Pacemaker tweak could tame tough blood pressure

NCT ID NCT06059638

Recruiting now Disease control Sponsor: Orchestra BioMed, Inc Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 27 times

Summary

This study tests a special setting in a pacemaker that may help lower blood pressure. About 500 people who already have or need a pacemaker and have high blood pressure will take part. The setting adjusts the timing between heartbeats to improve blood pressure control. Participants continue their usual blood pressure medications during the study.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

AP-HP Hôpital Pitié Salpêtrière
RECRUITING

Paris, France
ASST Grande Ospedale Metropolitano Niguarda
NOT_YET_RECRUITING

Milan, Italy
Adventist Health Glendale
RECRUITING

Glendale, California, 91206, United States
Advocate Aurora Research Institute, LLC
RECRUITING

Milwaukee, Wisconsin, 53233, United States
Alfred Health Hospital
NOT_YET_RECRUITING

Melbourne, Victoria, 3004, Australia
Amsterdam University Medical Centre
RECRUITING

Amsterdam, Netherlands
Ascension Seton
RECRUITING

Austin, Texas, 78723, United States
Ascension St. Thomas Hospital
RECRUITING

Nashville, Tennessee, 37203, United States
Atrium Health - Sanger Heart
RECRUITING

Charlotte, North Carolina, 28210, United States
Azienda Ospedaliera Universitaria Integrata Verona
RECRUITING

Verona, Italy
Baptist Health Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Baptist Health Lexington
RECRUITING

Lexington, Kentucky, 40503, United States
Baptist Health South Florida
RECRUITING

Miami, Florida, 33176, United States
Baylor Scott & White Research Institute
RECRUITING

Dallas, Texas, 75204, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
CHRU Tours
RECRUITING

Tours, France
CHU Grenoble
RECRUITING

Grenoble, France
CHU de Nantes
RECRUITING

Nantes, France
Campus Bio-Medico University Hospital
RECRUITING

Rome, Italy
Cardioangiologisches Centrum Bethanien (CCB) am AGAPLESION Markus Krankenhaus
RECRUITING

Frankfurt, Germany
Cardiocentro Ticino Lugano
RECRUITING

Lugano, Switzerland
Cardiovascular Research Solutions (MyCardiologist)
RECRUITING

Celebration, Florida, 34747, United States
Centra Health dba Stroobants Cardiovascular Center
RECRUITING

Lynchburg, Virginia, 24501, United States
Central Hospital of Northern Pest - Military Hospital
RECRUITING

Budapest, Hungary
Centralny Szpital Kliniczny Uniwersytetu Medycznego w Łodzi
NOT_YET_RECRUITING

Lodz, Poland
ChristChurch Hospital
NOT_YET_RECRUITING

Christchurch, Canterbury, 8140, New Zealand
Citrus Cardiology Consultants
RECRUITING

Crystal River, Florida, 34429, United States
Clearwater Cardiovascular Consultants
RECRUITING

Clearwater, Florida, 33756, United States
Fakultní nemocnice Královské Vinohrady (FNKV)
RECRUITING

Prague, Czechia
Górnośląskie Centrum Medyczne im prof Leszka Gieca Śląskiego Uniwersytetu Medycznego w Katowicach
RECRUITING

Katowice, Poland
HCA Asheville Cardiology Associates
RECRUITING

Asheville, North Carolina, 28801, United States
HCA Florida JFK Hospital
RECRUITING

Atlantis, Florida, 33462, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Health Partners Institute (Methodist Heart and Vascular Center)
RECRUITING

Bloomington, Minnesota, 55425, United States
Henry Ford Health
RECRUITING

Detroit, Michigan, 48202-2689, United States
Herzzentrum Bonn am Universitätsklinikum Bonn
RECRUITING

Bonn, Germany
Herzzentrum Leipzig
NOT_YET_RECRUITING

Leipzig, Germany
Hightower Clinical Trials
RECRUITING

Oklahoma City, Oklahoma, 73102, United States
Hoag Memorial Hospital Presbyterian
RECRUITING

Newport Beach, California, 92633, United States
HonorHealth
RECRUITING

Scottsdale, Arizona, 85258, United States
Hospices Civils de Lyon (HCL)
RECRUITING

Lyon, France
Hospital Clínico de Barcelona
RECRUITING

Barcelona, Spain
Hospital Germans Trias i Pujol
RECRUITING

Badalona, Spain
Hospital Universitario Nuestra Señora de Candelaria
RECRUITING

Santa Cruz de Tenerife, Spain
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Hôpitaux Universitaires de Genève
RECRUITING

Geneva, Switzerland
IRCCS Sacro Cuore Don Calabria
RECRUITING

Verona, Italy
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Institute for Clinical and Experimental Medicine (IKEM)
RECRUITING

Prague, Czechia
Intermountain Health Lutheran Hospital
RECRUITING

Golden, Colorado, 80401, United States
Isala Klinieken
RECRUITING

Zwolle, Netherlands
Jagiellonian University Hospital
RECRUITING

Krakow, Poland
Jersey Shore University Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
John Radcliffe Hospital
RECRUITING

Oxford, United Kingdom
Krankenhaus der Barmherzigen Brüder Trier
RECRUITING

Trier, Germany
La Paz University Hospital
RECRUITING

Madrid, Spain
Lovelace Medical Center (New Mexico Heart Institute)
RECRUITING

Albuquerque, New Mexico, 87110, United States
Lyell McEwin Hospital
NOT_YET_RECRUITING

Elizabeth Vale, South Australia, 5112, Australia
Maastricht UMC+
RECRUITING

Maastricht, Netherlands
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Medstar Union Memorial Hospital
RECRUITING

Baltimore, Maryland, 21218, United States
Memorial Healthcare System
RECRUITING

Hollywood, Florida, 33021, United States
Michigan Heart
RECRUITING

Ypsilanti, Michigan, 48197, United States
Middelheim Ziekenhuis
RECRUITING

Antwerp, Belgium
Minneapolis Heart Institute
RECRUITING

Minneapolis, Minnesota, 55407, United States
Mount Sinai Medical Center of Florida
RECRUITING

Miami Beach, Florida, 33140, United States
Na Homolce Hospital
RECRUITING

Prague, Czechia
Northwell Health, Inc.
WITHDRAWN

New Hyde Park, New York, 11042, United States
OLV Ziekenhuis
RECRUITING

Aalst, Belgium
Ochsner Medical Center
RECRUITING

New Orleans, Louisiana, 70121, United States
OhioHealth Corporation
RECRUITING

Columbus, Ohio, 43214, United States
Penn Medicine Lancaster General Health
RECRUITING

Lancaster, Pennsylvania, 17602, United States
Penn Medicine at Doylestown Health Cardiology
RECRUITING

Doylestown, Pennsylvania, 18901, United States
Penn Presbyterian Medical Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Piedmont Healthcare, Inc.
RECRUITING

Atlanta, Georgia, 30309, United States
Policlinico Di Sant Orsola Malpighi
RECRUITING

Bologna, Italy
Royal Brompton
RECRUITING

London, United Kingdom
Saarland University Hospital
RECRUITING

Saarbrücken, Germany
Sarasota Memorial Hospital
RECRUITING

Sarasota, Florida, 34239, United States
Scripps Clinic
RECRUITING

San Diego, California, 92121, United States
Semmelweis University
RECRUITING

Budapest, Hungary
Silesian Center for Heart Diseases
RECRUITING

Zabrze, Poland
South Denver Cardiology
RECRUITING

Denver, Colorado, 80210, United States
South Oklahoma Heart Research
RECRUITING

Oklahoma City, Oklahoma, 73135, United States
Southampton General Hospital
RECRUITING

Southhampton, United Kingdom
St. Bartholomew's Hospital
RECRUITING

London, United Kingdom
St. Elizabeth's Medical Center
RECRUITING

Boston, Massachusetts, 02135, United States
St. Luke's Idaho Cardiology
RECRUITING

Boise, Idaho, 83712, United States
St. Thomas Hospital
RECRUITING

London, United Kingdom
Stanford
RECRUITING

Redwood City, California, 94063, United States
Stern Cardiovascular Foundation, Inc.
RECRUITING

Germantown, Tennessee, 38138, United States
Sutter Valley Hospitals
RECRUITING

San Francisco, California, 94109, United States
The Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
The Cardiac and Vascular Institute
RECRUITING

Gainesville, Florida, 32605, United States
The Cooper Health System
RECRUITING

Camden, New Jersey, 08103, United States
The Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States
The Lindner Research Center
RECRUITING

Cincinnati, Ohio, 45219, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
The Valley Hospital
TERMINATED

Ridgewood, New Jersey, 07450, United States
UMH-Sparrow Clinical Research
RECRUITING

Lansing, Michigan, 48912, United States
UZ Brussel
RECRUITING

Brussels, Belgium
UZ Leuven
RECRUITING

Leuven, Belgium
Universitaetsspital Basel
RECRUITING

Basel, Switzerland
Universitaetsspital Bern
RECRUITING

Bern, Switzerland
Universite Libre de Bruxelles-Erasme Hospital
RECRUITING

Brussels, Belgium
University Hospital Luebeck
RECRUITING

Lübeck, Germany
University Medical Centre Mannheim
RECRUITING

Mannheim, Germany
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Debrecen
RECRUITING

Debrecen, Hungary
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73019, United States
University of Rochester - Cardiology CCTU
NOT_YET_RECRUITING

Rochester, New York, 14642, United States
University of Szeged
RECRUITING

Szeged, Hungary
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, Germany
Universitätsmedizin Berlin, Deutsches Herzzentrum der Charité (DHZC)
RECRUITING

Berlin, Germany
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
RECRUITING

Wroclaw, Poland
Uniwersytecki Szpital Kliniczny nr 2 PUM
RECRUITING

Szczecin, Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, Poland
Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego
RECRUITING

Warsaw, Poland
Virtua Medical Group, P.A.
RECRUITING

Marlton, New Jersey, 08053, United States
WakeMed
RECRUITING

Raleigh, North Carolina, 27610, United States
Washington University St. Louis
RECRUITING

St Louis, Missouri, 63130, United States
Wellstar Research Institute
RECRUITING

Marietta, Georgia, 30060, United States
West Houston Area Clinical Trial Consultants (Wichita, KS)
RECRUITING

Wichita, Kansas, 67226, United States
West Virginia University
RECRUITING

Morgantown, West Virginia, 26506, United States
Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego
RECRUITING

Lublin, Poland

Conditions

Explore the condition pages connected to this study.

HYPERTENSION HYPERTENSION, SYSTOLIC HYPERTENSION,ESSENTIAL