposur…

This study tests whether a simple isometric wall squat exercise can lower blood pressure in adults with both hypertension and obstructive sleep apnea treated with CPAP. Each participant will complete one session of wall squats and one rest-only session, with blood pressure monito…

This trial tests whether a diet adapted to Puerto Rican culture can lower the risk of heart disease, type 2 diabetes, and obesity. Researchers will compare culturally tailored nutrition advice—emphasizing traditional healthy foods and limiting unhealthy ones—with standard healthy…

This trial tests whether using a handgrip device for isometric exercise can lower blood pressure in people with elevated blood pressure or hypertension who are not on medication. Half the participants will use the Zona Plus handgrip device, while the other half will listen to rel…

This trial tests whether a digital health tool that uses artificial intelligence can help people with high blood pressure lower their numbers. The AI analyzes daily habits and blood pressure readings to give each person personalized lifestyle suggestions. Researchers will compare…

This study looks at whether giving people with high blood pressure and food insecurity free food and kitchen skills training can improve their health. About 200 adults aged 35-75 will either get the program or standard care. Researchers will measure blood pressure and blood sugar…

This early-stage study tests a new drug called HJB647 in Japanese adults with elevated blood pressure or mild-to-moderate hypertension. The main goal is to check safety and how the drug moves through the body. About 74 participants will receive either HJB647 or a placebo, with do…

This study in Nepal tests whether a blood test before delivery can predict which women will develop dangerous high blood pressure after giving birth. Women at high risk will receive a care bundle including remote blood pressure monitoring, education, and medication to manage thei…

This study tests whether a structured nutrition counselling program can improve diet, blood sugar, blood pressure, and quality of life in adults who have both type 2 diabetes and hypertension. About 308 participants from 14 hospitals in Ethiopia will either receive six individual…

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns, instead of standard care. The goal is to lower the risk of dangerously low blood pressure during treatment and improve overall blood pressure control. About 6…

This study looks at how well a device that uses ultrasound to calm kidney nerves can lower blood pressure in people 65 and older whose blood pressure is not well controlled. Researchers will track 1,000 patients over time using electronic health records. The goal is to see if thi…

This study tests whether an AI-powered digital health platform can help people manage their blood pressure better than support from a human case manager. Adults aged 18 to 75 with high blood pressure use the platform to get reminders, health education, and alerts for abnormal rea…

This study tests a program to help new mothers with chronic conditions like high blood pressure, diabetes, or depression transition smoothly from obstetric to primary care after giving birth. The program includes automatically scheduling a primary care visit, sending personalized…

This study tests whether a mobile health program, including self-measured blood pressure monitoring and help scheduling doctor visits, can lower blood pressure better than usual care. It enrolls adults who have very high blood pressure during a safety-net emergency department vis…

This study tests whether a 12-week program of home-delivered DASH-diet groceries and cooking classes can help adults with high blood pressure and obesity lower their blood pressure and lose weight. 150 participants will be randomly assigned to either the food program or usual car…

This study tests if the drug eplerenone can improve blood flow to the heart better than another drug (chlorthalidone) in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take one of the two medications daily for 48 weeks. Researche…

This study tests whether regular phone calls and text messages with lifestyle advice can help adults in Nepal with uncontrolled high blood pressure lower their numbers. Five hundred participants will receive either the mobile health program or usual care for six months. The goal …

This study tests whether a simple breathing exercise, called Inspiratory Muscle Strength Training (IMST), can safely lower blood pressure in pregnant women during their third trimester. Participants do 5 to 8 minutes of breathing against light or moderate resistance each day for …

This study is testing a 20-week exercise program that combines endurance and resistance training in postmenopausal women with or without high blood pressure. Researchers want to see which mix of exercises best improves heart health, body composition, and quality of life. Sixty ph…

This early-stage study tests STX-1150, a new medicine that temporarily turns off a gene (PCSK9) in the liver to lower bad cholesterol (LDL-C). It does not change your DNA. Up to 64 adults with high LDL-C will receive one or more doses and be followed for a year. The main goal is …

This study tests whether doing simple handgrip exercises—squeezing a device for two minutes at a time—can lower blood pressure in people with hypertension. Participants will perform these exercises either two or four times a week for six weeks. The goal is to find the smallest ef…

This trial compares two different dual blood pressure medications in people aged 50–70 with high blood pressure and heart disease who have just received a heart stent. Participants are randomly assigned to one of two drug combinations: losartan plus hydrochlorothiazide or amlodip…

This trial studies two experimental drugs, UIC202601 and UIC202602, designed to treat high blood pressure and high cholesterol. It enrolls healthy adults aged 19 to 55 to see how the drugs interact when taken together, focusing on safety and how the body processes them. Participa…

This trial tests whether intermittent dietary restrictions—either low-carb or calorie-restricted diets on two days per week—can reverse early signs of heart and metabolic problems in school-aged children aged 7 to 18. Participants have at least one risk factor like prediabetes, a…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. About 130 adults with uncontrolled high blood pressure will receive the quicker procedure. The goal is to see if it works…

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This study tests a device that uses radiofrequency energy to disrupt nerve signals in the kidney and liver arteries, aiming to lower blood pressure in people with uncontrolled hypertension. About 175 adults aged 18-80 with high blood pressure despite medication will be enrolled. …

This trial investigates whether 16 weeks of yoga—including breathing, postures, relaxation, and meditation—can improve blood pressure, heart health, mental well-being, and thinking skills in adults aged 40 and older with high blood pressure. Participants are randomly assigned to …

This study tests whether eating only between about 6:30 am and 2:30 pm (an 8-hour window) for 6 days a week can improve blood pressure, blood sugar, and heart rate in adults aged 60 and older with high blood pressure. Participants will follow this pattern for 12 weeks. The goal i…

This study tests a technology-based program to help women aged 18-44 with high blood pressure lower their blood pressure before getting pregnant. Participants will receive support through their primary care clinic and use online tools. The goal is to improve heart health and medi…

This study tests whether a team of a remote pharmacist, social worker, and nurse, working with patients through a phone app, can help African American and Latinx adults with uncontrolled high blood pressure lower their numbers. Two hundred participants will either get this team-b…

This study tests an experimental drug called SAL0140 in people whose high blood pressure remains high despite current treatments. About 252 adults aged 18-75 with uncontrolled hypertension will receive either the drug or a placebo for 12 weeks. The goal is to see if SAL0140 safel…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This study tests a health coaching program called STAR-MAP to help older adults (age 40+) with high blood pressure take their medication regularly. About 402 participants with uncontrolled blood pressure and low medication adherence will be recruited through a Louisiana health in…

This study compares two treatments for a condition called primary aldosteronism, where a small adrenal gland tumor causes high blood pressure. One treatment is laparoscopic surgery to remove the tumor; the other is radiofrequency ablation (RFA), which uses heat delivered through …

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This study tests whether a program called BETTER can help pregnant women have healthier births. The program includes a one-on-one coaching session and regular text messages to help women connect with resources for housing, food, and transportation. Researchers will compare outcom…

This study looks at whether giving older adults with high blood pressure practical advice and air cleaners can reduce their exposure to heat and air pollution. About 100 people aged 65 and older from Barcelona and Nicosia will take part. They will wear sensors to track temperatur…

This study is tracking 3000 people with high blood pressure who have been treated with the Paradise Ultrasound Renal Denervation System, a device that uses ultrasound to calm overactive kidney nerves. The goal is to see how safe and effective the treatment is over many years by m…

This Phase 3 trial tests whether the drug HRS-7535 can lower blood pressure better than a placebo in 648 adults with hypertension who are also overweight or obese. Participants will take the drug or placebo for up to 48 weeks, and researchers will measure changes in blood pressur…

This study tests whether taking low-dose aspirin for six months after childbirth can help blood vessels heal and lower blood pressure in women who had preeclampsia. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple treatment can redu…

This study tests whether Yufeng Ningxin, a traditional Chinese medicine, can safely lower blood pressure in adults with mild hypertension. About 350 people aged 18-65 with untreated or washed-out high blood pressure will receive either the herbal tablet or a placebo for 8 weeks. …

This study enrolls 864 Black adults with uncontrolled high blood pressure to see if a home monitoring program with pharmacist and community health worker support works better than usual clinic care. Participants will either get a home BP monitor plus remote medication management …

This study tests whether a program to improve sleep can help lower blood pressure in adults. Two hundred people with high blood pressure and poor sleep will either get standard heart health advice or a sleep improvement program with coaching and tips. The goal is to see if better…

This study is testing a community-based program that uses exercise training and lifestyle changes to help people with high blood pressure, high blood sugar, or high cholesterol. The goal is to improve heart and lung function and overall disease control. The program will enroll 10…

This Phase 3 trial tests a drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese. Participants receive weekly injections of either the drug or a placebo for 48 weeks. The main goal is to see if IBI362 lowers blood pressure more th…

This study tests whether a supplement called 2-HOBA can help people with lupus by lowering blood pressure and reducing harmful immune activity. About 42 women with stable lupus and mild-to-moderate high blood pressure will take either 2-HOBA or a placebo for 8 weeks, then switch.…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This early-phase study aims to see if a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a placebo infusion, and researchers…

This study looks at whether royal jelly, a substance made by bees, can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will give 34 participants royal jelly or a placebo for two months and measure changes in blood markers. The goal is to s…

This study tests whether taking propolis and royal jelly supplements for two months can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will measure inflammatory markers in blood samples from 48 participants. The goal is to see if these na…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study is testing whether taking green propolis extract and royal jelly together can reduce inflammation and oxidative stress in people with high blood pressure or chronic kidney disease. Over two months, 153 participants will take capsules of the supplements or a placebo. Re…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study looks at whether adding a slow breathing technique (coherent breathing) to aerobic exercise improves heart and lung health and quality of life more than exercise alone. Forty adults with stage 1 high blood pressure will take part in a 4-week program. Researchers will m…

This study tests whether taking a daily low-dose aspirin for six months after childbirth can improve heart function in women who had preeclampsia. Preeclampsia can raise a protein called Activin A, which may harm the heart. The trial will compare aspirin to a placebo in 180 women…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This pilot study is testing whether providing free produce boxes and nutrition education can improve health outcomes for Veterans with kidney disease and food insecurity. The study will enroll 20 participants and measure changes in blood pressure and kidney function. Researchers …

This study tests whether adding a 10-week health coaching program from a community health worker to remote blood pressure monitoring helps women who had high blood pressure during pregnancy. 240 women will be followed for 6 months after delivery. The goal is to see if the combine…

This study is testing whether providing information about local food resources, help from a community health worker, or medically-tailored meals can improve blood pressure and medication adherence in people with uncontrolled hypertension who also face food insecurity. About 224 p…

This study looks at whether two types of strength training (dynamic and isometric) can improve heart health, mental well-being, and physical fitness in adults aged 60 and older who have high blood pressure. Sixty participants will be randomly assigned to one of the two exercise p…

This study tests a new wearable device that measures blood pressure without a cuff, called CART BP Pro, to help manage high blood pressure in Korean adults whose condition is not well controlled by current medications. About 400 participants will either use the device to guide th…

This study is testing a new educational tool called the Decreased Salt High Potassium (DSHP) Tool, designed to help adults with high blood pressure reduce their salt intake and eat more potassium-rich foods. About 190 participants from two clinics in Singapore will either receive…

This study tests whether a new combination drug works better than taking two separate medicines for people with both high blood pressure and type 2 diabetes. About 228 adults will take either the combo pill or a single-ingredient pill for 12 weeks. Researchers will check changes …

This registry follows 5,000 people with high blood pressure who undergo a procedure called renal denervation. The procedure uses a catheter to deliver radiofrequency energy to nerves in the kidney arteries, which may help lower blood pressure. Participants are tracked for up to 5…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe …

This pilot study tests a 12-week community-based program to help adults with uncontrolled high blood pressure. A team including a pharmacist, nurse, and community health workers provides medication management, monitoring, and education in local settings. The goal is to see if thi…

This study tracks 1,000 Medicare patients with uncontrolled high blood pressure to see if a procedure called renal denervation (using the Symplicity Spyral device) helps lower blood pressure and prevent heart attacks or strokes over two years. Researchers will compare patients wh…

This study tests whether a natural substance called inorganic nitrate can safely lower blood pressure in pregnant women with chronic hypertension. About 144 women will receive either nitrate or a placebo from the second trimester onward. The goal is to see if nitrate reduces the …

This study looks at whether community health workers can help emergency department patients with high blood pressure connect to local resources that address their social needs, like food or housing. Fifteen adults with uncontrolled hypertension will complete surveys and receive r…

This study looks at whether adding Pilates breathing or diaphragmatic breathing to moderate cycling can improve blood pressure, chest expansion, lung function, and quality of life in people with hypertension. 45 adults aged 20–55 with stage 1 or 2 high blood pressure will be spli…

This study tests whether adding sleep health coaching to a diet and exercise program can improve heart health, especially blood pressure. About 150 adults with high blood pressure from underserved NYC neighborhoods will take part. The program includes sleep education, a Fitbit tr…

This study tests whether showing smokers graphic health warnings (like pictures of diseased lungs) along with personalized advice from a pharmacist can help them quit. About 3,400 adult smokers in Bangladesh and Pakistan will be split into three groups: one gets only the warning …

This study tests whether combining pharmacist advice with help from community health workers can improve blood pressure control in African American adults aged 55 and older. Participants will receive support for 24 months to help them take their medications and make healthier lif…

This study tests whether beetroot powder, which is rich in nitrates, can help lower blood pressure in people with resistant hypertension (high blood pressure that doesn't respond well to standard medications). Researchers will monitor blood pressure changes in 50 participants ove…

This study compares a wearable blood pressure monitor (Aktiia G1) to a traditional arm cuff in adults with uncontrolled high blood pressure. Over 6 months, researchers will see which method leads to better blood pressure control. Participants must have a smartphone and attend two…

This study tests whether eating grape powder daily for 3 weeks can improve gut health, reduce inflammation, and improve blood vessel function in 40 overweight adults aged 45-70. Participants will drink grape or placebo powder twice a day and provide blood and stool samples. The g…

This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participa…

This observational study will follow 12,000 Korean adults with stage 1 hypertension who are newly prescribed OLMETEC or OLMETEC Plus. The main goal is to see how well the medication controls blood pressure over 24 hours, especially at night. Participants will have their blood pre…

This study tests whether a non-invasive technique called remote ischemic preconditioning (RIPC) can help lower blood pressure in people with mild hypertension. RIPC involves briefly restricting blood flow to an arm using a cuff, which may trigger protective effects. Researchers w…

This study compares two blood pressure medications, eplerenone and chlorthalidone, in 75 adults with high blood pressure and thickened heart muscle. Researchers want to see if eplerenone improves blood flow to the heart and how efficiently the heart uses oxygen. Participants will…

This study tests whether spironolactone, a blood pressure pill, can help women who had high blood pressure during pregnancy avoid long-term heart issues. About 200 women with overweight and recent hypertensive pregnancy will take the drug or a placebo daily for 12 weeks after del…

This study tests a program that combines online education, a medication reminder app, and a home blood pressure monitor to help African American adults aged 50+ better manage their hypertension. Participants use these tools for 6 months while continuing their regular care. The go…

This study tests a home blood pressure monitoring program for 1,200 women in Nigeria who had high blood pressure during pregnancy. The program includes patient education, home BP monitors, follow-up care, and free medication if needed. Researchers want to see if this approach lea…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This Yale study tests two ways to help people with high blood pressure: a remote monitoring program alone, or that program plus a community health worker who helps with home monitoring, appointments, and social needs like food or housing. 1,440 participants with elevated blood pr…

This study looks at whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to fresh groceries. About 80 participants from Baltimore will be randomly assigned to receive either standa…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study tests whether a smartphone app that offers small cash rewards for daily pill photos can help people with high blood pressure stick to their medication. Six hundred participants will either get the app with rewards, the app plus a personal action plan, or standard care.…

This study tests a program designed to help people with high blood pressure and high cholesterol lower their risk of heart disease. About 1,980 adults from Penn Medicine primary care clinics in West/Southwest Philadelphia and Lancaster will take part. The program uses tools and b…

This Phase 3 trial compares two treatments for people with high blood pressure and chronic kidney disease: finerenone versus a fixed-dose combination of torsemide and spironolactone. The study will enroll 30 adults to see which approach better lowers blood pressure, reduces prote…

This study tests whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes. The health workers will lead group meetings, provide health education, and coordinate care with local clinics. About 398 adults with both c…

This study tests a new way to program pacemakers to help lower blood pressure in people who have both high blood pressure and a slow heart rate. About 30 adults who already have or need a special pacemaker will try two different setup sessions. Researchers will check if the new s…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, high cholesterol, and overweight. About 1,780 adults will take part in cooking demonstrations and learn how to eat more traditional Hawaiian foods. The goal is to…

This study tests whether the drug Isturisa can improve blood sugar, cholesterol, blood pressure, weight, and bone strength in people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Ten adults with MACS will take Isturisa for two…

This study tests whether a daily pill called engagliflozin (a type of SGLT2 inhibitor) can improve heart function in people who have high blood pressure and early signs of heart failure but do not have diabetes. About 120 adults will receive either the drug or a placebo for 6 mon…

This study tests a program called PILI 'Āina that combines lifestyle lessons, home gardens, and cooking classes to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity. About 210 overweight or obese Native Hawaiian adults with these conditions will take …

This study tests if dapagliflozin, a diabetes drug, can reduce heart and blood vessel risks in women who had high blood pressure during pregnancy. About 200 participants will take either the drug or a placebo daily for six months after delivery. The goal is to see if the drug imp…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study tests whether a smartphone app called FAITH! can help African-American adults with uncontrolled high blood pressure lower their numbers and improve heart-healthy habits. About 100 participants will use the app or receive standard care, and their blood pressure and self…

This study tests a program where trained peers deliver blood pressure medications directly to patients' homes and use health technology to support adherence. The goal is to see if this approach helps people with uncontrolled high blood pressure take their pills regularly and lowe…

This study tests whether iloperidone, a drug already used for schizophrenia, can help lower blood pressure in people whose hypertension is not controlled by their current medications. About 240 adults will receive either iloperidone or a placebo for 4 weeks, and researchers will …

This study aims to see if a mobile health program called mGlide-Care can help control high blood pressure in people with mild cognitive impairment or early Alzheimer's. Caregivers will assist participants in using the program. The study will compare blood pressure control between…

This study tests whether artificial intelligence (AI) can help doctors in China pick better blood pressure medications for their patients. Over 2,000 adults with high blood pressure will be treated at primary care clinics. Some clinics will use AI software that considers patient …

This study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will track changes in blood pressure and blood sugar over 6 months in 100 adults aged 18-60. The goal is to see if home-based care leads to better control o…

This study tests whether a program led by community health workers can help refugees with high blood pressure take their medication as prescribed and lower their blood pressure. The program includes an education booklet, a pill organizer, and two counseling sessions. Researchers …

This study is testing a mini-program (like a smartphone app) that gives personalized exercise advice to people with high blood pressure, high blood sugar, high cholesterol, and high uric acid. Over six months, 100 participants will use the app to increase their daily steps and ph…

This study tests whether trained community health workers can help people in Nepal prevent and control high blood pressure. Over 3,500 participants with high blood pressure will receive home visits and group counseling from health workers. The goal is to see if this approach lowe…

This study compares a new optical blood pressure monitor worn on the wrist to the standard arm cuff for home use. About 35 adults with high blood pressure (stage 1 or 2) will use both devices while taking medication. The goal is to see if the wrist monitor is as accurate and easy…

This study compares two common blood pressure medications, Nifedipine and Labetalol, to see which works better and is safer for women who develop high blood pressure after giving birth. About 500 new mothers will be randomly assigned to one of the two drugs. The goal is to reduce…

This study tests whether combining transcutaneous electrical nerve stimulation (TENS) with isometric exercise can improve blood pressure in people with resistant hypertension. Resistant hypertension means blood pressure stays high despite taking three or more medications. The tri…

This study tests whether powerful weight loss drugs (like semaglutide or tirzepatide) can lower blood pressure enough for young adults (ages 18-40) with obesity and early-stage hypertension to stop taking daily blood pressure pills. Sixty participants will either receive the weig…

This study tests whether community health workers (CHWs) using a mobile app can manage high blood pressure as effectively as doctors. 460 adults with hypertension in rural Guatemala will be randomly assigned to either CHW-led care with app support and remote doctor supervision, o…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests if using focused ultrasound to modify fat around the kidney can safely lower blood pressure in people with hypertension. About 30 adults with mild high blood pressure despite medication will be enrolled. The treatment is compared to a sham procedure to see if it …

This study tests whether gentle shockwaves applied to the kidneys can lower blood pressure in people with chronic kidney disease. Thirty adults with high blood pressure and moderate-to-severe kidney disease will receive either real or fake (sham) treatments over three weeks. The …

This study looks at whether using a CPAP machine, sometimes with a mild sleep aid, can help lower blood pressure in people with both sleep apnea and high blood pressure. About 200 adults aged 18-70 will use CPAP every night for 3 months. Those with insomnia can also take trazodon…

This study compares a 5-minute daily breathing exercise (IMST) to brisk walking for lowering blood pressure in postmenopausal women aged 50 and older with above-normal blood pressure. Researchers will measure changes in blood pressure and blood vessel function after 3 months of t…

This study tests a program to help 800 adults in Africa get their high blood pressure under control. It combines patient education, provider training, and health system improvements. The goal is to lower blood pressure and reduce the risk of heart disease, stroke, and kidney prob…

This study tests whether a pharmacist-led care pathway can improve blood sugar control in 600 adults with type 2 diabetes who are not meeting their A1C targets. Participants will receive step-by-step guidance from pharmacists using a web-based tool, compared to usual care from th…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves in people whose high blood pressure isn't controlled by two medications. The device is placed through the body's natural openings, so no cuts are needed. About 60 adults will take part to s…

This study tests a procedure called superselective adrenal artery embolization (SAAE) against the standard pill spironolactone for people with idiopathic hyperaldosteronism, a condition that causes high blood pressure. About 172 participants will be randomly assigned to either th…

This Cleveland Clinic study tests a team-based approach where patients with uncontrolled high blood pressure measure their BP at home and adjust medications with help from pharmacists and providers via phone or video visits. About 1520 adults aged 18-85 with BP over 150/95 will t…

This study tests if a mobile health app can help people who had a bleeding stroke better control their blood pressure. About 140 participants will use the app to track their numbers and get health tips. The goal is to see if the app helps more people reach safe blood pressure lev…

This study looks at whether a program that combines digital health coaching for patients and support for clinics can help low-income people with diabetes better manage their condition. Researchers will enroll 600 adults with uncontrolled diabetes or high blood pressure. The goal …

This study tests a program called MINDSET for veterans with chronic conditions like heart disease or diabetes who smoke or drink too much. Participants receive a mailed packet with personalized health information and a brief motivational phone call. The goal is to see if this app…

This study tests if doing wall squats (a type of isometric exercise) can lower blood pressure better than stretching in people with hypertension. About 390 adults who are not very active will be randomly assigned to either a wall-squat or stretching program for 24 weeks, with fol…

This study tests whether a daily SGLT2 inhibitor pill can reduce heart attacks, strokes, and other cardiovascular events in 3,000 adults aged 60+ with high blood pressure and a history of heart or blood vessel problems. Participants will receive either the drug or a placebo for s…

This study compares a standard smartphone app with a more interactive version to see which helps people better follow their care plan after weight-loss surgery. About 200 adults having bariatric surgery will participate. Researchers will measure weight loss, quality of life, and …

This study tests whether watching virtual reality (VR) cycling videos can produce exercise-like benefits in 48 sedentary adults with prediabetes or high blood pressure. Participants will either do 20 minutes of real cycling or watch VR cycling, and researchers will measure change…

This study compares stevia-sweetened drinks, sugary drinks, and flavored water in children ages 8-12 who regularly drink sugary beverages. Over 8 to 14 weeks, researchers will measure changes in weight, body fat, insulin resistance, blood fats, and blood pressure. The goal is to …

This study tests whether patiromer, a drug that lowers potassium, allows people with moderate-to-severe chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this leads to better kidney protection and lower …

This study looks at whether dietary nitrate, given as beetroot juice, can help people with high blood pressure and early-stage kidney damage. About 14 to 20 adults will receive either nitrate or a placebo for two weeks, then switch after a break. Researchers will measure changes …

This study tests whether dotinurad is better than febuxostat at improving blood vessel stiffness in 360 adults with high uric acid and high blood pressure. Participants will take one of the two drugs for 24 weeks. The goal is to see which drug better controls uric acid and suppor…

This study looks at whether time-restricted eating (eating only during certain hours) can improve blood pressure and insulin sensitivity in people who work night shifts. Night shift workers are at higher risk for heart disease and type 2 diabetes. Researchers will compare 4 weeks…

This study tests whether a special high-intensity interval training (HIIT) program can improve heart health in school-age children who are at high risk for cardiovascular disease. The program involves short bursts of intense exercise, done several times a week. Researchers will t…

The ACHIEVE trial is testing whether giving pregnant women with preeclampsia or high blood pressure medication to keep their blood pressure below 140/90 mmHg can safely prolong their pregnancy. The study will enroll 132 women between 23 and 35 weeks of pregnancy who have mild for…

This study tests whether a telemedicine system (HealthCap app) can keep blood pressure under control as well as regular face-to-face doctor visits in people with stable hypertension. About 364 participants will either use the app for remote monitoring and automatic medication ref…

This study tests whether thiazide diuretics (water pills) can lower blood pressure in people on peritoneal dialysis who have high blood pressure. About 40 adults with end-stage kidney disease will take the drug and have their blood pressure, weight, and body fluid levels measured…

This study tests whether an AI-powered smartphone app, called 'Smart family doctor,' can help people who have had heart bypass surgery or stents better control their blood pressure, diabetes, and cholesterol. About 536 adults who already have these conditions will use the app to …

This study tests whether adding stair climbing to a brisk walking routine lowers blood pressure more than walking alone. 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk walking onl…

This study tests whether taking 20 grams of beetroot powder daily for a week can help lower blood pressure in men with hypertension who are already on medication. Sixty men will be randomly assigned to either take the powder or continue their usual treatment, then switch after a …

This study tests whether combining remote blood pressure monitors with support from community health workers helps Latinx patients better manage their high blood pressure. About 300 adults with uncontrolled hypertension will take part. The goal is to see if this approach lowers b…

This study tests whether a single daily pill containing three blood pressure medications can better control resistant hypertension compared to taking multiple separate drugs. Researchers will enroll 142 adults with high blood pressure that is not well controlled despite using 3 t…

This early-stage study tests a new tablet called VB19055 in 86 healthy Chinese adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo. The goal is to gather initial safety data before testing in people with high blood pre…

This study looks at three ways to lose weight—medication, surgery, or diet—to see which helps people with metabolic syndrome (a mix of diabetes, high blood pressure, and obesity) live longer and healthier. About 220 adults aged 35-65 will take part for 24 weeks. Researchers will …

This study tests whether a device that strengthens breathing muscles can lower blood pressure in adults with high systolic blood pressure (120 mmHg or higher). Over 6 weeks, 144 participants will use the device at different training intensities. The goal is to see if this simple,…

This study looks at whether adding baked potatoes (with skin) to a Mediterranean diet can improve blood sugar control, blood pressure, and cholesterol in adults aged 45-80 with pre-diabetes. Sixty participants will either get diet education alone or education plus pre-prepared ba…

This study tests a home blood pressure monitoring program paired with health education and coaching for rural adults with uncontrolled hypertension. About 334 participants will either get the coaching program or a standard health app. The goal is to see if the program lowers bloo…

This study compares two types of exercise—short, intense bursts (SIT) versus steady moderate activity (MICT)—to see which better lowers blood pressure in adults aged 30-59 with hypertension. Participants will do supervised workouts three times a week for 12 weeks. The goal is to …

This study tests a 12-week program for African-American women who have had breast cancer and now have high blood pressure or obesity. The program provides grocery delivery, cooking classes, and nutrition education to help them eat healthier and control their blood pressure. The g…

This study tests whether providing healthy frozen meals, produce boxes, and nutrition counseling helps adults in Anson County eat better compared to those who only get physical activity coaching. About 120 participants with or at risk for chronic diseases like obesity, diabetes, …

This study looks at two common blood pressure drugs, nifedipine and enalapril, to see how well they control high blood pressure in women after giving birth. About 850 women with pregnancy-related or chronic high blood pressure will be randomly assigned to one of the medicines. Th…

This study tests whether taking atorvastatin (a statin) for 3 months after childbirth can reduce the long-term risk of heart disease in women who had high blood pressure disorders during pregnancy. 76 postpartum women will receive either atorvastatin or a placebo, and their cardi…

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems stick to their blood pressure medication schedule. One hundred participants will use either the full app with reminders or just the education part for …

This study will test different methods to help people with high blood pressure get it under control. It involves nearly 17,000 adults receiving care at nine community health centers. The goal is to find the most effective strategies for managing blood pressure in diverse populati…

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health at home. Participants use a blood pressure monitor that sends readings to their care team, and they get support from community health workers and pharmacists. Th…

This early-phase study tests whether empagliflozin, a drug originally for diabetes, can improve left atrial function in 80 adults over 60 with hypertension and obesity who are at risk for heart failure. Participants take either a 10 mg empagliflozin tablet or a placebo daily for …

This study tests whether a community-based lifestyle program can help control high blood pressure in adults at risk. 220 participants will receive coaching on diet, exercise, and self-management, and be followed for 12 months. The program adds to usual medical care, not replace i…

This study is testing whether wearing a smartwatch and getting personalized health coaching through a mobile app can help people with high blood pressure, diabetes, obesity, or related conditions improve their lifestyle. About 1,700 adults aged 21-75 will wear a smartwatch for at…

This early-stage trial is testing a new drug called KN060 for people with essential hypertension (high blood pressure). Sixty adults aged 18 to 65 will receive either KN060 or a placebo by IV drip every two weeks for 12 weeks. The main goal is to see if KN060 safely lowers blood …

This study compares two ways to help stroke survivors control their blood pressure: home monitoring alone versus home monitoring plus group medical visits. High blood pressure is the leading cause of a second stroke, so the goal is to find a better method to keep blood pressure i…

This Phase 3 trial tests whether taking dapagliflozin and telmisartan together works better than either drug alone for people with type 2 diabetes and high blood pressure. About 221 adults will receive either the combo or a single drug for 12 weeks. Researchers will measure chang…

This phase 3 trial is testing whether a new combination drug (JW0104+C2402) can safely lower both blood pressure and LDL cholesterol in people with hypertension and dyslipidemia. 162 participants will take the drug once daily for 8 weeks. The study is randomized and double-blind,…

Researchers are testing whether the Hilo Band, a cuffless wrist device, can measure blood pressure as accurately as the standard 24-hour ambulatory monitor. The study enrolls 40 young adults aged 21 to 35, including those with normal, low, or high blood pressure. Participants wea…

This study is testing a new wrist device that uses light to measure blood pressure without needing a traditional arm cuff. Researchers will compare its readings to standard methods in 200 adults aged 22 to 59 over one week. The goal is to see if the device is accurate and safe en…

This study tests whether a non-invasive imaging technique called hyperspectral imaging can help predict how preeclampsia will progress in pregnant women. Preeclampsia is a serious condition that can harm both mother and baby, and it is linked to problems in the tiny blood vessels…

This observational study is testing whether a combination of non-invasive measurements—including blood pressure monitoring, ultrasound, blood and urine tests, and a light-based technique called photoplethysmography—can detect early damage to blood vessels and organs in adults at …

This study tests a wearable ring that measures blood pressure, comparing it to the standard 24-hour monitor in 100 people with heart failure and reduced pumping ability. The goal is to see if the ring is accurate and easy to use. If successful, it could make blood pressure tracki…

This study tests whether the Withings BPM Pro 2, an automatic blood pressure cuff, gives accurate readings for pregnant women, including those with high blood pressure or pre-eclampsia. About 45 participants will have their blood pressure measured with both the device and a stand…

This study tests a new steroid-based blood test to see if it can more accurately diagnose primary aldosteronism—a common, treatable cause of high blood pressure—in people who are already taking blood pressure medications. Current tests often require patients to temporarily stop o…

This study will test if the Oura Ring can identify signs of high blood pressure using a new algorithm. Researchers will compare the ring's readings to what participants report about their own blood pressure. Up to 2 million adults in the US who already use an Oura Ring will take …

This study is testing a wrist-worn device that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings to standard blood pressure measurements in 355 adults over four weeks. The goal is to see if this optical method is accurate e…

This study explores whether a smartphone can reliably screen for high blood pressure by analyzing video recorded at your fingertip. About 100 adults will record their blood pressure using both a smartphone and a standard arm cuff, three times each morning and evening for a week. …

This study tests a wrist-worn device called ViTrack that measures blood pressure continuously without needles. Researchers will compare its readings to standard invasive monitoring in 40 adults having noncardiac surgery. The goal is to see if the device can accurately track blood…

This study is testing whether a quick, non-invasive test of blood vessel function can help predict and diagnose preeclampsia and other high blood pressure disorders in pregnancy. Researchers will follow 400 first-time pregnant women, measuring vessel health early in pregnancy and…

This study is testing whether three substances in the blood can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 120 pregnant women between 20 and 36 weeks. The goal is to find a…

This study looks at whether home blood pressure monitoring can reliably diagnose high blood pressure in African American teenagers, who are at higher risk. Researchers will compare home readings to the gold standard 24-hour ambulatory monitoring in 750 teens. The goal is to find …

This study tests a new camera system that measures vital signs like pulse, blood pressure, and temperature without touching the body. The goal is to see if it works as well as standard devices, which require physical contact and can spread infections. About 860 adults visiting he…

This study compares a new wrist-worn device (ViTrack) that measures blood pressure without a cuff to traditional arm-cuff devices. About 91 healthy volunteers with normal or high blood pressure will have their readings compared. The goal is to see if the wrist wearable is accurat…

Researchers in Pakistan are testing whether a mobile app that uses artificial intelligence to send personalized heat-risk alerts can reduce heat-related illness symptoms in adults with chronic conditions such as hypertension, diabetes, kidney disease, heart disease, or obesity. T…

This trial tests whether a personalized health program delivered through a WeChat mini-program and community health workers can lower blood pressure in adults at high risk of developing hypertension. Researchers will enroll 500 adults aged 35 to 65 in Beijing who have a predicted…

Researchers test whether lowering systolic blood pressure to below 120 mm Hg prevents major cardiovascular events in adults with type 2 diabetes and high-normal blood pressure. The trial enrolls about 11,400 people aged 45 to 79. Participants receive either intensive treatment wi…

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This study tests whether using a low-sodium salt substitute instead of regular salt can lower blood pressure and prevent pregnancy-related high blood pressure disorders in women at high risk. About 3,200 pregnant women in China will be randomly assigned to use either the salt sub…

This study tests whether regular, personalized health coaching—delivered virtually and during community screenings—can reduce the 10-year risk of heart attack or stroke in adults aged 40-75 who have at least one cardiometabolic risk factor like high blood pressure, high cholester…

This study tests whether taking progesterone early in pregnancy can prevent preeclampsia, a condition that causes high blood pressure and organ damage. Over 600 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. Researchers will track who d…

This trial tests whether a single polypill combining three medications—finerenone, empagliflozin, and losartan—can help prevent heart failure and maintain exercise capacity in people with type 2 diabetes who are at high risk. Participants will take either the polypill or the same…

This study looks at whether combining the MIND diet (a mix of Mediterranean and DASH diets) with aerobic exercise can help prevent memory and thinking problems in Black adults aged 35-75 who have high blood pressure. Participants will be randomly assigned to either receive food d…

This trial tests whether starting intensive blood pressure medication soon after childbirth can prevent chronic hypertension in women who had preeclampsia. Participants are randomly assigned to receive nifedipine ER when their blood pressure reaches different thresholds during th…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) in pregnant women at risk. Over 10,000 participants will be assigned to one of the two doses early in pregnancy. The goa…

This study tests whether personalized telehealth coaching from a pharmacist can help people adopt preventive health strategies like better nutrition, exercise, and medication use. Researchers will enroll 360 adults from industries like healthcare and food service in Louisiana. Pa…

This study tests whether helping doctors manage high blood pressure more aggressively can prevent cognitive decline and dementia in adults aged 70 and older. Researchers will use a smartphone app and a clinical decision support tool to guide treatment. 4,000 participants will be …

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study compares two methods of releasing a tourniquet (a tight band that stops blood flow) during arm surgery in patients with high blood pressure. The goal is to see which method causes less of a sudden drop in blood pressure. The trial will include 68 adults whose blood pre…

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This study is testing a mobile health app called Moms@Home to help pregnant women with high blood pressure monitor their readings at home. About 100 women with gestational or chronic hypertension will use the app and share their home blood pressure data. The goal is to see if the…

This study looks at whether drinking beetroot juice every day for 12 weeks can help postmenopausal women get more heart and blood vessel benefits from exercise. The researchers will compare two groups of women doing the same exercise program—one group gets real beetroot juice, th…

This study tests whether a simple handgrip exercise can safely lower blood pressure and improve thinking skills in pregnant women with and without chronic hypertension. Thirty pregnant women will either perform short handgrip squeezes or rest quietly, and researchers will measure…

This study tests whether diaphragmatic breathing exercises can reduce heart rate, blood pressure, and dizziness in pregnant women with Postural Orthostatic Tachycardia Syndrome (POTS). 44 pregnant women will be split into two groups: one doing breathing exercises, the other recei…

This study has two parts. First, it looks at genes that might be linked to high blood pressure in Thai people. Second, it tests whether a specific breathing pattern called 4-7-8 (inhale for 4 seconds, hold for 7, exhale for 8) can help lower blood pressure. About 200 adults with …

This study tests whether doing very short wall-squats (just a few minutes) at four different times each day can lower blood pressure in people with hypertension or pre-hypertension. Researchers will compare this approach to doing all the squats at once. The goal is to find a simp…

This study tests an 8-week group mindfulness program designed for African American adults who have both high blood pressure and depression. Researchers want to see if the program improves mood and blood pressure, and if it works well in a community setting. Participants will lear…

This study tests whether an 8-week program of supervised physical and cognitive exercises can improve walking, thinking, strength, and quality of life in 374 adults with Long COVID and conditions like high blood pressure or diabetes. Participants are randomly assigned to either t…

This study tests whether a medication given as a nose spray (dexmedetomidine) can keep blood pressure stable in elderly patients with high blood pressure who are having cataract surgery. About 126 people aged 65 and older will take part. The goal is to see if the spray reduces da…

This study looks at whether using a CPAP machine (a device that gently blows air through a mask) can safely lower high blood pressure when lying down at night and help reduce dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study is testing whether a beetroot extract supplement can lower blood pressure and improve muscle oxygen levels in older women (ages 60-70) with high blood pressure during a single aerobic exercise session. Twenty participants will take either the beetroot supplement or a p…

This study is testing whether an 8-week telephone-based mindfulness program (MIND-BP) can help Black women with high blood pressure lower their blood pressure and reduce stress. The study will compare the mindfulness program to a general support group (BOOST). 300 Black women fro…

This study tests whether a smartphone game that responds to your activity can help Native American adults with high blood pressure become more active. Half of the 220 participants will get the game plus a fitness tracker, while the other half gets only the tracker. Researchers wi…

This study tests whether applying gentle heat to the abdomen overnight can safely lower high blood pressure that occurs when lying down in people with autonomic failure. About 20 adults with conditions like Parkinson's or Multiple System Atrophy who have this nighttime hypertensi…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tests whether a nutritional supplement called 'Think Tank' can improve thinking and memory in middle-aged women after they experience stress. Forty healthy women aged 40-60 will take either the supplement or a placebo and then complete cognitive tests. The goal is to s…

This study tests whether brief, mild low-oxygen breathing sessions can improve blood vessel function, lower blood pressure, and reduce tiredness in people with obstructive sleep apnea. Researchers will enroll 60 adults aged 30-60 who are newly diagnosed and not yet using CPAP. Th…

This study looks at 600 adults with chronic insomnia to see if those who sleep less than 6 hours respond differently to treatment than those who sleep longer. Participants first receive 8 weeks of cognitive behavioral therapy (CBT-I). If that doesn't help, they are randomly assig…

This study looks at whether using a CPAP machine at night can lower dangerously high blood pressure that happens when people with autonomic failure lie down. About 12 participants will use CPAP or a placebo pill/patch. The main goal is to see if CPAP reduces blood pressure while …

This study looks at whether exercising in the morning or early evening makes a difference in lowering blood pressure and improving blood vessel health. Researchers will study 79 postmenopausal women aged 55-80 who have high blood pressure. Participants will be assigned to either …

This study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …

This study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study looks at sleep problems in healthy Somali Americans and how they might raise the risk of high blood pressure. Researchers will use sleep studies and 24-hour blood pressure monitors on 240 adults. The goal is to find hidden sleep issues and understand their link to bloo…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

This observational study is looking at whether people with primary aldosteronism (a cause of high blood pressure) have hormone levels that vary in cycles or differ between day and night. Researchers will collect urine samples over 24 hours from 100 participants to see if this met…

This study aims to find genes that cause high blood pressure starting in childhood. Researchers will follow 2,300 people aged 2 and older, including those with childhood-onset hypertension and their healthy relatives, for up to 10 years. Participants provide blood, urine, and che…

This study will analyze health records from 15,000 adults with high blood pressure in Brazil's public primary care system. Researchers want to see how often patients with uncontrolled blood pressure get their treatment adjusted. The goal is to understand patterns of care and iden…

This study asks how the nervous system tells blood vessels to narrow during stress, and whether obesity or high blood pressure changes that signal. Researchers will measure nerve activity and blood flow in about 100 adults, some with obesity, some with hypertension, and some with…

This study looks at how people with slightly high blood pressure react to salt. Participants will eat both high-salt and low-salt meals to see if their blood pressure changes. The goal is to find out who is salt-sensitive and who is not. No new treatments are tested—just careful …

Researchers at GE Healthcare are testing an investigational system that aims to estimate blood pressure changes using SpO2 data, which is typically measured with a finger sensor. The study will enroll 50 adults in intensive care, operating rooms, or recovery areas who already hav…

This trial tests whether wearable devices like smartwatches can measure blood pressure as accurately as standard arm cuffs or invasive arterial lines. Hospitalized patients will wear multiple devices using light-based (PPG) and wrist-cuff methods, with readings compared to clinic…

This study looks at data from over 6,000 Brazilian patients with heart failure, kidney disease, diabetes, or high blood pressure to understand how common high potassium levels (hyperkalemia) are and how doctors manage it. By analyzing medical records, researchers hope to identify…

This study looks at whether a hormone called aldosterone plays a key role in high blood pressure. Researchers will follow 500 adults with hypertension, tracking aldosterone levels and related health measures over six months. The goal is to better understand how aldosterone change…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study investigates why arteries stiffen and harden faster in children and young people with chronic kidney disease (CKD) and high blood pressure. Researchers will use non-invasive tests to compare arterial stiffness between those with CKD and matched controls, including heal…

This study looks at how partial sleep deprivation affects blood pressure in healthy young adults whose parents have high blood pressure compared to those whose parents have normal blood pressure. Participants will spend 10 days in a sleep lab, with some nights allowing only 5 hou…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study explores whether a measure called perfusion index (PI), taken from a pulse oximeter on the ear, finger, or toe, can reliably predict changes in blood pressure in people with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI and healthy…

This study explores whether work-related frustration and stress are linked to higher-risk blood pressure patterns, such as masked or white-coat hypertension. Researchers will monitor the blood pressure of working adults aged 40 to 65 over 24 hours and compare it with their percei…

This study looks at what happens to blood pressure when healthy adults sleep only 4 hours a night. Researchers will compare normal-weight and obese participants to see if lack of sleep affects their blood pressure differently. The goal is to better understand the link between sle…

This study looks at whether tiny particles shed from blood vessels, called endothelial extracellular vesicles, can serve as early warning signs for hypertensive disorders of pregnancy, such as preeclampsia. Researchers will compare levels of these particles in pregnant women with…

This study compares levels of tiny particles shed from blood vessels in people with newly diagnosed, untreated high blood pressure versus those with normal blood pressure. Researchers want to see if these particles can serve as early, non-invasive markers of blood-vessel injury. …

This study follows 200 pregnant women in Ghana from their third trimester through six months after birth. It measures blood pressure and artery stiffness to see if a structured education program on heart health, nutrition, and stress management can reduce long-term cardiovascular…

This study checks how well a non-invasive blood pressure cuff matches the readings from an arterial line, the current gold standard. Adults aged 18 and older who already have an arterial line as part of their care may join. The goal is to see if the cuff-based device can provide …

This study measures how common heart disease, diabetes, obesity, and infections like dengue and COVID-19 are among adults in La Reunion. Researchers will also look at possible risk factors, including gut bacteria, genetics, and social conditions. Participants provide blood, DNA, …

This early-stage study looks at how the body's nervous system controls blood pressure when veins are stretched. Researchers will use a blood pressure cuff to temporarily block blood flow in the arm and measure nerve activity in the leg, along with vein size using an MRI. They wil…

This study looks at whether stretching the veins in your legs causes a rise in blood pressure when you stand up, a condition called orthostatic hypertension. Researchers will use a tilt table and inflatable trousers to gently stretch leg veins in 30 healthy adults and people with…

This study compares standard arm-cuff blood pressure checks to a new continuous monitor worn on the finger during outpatient surgery. Researchers want to see if the finger cuff catches low blood pressure episodes better than the usual method. About 188 adults having elective nonc…

This study tests a new monitoring tool called the Cerebral Adaptive Index (CAI) that may help doctors set personalized blood pressure targets during heart surgery. The tool tracks brain blood flow in real time. Researchers will observe 120 adults aged 45 and older who are at high…

This study is testing a new non-invasive blood pressure device that uses a cuff and special algorithm to measure blood pressure. Researchers will compare its readings to those from an arterial line, which is the most accurate method but requires a needle in an artery. The study i…

This study tests a new non-invasive blood pressure (NIBP) device in newborns and children up to 18 years old. The device uses a cuff on the arm or thigh to measure blood pressure without needles. Researchers compare these readings to standard invasive measurements to see how accu…

This study looks at whether home blood pressure readings can correctly identify different types of high blood pressure (like masked or white coat hypertension) in children aged 6 to 18. Researchers will compare home measurements to 24-hour ambulatory monitors in 52 kids referred …

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the back of the eye. Researchers will follow about 1,050 people with retinal diseases like diabetic retinopathy and healthy volunteers to see how these images can help detect early …

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study compares three new wearable blood pressure monitors (ABPMPro, Aktiia, and Spacelabs) to see how well they measure blood pressure and physical activity. One hundred adults with normal or high blood pressure will wear the devices for 48 hours. The goal is to find out if …

This study looks at how binge drinking in mid-life (ages 50-64) affects blood pressure, small blood vessels, and nerve activity. It compares binge drinkers to non-drinkers and moderate drinkers. In a second phase, binge drinkers will try 8 weeks of aerobic exercise to see if it i…

This study looks at whether women with high blood pressure who skip their medication have more sexual problems than those who take it regularly. Researchers will compare sexual function in 348 women using questionnaires and blood tests. The goal is to understand if not taking med…

This study follows 27 pregnant women living at high altitude in Bolivia and compares them to women at sea level. Researchers will use heart ultrasounds and blood tests to see how the body adapts to low oxygen levels during pregnancy. The goal is to better understand why some wome…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section, so better …

This study looks at the connection between high blood pressure and obstructive sleep apnea (OSA) using heart rate variability (HRV), a simple heart monitoring method. Researchers will track 100 adults with high blood pressure who are at risk for OSA, using heart monitors and slee…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and often experience high blood pressure during physical activity. Researchers will test whether regular cycling exercise, a drug called Kuvan, or supplements like histidine and beta-alanine …

This study looks at whether giving older adults (65+) with diabetes or high blood pressure access to their visit notes and audio recordings of their appointments helps them feel better and manage their health. About 1,022 participants will be randomly assigned to receive either w…

This study uses a quick, painless eye scan (OCT) to see if blood vessels in the eye look different in people with high blood pressure or chronic kidney disease compared to healthy people. Researchers want to learn if these differences improve with treatment. About 150 adults aged…

This study is looking at 150 Division I athletes from historically Black colleges and universities (HBCUs) to see how not getting enough calories—called low energy availability—might harm their hearts. Researchers will measure things like artery stiffness, blood sugar, and choles…

This study aims to see if a short, interval fitness test (the IFT 30-15) can reliably measure heart and lung fitness in both healthy people and those with high blood pressure or obesity. Researchers will compare results from this test with a standard treadmill test and a six-minu…

This study looks at whether a structured goal-setting program can help people with chronic conditions like high blood pressure, diabetes, or high cholesterol adopt healthier behaviors. Researchers will compare 600 participants who receive the program to those who get usual care. …

This study looks at whether giving low-income adults aged 40 and older free meal kits and nutrition education can improve their food security, diet quality, mental health, and heart health. About 120 participants will be split into two groups: one gets meal kits plus nutrition cl…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is testing a new way to understand how nerves in the kidney affect blood pressure. About 19 adults with high blood pressure will receive mild electrical stimulation to kidney nerves before and after a procedure that quiets those nerves. The goal is to learn how the bod…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study from the University of Oxford looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel disease later in life. Researchers will follow 200 women who gave birth 10 to 25 years ago, using heart scans, exercise tests…

This study looks at whether adding a heart ultrasound (echocardiogram) to regular check-ups helps doctors better manage high blood pressure in young adults aged 18 to 40. Researchers will collect data from 750 participants during their routine clinic visits and follow them for up…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study looks at how different arm positions change blood pressure readings in pregnant women. About 300 pregnant women will have their blood pressure taken with their arm in three positions: supported at heart level, on the lap, and hanging at the side. The goal is to find ou…

This study aims to find early signs of heart failure in women who had preeclampsia, a pregnancy complication involving high blood pressure. Researchers will use exercise stress tests and heart imaging to compare 250 women with a history of preeclampsia to 250 women with normal pr…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will measure stiffness caused by blood pressure itself and by changes in the artery wall, and explore genetic factors. The goal is to…

This study follows 462 women pregnant after egg donation or standard IVF to learn why pre-eclampsia is more common in egg donation pregnancies. Participants give blood samples and have regular check-ups throughout pregnancy. The goal is to find early warning signs and improve car…

This study is creating a registry of over 10,000 people with high blood pressure. Researchers will collect data on their health, treatments, and outcomes to find patterns and improve care. The goal is to help doctors provide more personalized and effective treatment based on real…

This study observes 50 adults having surgery to understand why their blood pressure drops. Researchers will use machine learning to find patterns in how different patients respond to treatment. The goal is to create personalized recommendations for managing low blood pressure dur…

This observational study will enroll 8,000 adults undergoing routine health checkups. Researchers will measure hormone levels and collect health data to understand how environment, genes, and proteins interact in conditions like high blood pressure and diabetes. The goal is to cr…

This study will screen blood pressure in over 22,000 children aged 5-18 across South Africa. The goal is to create the country's first reference charts for normal blood pressure, since current charts are based on US and European data. This will help doctors correctly diagnose and…

This pilot study looks at whether placing stents in narrowed arteries in the lower belly or pelvis can help lower blood pressure. About 20 adults with chronic blockages in these arteries will have their blood pressure measured before and 12 months after the procedure. The goal is…

This study watches 220 adults aged 75 and older who have high blood pressure. Researchers want to see if brief drops in daytime blood pressure (below 90 mmHg) raise the risk of falls, hospital stays, heart problems, or death. Participants wear a 24-hour blood pressure monitor and…

This study is checking whether people newly diagnosed with high blood pressure who also have high homocysteine levels are more likely to have early signs of heart stiffness. Researchers will measure homocysteine in blood and use ultrasound to look at heart function in 500 adults.…

This study looks at how the body controls blood pressure and heart rate in healthy young adults and older adults with high blood pressure. Participants will do tests like standing up and cycling while their heart and blood vessels are monitored. The goal is to better understand t…

This study tests whether a simple fetal ECG monitor worn at home can effectively track the health of babies in high-risk pregnancies. Fifty pregnant women who need weekly fetal testing will use the device for 30-minute sessions, three times a week, starting at 32 weeks. The goal …

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study partners with community organizations to improve participation in health research among Black, Latino, and Native American communities in Colorado. Researchers will track changes in diet, transportation access, and social support over time. The goal is to build lasting…

This study looks at how blocking certain nerve signals for two weeks changes the way the body produces sugar in people who have both obesity and high blood pressure. Twelve participants will receive a placebo, a blood pressure drug, or a nerve-blocking drug in a random order. The…

This study looks at whether fat around the kidney (called PRAT) affects kidney function and blood pressure in living kidney donors. Researchers will compare donors with more or less of this fat by taking blood, urine, and fat samples during surgery. The goal is to better manage b…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some have a 'non-dipping' pattern where blood pressure stays high at night. The goal is to uncover mec…

This study is building a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to explore how genetic variations relate to heart disease, high blood pressure, diabetes, and obesity. Participants provide samples and data, but no experime…

This study looks at whether three common blood pressure medications (beta-blockers, ACE inhibitors, and calcium channel blockers) affect balance and fall risk in adults newly diagnosed with high blood pressure. About 186 participants will be randomly assigned to one of the three …

This study looks at whether trained community health workers can effectively screen and manage chronic diseases like high blood pressure and diabetes in rural Lesotho. About 17,500 adults will take part, with health workers using simple tools and eHealth apps to monitor and refer…

This study looks at how different salty condiments, like soy sauce or fish sauce, affect blood pressure and blood vessel health shortly after eating. Researchers want to create a system to rank these condiments based on heart risks. The study involves 32 adults aged 50 to 75 with…

This study looks at how often people with cystic fibrosis and diabetes develop complications like eye, kidney, and nerve problems. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks in a diverse group of 200 adolescents and ad…

This study looks at why people with rheumatoid arthritis often have trouble controlling high blood pressure, which raises their risk of heart disease. Researchers will work with 25 adults to test a program that helps them monitor their blood pressure and share results with their …

This early-phase study tests a new MRI method that uses a special injection called hyperpolarized pyruvate to see how the heart uses energy. Researchers will scan the hearts of up to 112 people with high blood pressure, heart thickening, or heart failure. The goal is to see if th…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study looks at whether a specific change in the Corin gene (called I555/P568) makes high blood pressure more likely in people of African descent in Guadeloupe. Researchers will compare 370 adults with and without high blood pressure to see if this gene variant is more common…

This study looks at how early menopause (before age 45) affects the nerves that control blood pressure. Researchers will measure nerve activity and blood pressure in 160 women aged 35-70. The goal is to understand why these women may have higher blood pressure and find ways to he…

This pilot study tests whether a hospital unit-based program can reduce unnecessary changes to blood pressure medications for patients with high readings but no symptoms. The study will enroll 4 hospital units and track how often new or increased blood pressure drugs are ordered.…

This study will follow 20,000 adults in rural China for three years to understand how chronic diseases like high blood pressure, diabetes, and frailty develop. Participants will provide health data and samples to build a comprehensive database. The goal is to create better diseas…

This study is testing a new food questionnaire called EvalSel to see how well it measures salt intake in hospitalized patients with high blood pressure or kidney problems. Researchers will compare the questionnaire results with a 24-hour urine test, which is the gold standard for…

This study looks at how a single session of moderate or high-intensity exercise changes blood vessel function in healthy people and those with slightly high blood pressure. 45 adults will do three separate sessions: rest, moderate exercise, and high-intensity interval exercise. R…

This study looks at whether monitoring blood pressure through the femoral artery (in the groin) is better than the usual radial artery (in the wrist) during and after heart surgery. The goal is to see if femoral monitoring reduces the need for strong blood pressure medications an…

This study looks at data from the HeartMate 3 heart pump to see if it can help predict problems like bleeding, infection, or frailty in people with advanced heart failure. Researchers will track 150 adults getting the pump and compare pump alarms and readings to their health over…

This study is looking at children ages 7 to 18 who have been newly diagnosed with high blood pressure. Researchers want to understand how certain hormones in the body, like angiotensin-(1-7), may contribute to damage in the heart, kidneys, and blood vessels. Over two years, they …

This early-phase study is testing a new radioactive tracer called [18F]FNP-59 to see if it can safely and clearly image cholesterol in the adrenal glands using PET scans. Six healthy volunteers will receive a tiny, non-therapeutic dose of the tracer. The goal is to improve imagin…

This study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …

This study looks at how eating habits and zinc levels in hair are connected to body fat, inflammation, and blood pressure in women aged 19-49 from different ethnic groups in Jakarta. Researchers will measure diet, body composition, and blood markers in 188 women. The goal is to b…

This study aims to find out how common high blood pressure is in children and teenagers (ages 12-17) who are at risk for autosomal dominant polycystic kidney disease (ADPKD) because a parent has it. Researchers will use MRI scans and genetic tests to detect early signs of the dis…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study tests a 12-week program that provides education, navigation, and self-management support to African American adults hospitalized with advanced chronic kidney disease. The goal is to see if the program improves patients' understanding of kidney disease, blood pressure, …

This study looks at whether a non-invasive lung maneuver can help doctors predict if a child under general anesthesia will benefit from receiving fluids. The goal is to avoid giving unnecessary fluids when they won't help. The study will include 48 children having surgery at Bost…

This study tests whether wearing noise-canceling earplugs can lower stress and reduce heart disease risk in people annoyed by traffic noise. Researchers will use brain and blood vessel scans to measure changes over 6 months in 26 adults with heart risk factors. The goal is to see…

This study follows 300 people who are having weight-loss (metabolic) surgery to see how their gut bacteria change over time and how those changes relate to heart health, diabetes, and cholesterol. Participants provide blood and stool samples before surgery and at several follow-u…

This study from Indiana University looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, diet, blood pressure, and mental stress. Researchers will track 100 adults aged 18-75 using wearable devices, fitness tests, blood samples, and blood pressure…

This pilot study tests a program called PhytoRx Families that provides free fruits and vegetables to rural North Carolina families. The goal is to see if it helps them eat healthier and improve food security. The study will enroll 30 adult-child pairs (children ages 8-14) and mea…

This registry will follow 100 adults in France who undergo renal denervation (RDN) for high blood pressure. The procedure uses radiofrequency or ultrasound to calm overactive kidney nerves. Researchers will measure blood pressure changes at home and in the clinic over one year to…

This study looks at whether taking one dose of dexamethasone at bedtime can make screening for primary aldosteronism more accurate in people already taking blood pressure medications. Primary aldosteronism is a condition where the adrenal gland makes too much aldosterone, causing…

This study looks at how blood pressure and artery stiffness change over 24 hours in people at increased risk for heart disease, especially those with kidney problems. Researchers will monitor 120 participants using a wearable device and collect blood and urine samples. The goal i…

This study will monitor 1,000 hospitalized patients who receive tropicamide/phenylephrine eye drops, commonly used to dilate pupils before eye surgery. Researchers will measure vital signs and ask about side effects at several time points after the drops are given. The goal is to…

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…

This study tests whether using a blood pressure cuff to create short periods of reduced blood flow in the arm can improve how the brain regulates its own blood supply. 45 healthy adults aged 65-85 will either do the therapy daily, three times a week, or a sham version for 6 weeks…

This study will follow 9,000 people with type 2 diabetes and high blood pressure who are already taking dapagliflozin. Researchers want to see how well the drug controls blood sugar and blood pressure in real-life settings. It is an observational study, meaning no new treatment i…

Researchers at Mayo Clinic are studying 600 Somali-American adults to understand how common obstructive sleep apnea is and how it affects heart health. Participants will have sleep tests, blood pressure monitoring, and glucose testing. The goal is to learn about unique risk facto…

This study examines how a park-based afterschool program called Fit2Lead affects the mental health, resilience, physical fitness, and violence prevention of teens aged 12-17 in Miami-Dade County. Researchers will analyze data from 1,000 participants to see changes in weight, bloo…

This study follows 4,094 adults in Shanghai who were part of an earlier health survey. Researchers will track them for up to 10 years to see how heart disease, kidney problems, and metabolic conditions like diabetes and obesity develop and interact. The goal is to better understa…

This study looks at how different weights during resistance exercise affect blood pressure in women aged 50-70 with high blood pressure. Participants will do low-load or high-load exercises, or a non-exercise control task. Researchers will measure blood pressure changes right aft…

This study looks at how a natural gut hormone called GIP affects blood pressure after a meal. Sixteen healthy adults will receive either a GIP-blocking drug, a GIP-activating drug, or a placebo during a tilt-table test. The goal is to see if blocking or boosting GIP changes how b…

This study examines whether community park-based fitness programs can improve cardiovascular health in adults aged 50 and older. Researchers will analyze data from 1,000 participants who took part in exercise sessions including aerobics, strength training, and balance exercises. …

This study follows 5,000 children in a Miami-Dade park-based after-school program called Fit2Play. The program includes daily physical activity and nutrition lessons. Researchers will track changes in weight, fitness, blood pressure, and mental health over time to see if the prog…

This study tests whether giving young and middle-aged adults with high blood pressure a personalized genetic risk score helps them lower their blood pressure and adopt healthier habits. 300 participants will either receive standard care or get their genetic risk results along wit…